A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Diabetes

• Publication date

  1999-10-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.2337/DIABETES.48.10.2090PMID 10512378
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Polyol pathway hyperactivity is closely related to carnitine deficiency in the pathogenesis of diabetic neuropathy of streptozotocin-diabetic rats.

  1998cited by this paper
• Protein kinase C activation and the development of diabetic complications.

  1998cited by this paper
• Abnormalities of retinal metabolism in diabetes or experimental galactosemia: V. Relationship between protein kinase C and ATPases.

  1998cited by this paper
• The potential for isoenzyme‐selective modulation of protein kinase C

  1997cited by this paper
• Diabetic neuropathy in sucrose-fed Otsuka Long-Evans Tokushima fatty rats: effect of an aldose reductase inhibitor, TAT.

  1997cited by this paper
• Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats.

  1997cited by this paper
• Metabolic and Vascular Factors in the Pathogenesis of Diabetic Neuropathy

  1997cited by this paper
• Protein kinase C isozyme expression in sciatic nerves and spinal cords of experimentally diabetic rats.

  1997cited by this paper
• Nerve function and regeneration in diabetic and galactosaemic rats: antioxidant and metal chelator effects.

  1996cited by this paper
• Highly selective aldose reductase inhibitors. 1. 3-(Arylalkyl)-2,4,5-trioxoimidazolidine-1-acetic acids.

  1996cited by this paper
• Effects of Beraprost Sodium and Insulin on the Electroretinogram, Nerve Conduction, and Nerve Blood Flow in Rats with Streptozotocin-Induced Diabetes

  1996cited by this paper
• Nerve function and blood flow in Otsuka Long-Evans Tokushima Fatty rats with sucrose feeding: effect of an anticoagulant.

  1996cited by this paper
• Reversal of defective peripheral nerve conduction velocity, nutritive endoneurial blood flow, and oxygenation by a novel aldose reductase inhibitor, WAY-121,509, in streptozotocin-induced diabetic rats.

  1996cited by this paper
• Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor.

  1996cited by this paper
• Effect of a potent new aldose reductase inhibitor, (5-(3-thienyltetrazol-1-yl)acetic acid (TAT), on diabetic neuropathy in rats.

  1995cited by this paper
• Nerve function in galactosaemic rats: effects of evening primrose oil and doxazosin.

  1995cited by this paper
• Nerve function and regeneration in diabetic rats: effects of ZD-7155, an AT1 receptor antagonist.

  1995cited by this paper
• Prevention of abnormalities in motor nerve conduction and nerve blood-flow by a prostacyclin analog, beraprost sodium, in streptozotocin-induced diabetic rats.

  1995cited by this paper
• Vascular factors in diabetic neuropathy

  1994cited by this paper
• Alpha, beta I, beta II, delta, and epsilon protein kinase C isoforms and compound activity in the sciatic nerve of normal and diabetic rats.

  1994cited by this paper
• The relationship of vascular changes to metabolic factors in diabetes mellitus and their role in the development of peripheral nerve complications.

  1994cited by this paper
• Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues.

  1994cited by this paper
• Sustained Recovery of Na+-K+-ATPase Activity in Sciatic Nerve of Diabetic Mice by Administration of H7 or Calphostin C, Inhibitors of PKC

  1993cited by this paper
• Ambient glucose and aldose reductase-induced myo-inositol depletion modulate basal and carbachol-stimulated inositol phospholipid metabolism and diacylglycerol accumulation in human retinal pigment epithelial cells in culture.

  1993cited by this paper
• Inhibition of Protein Kinase C Restores Na+, K+‐ATPase Activity in Sciatic Nerve of Diabetic Mice

  1992cited by this paper
• Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation.

  1992cited by this paper
• Effect of Niceritrol on Streptozocin-Induced Diabetic Neuropathy in Rats

  1992cited by this paper
• Effects of a new aldose reductase inhibitor, (2S, 4S)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-ca rboxamid e (SNK-860), on the slowing of motor nerve conduction velocity and metabolic abnormalities in the peripheral nerve in acute streptozotocin-induced diabetic rats.

  1992cited by this paper
• Inhibition of phosphatidylinositol synthase by glucose in human retinal pigment epithelial cells.

  1992cited by this paper
• Aldose reductase inhibitors and diabetic complications.

  1992cited by this paper
• Complications: Neuropathy, Pathogenetic Considerations

  1992cited by this paper
• Diminished Specific Activity of Cytosolic Protein Kinase C In Sciatic Nerve of Streptozocin-Induced Diabetic Rats and Its Correction by Dietary myo-Inositol

  1991cited by this paper
• Normalization of Na+-K+-ATPase Activity in Isolated Membrane Fraction From Sciatic Nerves of Streptozocin-Induced Diabetic Rats by Dietary myo-Inositol Supplementation in Vivo or Protein Kinase C Agonists in Vitro

  1991cited by this paper
• Dose-dependent alterations in nerve polyols and (Na+,K+)-ATPase activity in galactose intoxication.

  1991cited by this paper
• 1,2‐Diacylglycerol Content and Its Arachidonyl‐Containing Molecular Species Are Reduced in Sciatic Nerve from Streptozotocin‐induced Diabetic Rats

  1990cited by this paper
• Pathogenesis of diabetic neuropathy: role of altered phosphoinositide metabolism.

  1989cited by this paper
• Effect of Prostaglandin E1 Analogue TFC 612 on Diabetic Neuropathy in Streptozocin-Induced Diabetic Rats Comparison With Aldose Reductase Inhibitor ONO 2235

  1989cited by this paper
• Adenosine triphosphatase in nerves and ganglia of rats with streptozotocin-induced diabetes or galactosaemia; effects of aldose reductase inhibition

  1988cited by this paper
• The development of electroretinogram abnormalities and the possible role of polyol pathway activity in diabetic hyperglycemia and galactosemia.

  1988cited by this paper
• Measurement of regional blood flow using hydrogen gas generated by electrolysis.

  1982cited by this paper
• Serial in vivo determinations of nerve conduction velocity in rat tails. Physiological and pathological changes.

  1973cited by this paper
• CLINICAL STUDIES ON THE OSCILLATORY POTENTIALS OF THE HUMAN ELECTRORETINOGRAM WITH SPECIAL REFERENCE TO THE SCOTOPIC b‐WAVE

  1968cited by this paper

• Unravelling the pathophysiology of diabetic foot ulcer: insights into a complex wound healing process.

  2026cites this paper
• The intricacies of advanced glycation end products (AGEs) in diabetic neuropathy

  2025cites this paper
• Hyperglycaemia Aggravates Oxidised Low-Density Lipoprotein-Induced Schwann Cell Death via Hyperactivation of Toll-like Receptor 4

  2024cites this paper
• Combination therapy is it in the future for successfully treating peripheral diabetic neuropathy?

  2024cites this paper
• New horizons of biomaterials in treatment of nerve damage in diabetes mellitus: A translational prospective review

  2022cites this paper
• NAD+ metabolism in peripheral neuropathic pain.

  2022cites this paper
• Mechanistic approach towards diabetic neuropathy screening techniques and future challenges: A review.

  2022cites this paper
• Molecular Insights on the Therapeutic Effect of Selected Flavonoids on Diabetic Neuropathy.

  2022cites this paper
• Drug repurposing - A search for novel therapy for the treatment of diabetic neuropathy.

  2022cites this paper
• Thermal gradient ring reveals thermosensory changes in diabetic peripheral neuropathy in mice

  2021cites this paper
• A Comprehensive Review of Neuronal Changes in Diabetics

  2021cites this paper
• Correlation between the accumulation of skin glycosylation end products and the development of type 2 diabetic peripheral neuropathy

  2021cites this paper
• The Role of Molecular and Inflammatory Indicators in the Assessment of Cognitive Dysfunction in a Mouse Model of Diabetes

  2021cites this paper
• Physiological and Pathological Roles of Aldose Reductase

  2021cites this paper
• Early Neural Changes as Underlying Pathophysiological Mechanism in Diabetic Retinopathy

  2021cites this paper
• Exercise and Nutraceuticals: Eminent approach for Diabetic Neuropathy.

  2021cites this paper
• Oxidative Stress and Mitochondrial Dysfunction Associated with Peripheral Neuropathy in Type 1 Diabetes

  2021cites this paper
• The Effects of Insulin on Immortalized Rat Schwann Cells, IFRS1

  2021cites this paper
• Pathogenesis of Microvascular Complications

  2020cites this paper
• Influence of the complex drug Cocarnit on the sciatic nerve in the development of diabetic polyneuropathy in rats

  2020cites this paper
• Understanding Diabetic Neuropathy: Focus on Oxidative Stress

  2020cites this paper
• Understanding the signaling pathways related to the mechanism and treatment of diabetic peripheral neuropathy.

  2019cites this paper
• Role of Protein Kinase C in Diabetic Complications

  2019cites this paper
• Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets

  2018cites this paper
• Metabolic Syndrome and Neuroprotection

  2018cites this paper
• Correlation between markers of peripheral nerve function and structure in type 1 diabetes

  2018cites this paper
• Diabetes-induced mitochondrial changes are tissue- and model-dependent and elevated glucose levels do not activate the pathways of hyperglycemic damage in the kidney

  2018cites this paper
• Avaliação dos mecanismos neuroquímicos envolvidos na hipoalgesia em ATM de ratos com diabetes induzida : Evaluation of neurochemical mechanisms involving hypoalgesia in TMJ'rats with diabetes-induced

  2018cites this paper
• Balance Training in Diabetic Peripheral Neuropathy : A Narrative Review

  2017cites this paper
• Role of Transient Receptor Potential Channels Trpv1 and Trpm8 in Diabetic Peripheral Neuropathy.

  2017cites this paper
• MiR-29c/PRKCI Regulates Axonal Growth of Dorsal Root Ganglia Neurons Under Hyperglycemia

  2017cites this paper
• Diabetic Microvascular Disease: An Endocrine Society Scientific Statement

  2017cites this paper
• Effect of Phytochemicals on Diabetes‐Related Neurological Disorders

  2017cites this paper
• Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF‐β1/Smad and GRAP pathways

  2016cites this paper
• Emerging drugs for diabetic peripheral neuropathy and neuropathic pain

  2016cites this paper
• Neuroprotective effects of chronic administration of levetiracetam in a rat model of diabetic neuropathy.

  2016cites this paper
• Role of A3 adenosine receptor in diabetic neuropathy

  2016cites this paper
• Glucotoxic Mechanisms and Related Therapeutic Approaches.

  2016cites this paper
• Molecular and biochemical mechanisms in streptozotocin-induced diabetes and associated behavioral indices

  2015cites this paper
• Antioxidant Strategies in the Management of Diabetic Neuropathy

  2015cites this paper
• Novologue Therapy Improves Mitochondrial Bioenergetics and Modulates Transcriptome Changes in Diabetic Sensory Neurons

  2015cites this paper
• Complex Regulation of PKCβ2 and PDK-1/AKT by ROCK2 in Diabetic Heart

  2014cites this paper
• Physiological and Pathological Roles of Aldose Reductase in Schwann Cells

  2014cites this paper
• Nerve Blood Flow Control in Health & Disease:The Effects of Type 1 Diabetes and Exercise Training

  2014influential citation
• Schwann Cell Development and Pathology

  2014cites this paper
• Mechanisms of diabetic neuron damage: Molecular pathways.

  2014cites this paper
• Animal models of diabetic neuropathic pain.

  2014cites this paper
• Therapeutic efficacy of bone marrow-derived mononuclear cells in diabetic polyneuropathy is impaired with aging or diabetes

  2014cites this paper
• Pathogenesis of Diabetic Neuropathy from the Point of View of Schwann Cell Abnormalities

  2014cites this paper
• Exercise training enhances insulin-stimulated nerve arterial vasodilation in rats with insulin-treated experimental diabetes.

  2014cites this paper
• The Role of Glutamate Signalling In Diabetic Neuropathy

  2014cites this paper
• Diabetic Peripheral Neuropathy: Role of Reactive Oxygen and Nitrogen Species

  2013cites this paper
• Mechanisms of axonal dysfunction in diabetic and uraemic neuropathies.

  2013cites this paper
• 12/15-Lipoxygenase inhibition counteracts MAPK phosphorylation in mouse and cell culture models of diabetic peripheral neuropathy.

  2013cites this paper
• Chapter 46 – Diabetic Retinopathy: Genetics and Etiologic Mechanisms

  2013cites this paper
• Pathogenesis of diabetic neuropathy: focus on neurovascular mechanisms.

  2013cites this paper
• Bradykinin B₁ antagonism inhibits oxidative stress and restores Na+K+ ATPase activity in diabetic rat peripheral nervous system.

  2013cites this paper
• Impact and Mechanisms of Extracellular Electrical Stimulation on Peripheral Nerve Regeneration

  2013cites this paper
• From Animal Models to Clinical Practicality: Lessons Learned from Current Translational Progress of Diabetic Peripheral Neuropathy

  2013cites this paper
• Interplay of sorbitol pathway of glucose metabolism, 12/15-lipoxygenase, and mitogen-activated protein kinases in the pathogenesis of diabetic peripheral neuropathy.

  2012cites this paper
• Exclusion of aldose reductase as a mediator of ERG deficits in a mouse model of diabetic eye disease

  2012cites this paper
• Novel Pharmacological Approaches to the Treatment of Type 2 Diabetes

  2012cites this paper
• Type 1 diabetes mellitus in mice increases hippocampal D-serine in the acute phase after streptozotocin injection.

  2012cites this paper
• Treatment of diabetic neuropathy with baicalein: intervention at multiple sites.

  2011cites this paper
• Pharmacological Treatment of Diabetic Neuropathic Pain

  2011influential citation
• Aldose Reductase Inhibitor Fidarestat Prevents Diabetic Ocular Complications in Spontaneously Diabetic Torii Rats

  2011cites this paper
• Prevention of Proliferative Diabetic Retinopathy and Cataract in SDT Rats with Aminoguanidine, an Anti-Advanced Glycation End Product Agent

  2011influential citation
• Beneficial Effects of Exendin-4 on Experimental Polyneuropathy in Diabetic Mice

  2011cites this paper
• Evaluation of PMI-5011, an ethanolic extract of Artemisia dracunculus L., on peripheral neuropathy in streptozotocin-diabetic mice.

  2011cites this paper
• Aldose reductase / polyol inhibitors for diabetic retinopathy.

  2011cites this paper
• Methylcobalamin effects on diabetic neuropathy and nerve protein kinase C in rats

  2011cites this paper
• Matrix metalloproteinases and experimental diabetic neuropathy

  2011cites this paper
• PARP inhibition alleviates diabetes-induced systemic oxidative stress and neural tissue 4-hydroxynonenal adduct accumulation: correlation with peripheral nerve function.

  2011cites this paper
• Baicalein alleviates diabetic peripheral neuropathy through inhibition of oxidative-nitrosative stress and p38 MAPK activation.

  2011cites this paper
• Palmitate induces apoptosis in Schwann cells via both ceramide-dependent and independent pathways.

  2011cites this paper
• Dérivés d'amide d'acide 6-(4-hydroxy-phényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase

  2011cites this paper
• Neurovascular Interaction and the Pathophysiology of Diabetic Retinopathy

  2011cites this paper
• Accumulation of AGEs and VEGF in Eyes of SDT Rats

  2011influential citation
• Molecular mechanisms of diabetic vascular complications

  2010cites this paper
• Different roles of 12/15-lipoxygenase in diabetic large and small fiber peripheral and autonomic neuropathies.

  2010cites this paper
• POSSIBLE MECHANISM OF HYPERGLYCEMIA INDUCED DECREASE IN ANTINOCICEPTIVE EFFECT OF ANALGESICS IN RATS

  2010cites this paper
• Neuropathy induced by exogenously administered advanced glycation end‐products in rats

  2010cites this paper
• Role of 12/15-lipoxygenase in nitrosative stress and peripheral prediabetic and diabetic neuropathies.

  2010cites this paper
• Role of protein kinase C in diabetic complications

  2010cites this paper
• Effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy in patients with type 2 diabetes, in relation to suppression of N(ɛ)-carboxymethyl lysine.

  2010cites this paper
• Taurine depletion and Schwann cell dysfunction in diabetic neuropathy

  2010cites this paper
• Evaluation of the aldose reductase inhibitor fidarestat on ischemia-reperfusion injury in rat retina.

  2010cites this paper
• Mechanism of diabetic neuropathy: Where are we now and where to go?

  2010cites this paper
• An Efficient Synthesis of the Protein Kinase Cβ Inhibitor JTT‐010

  2010cites this paper
• High-Fat Diet-Induced Neuropathy of Prediabetes and Obesity: Effect of PMI-5011, an Ethanolic Extract of Artemisia dracunculus L.

  2010cites this paper
• Activation of protein kinase C isoforms and its impact on diabetic complications.

  2010cites this paper
• Beneficial effects of a Cannabis sativa extract treatment on diabetes‐induced neuropathy and oxidative stress

  2009cites this paper
• Diabetic neuropathy: therapies on the horizon

  2009cites this paper
• Regulation of mitochondrial aconitase by phosphorylation in diabetic rat heart

  2009cites this paper
• Diabetes and the peripheral nerve.

  2009cites this paper
• Alpha-lipoic Acid and diabetic neuropathy.

  2009cites this paper
• Protein kinase C: from its specific molecular structure to its role in diabetic neuropathy

  2009cites this paper
• Caveolin-1 and Altered Neuregulin Signaling Contribute to the Pathophysiological Progression of Diabetic Peripheral Neuropathy

  2009cites this paper
• Ruboxistaurin: PKC-β inhibition for complications of diabetes

  2009cites this paper
• Mice deficient in PKC β and apolipoprotein E display decreased atherosclerosis

  2009cites this paper