Traditional Chinese Medicine Regulating Lymphangiogenesis: A Literature Review

Lymphatic vessels, as an important part of the lymphatic system, form a fine vascular system in humans and play an important role in regulating fluid homeostasis, assisting immune surveillance and transporting dietary lipids. Dysfunction of lymphatic vessels can cause many diseases, including cancer, cardiovascular diseases, lymphedema, inflammation, rheumatoid arthritis. Research on lymphangiogenesis has become increasingly important over the last few decades. Nevertheless, the explicit role of regulating lymphangiogenesis in preventing and treating diseases remains unclear owing to the lack of a deeper understanding of the cellular and molecular pathways of the specific and tissue-specific changes in lymphangiopathy. TCM, consisting of compound extracted from TCM, Injections of single TCM and formula, is an important complementary strategy for treating disease in China. Lots of valuable traditional Chinese medicines are used as substitutes or supplements in western countries. As one of the main natural resources, these TCM are widely used in new drug research and development in Asia. Moreover, as a historical and cultural heritage, TCM has been widely applied to clinical research on lymphangiogenesis leveraging new technologies recently. Available studies show that TCM has an explicit effect on the regulation of lymphatic regeneration. This review aims to clarify the function and mechanisms, especially the inhibitory effect of TCM in facilitating and inhibiting lymphatic regeneration.

• Publication year

  2020

• Venue

  Frontiers in Pharmacology

• Publication date

  2020-09-03

• Fields of study

  Medicine

• Identifiers
  DOI 10.3389/fphar.2020.01259PMID 33013360PMCID 7495091
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hedyotis diffusa Willd. inhibits VEGF‑C‑mediated lymphangiogenesis in colorectal cancer via multiple signaling pathways.

  2019cited by this paper
• Curcumin inhibits the lymphangiogenesis of gastric cancer cells by inhibiton of HMGB1/VEGF-D signaling

  2019cited by this paper
• Shikonin Suppresses Lymphangiogenesis via NF-κB/HIF-1α Axis Inhibition.

  2018influential reference
• Oxyresveratrol prevents murine H22 hepatocellular carcinoma growth and lymph node metastasis via inhibiting tumor angiogenesis and lymphangiogenesis

  2018cited by this paper
• Cardiac lymphatics in health and disease

  2018cited by this paper
• Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1

  2017cited by this paper
• Lymphangiogenesis guidance by paracrine and pericellular factors

  2017cited by this paper
• Anti-metastatic Efficacy of Traditional Chinese Medicine (TCM) Ginsenoside Conjugated to a VEFGR-3 Antibody on Human Gastric Cancer in an Orthotopic Mouse Model.

  2017cited by this paper
• Interleukin-33 promotes inflammation-induced lymphangiogenesis via ST2/TRAF6-mediated Akt/eNOS/NO signalling pathway

  2017cited by this paper
• The Lymphatic System: Integral Roles in Immunity.

  2017cited by this paper
• Bone Marrow Derived Mesenchymal Stem Cells Involve in the Lymphangiogenesis of Lung Cancer and Jinfukang Inhibits the Involvement In Vivo

  2017cited by this paper
• Lymphatic System in Cardiovascular Medicine.

  2016cited by this paper
• Jin Fu Kang Oral Liquid Inhibits Lymphatic Endothelial Cells Formation and Migration

  2016cited by this paper
• The Antitumor Effect of Gekko Sulfated Glycopeptide by Inhibiting bFGF-Induced Lymphangiogenesis

  2016cited by this paper
• VEGF Pathways in the Lymphatics of Healthy and Diseased Heart

  2016cited by this paper
• Carbohydrate-binding protein CLEC14A regulates VEGFR-2– and VEGFR-3–dependent signals during angiogenesis and lymphangiogenesis

  2016cited by this paper
• TNF-alpha promotes lymphangiogenesis and lymphatic metastasis of gallbladder cancer through the ERK1/2/AP-1/VEGF-D pathway

  2016cited by this paper
• Pien Tze Huang suppresses VEGF-C-mediated lymphangiogenesis in colorectal cancer.

  2016cited by this paper
• Total saponins of panaxnotoginseng promotes lymphangiogenesis by activation VEGF-C expression of lymphatic endothelial cells.

  2016cited by this paper
• Resveratrol Prevents Tumor Growth and Metastasis by Inhibiting Lymphangiogenesis and M2 Macrophage Activation and Differentiation in Tumor-associated Macrophages

  2016cited by this paper
• Ginsenoside Rg1 enhances lymphatic transport of intrapulmonary silica via VEGF-C/VEGFR-3 signaling in silicotic rats.

  2016influential reference
• Selective Stimulation of Cardiac Lymphangiogenesis Reduces Myocardial Edema and Fibrosis Leading to Improved Cardiac Function Following Myocardial Infarction

  2016cited by this paper
• in vitro and in vivo

  2016cited by this paper
• Lymphatic endothelial cells efferent to inflamed joints produce iNOS and inhibit lymphatic vessel contraction and drainage in TNF-induced arthritis in mice

  2016cited by this paper
• [Effect of Jinlongshe Granule Drug-containing Serum on Tube Formation, Migration and Apoptosis of Human Lymphatic Endothelial Cells in vitro].

  2016influential reference
• Licoricidin, an Active Compound in the Hexane/Ethanol Extract of Glycyrrhiza uralensis, Inhibits Lung Metastasis of 4T1 Murine Mammary Carcinoma Cells

  2016influential reference
• Du-Huo-Ji-Sheng-Tang Attenuates Inflammation of TNF-Tg Mice Related to Promoting Lymphatic Drainage Function

  2016influential reference
• Curcumin inhibits lymphangiogenesis in vitro and in vivo.

  2015cited by this paper
• Cardiac lymphatics are heterogeneous in origin and respond to injury

  2015cited by this paper
• Expression of hepatocyte growth factor and c-Met in non-small-cell lung cancer and association with lymphangiogenesis.

  2015cited by this paper
• Norcantharidin Inhibits Lymphangiogenesis by Downregulating the Expression of VEGF-C and VEGF-D in Human Dermal Lymphatic Endothelial Cells in vitro

  2015cited by this paper
• A potential small-molecule synthetic antilymphangiogenic agent norcantharidin inhibits tumor growth and lymphangiogenesis of human colonic adenocarcinomas through blocking VEGF-A,-C,-D/VEGFR-2,-3 “multi-points priming” mechanisms in vitro and in vivo

  2015influential reference
• Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum

  2015cited by this paper
• Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate.

  2014cited by this paper
• Effects of Adenosine on Lymphangiogenesis

  2014cited by this paper
• β-Elemene inhibits lymphangiogenesis by regulating the VEGF-C/VEGFR-3 signaling in gastric cancer cells xenografted nude mice

  2014influential reference
• Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy.

  2014cited by this paper
• Effects of Shugan Jianpi Formula on urine metabonomic in rats with hepatic fibrosis induced by CCl_4

  2014cited by this paper
• Bone Morphogenetic Protein 2 Signaling Negatively Modulates Lymphatic Development in Vertebrate Embryos

  2014cited by this paper
• Effects of Astragalus Injection on Micro Lymphatic Vessel Density and HIF-1αExpressions in Organization for Differentiated Thyroid Cancer

  2014influential reference
• Lymphangiogenesis and lymphatic vessel remodelling in cancer

  2014cited by this paper
• Use of traditional Chinese medicine in Chinese patients with coronary heart disease.

  2013cited by this paper
• Insulin-like growth factor-1 induces lymphangiogenesis and facilitates lymphatic metastasis in colorectal cancer.

  2013cited by this paper
• EGFR-TKI resistance due to BIM polymorphism can be circumvented in combination with HDAC inhibition.

  2013cited by this paper
• Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis.

  2013cited by this paper
• Thrombocytes Correlate with Lymphangiogenesis in Human Esophageal Cancer and Mediate Growth of Lymphatic Endothelial Cells In Vitro

  2013cited by this paper
• Serum insulin-like growth factor 1 correlates with the risk of nodal metastasis in endocrine-positive breast cancer.

  2013cited by this paper
• The effect of cinobufacini injection on proliferation and tube-like structure formation of human lymphatic endothelial cells

  2013cited by this paper
• Transgenic overexpression of interleukin-1β induces persistent lymphangiogenesis but not angiogenesis in mouse airways.

  2013cited by this paper
• Collaborative interplay between FGF-2 and VEGF-C promotes lymphangiogenesis and metastasis

  2012cited by this paper
• In Vitro Assays Using Primary Embryonic Mouse Lymphatic Endothelial Cells Uncover Key Roles for FGFR1 Signalling in Lymphangiogenesis

  2012cited by this paper
• Suppression of lymphangiogenesis in human lymphatic endothelial cells by simultaneously blocking VEGF-C and VEGF-D/VEGFR-3 with norcantharidin.

  2012cited by this paper
• [Drug discovery and natural products: end of era or an endless frontier?].

  2011cited by this paper
• Shikonin extracted from medicinal Chinese herbs exerts anti-inflammatory effect via proteasome inhibition.

  2011cited by this paper
• Norcantharidin analogues: a patent review (2006 – 2010)

  2011cited by this paper
• [Intervention of rukangyin on the lymphangiogenesis in breast cancer metastasis nude spontaneous mouse model].

  2011cited by this paper
• Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytes

  2011influential reference
• T lymphocytes negatively regulate lymph node lymphatic vessel formation.

  2011cited by this paper
• The lymphatic vasculature in disease

  2011cited by this paper
• Norcantharidin: a potential antiangiogenic agent for gallbladder cancers in vitro and in vivo.

  2011cited by this paper
• Effects of Shenmai Injection on Proliferation and Apoptosis of Lymphatic Endothelial Cells

  2011cited by this paper
• Intervention of Rukangyin on the Lymphangiogenesis in Breast Cancer Spontaneous Metastasis Nude Mouse Model

  2011cited by this paper
• Cryptotanshinone Inhibits Lymphatic Endothelial Cell Tube Formation by Suppressing VEGFR-3/ERK and Small GTPase Pathways

  2011cited by this paper
• Lymphatic vasculature is increased in heart valves, ischaemic and inflamed hearts and in cholesterol‐rich and calcified atherosclerotic lesions

  2011cited by this paper
• Lymphotoxin-alpha contributes to lymphangiogenesis.

  2010cited by this paper
• Netrin-4 induces lymphangiogenesis in vivo.

  2010cited by this paper
• Blockade of transforming growth factor-beta1 accelerates lymphatic regeneration during wound repair.

  2010cited by this paper
• Norcantharidin inhibits growth of human gallbladder carcinoma xenografted tumors in nude mice by inducing apoptosis and blocking the cell cycle in vivo.

  2010cited by this paper
• The role of lymphatic vessels in the heart.

  2010cited by this paper
• Tumor metastasis and the lymphatic vasculature

  2009cited by this paper
• Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

  2009cited by this paper
• Liposomal honokiol inhibits VEGF‐D‐induced lymphangiogenesis and metastasis in xenograft tumor model

  2009cited by this paper
• Norcantharidin is a small-molecule synthetic compound with anti-angiogenesis effect.

  2009cited by this paper
• Hyperforin and aristoforin inhibit lymphatic endothelial cell proliferation in vitro and suppress tumor‐induced lymphangiogenesis in vivo

  2009cited by this paper
• The experiment research of inhibitory effect of ATU-Ion lymphangiogenesis of HCa-F liver cancer in 615 mice

  2009cited by this paper
• Endothelin-1 stimulates lymphatic endothelial cells and lymphatic vessels to grow and invade.

  2009cited by this paper
• Artemether-lumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: a longitudinal, randomized trial in young Ugandan children.

  2009cited by this paper
• Influence of 20(R)-ginsenoside Rg3 on lymphangenesis

  2009influential reference
• Tumour necrosis factor blockade increases lymphangiogenesis in murine and human arthritic joints

  2008cited by this paper
• Drug delivery with carbon nanotubes for in vivo cancer treatment.

  2008influential reference
• Shikonin, acetylshikonin, and isobutyroylshikonin inhibit VEGF-induced angiogenesis and suppress tumor growth in lewis lung carcinoma-bearing mice.

  2008cited by this paper
• Inhibition of endogenous TGF-beta signaling enhances lymphangiogenesis.

  2008cited by this paper
• TGF- (cid:1) 1 is a negative regulator of lymphatic regeneration during wound repair

  2008cited by this paper
• Antitumor effect and mechanism of Gecko on human esophageal carcinoma cell lines in vitro and xenografted sarcoma 180 in Kunming mice.

  2008cited by this paper
• Artemisinin Inhibits Tumor Lymphangiogenesis by Suppression of Vascular Endothelial Growth Factor C

  2008cited by this paper
• Calcitonin receptor-like receptor guides arterial differentiation in zebrafish.

  2008influential reference
• Adrenomedullin stimulates angiogenic response in cultured human vascular endothelial cells: involvement of the vascular endothelial growth factor receptor 2.

  2008cited by this paper
• [Effect of ginsenoside Rh2 on transplanted-tumor and expression of JAM in mice].

  2008cited by this paper
• Traditional Chinese medicine.

  2008cited by this paper
• TGF-beta1 is a negative regulator of lymphatic regeneration during wound repair.

  2008cited by this paper
• Curcumin inhibits the formation of capillary-like tubes by rat lymphatic endothelial cells.

  2007cited by this paper
• Lymphotoxin β receptor signaling is required for inflammatory lymphangiogenesis in the thyroid

  2007cited by this paper
• Hypoxia alters the adhesive properties of lymphatic endothelial cells. A transcriptional and functional study.

  2007cited by this paper
• Inhibitory effect of norcantharidin on the growth of human gallbladder carcinoma GBC-SD cells in vitro.

  2007cited by this paper
• Endostatin overexpression inhibits lymphangiogenesis and lymph node metastasis in mice.

  2007cited by this paper
• In Vivo Actions of Angiopoietins on Quiescent and Remodeling Blood and Lymphatic Vessels in Mouse Airways and Skin

  2007cited by this paper
• Hypoxia/Notch signaling in primary culture of rat lymphatic endothelial cells

  2007cited by this paper
• Induction of Apoptosis and Inhibition of Cell Migration and Tube-Like Formation by Dihydroartemisinin in Murine Lymphatic Endothelial Cells

  2007cited by this paper
• Lymphangiogenesis in myocardial remodelling after infarction

  2007cited by this paper
• Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of action.

  2006cited by this paper

• Lymphangiogenesis: A new strategy for heart disease treatment (Review)

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• Terpene extract from the stem of Celastrus orbiculatus inhibits actin cytoskeleton remodelling in gastric cancer cells by regulating the protein interaction between PTBP1 and ACTN4

  2024cites this paper
• Promising Strategies to Reduce the SARS-CoV-2 Amyloid Deposition in the Brain and Prevent COVID-19-Exacerbated Dementia and Alzheimer’s Disease

  2024cites this paper
• Hydroxysafflor yellow A regulates lymphangiogenesis and inflammation via the inhibition of PI3K on regulating AKT/mTOR and NF-κB pathway in macrophages to reduce atherosclerosis in ApoE-/- mice.

  2023cites this paper
• Kuoxin Decoction promotes lymphangiogenesis in zebrafish and in vitro based on network analysis

  2022cites this paper
• Prostate cancer treatment - China's perspective.

  2022cites this paper