The B cell antigen receptor activates the Akt (protein kinase B)/glycogen synthase kinase-3 signaling pathway via phosphatidylinositol 3-kinase.

We have previously shown that the B cell Ag receptor (BCR) activates phosphatidylinositol (PI) 3-kinase. We now show that a serine/threonine kinase called Akt or protein kinase B is a downstream target of PI 3-kinase in B cells. Akt has been shown to promote cell survival as well as the transcription and translation of proteins involved in cell cycle progression. Using an Ab that specifically recognizes the activated form of Akt that is phosphorylated on serine 473, we show that BCR engagement activates Akt in a PI 3-kinase-dependent manner. These results were confirmed using in vitro kinase assays. Moreover, BCR ligation also induced phosphorylation of Akt of threonine 308, another modification that is required for activation of Akt. In the DT40 chicken B cell line, phosphorylation of Akt on serine 473 was completely dependent on the Lyn tyrosine kinase, while the Syk tyrosine kinase was required for sustained phosphorylation of Akt. Complementary experiments in BCR-expressing AtT20 endocrine cells confirmed that Src kinases are sufficient for BCR-induced Akt phosphorylation, but that Syk is required for sustained phosphorylation of Akt on both serine 473 and threonine 308. In insulin-responsive cells, Akt phosphorylates and inactivates the serine/threonine kinase glycogen synthase kinase-3 (GSK-3). Inactivation of GSK-3 may promote nuclear accumulation of several transcription factors, including NF-ATc. We found that BCR engagement induced GSK-3 phosphorylation and decreased GSK-3 enzyme activity. Thus, BCR ligation initiates a PI 3-kinase/Akt/GSK-3 signaling pathway.

• Publication year

  1999

• Venue

  Journal of Immunology

• Publication date

  1999-08-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.4049/jimmunol.163.4.1894PMID 10438924
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast.

  1999cited by this paper
• Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.

  1999cited by this paper
• Rapid and efficient retrovirus-mediated gene transfer into B cell lines.

  1999cited by this paper
• Mammalian target of rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling.

  1998cited by this paper
• SHIP modulates immune receptor responses by regulating membrane association of Btk.

  1998cited by this paper
• Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.

  1998cited by this paper
• Regulation of cell death protease caspase-9 by phosphorylation.

  1998cited by this paper
• Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway*

  1998cited by this paper
• Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.

  1998cited by this paper
• The Gab1 Protein Is a Docking Site for Multiple Proteins Involved in Signaling by the B Cell Antigen Receptor*

  1998cited by this paper
• Construction and Characterization of a Conditionally Active Version of the Serine/Threonine Kinase Akt*

  1998cited by this paper
• Insulin, but Not Contraction, Activates Akt/PKB in Isolated Rat Skeletal Muscle*

  1998cited by this paper
• Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B‐cell receptor activation

  1998cited by this paper
• Phosphatidylinositol‐3,4,5‐trisphosphate (PtdIns‐3,4,5‐P3)/Tec kinase‐dependent calcium signaling pathway: a target for SHIP‐mediated inhibitory signals

  1998cited by this paper
• μ-Opioid Receptor Activates Signaling Pathways Implicated in Cell Survival and Translational Control*

  1998cited by this paper
• Role of Glycogen Synthase Kinase-3 in the Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway*

  1998cited by this paper
• Akt activation by growth factors is a multiple-step process: the role of the PH domain

  1998cited by this paper
• Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: involvement of MEK upstream of Bad phosphorylation.

  1998cited by this paper
• TCF: transcriptional activator or repressor?

  1998cited by this paper
• Essential Role for Protein Kinase B (PKB) in Insulin-induced Glycogen Synthase Kinase 3 Inactivation

  1998cited by this paper
• Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

  1998cited by this paper
• Protein Kinase B and Rac Are Activated in Parallel within a Phosphatidylinositide 3OH-kinase-controlled Signaling Pathway*

  1998cited by this paper
• 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway.

  1998cited by this paper
• Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK‐3β and β‐catenin and promotes GSK‐3β‐dependent phosphorylation of β‐catenin

  1998cited by this paper
• Positive versus negative signaling by lymphocyte antigen receptors.

  1998influential reference
• Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.

  1998cited by this paper
• Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase‐3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin

  1998cited by this paper
• Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B.

  1998cited by this paper
• Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav.

  1998cited by this paper
• Mechanisms and consequences of activation of protein kinase B/Akt.

  1998cited by this paper
• Regulation of protein kinase C ζ by PI 3-kinase and PDK-1

  1998cited by this paper
• CD19 as a membrane-anchored adaptor protein of B lymphocytes: costimulation of lipid and protein kinases by recruitment of Vav.

  1998cited by this paper
• 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro.

  1998cited by this paper
• Molecular mechanisms in B cell antigen receptor signaling.

  1997cited by this paper
• Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha.

  1997cited by this paper
• PI3K: downstream AKTion blocks apoptosis.

  1997cited by this paper
• Phosphorylation of tau by glycogen synthase kinase 3beta affects the ability of tau to promote microtubule self-assembly.

  1997cited by this paper
• Activation of the Sire-family tyrosine kinase Hck by SH3 domain displacement

  1997cited by this paper
• Akt Signaling--Linking Membrane Events to Life and Death Decisions

  1997cited by this paper
• Role of Translocation in the Activation and Function of Protein Kinase B*

  1997cited by this paper
• Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

  1997cited by this paper
• Qualitative Regulation of B Cell Antigen Receptor Signaling by CD19: Selective Requirement for PI3-Kinase Activation, Inositol-1,4,5-Trisphosphate Production and Ca2+ Mobilization

  1997cited by this paper
• Rapid targeting of nuclear proteins to the cytoplasm.

  1997cited by this paper
• Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.

  1997cited by this paper
• Activated Phosphatidylinositol 3-Kinase and Akt Kinase Promote Survival of Superior Cervical Neurons

  1997cited by this paper
• Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt.

  1997cited by this paper
• Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3

  1997cited by this paper
• High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity*

  1997cited by this paper
• The complexity of signaling pathways activated by the BCR.

  1997influential reference
• Phosphatidylinositol 3-Kinase Links the Interleukin-2 Receptor to Protein Kinase B and p70 S6 Kinase*

  1997cited by this paper
• Different nuclear signals are activated by the B cell receptor during positive versus negative signaling.

  1997cited by this paper
• Initiation and processing of signals from the B cell antigen receptor.

  1997cited by this paper
• Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and beta-adrenergic agonists in rat epididymal fat cells. Activation of protein kinase B by wortmannin-sensitive and -insensitive mechanisms.

  1997cited by this paper
• Regulatory recruitment of signalling molecules to the cell membrane by pleckstrinhomology domains.

  1997cited by this paper
• B cell receptor cross-linking prevents Fas-induced cell death by inactivating the IL-1 beta-converting enzyme protease and regulating Bcl-2/Bcl-x expression.

  1997cited by this paper
• Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F.

  1997cited by this paper
• Transcription factors of the NFAT family: regulation and function.

  1997cited by this paper
• Regulatory recruitment of signalling molecules to the cell membrane by pleckstrinhomology domains

  1997cited by this paper
• GSK3: a SHAGGY frog story.

  1996cited by this paper
• Physical and functional association of the cbl protooncogen product with an src-family protein tyrosine kinase, p53/56lyn, in the B cell antigen receptor-mediated signaling

  1996cited by this paper
• Phosphatidylinositol-3-kinase activity is required for the anti-ig-mediated growth inhibition of a human B-lymphoma cell line.

  1996cited by this paper
• p120 Is a Major Substrate of Tyrosine Phosphorylation upon B Cell Antigen Receptor Stimulation and Interacts in Vivo with Fyn and Syk Tyrosine Kinases, Grb2 and Shc Adaptors, and the p85 Subunit of Phosphatidylinositol 3-Kinase (*)

  1996cited by this paper
• Mechanism of activation of protein kinase B by insulin and IGF‐1.

  1996cited by this paper
• Physical association of the small GTPase Rho with a 68-kDa phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells.

  1996cited by this paper
• A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2

  1996influential reference
• Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

  1996cited by this paper
• Phosphatidylinositol 3-kinase activation in normal human B lymphocytes.

  1996cited by this paper
• Reconstitution of B Cell Antigen Receptor-induced Signaling Events in a Nonlymphoid Cell Line by Expressing the Syk Protein-tyrosine Kinase (*)

  1996cited by this paper
• Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase.

  1995cited by this paper
• Rho Family GTPases Bind to Phosphoinositide Kinases (*)

  1995cited by this paper
• Loss of surface immunoglobulin expression precedes B cell death by apoptosis in the bursa of Fabricius

  1995cited by this paper
• Requirement of phospholipase C-gamma 2 activation in surface immunoglobulin M-induced B cell apoptosis

  1995cited by this paper
• Role of phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoietic cells: phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in signalling between interleukin-3 and granulocyte-macrophage colony stimulating factor.

  1995cited by this paper
• Insulin stimulates the kinase activity of RAC‐PK, a pleckstrin homology domain containing ser/thr kinase.

  1995cited by this paper
• The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase.

  1995cited by this paper
• Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

  1995cited by this paper
• Association of Activated Phosphatidylinositol 3-Kinase with p120cbl in Antigen Receptor-ligated B Cells (*)

  1995cited by this paper
• Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

  1995influential reference
• Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor.

  1995cited by this paper
• Inactivation of Glycogen Synthase Kinase-3 by Epidermal Growth Factor Is Mediated by Mitogen-activated Protein Kinase/p90 Ribosomal Protein S6 Kinase Signaling Pathway in NIH/3T3 Cells (*)

  1995cited by this paper
• Signal transduction by the antigen receptors of B and T lymphocytes.

  1995cited by this paper
• Both phosphatidylinositol 3-kinase and phosphatidylinositol 4-kinase products are increased by antigen receptor signaling in B cells.

  1994cited by this paper
• Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

  1994cited by this paper
• Tyrosine kinases Lyn and Syk regulate B cell receptor‐coupled Ca2+ mobilization through distinct pathways.

  1994influential reference
• Cyclosporin-A sensitive induction of NF-AT in murine B cells.

  1994cited by this paper
• Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit.

  1994cited by this paper
• The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells.

  1994cited by this paper
• The CR2/CD19 complex on human B cells contains the src-family kinase Lyn.

  1993cited by this paper
• Production of high-titer helper-free retroviruses by transient transfection.

  1993cited by this paper
• CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase.

  1993cited by this paper
• The membrane IgM-associated proteins MB-1 and Ig-beta are sufficient to promote surface expression of a partially functional B-cell antigen receptor in a nonlymphoid cell line.

  1992cited by this paper

• Interferon-γ production in response to the cytotoxic T lymphocyte epitope within an antigen incorporated in simian virus 40 virus-like particles

  2025cites this paper
• Expansion of B10 cells in vitro: Pathways, techniques and applications in transplantation (Review)

  2024cites this paper
• Vagus nerve stimulation modulates distinct acetylcholine receptors on B cells and limits the germinal center response

  2024cites this paper
• PI3Kδ Pathway Dysregulation and Unique Features of Its Inhibition by Leniolisib in Activated PI3Kδ Syndrome and Beyond.

  2023cites this paper
• Vagus nerve stimulation limits the germinal center B cell response via CD4+ T cell-derived acetylcholine

  2023cites this paper
• Understanding AKT-mediated chemoresistance: the relationship between ion channels and AKT activation

  2023cites this paper
• Involvement of calcium channels Orai3 in the chemoresistance to cisplatin in non-small cell lung cancer (NSCLC)

  2023cites this paper
• Strategies for targeting chondrosarcomas in vivo and molecular dissection of oncogenic events in chondrosarcomas: is epigenetics the culprit?

  2023cites this paper
• The molecular rationale for the combination of polatuzumab vedotin plus rituximab in diffuse large B‐cell lymphoma

  2022cites this paper
• Modeling the B‐cell receptor signaling on single cell level reveals a stable network circuit topology between nonmalignant B cells and chronic lymphocytic leukemia cells and between untreated cells and cells treated with kinase inhibitors

  2022cites this paper
• GSK3β is a critical, druggable component of the network regulating the active NOTCH1 protein and cell viability in CLL

  2022cites this paper
• Pathogenic, glycolytic PD-1+ B cells accumulate in the hypoxic RA joint

  2020cites this paper
• Network Based Integration of Proteomic and Transcriptomic Data: Study of BCR and WNT11 Signaling Pathways in Cancer Cells

  2020cites this paper
• Network Based Integration of Proteomic and Transcriptomic Data: Study of BCR and WNT11 Signaling Pathways in Cancer Cells

  2020cites this paper
• PIK3IP1 Promotes Extrafollicular Class Switching in T-Dependent Immune Responses

  2020cites this paper
• Stabilization of β-catenin upon B-cell receptor signaling promotes NF-kB target genes transcription in mantle cell lymphoma

  2020cites this paper
• Turning to Computer-Aided Drug Design in the treatment of Diffuse Large B-cell Lymphoma: Has it been helpful?

  2019cites this paper
• Nanosome-Mediated Delivery Of Protein Kinase D Inhibitor Protects Chondrocytes From Interleukin-1β-Induced Stress And Apoptotic Death

  2019cites this paper
• 'Piperazining' the catalytic gatekeepers: unraveling the pan-inhibition of SRC kinases; LYN, FYN and BLK by masitinib.

  2019cites this paper
• From zero to sixty and back to zero again: the metabolic life of B cells.

  2019cites this paper
• Siblings Presenting with Mild and Severe Lymphoproliferation

  2019cites this paper
• This information is current as Inhibitors Represses Cyclin-Dependent Kinase Proliferation of B Lymphocytes and Induced − Bach 2 Promotes B Cell Receptor Matsumoto

  2018cites this paper
• NFATC1 activation by DNA hypomethylation in chronic lymphocytic leukemia correlates with clinical staging and can be inhibited by ibrutinib

  2018cites this paper
• Bach2 Promotes B Cell Receptor–Induced Proliferation of B Lymphocytes and Represses Cyclin-Dependent Kinase Inhibitors

  2018cites this paper
• Pan-SRC kinase inhibition blocks B-cell receptor oncogenic signaling in non-Hodgkin lymphoma.

  2018cites this paper
• The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition

  2017cites this paper
• The Rap GTPases coordinate actin and microtubule cytoskeleton reorganization, and promote antigen extraction at the B cell immune synapse

  2017cites this paper
• PDK2 and ABCG2 genes polymorphisms are correlated with blood glucose levels and uric acid in Tibetan gout patients.

  2016cites this paper
• Molecular mechanisms controlling SH2 domain-containing inositol 5’phosphatase (SHIP) function in B cells

  2016cites this paper
• The role and regulation of AKT in CD40-mediated survival and proliferation of CLL cells

  2016cites this paper
• The roles of SH2-containing inositol 5'-phosphatase 1 (SHIP1) and signal transducer and activator of transcription 3 (STAT3) in interleukin-10 regulation of activated macrophages

  2016cites this paper
• In B cells, phosphatidylinositol 5-phosphate 4-kinase–α synthesizes PI(4,5)P2 to impact mTORC2 and Akt signaling

  2016cites this paper
• Regulation of B cell metabolic activation, germinal center responses and autoimmunity by Tandem PH domain-containing proteins

  2016cites this paper
• Targeting B-cell receptor signaling in leukemia and lymphoma: how and why?

  2016cites this paper
• Expression and pro-survival function of phospholipase Cγ2 in diffuse large B-cell lymphoma

  2015cites this paper
• Advanced flow cytometry to study signaling pathways and predict outcome in B cell malignancies

  2015influential citation
• Overexpression of Aiolos in Nalm-6 acute lymphoblastic leukaemia cells reduces apoptosis by suppressing phosphatase and tensin homologue deleted on chromosome 10 and activating the phosphatidylinositol-3-kinase/Akt signalling pathway.

  2015cites this paper
• Effects of p66shc expression on bioenergetics and cell viability of b-cell chronic lymphocytic leukemia

  2015cites this paper
• Emerging protein kinase inhibitors for the treatment of non-Hodgkin’s lymphoma

  2014cites this paper
• Identification of LCK as a key mediator of B cell receptor (BCR)signalling in chronic lymphocytic leukaemia (CLL)

  2013cites this paper
• Groups of B-Chronic Lymphocytic Leukemia Cross-Linking Identifies Different Prognostic B Cell Response to Surface IgM

  2013cites this paper
• membrane localization SHIP inhibits Akt activation in B cells through regulation of Akt

  2013cites this paper
• The B-cell receptor signaling pathway as a therapeutic target in CLL.

  2012cites this paper
• The role of connexin 43 in B cell receptor signaling and the high throughput screen for novel B cell receptor signaling inhibitors

  2012cites this paper
• Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores.

  2012cites this paper
• Quantitative Immunofluorescence Reveals the Signature of Active B-cell Receptor Signaling in Diffuse Large B-cell Lymphoma

  2012cites this paper
• The molecular regulation of apoptosis in b-cell neoplasms

  2012influential citation
• ROLE OF PI3K-AKT PATHWAY IN THE AGE ASSOCIATED DECLINE IN TLR MEDIATED ACTIVATION OF INNATE AND ADAPTIVE IMMUNE RESPONSES

  2011cites this paper
• Characterisation of the voltage gated proton channel HVCN1 in B cells

  2011cites this paper
• B‐cell stage and context‐dependent requirements for survival signals from BAFF and the B‐cell receptor

  2010cites this paper
• A participação da glicogênio sintase cinase 3 na modulação de vias hipertróficas musculares e as influências exercidas pelo exercíco de forças nestas sinalizações

  2010cites this paper
• Immunoglobulin Gene Rearrangements, Oncogenic Translocations, B-Cell Receptor Signaling, and B Lymphomagenesis

  2010cites this paper
• A protein phosphatase feedback mechanism regulates the basal phosphorylation of Chk2 kinase in the absence of DNA damage.

  2010cites this paper
• Aberrant Reactive Oxygen and Nitrogen Species Generation in Rheumatoid Arthritis (RA): Causes and Consequences for Immune Function, Cell Survival, and Therapeutic Intervention

  2010cites this paper
• Probing lymphocyte responses to modulation of the F0F1-ATPase by BZ-423

  2009cites this paper
• Rac GTPases are involved in development, survival and homeostasis of T cells.

  2009cites this paper
• High TCL1 levels are a marker of B-cell receptor pathway responsiveness and adverse outcome in chronic lymphocytic leukemia.

  2009cites this paper
• Regulation of the Src Homology 2 Domain-containing Inositol 5′-Phosphatase (SHIP1) by the Cyclic AMP-dependent Protein Kinase*

  2009cites this paper
• IgG-mediated Immune Suppression: the Effect on the Host Immune System

  2008cites this paper
• The life of a cell: apoptosis regulation by the PI3K/PKB pathway.

  2008cites this paper
• PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity.

  2008cites this paper
• The kinase Syk as an adaptor controlling sustained calcium signalling and B‐cell development

  2008cites this paper
• Critical Role for Endocytosis in the Regulation of Signaling by the Kaposi's Sarcoma-Associated Herpesvirus K1 Protein

  2008cites this paper
• Expression and Mechanism of Spleen Tyrosine Kinase Activation by Angiotensin II and Its Implication in Protein Synthesis in Rat Vascular Smooth Muscle Cells*

  2007cites this paper
• CD44 regulates cell migration in human colon cancer cells via Lyn kinase and AKT phosphorylation.

  2007cites this paper
• Spleen Tyrosine Kinase (Syk), a Novel Target of Curcumin, Is Required for B Lymphoma Growth1

  2007influential citation
• Differential role of reactive oxygen species in the activation of mitogen-activated protein kinases and Akt by key receptors on B-lymphocytes: CD40, the B cell antigen receptor, and CXCR4

  2007cites this paper
• Distinct Roles of Phosphoinositide-3 Kinase and Phospholipase Cγ2 in B-Cell Receptor-Mediated Signal Transduction

  2006cites this paper
• Regulation of class IA phosphoinositide 3-kinase signalling enzymes by post-translational modifications, protein interactions and absolute protein expression levels.

  2006cites this paper
• Role of PKC during B cell development and transformation.

  2006cites this paper
• A Role for Phosphatidylinositol 3-Kinase in TCR-Stimulated ERK Activation Leading to Paxillin Phosphorylation and CTL Degranulation1

  2005cites this paper
• Differential signalling during B-cell maturation.

  2005cites this paper
• The BCR signalosome: where cell fate is decided.

  2005cites this paper
• Activation of Src kinase Lyn by the Kaposi sarcoma-associated herpesvirus K1 protein: implications for lymphomagenesis.

  2005cites this paper
• The Adaptor Protein HSH2 Attenuates Apoptosis in Response to Ligation of the B Cell Antigen Receptor Complex on the B Lymphoma Cell Line, WEHI-231*

  2005cites this paper
• B Cell Response to Surface IgM Cross-Linking Identifies Different Prognostic Groups of B-Chronic Lymphocytic Leukemia Patients 1

  2005influential citation
• Dissection of the differential mechanisms of apoptosis used during B cell maturation.

  2005cites this paper
• Degranulation Paxillin Phosphorylation and CTL TCR-Stimulated ERK Activation Leading to A Role for Phosphatidylinositol 3-Kinase in Ostergaard

  2005cites this paper
• Phosphatidylinositol 3-Kinase-Dependent Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase 1/2 and NF-κB Signaling Pathways Are Required for B Cell Antigen Receptor-Mediated Cyclin D2 Induction in Mature B Cells1

  2004cites this paper
• PI3K signaling controls cell fate at many points in B lymphocyte development and activation.

  2004cites this paper
• PI3-Kinase Regulates Survival of Chronic Lymphocytic Leukemia B-Cells by Preventing Caspase 8 Activation

  2004cites this paper
• The Adaptor Protein Bam32 Regulates Rac1 Activation and Actin Remodeling through a Phosphorylation-dependent Mechanism*

  2004cites this paper
• Inhibition of Phosphatidylinositol 3-Kinase Causes Apoptosis in Retinoic Acid-Differentiated HL-60 Leukemia Cells

  2004cites this paper
• Antigen receptor-mediated signaling pathways in transitional immature B cells.

  2004cites this paper
• Induction in Mature B Cells Cell Antigen Receptor-Mediated Cyclin D 2 B Signaling Pathways Are Required for B κ Signal-Regulated Kinase Kinase 1 / 2 and NF-Mitogen-Activated Protein / Extracellular Phosphatidylinositol 3-Kinase-Dependent

  2004cites this paper
• Targeting Syk as a treatment for allergic and autoimmune disorders

  2004cites this paper
• FcγRII expression on follicular dendritic cells and immunoreceptor tyrosine‐based inhibition motif signaling in B cells

  2004cites this paper
• Contribution of RasGRP1 to BCR-induced deletion in the immature B cell line WEHI 231

  2004cites this paper
• The B cell antigen receptor controls integrin activity through Btk and PLC gamma 2

  2003cites this paper
• Cell death during lymphocyte development and activation.

  2003cites this paper
• PI 3 K and Btk differentially regulate B cell antigen receptor-mediated signal transduction

  2003cites this paper
• Subversion of B lymphocyte signaling by infectious agents

  2003cites this paper
• Exonic Splicing Enhancer-Dependent Selection of the Bovine Papillomavirus Type 1 Nucleotide 3225 3′ Splice Site Can Be Rescued in a Cell Lacking Splicing Factor ASF/SF2 through Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway

  2003influential citation
• This information is current as Activation Engagement and Phosphoinositide 3-Kinase Cells Requires Sustained Antigen Receptor Proliferation and Survival of Activated B

  2003cites this paper
• Biochemical basis of B cell dysfunction in Lyn kinase deficient mice

  2003cites this paper
• The B Cell Antigen Receptor Controls Integrin Activity through Btk and PLCγ2

  2003cites this paper
• Epstein-Barr virus, the TCL-1 oncogene and Burkitt's lymphoma.

  2003cites this paper
• Activation of Epstein‐Barr virus/C3d receptor (gp140, CR2, CD21) on human cell surface triggers pp60src and Akt‐GSK3 activities upstream and downstream to PI 3‐kinase, respectively

  2003cites this paper
• CHAPTER 344 – Signal Transduction via the B-Cell Antigen Receptor: A Crucial Regulator of B-Cell Biology

  2003cites this paper
• PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction

  2003cites this paper