PIP Kinase Iγ Is the Major PI(4,5)P2 Synthesizing Enzyme at the Synapse

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Neuron

• Publication date

  2001-10-11

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0896-6273(01)00456-1
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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  2001cited by this paper
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• Epsin 1 Undergoes Nucleocytosolic Shuttling and Its Eps15 Interactor Nh2-Terminal Homology (Enth) Domain, Structurally Similar to Armadillo and Heat Repeats, Interacts with the Transcription Factor Promyelocytic Leukemia Zn2+ Finger Protein (Plzf)

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• The Class II Phosphoinositide 3-Kinase PI3K-C2α Is Concentrated in the Trans-Golgi Network and Present in Clathrin-coated Vesicles*

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  2000cited by this paper
• A Pleckstrin Homology Domain Specific for Phosphatidylinositol 4,5-Bisphosphate (PtdIns-4,5-P2) and Fused to Green Fluorescent Protein Identifies Plasma Membrane PtdIns-4,5-P2 as Being Important in Exocytosis*

  2000cited by this paper
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• Localization of a class II phosphatidylinositol 3-kinase, PI3KC2alpha, to clathrin-coated vesicles.

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• The Role of Phosphatases in Inositol Signaling Reactions*

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• The Interaction of Epsin and Eps15 with the Clathrin Adaptor AP-2 Is Inhibited by Mitotic Phosphorylation and Enhanced by Stimulation-dependent Dephosphorylation in Nerve Terminals*

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• Effects of Docosahexaenoic Acid and Sex on Inflammatory Markers, Phagocytic Capacity, and Oxidative Stress After Controlled Cortical Impact in Rat Pups

  2026cites this paper
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  2025cites this paper
• Synaptic vesicle fusion promotes phosphatidylinositol 4-phosphate synthesis for efficient synaptic transmission.

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• Enhanced Notch dependent gliogenesis and delayed physiological maturation underlie neurodevelopmental defects in Lowe syndrome

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• Phosphoinositides: Nanoscale Effects on Neuronal Membranes

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• Synaptotagmin 1-triggered lipid signaling facilitates coupling of exo- and endocytosis.

  2023cites this paper
• α-Synuclein-dependent increases in PIP5K1γ drive inositol signaling to promote neurotoxicity

  2023cites this paper
• De novo missense variants in phosphatidylinositol kinase PIP5KIγ underlie a neurodevelopmental syndrome associated with altered phosphoinositide signaling.

  2023cites this paper
• Functional Characterization of Two Variants at the Intron 6—Exon 7 Boundary of the KCNQ2 Potassium Channel Gene Causing Distinct Epileptic Phenotypes

  2022cites this paper
• Hippocampal neurons maintain a large PtdIns(4)P pool that results in faster PtdIns(4,5)P2 synthesis

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• The Polarized Redistribution of the Contractile Vacuole to the Rear of the Cell is Critical for Streaming and is Regulated by PI(4,5)P2-Mediated Exocytosis

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• Localization of PIP5Kγ selectively in proprioceptive peripheral fields and also in sensory ganglionic satellite cells as well as neuronal cell membranes and their central terminals

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• Synaptotagmin-1 interacts with PI(4,5)P2 to initiate synaptic vesicle docking in hippocampal neurons.

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• Differential Regulation of Ca2+-Activated Cl− Channel TMEM16A Splice Variants by Membrane PI(4,5)P2

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• PtdIns(4,5)P2 is generated by a novel phosphatidylinositol 4‐phosphate 5‐kinase in the protist parasite Entamoeba histolytica

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• Kv7.3 Compound Heterozygous Variants in Early Onset Encephalopathy Reveal Additive Contribution of C-Terminal Residues to PIP2-Dependent K+ Channel Gating

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• Development of a High-Throughput Screening Assay to Identify Inhibitors of the Lipid Kinase PIP5K1C

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• A dPIP5K Dependent Pool of Phosphatidylinositol 4,5 Bisphosphate (PIP2) Is Required for G-Protein Coupled Signal Transduction in Drosophila Photoreceptors

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• Phosphoinositide-dependent perimembrane mechanisms of regulating cellular processes

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• The lipid kinase PIP5K1C regulates pain signaling and sensitization.

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