Role of phosphoinositide signaling in the control of insulin exocytosis.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Molecular Endocrinology

• Publication date

  2005-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/ME.2004-0530PMID 16081518
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Neuronal calcium sensor-1 potentiates glucose-dependent exocytosis in pancreatic beta cells through activation of phosphatidylinositol 4-kinase beta.

  2005cited by this paper
• Neuronal calcium sensor-1 potentiates glucose-dependent exocytosis in pancreatic β cells through activation of phosphatidylinositol 4-kinase β

  2005cited by this paper
• Phosphatidylinositol phosphate kinase type I gamma regulates dynamics of large dense-core vesicle fusion.

  2005cited by this paper
• Phospholipase D1 Regulates Secretagogue-stimulated Insulin Release in Pancreatic β-Cells*

  2004influential reference
• Mint1, a Munc-18-interacting protein, is expressed in insulin-secreting beta-cells.

  2004cited by this paper
• Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking

  2004cited by this paper
• PI-loting membrane traffic

  2004cited by this paper
• Inaugural Article: Protein-lipid interactions and phosphoinositide metabolism in membrane traffic: Insights from vesicle recycling in nerve terminals

  2004cited by this paper
• CAPS acts at a prefusion step in dense-core vesicle exocytosis as a PIP2 binding protein.

  2004cited by this paper
• Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells.

  2004cited by this paper
• Mint1, a Munc-18-interacting protein, is expressed in insulin-secreting β-cells

  2004cited by this paper
• Insulin granule dynamics in pancreatic beta cells

  2003influential reference
• Differential gene expression in well-regulated and dysregulated pancreatic beta-cell (MIN6) sublines.

  2003cited by this paper
• Protein-lipid interplay in fusion and fission of biological membranes.

  2003cited by this paper
• Phosphatidylinositol 4-OH Kinase Is a Downstream Target of Neuronal Calcium Sensor-1 in Enhancing Exocytosis in Neuroendocrine Cells*

  2003cited by this paper
• ARF6 regulates a plasma membrane pool of phosphatidylinositol(4,5)bisphosphate required for regulated exocytosis

  2003cited by this paper
• Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic β cells

  2003influential reference
• Regulation of phospholipase D1 subcellular cycling through coordination of multiple membrane association motifs

  2003cited by this paper
• A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission

  2003cited by this paper
• ADP-ribosylation factor 6 regulates insulin secretion through plasma membrane phosphatidylinositol 4,5-bisphosphate

  2003cited by this paper
• Neuronal Calcium Sensor-1 and Phosphatidylinositol 4-Kinase β Regulate IgE Receptor-Triggered Exocytosis in Cultured Mast Cells 1

  2003cited by this paper
• Neuronal calcium sensor 1 and phosphatidylinositol 4-OH kinase β interact in neuronal cells and are translocated to membranes during nucleotide-evoked exocytosis

  2002cited by this paper
• Membrane Association Domains in Ca2+-dependent Activator Protein for Secretion Mediate Plasma Membrane and Dense-core Vesicle Binding Required for Ca2+-dependent Exocytosis*

  2002cited by this paper
• Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells.

  2002cited by this paper
• RNA interference

  2002cited by this paper
• Glucose‐stimulated signaling pathways in biphasic insulin secretion

  2002cited by this paper
• A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

  2002cited by this paper
• Beta-cell mitochondria and insulin secretion: messenger role of nucleotides and metabolites.

  2002cited by this paper
• PIP kinase Igamma is the major PI(4,5)P(2) synthesizing enzyme at the synapse.

  2001cited by this paper
• Phosphoinositides, key molecules for regulation of actin cytoskeletal organization and membrane traffic from the plasma membrane.

  2001cited by this paper
• Phospholipase D1: a key factor for the exocytotic machinery in neuroendocrine cells

  2001cited by this paper
• The role of impaired early insulin secretion in the pathogenesis of Type II diabetes mellitus

  2001influential reference
• PIP Kinase Iγ Is the Major PI(4,5)P2 Synthesizing Enzyme at the Synapse

  2001cited by this paper
• Beta-granule transport and exocytosis.

  2000cited by this paper
• β-granule transport and exocytosis

  2000cited by this paper
• Munc-18 Associates with Syntaxin and Serves as a Negative Regulator of Exocytosis in the Pancreatic β-Cell*

  2000cited by this paper
• Mints as Adaptors

  2000cited by this paper
• RNA Interference

  2000cited by this paper
• Rapid regulated dense-core vesicle exocytosis requires the CAPS protein.

  2000cited by this paper
• ARF mediates recruitment of PtdIns-4-OH kinase-β and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex

  1999cited by this paper
• Ca2+-Dependent Activator Protein for Secretion Is Critical for the Fusion of Dense-Core Vesicles with the Membrane in Calf Adrenal Chromaffin Cells

  1999cited by this paper
• Visualization of Phosphoinositides That Bind Pleckstrin Homology Domains: Calcium- and Agonist-induced Dynamic Changes and Relationship to Myo-[3H]inositol-labeled Phosphoinositide Pools

  1998influential reference
• Specific Binding of Phosphatidylinositol 4,5-Bisphosphate to Calcium-dependent Activator Protein for Secretion (CAPS), a Potential Phosphoinositide Effector Protein for Regulated Exocytosis*

  1998cited by this paper
• Mints: Munc18-interacting proteins in synaptic vesicle exocytosis

  1998cited by this paper
• Ishihara, H. et al. Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family. J. Biol. Chem. 273, 8741-8748

  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
• Phosphatidylinositol 4-kinases.

  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
• A novel 145 kd brain cytosolic protein reconstitutes Ca(2+)-regulated secretion in permeable neuroendocrine cells.

  1992cited by this paper
• Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.

  1992cited by this paper
• Insight Review Articles

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  2020cites this paper
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  2015cites this paper
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  2015cites this paper
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  2013cites this paper
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  2013cites this paper
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