The gene for a new brain specific RhoA exchange factor maps to the highly unstable chromosomal region 1p36.2–1p36.3.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Oncogene

• Publication date

  2001-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.onc.1204921PMID 11704860
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characterization of p190RhoGEF, A RhoA-specific Guanine Nucleotide Exchange Factor That Interacts with Microtubules*

  2001cited by this paper
• Chromosome bands 1p35–36 contain two distinct neuroblastoma tumor suppressor loci, one of which is imprinted

  2001cited by this paper
• Role of the p53-homologue p73 in E2F1-induced apoptosis

  2000cited by this paper
• TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of rhoG.

  2000cited by this paper
• The yeast exchange assay, a new complementary method to screen for Dbl‐like protein specificity: identification of a novel RhoA exchange factor

  2000cited by this paper
• Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway.

  2000cited by this paper
• Genomic analysis of metastasis reveals an essential role for RhoC

  2000cited by this paper
• Identification and characterization of a novel Rho-specific guanine nucleotide exchange factor.

  2000cited by this paper
• Leukemia‐associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G12 family to Rho

  2000cited by this paper
• Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42.

  2000cited by this paper
• Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia.

  2000cited by this paper
• Frequent allelic imbalance suggests involvement of a tumor suppressor gene at 1p36 in the pathogenesis of human lung cancers

  2000influential reference
• Linkage and linkage disequilibrium in chromosome band 1p36 in American Chaldeans with inflammatory bowel disease.

  2000cited by this paper
• Neurodevelopmental profile of a new dysmorphic syndrome associated with submicroscopic partial deletion of 1p36.3

  2000cited by this paper
• Low frequency of allelic imbalance at the prostate cancer susceptibility loci HPC1 and 1p36 in Swedish men with hereditary prostate cancer

  2000cited by this paper
• Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation

  2000cited by this paper
• Characterization of TCL, a New GTPase of the Rho Family related to TC10 and Cdc42* 210

  2000cited by this paper
• Fine mapping of the human preprocortistatin gene (CORT) to neuroblastoma consensus deletion region 1p36.3→p36.2, but absence of mutations in primary tumors

  2000cited by this paper
• Identification and characterization of novel genes located at the t(1;15)(p36.2;q24) translocation breakpoint in the neuroblastoma cell line NGP.

  2000cited by this paper
• Identification of a 1-megabase consensus region of deletion at 1p36.3 in primary neuroblastomas.

  2000influential reference
• Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell line

  2000cited by this paper
• Augmentation of human leukemic cell invasion by activation of a small GTP-binding protein Rho.

  2000cited by this paper
• Rho family proteins and regulation of the actin cytoskeleton.

  1999cited by this paper
• Small GTPases of the Rho family and cell transformation.

  1999cited by this paper
• Human Ect2 Is an Exchange Factor for Rho Gtpases, Phosphorylated in G2/M Phases, and Involved in Cytokinesis

  1999cited by this paper
• Rho‐specific binding and guanine nucleotide exchange catalysis by KIAA0380, a Dbl family member

  1999cited by this paper
• A balance of signaling by Rho family small GTPases RhoA, Rac1 and Cdc42 coordinates cytoskeletal morphology but not cell survival

  1999cited by this paper
• Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction and cell growth

  1999cited by this paper
• Rac Downregulates Rho Activity

  1999cited by this paper
• Different Roles for RhoA During Neurite Initiation, Elongation, and Regeneration in PC12 Cells

  1999cited by this paper
• The DH protein family, exchange factors for Rho-like GTPases.

  1999cited by this paper
• Biological and Regulatory Properties of Vav-3, a New Member of the Vav Family of Oncoproteins

  1999cited by this paper
• A Novel Calcium Signaling Pathway Targets the c-fosIntragenic Transcriptional Pausing Site*

  1999cited by this paper
• Dependence of Dbl and Dbs transformation on MEK and NF-kappaB activation.

  1999cited by this paper
• The IL-1 receptor and Rho directly associate to drive cell activation in inflammation.

  1999cited by this paper
• A Novel PDZ Domain Containing Guanine Nucleotide Exchange Factor Links Heterotrimeric G Proteins to Rho*

  1999influential reference
• Molecular and clinical characterization of a patient with duplication of 1p36.3 and metopic synostosis

  1999cited by this paper
• Spectrum of transforming sequences detected by tumorigenicity assay in a large series of human neoplasms

  1999cited by this paper
• Dependence of Dbl and Dbs Transformation on MEK and NF-κB Activation

  1999cited by this paper
• Rac Downregulates Rho Activity: Reciprocal Balance between Both Gtpases Determines Cellular Morphology and Migratory Behavior

  1999cited by this paper
• Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton.

  1998cited by this paper
• PAK kinases are directly coupled to the PIX family of nucleotide exchange factors.

  1998cited by this paper
• Structure and mutagenesis of the Dbl homology domain

  1998cited by this paper
• Analysis of RhoA-binding Proteins Reveals an Interaction Domain Conserved in Heterotrimeric G Protein β Subunits and the Yeast Response Regulator Protein Skn7*

  1998cited by this paper
• RhoG GTPase controls a pathway that independently activates Rac1 and Cdc42Hs.

  1998cited by this paper
• Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1

  1998influential reference
• Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1.

  1998cited by this paper
• p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13.

  1998cited by this paper
• Cloning and Characterization of GEF-H1, a Microtubule-associated Guanine Nucleotide Exchange Factor for Rac and Rho GTPases*

  1998cited by this paper
• The two guanine nucleotide exchange factor domains of Trio link the Rac1 and the RhoA pathways in vivo

  1998influential reference
• p115 RhoGEF, a GTPase activating protein for Gα12 and Gα13

  1998influential reference
• Activation of RhoA and SAPK/JNK signalling pathways by the RhoA‐specific exchange factor mNET1

  1998cited by this paper
• Phosphorylation‐dependent and constitutive activation of Rho proteins by wild‐type and oncogenic Vav‐2

  1998influential reference
• Duplication of the DR3 gene on human chromosome 1p36 and its deletion in human neuroblastoma.

  1998influential reference
• Identification of a ligand for the death-domain-containing receptor Apo3.

  1998influential reference
• Dbl family proteins.

  1997influential reference
• The small GTPases Cdc42Hs, Rac1 and RhoG delineate Raf-independent pathways that cooperate to transform NIH3T3 cells.

  1997cited by this paper
• A Conditionally Expressed Third Partner Stabilizes or Prevents the Formation of a Transcriptional Activator in a Three-hybrid System*

  1997cited by this paper
• Lck regulates Vav activation of members of the Rho family of GTPases

  1997cited by this paper
• Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers.

  1997influential reference
• Effect of Bcr sequences on the cellular function of the Bcr-Abl oncoprotein

  1997cited by this paper
• Identification of a Novel Guanine Nucleotide Exchange Factor for the Rho GTPase*

  1996cited by this paper
• Lfc and Lsc Oncoproteins Represent Two New Guanine Nucleotide Exchange Factors for the Rho GTP-binding Protein*

  1996influential reference
• Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation

  1995influential reference
• A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways.

  1994cited by this paper
• Growth-regulated expression of rhoG, a new member of the ras homolog gene family

  1992cited by this paper
• Activation of a mcf.2 oncogene by deletion of amino-terminal coding sequences.

  1988cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• Isolation of a new human oncogene from a diffuse B-cell lymphoma

  1985cited by this paper

• PLEKHG2 and the PLEKHG family: Linking Rho family GTPases to neural development and disorders.

  2025cites this paper
• The RhoGEF protein Plekhg5 self-associates via its PH domain to regulate apical cell constriction

  2024cites this paper
• Airspaces-derived exosomes contain disease-relevant protein signatures in a mouse model of cystic fibrosis (CF)-like mucoinflammatory lung disease

  2024cites this paper
• Homozygous N-terminal missense variant in PLEKHG5 associated with intermediate CMT: A case report

  2021cites this paper
• Effects of stanniocalcin-1 overexpressing hepatocellular carcinoma cells on macrophage migration

  2020cites this paper
• MicroRNA Regulation of the Small Rho GTPase Regulators—Complexities and Opportunities in Targeting Cancer Metastasis

  2020cites this paper
• Novel PLEKHG5 mutations in a patient with childhood‐onset lower motor neuron disease

  2020cites this paper
• Absence of Plekhg5 Results in Myelin Infoldings Corresponding to an Impaired Schwann Cell Autophagy, and a Reduced T-Cell Infiltration Into Peripheral Nerves

  2020cites this paper
• PLEKHG5 is a novel prognostic biomarker in glioma patients

  2019cites this paper
• The versatility of RhoA activities in neural differentiation

  2019cites this paper
• Analysis of the NF-κB Signal Transduction Pathway in Neurological Disorders and Cancer

  2018cites this paper
• NRP‐1 interacts with GIPC1 and SYX to activate p38 MAPK signaling and cancer stem cell survival

  2018cites this paper
• UnPAKing RUNX3 functions–Both sides of the coin

  2017cites this paper
• Carboxymethyl-lysine-modified plasma proteins in age-related macular degeneration

  2017cites this paper
• Tensins are versatile regulators of Rho GTPase signalling and cell adhesion

  2017cites this paper
• Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease

  2017cites this paper
• RhoA inhibits neural differentiation in murine stem cells through multiple mechanisms

  2016cites this paper
• Quantitative GTPase Affinity Purification Identifies Rho Family Protein Interaction Partners*

  2016cites this paper
• VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells

  2015cites this paper
• Phosphorylation-mediated regulation of GEFs for RhoA

  2014cites this paper
• RhoGEFs in cell motility: novel links between Rgnef and focal adhesion kinase.

  2014cites this paper
• PLEKHG 5 deficiency leads to an intermediate form of autosomal-recessive Charcot – Marie – Tooth disease

  2013cites this paper
• The Rho Guanine Nucleotide Exchange Factor Syx Regulates the Balance of Dia and ROCK Activities To Promote Polarized-Cancer-Cell Migration

  2013influential citation
• Ras GTPases’ interaction with effector domains

  2013cites this paper
• Targeting the Dbl and dock-family RhoGEFs: a yeast-based assay to identify cell-active inhibitors of Rho-controlled pathways.

  2013cites this paper
• Rho GEFs in endothelial junctions

  2013cites this paper
• Phosphorylation-mediated 14-3-3 Protein Binding Regulates the Function of the Rho-specific Guanine Nucleotide Exchange Factor (RhoGEF) Syx*

  2013influential citation
• PLEKHG5 deficiency leads to an intermediate form of autosomal-recessive Charcot-Marie-Tooth disease.

  2013cites this paper
• Guanosine Triphosphatases and Their Regulators

  2013cites this paper
• Dual-Specificity Protein Kinases

  2013cites this paper
• Mitogen-Activated Protein Kinase Module

  2013cites this paper
• Preamble to Cytoplasmic Protein Kinases

  2013cites this paper
• Cytoplasmic Protein Serine/Threonine Kinases

  2013cites this paper
• Other Major Types of Signaling Mediators

  2013cites this paper
• Cytosolic Protein Phosphatases

  2013cites this paper
• Cytoplasmic Protein Tyrosine Kinases

  2013cites this paper
• A Thesis entitled Caenorhabditis elegans RHGF-2 is Required for Embryonic Elongation and Co-localizes in vivo with the PDZ-domain Containing Scaffold Protein MPZ-1 by

  2012influential citation
• Stabilized by Their Effectors The GTPase-deficient Rnd Proteins Are Protein Synthesis and Degradation :

  2012cites this paper
• The GTPase-deficient Rnd Proteins Are Stabilized by Their Effectors

  2012cites this paper
• Mechanistic investigation of small molecule inhibitors of kinesin-5 and kinesin-6 family members in cancer drug development

  2012cites this paper
• RHGF-2 Is an Essential Rho-1 Specific RhoGEF that binds to the Multi-PDZ Domain Scaffold Protein MPZ-1 in Caenorhabditis elegans

  2012cites this paper
• Caenorhabditis elegans RHGF-2 is Required for Embryonic Elongation and Co-localizes in vivo with the PDZ-domain Containing Scaffold Protein MPZ-1

  2012influential citation
• RhoE Deficiency Produces Postnatal Lethality, Profound Motor Deficits and Neurodevelopmental Delay in Mice

  2011cites this paper
• Membrane traffic as a coordinator of cell migration and junction remodeling

  2011cites this paper
• Molecular genetics and mechanisms of disease in distal hereditary motor neuropathies: insights directing future genetic studies.

  2011cites this paper
• The RhoA GEF Syx Is a Target of Rnd3 and Regulated via a Raf1-Like Ubiquitin-Related Domain

  2010cites this paper
• The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells.

  2009cites this paper
• A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway.

  2009cites this paper
• Branching morphogenesis.

  2009cites this paper
• Branching morphogenesis.

  2008cites this paper
• Syx, a RhoA Guanine Exchange Factor, Is Essential for Angiogenesis In Vivo

  2008cites this paper
• This Review is part of a thematic series on Arterial Specification: A Finishing School for the Endothelium, which includes the following articles: Role of Crosstalk Between Phosphatidylinositol 3-Kinase and Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Pathways in Artery-Vei

  2008cites this paper
• Branching Morphogenesis

  2008cites this paper
• CONTROLLING ANGIOGENESIS – FUNCTIONAL STUDIES OF ANGIOMOTIN MIRA ERNKVIST

  2007cites this paper
• Controlling angiogenesis : Functional studies of angiomotin

  2007cites this paper
• A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotype.

  2006cites this paper
• Rho GTPase expression in tumourigenesis: Evidence for a significant link

  2005influential citation
• Definition and characterization of a region of 1p36.3 consistently deleted in neuroblastoma

  2005cites this paper
• Nuclear translocation of the SRF co‐activator MAL in cortical neurons: role of RhoA signalling

  2005cites this paper
• Tech: a RhoA GEF selectively expressed in hippocampal and cortical neurons

  2005cites this paper
• Requirement For C-terminal Sequences in Regulation of Ect2 Guanine Nucleotide Exchange Specificity and Transformation*

  2004cites this paper
• Characterisation of PGs1, a subunit of a protein complex co-purifying with tubulin polyglutamylase

  2003cites this paper
• Rho GTPases in human carcinogenesis: a tale of excess

  2003cites this paper
• Jcb: Article

  year unknowncites this paper
• Jcb: Article

  year unknowncites this paper
• Jcb: Article

  year unknowncites this paper