Activity/Stability of Human Pepsin: Implications for Reflux Attributed Laryngeal Disease

No abstract is available for this paper.

• Publication year

  2007

• Venue

  The Laryngoscope

• Publication date

  2007-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/MLG.0b013e31804154c3PMID 17417109
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Gastroesophageal and pharyngeal reflux detection using impedance and 24-hour pH monitoring in asymptomatic subjects: Defining the normal environment

  2007cited by this paper
• Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive therapy: a multicentre study using combined ambulatory impedance-pH monitoring

  2006cited by this paper
• Effect of Pepsin on Laryngeal Stress Protein (Sep70, Sep53, and Hsp70) Response: Role in Laryngopharyngeal Reflux Disease

  2006cited by this paper
• Is GERD a Risk Factor for Laryngeal Cancer?

  2005cited by this paper
• Omeprazole does not reduce gastroesophageal reflux: new insights using multichannel intraluminal impedance technology

  2004cited by this paper
• Pepsin and Carbonic Anhydrase Isoenzyme III as Diagnostic Markers for Laryngopharyngeal Reflux Disease

  2004cited by this paper
• Physical and pH Properties of Gastroesophagopharyngeal Refluxate: A 24-hour Simultaneous Ambulatory Impedance and pH Monitoring Study

  2004cited by this paper
• Cell Biology of Laryngeal Epithelial Defenses in Health and Disease: Further Studies

  2003cited by this paper
• Esomeprazole (40 mg) compared with lansoprazole (30 mg) in the treatment of erosive esophagitis

  2002cited by this paper
• The human oesophageal squamous epithelium exhibits a novel type of heat shock protein response.

  2001cited by this paper
• Cell Biology of Laryngeal Epithelial Defenses in Health and Disease: Preliminary Studies

  2001cited by this paper
• Assay of gastricsin and individual pepsins in human gastric juice.

  1993cited by this paper
• Lipoinjection for vocal card paralysis

  1991cited by this paper
• The Otolaryngologic Manifestations of Gastroesophageal Reflux Disease (GERD): A Clinical Investigation of 225 Patients Using Ambulatory 24‐Hour pH Monitoring and an Experimental Investigation of the Role of Acid and Pepsin in the Development of Laryngeal Injury

  1991cited by this paper
• A systematic series of synthetic chromophoric substrates for aspartic proteinases.

  1986cited by this paper
• pH stability and activity curves of pepsin with special reference to their clinical importance.

  1965cited by this paper

• Pathogenesis of pepsin-induced gastroesophageal reflux disease with advanced diagnostic tools and therapeutic implications

  2025cites this paper
• Diagnostic value of Peptest™ combined with gastroesophageal reflux disease questionnaire in identifying patients with gastroesophageal reflux-induced chronic cough

  2025cites this paper
• A Paper‐Based Sensor for the Detection of Gastroesophageal Reflux Disease Utilizing a Cleavable Fluorescent Polymer

  2025cites this paper
• Human Vocal Fold Tissue Modifications Related to Laryngopharyngeal Reflux Disease: A Systematic Review.

  2025cites this paper
• Pepsin, Mucosal Injury, and Pathophysiology of Non-acid Reflux.

  2025cites this paper
• Influence of Diet on the Bioaccessibility of Zn from Dietary Supplements: Findings from an In Vitro Digestion Model and Analytical Determinations

  2025cites this paper
• Laryngopharyngeal Reflux: The Impact of Obesity

  2025cites this paper
• Gastrointestinal Stability, Antimicrobial Retention, and Gut Microbiota Modulation by Bovine Lactoferrin: An Integrated in vitro and vivo Study

  2025cites this paper
• The Role of Laryngopharyngeal Reflux Disease in Laryngeal and Hypopharyngeal Squamous Cell Carcinoma: A Systematic Review.

  2025cites this paper
• Computational analysis of propeptide‐containing proteins and prediction of their post‐cleavage conformation changes

  2024cites this paper
• Does Extraesophageal Reflux Support the Development of Lung Adenocarcinoma? Analysis of Pepsin in Bronchoalveolar Lavage in Non-Smoker Patients

  2024cites this paper
• Cleavage Reaction Lateral Flow Assays for Salivary Pepsin Measurement Using a Pepsin-Susceptible Peptide Substrate

  2024cites this paper
• Acidic Pepsin Affects Laryngeal Carcinoma Cell Growth and Invasion Through Glycolysis

  2024cites this paper
• Effect of processing infant milk formula on protein digestion and gut barrier health (in vitro and preclinical).

  2024cites this paper
• Diagnostic value of fasting hypopharyngeal salivary pepsin concentration test for laryngopharyngeal reflux disease

  2024cites this paper
• A Novel Laryngopharyngeal Reflux Disease Model for Bama Pigs.

  2024cites this paper
• In Response to The Dubai Definition and Diagnostic Criteria of Laryngopharyngeal Reflux: The IFOS Consensus

  2024cites this paper
• Pepsin Inhibitors Prevent Inflammation and Loss of Laryngeal Barrier Function in Mice with Gastroesophageal Reflux

  2024cites this paper
• Global Transcriptomic Analysis of Topical Sodium Alginate Protection against Peptic Damage in an In Vitro Model of Treatment-Resistant Gastroesophageal Reflux Disease

  2024cites this paper
• CD-MOFs: From preparation to drug delivery and therapeutic application.

  2024cites this paper
• Spotlight on: Nature, assessment, and management of laryngopharyngeal reflux

  2023cites this paper
• Personalized Treatments Based on Laryngopharyngeal Reflux Patient Profiles: A Narrative Review

  2023influential citation
• Can pepsin immunohistochemical staining of laryngeal lesions accurately diagnose non-acid laryngeal reflux?

  2023cites this paper
• Association Between Chronic Rhinosinusitis and Reflux Diseases in Adults: A Systematic Review and Meta-Analysis

  2023cites this paper
• Amprenavir inhibits pepsin‐mediated laryngeal epithelial disruption and E‐cadherin cleavage in vitro

  2023cites this paper
• A One Health review of aerodigestive disease in dogs

  2023cites this paper
• Salivary pepsin as an independent predictor of treatment response for laryngopharyngeal reflux: prospective cohort study with multivariate analysis

  2023influential citation
• Is magnetic sphincter augmentation indicated in patients with laryngopharyngeal reflux?

  2023cites this paper
• The Protease Inhibitor Amprenavir Protects against Pepsin-Induced Esophageal Epithelial Barrier Disruption and Cancer-Associated Changes

  2023cites this paper
• Evaluating the effect of food components on the digestion of dietary nucleic acids in human gastric juice in vitro

  2023cites this paper
• Is it always Laryngopharyngeal Reflux? How Voice Disorders Can Manifest as LPR

  2023cites this paper
• Portable and Rapid Fluorescence Turn-On Detection of Total Pepsin in Saliva Based on Strong Electrostatic Interactions.

  2023cites this paper
• Pediatric Laryngopharyngeal Reflux in the Last Decade: What Is New and Where to Next?

  2023cites this paper
• The Exploration of Bioactive Peptides that Docked to SARS-CoV-2 Spike Protein from Goats’ Milk Beta-Casein by In Silico

  2023cites this paper
• Pepsin concentration in oral lavage fluid of rabbit reflux model constructed by dilating the lower esophageal sphincter

  2023cites this paper
• High antimicrobial activity of lactoferricin‐expressing Bacillus subtilis strains

  2022cites this paper
• The Profiles of Laryngopharyngeal Reflux in Patients With Different Vocal Fold Lesions.

  2022cites this paper
• Association of enteral feeding with microaspiration in critically ill adults.

  2022cites this paper
• Detergent-Free Decellularization of Notochordal Cell-Derived Matrix Yields a Regenerative, Injectable, and Swellable Biomaterial

  2022cites this paper
• Acoustic measurements are useful therapeutic indicators of patients with dysphonia-related to reflux

  2022cites this paper
• Ultrasonic analysis of effects of varying temperature, pH, and proteolytic enzymes on hydrolysis of lactose by neutral lactase formulations in infant milk and in the infant digestive system.

  2022cites this paper
• Extracellular Secretion and Simple Purification of Bacterial Collagen from Escherichia coli.

  2022cites this paper
• Monitoring food structure in plant protein gels during digestion: rheometry and Small Angle Neutron Scattering studies

  2022cites this paper
• Oral and Inhaled Fosamprenavir Reverses Pepsin‐Induced Damage in a Laryngopharyngeal Reflux Mouse Model

  2022cites this paper
• Impact of Acid, Weakly Acid and Alkaline Laryngopharyngeal Reflux on Voice Quality.

  2021cites this paper
• Proteomic Characterization of Canine Gastric Fluid by Liquid Chromatography–Mass Spectrometry for Development of Protein Biomarkers in Regurgitation, Vomiting, and Cough

  2021cites this paper
• Diagnosing Laryngopharyngeal Reflux: A Comparison between 24-hour pH-Impedance Testing and Pharyngeal Probe (Restech) Testing, with Introduction of the Sataloff Score.

  2021cites this paper
• Association between gastroesophageal reflux disease and vocal fold polyps

  2021cites this paper
• Synthesis of peptide derivative as bio adhesive

  2021cites this paper
• Pepsin and pH of Gastric Juice in Patients With Gastrointestinal Reflux Disease and Subgroups

  2021cites this paper
• Evaluation of the effects of isoniazid and rifampin on the structure and activity of pepsin enzyme by multi spectroscopy and molecular modeling methods.

  2021cites this paper
• Pepsin Promotes Activation of Epidermal Growth Factor Receptor and Downstream Oncogenic Pathways, at Slightly Acidic and Neutral pH, in Exposed Hypopharyngeal Cells

  2021cites this paper
• The efficacy of a personalised treatment depending on the characteristics of reflux at multichannel intraluminal impedance‐pH monitoring in patients with acid, non‐acid and mixed laryngopharyngeal reflux

  2021cites this paper
• Periprosthetic Leakage in Tracheoesophageal Prosthesis: Proposal of a Standardized Therapeutic Algorithm

  2021cites this paper
• Pepsin properties, structure, and its accurate measurement: a narrative review

  2021cites this paper
• Prevalence and Features of Laryngopharyngeal Reflux in Patients with Primary Burning Mouth Syndrome

  2021cites this paper
• How I Approach Laryngopharyngoesophageal Reflux (LPR)

  2021cites this paper
• Laryngopharyngeal reflux concept: what is known and what should we focus on?

  2021cites this paper
• Effects of acids, pepsin, bile acids, and trypsin on laryngopharyngeal reflux diseases: physiopathology and therapeutic targets

  2021cites this paper
• Phytotherapeutische Ansätze zur Behandlung des laryngopharyngealen Reflux in der HNO-Praxis

  2021cites this paper
• Laryngopharyngeal reflux concept: what is known and what should we focus on?

  2021cites this paper
• Association of Dry Eye with Laryngopharyngeal Reflux in Clinical Practice

  2021cites this paper
• Rapid and Simple Analysis of the Human Pepsin Secondary Structure Using a Portable Raman Spectrometer.

  2021cites this paper
• Laryngopharyngeal reflux concept: what is known and what should we focus on?

  2021cites this paper
• Gastric Acid and Pepsin Roles in Reflux Disease

  2020cites this paper
• The Pathophysiology of Gastroesophageal Re fl ux

  2020cites this paper
• The role of pepsin in epithelia‐mesenchymal transition in idiopathic subglottic stenosis

  2020cites this paper
• Aerodigestive Disease in Dogs.

  2020cites this paper
• Relationship Between Pepsin Expression and Dysplasia Grade in Patients With Vocal Cord Leukoplakia

  2020cites this paper
• Tracking Enzyme Hydrolysis of an Amide Bond Using Highly Simplified 4-nitroanilide Colorimetric Substrate

  2020cites this paper
• Is the pepsin immunohistochemical staining of laryngeal lesions an available way for diagnosing laryngopharyngeal reflux

  2020cites this paper
• Frequency of gastroesophageal reflux disease in children with adenoid hypertrophy.

  2020cites this paper
• Plant-Based Dietary Approach for the Treatment of LPR

  2020cites this paper
• [Intraoperative Aspiration].

  2020cites this paper
• H+/K+ATPase Expression in the Larynx of Laryngopharyngeal Reflux and Laryngeal Cancer Patients

  2020cites this paper
• Production of F(ab′)2 from Monoclonal and Polyclonal Antibodies

  2020cites this paper
• The Impact of Laryngopharyngeal Reflux on Patient-reported Measures of Chronic Rhinosinusitis

  2020cites this paper
• Pepsin in gastroesophageal and extraesophageal reflux: molecular pathophysiology and diagnostic utility

  2020cites this paper
• What is the truth about proton pump inhibitors?

  2020cites this paper
• Laryngopharyngeal and Gastroesophageal Reflux: A Comprehensive Guide to Diagnosis, Treatment, and Diet-Based Approaches

  2020cites this paper
• Laryngopharyngeal reflux and the Mediterranean diet

  2020cites this paper
• Evidence of Pepsin-Related Ocular Surface Damage and Dry Eye (PROD Syndrome) in Patients with Laryngopharyngeal Reflux

  2020cites this paper
• Management of Laryngopharyngeal Reflux: A Practical Algorithm Management for Primary care Physicians

  2020cites this paper
• Utilidad clínica de la determinación de pepsina en saliva en pacientes con tos crónica asociada a refujo

  2020cites this paper
• Therapeutic assessment of fractions of Gastrodiae Rhizoma on chronic atrophic gastritis by 1H NMR-based metabolomics.

  2020cites this paper
• RNA Sequencing Reveals Cancer‐Associated Changes in Laryngeal Cells Exposed to Non‐Acid Pepsin

  2020cites this paper
• Proximal reflux: biochemical mediators, markers, therapeutic targets, and clinical correlations

  2020cites this paper
• Laryngopharyngeal Reflux: Symptoms, Signs, and Presence of Pepsin in Saliva - A Reliable Diagnostic Triad

  2020cites this paper
• Comparative bioinformatic and structural analyses of pepsin and renin.

  2020cites this paper
• Association of pepsin and DNA damage in laryngopharyngeal reflux-related vocal fold polyps.

  2020cites this paper
• H.pylori and Pepsin as a Putative Risk Factors in Laryngeal Cancer Patients.

  2020cites this paper
• Association Between Laryngopharyngeal Reflux and Benign Lesions of the Vocal Folds

  2020cites this paper
• Lifestyle and Dietary Modifications

  2019cites this paper
• ACE Inhibitory and Antioxidative Bioactive Peptides Derived from Hydrolyzed Soy Milk

  2019cites this paper
• Laryngopharyngeal Reflux

  2019cites this paper
• The Approach to a Patient with Suspected Laryngopharyngeal Reflux Disease (LPRD)

  2019cites this paper
• Investigation of Pepsin in Laryngeal Squamous Cell Carcinoma Specimens

  2019cites this paper
• Evaluation of Important Analytical Parameters of the Peptest Immunoassay that Limit its Use in Diagnosing Gastroesophageal Reflux Disease

  2019cites this paper
• The role of Gastro Esophageal Reflux in Chronic Rhinosinusitis

  2019cites this paper
• Heat shock protein 70 is induced by pepsin via MAPK signaling in human nasal epithelial cells

  2019cites this paper