Restoring Blood-Brain Barrier P-Glycoprotein Reduces Brain Amyloid-β in a Mouse Model of Alzheimer's Disease

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Molecular Pharmacology

• Publication date

  2010-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1124/mol.109.061754PMID 20101004PMCID PMC2872973
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Alzheimer's disease.

  2011cited by this paper
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  2009cited by this paper
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  2009influential reference
• Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells.

  2009cited by this paper
• Modulation of P-Glycoprotein at the Blood-Brain Barrier: Opportunities to Improve Central Nervous System Pharmacotherapy

  2008cited by this paper
• Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P‐glycoprotein up‐regulation at the blood‐brain barrier

  2008influential reference
• Coordinated Nuclear Receptor Regulation of the Efflux Transporter, Mrp2, and the Phase-Ii Metabolizing Enzyme, GSTπ, at the Blood—Brain Barrier

  2008influential reference
• The blood-brain barrier in health and chronic neurodegenerative disorders.

  2008cited by this paper
• MDR1‐P‐Glycoprotein (ABCB1) Mediates Transport of Alzheimer’s Amyloid‐β Peptides—Implications for the Mechanisms of Aβ Clearance at the Blood–Brain Barrier

  2007influential reference
• Amyloid beta deposition is related to decreased glucose transporter-1 levels and hippocampal atrophy in brains of aged APP/PS1 mice.

  2007cited by this paper
• Alzheimer's disease

  2006cited by this paper
• RAGE, LRP-1, and amyloid-beta protein in Alzheimer’s disease

  2006cited by this paper
• In Vivo Activation of Human Pregnane X Receptor Tightens the Blood-Brain Barrier to Methadone through P-Glycoprotein Up-Regulation

  2006influential reference
• Neurovascular mechanisms of Alzheimer's neurodegeneration.

  2005cited by this paper
• P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model.

  2005influential reference
• A Randomized, Controlled Trial of Doxycycline and Rifampin for Patients with Alzheimer's Disease

  2004cited by this paper
• Neurovascular regulation in the normal brain and in Alzheimer's disease

  2004cited by this paper
• Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier.

  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004influential reference
• The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer's disease.

  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2002influential reference
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  2001influential reference
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway.

  1998cited by this paper
• Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833.

  1997influential reference
• GLUT-1 expression in the cerebra of patients with Alzheimer's disease.

  1997cited by this paper
• P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

  1996cited by this paper
• Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

  1996influential reference
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  1986cited by this paper

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  2025cites this paper
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  2025cites this paper
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