Near-infrared (NIR) fluorescence imaging has improved imaging depth relative to conventional fluorescence imaging in the visible region, demonstrating great potential in both fundamental biomedical research and clinical practice. To improve the detection specificity, NIR fluorescence imaging probes have been under extensive development. This review summarizes the particular application of optical imaging probes with the NIR-I window (700–900 nm) or the NIR-II window (1000–1700 nm) emission for diagnosis of nephron-urological diseases. These molecular probes have enabled contrast-enhanced imaging of anatomical structures and physiological function as well as molecular imaging and early diagnosis of acute kidney injury, iatrogenic ureteral injury and bladder cancer. The design strategies of molecular probes are specifically elaborated along with representative imaging applications. The potential challenges and perspectives in this field are also discussed.
Near-infrared fluorescent molecular probes for imaging and diagnosis of nephro-urological diseases
Published 2020 in Chemical Science
ABSTRACT
PUBLICATION RECORD
- Publication year
2020
- Venue
Chemical Science
- Publication date
2020-06-18
- Fields of study
Medicine, Chemistry
- Identifiers
- External record
- Source metadata
Semantic Scholar, PubMed
CITATION MAP
EXTRACTION MAP
CLAIMS
CONCEPTS
- acute kidney injury
A sudden decline in kidney function discussed as a diagnostic target for the probes.
Aliases: AKI
- bladder cancer
A malignant bladder disease discussed as a target for molecular imaging and diagnosis.
- challenges and perspectives
Open technical and translational issues, along with future directions, discussed at the end of the review.
Aliases: challenges, perspectives
- design strategies
Approaches used to construct and tune the near-infrared probes discussed in the review.
Aliases: probe design strategies
- iatrogenic ureteral injury
Ureter damage caused by medical intervention and discussed as a target condition for imaging.
- molecular probes
Fluorescent agents designed to target or report biological structures and processes in imaging.
Aliases: optical imaging probes, fluorescent molecular probes
- near-infrared fluorescence imaging
A fluorescence imaging modality that uses near-infrared wavelengths to improve imaging depth and tissue penetration.
Aliases: NIR fluorescence imaging
- nephro-urological diseases
Kidney and urinary tract disorders discussed as the application domain for the reviewed probes.
Aliases: nephron-urological diseases
- nir-ii window
The 1000-1700 nm near-infrared spectral range used for fluorescent probe emission in this review.
Aliases: NIR-II
- nir-i window
The 700-900 nm near-infrared spectral range used for fluorescent probe emission in this review.
Aliases: NIR-I
- representative imaging applications
Example use cases presented to illustrate how the probes are applied in imaging studies.
Aliases: imaging applications
REFERENCES
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