Structure-Based Identification of a Major Neutralizing Site in an Adenovirus Hexon

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Journal of Virology

• Publication date

  2006-11-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.02023-06PMID 17108028PMCID PMC1797575
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Large-scale purification and crystallization of adenovirus hexon.

  2007cited by this paper
• Chimpanzee-origin adenovirus vectors as vaccine carriers

  2006influential reference
• Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity

  2006cited by this paper
• Capsid-like arrays in crystals of chimpanzee adenovirus hexon.

  2006cited by this paper
• Chick embryo lethal orphan virus can be polymer-coated and retargeted to infect mammalian cells

  2006cited by this paper
• Immunogenicity of Recombinant Fiber-Chimeric Adenovirus Serotype 35 Vector-Based Vaccines in Mice and Rhesus Monkeys

  2005cited by this paper
• CryoEM structure at 9A resolution of an adenovirus vector targeted to hematopoietic cells.

  2005cited by this paper
• Evaluation of polyethylene glycol modification of first-generation and helper-dependent adenoviral vectors to reduce innate immune responses.

  2005cited by this paper
• A quasi‐atomic model of human adenovirus type 5 capsid

  2005cited by this paper
• Comparative transduction efficiencies of human and nonhuman adenoviral vectors in human, murine, bovine, and porcine cells in culture.

  2005cited by this paper
• Neutralizing Antibodies to Adenovirus Serotype 5 Vaccine Vectors Are Directed Primarily against the Adenovirus Hexon Protein1

  2005cited by this paper
• Neutralizing antibody evasion ability of adenovirus vector induced by the bioconjugation of methoxypolyethylene glycol succinimidyl propionate (MPEG-SPA).

  2004cited by this paper
• Use of chimeric adenoviral vectors to assess capsid neutralization determinants.

  2004cited by this paper
• Microsphere‐liposome complexes protect adenoviral vectors from neutralising antibody without losses in transfection efficiency, in‐vitro

  2004cited by this paper
• Postentry Neutralization of Adenovirus Type 5 by an Antihexon Antibody

  2004cited by this paper
• Structural and Phylogenetic Analysis of Adenovirus Hexons by Use of High-Resolution X-Ray Crystallographic, Molecular Modeling, and Sequence-Based Methods

  2003influential reference
• Structural studies on adenoviruses.

  2003cited by this paper
• A Simian Replication-Defective Adenoviral Recombinant Vaccine to HIV-1 Gag 1

  2003cited by this paper
• Hexon Gene Switch Strategy for the Generation of Chimeric Recombinant Adenovirus

  2002cited by this paper
• Construction and Characterization of Adenovirus Serotype 5 Packaged by Serotype 3 Hexon

  2002cited by this paper
• Novel, Chimpanzee Serotype 68-Based Adenoviral Vaccine Carrier for Induction of Antibodies to a Transgene Product

  2002influential reference
• Import of adenovirus DNA involves the nuclear pore complex receptor CAN/Nup214 and histone H1

  2001cited by this paper
• Replication-Defective Vector Based on a Chimpanzee Adenovirus

  2001cited by this paper
• Canine Adenovirus Vectors: an Alternative for Adenovirus-Mediated Gene Transfer

  2000cited by this paper
• Localization of a Binding Site for Herpes Simplex Virus Glycoprotein D on Herpesvirus Entry Mediator C by Using Antireceptor Monoclonal Antibodies

  2000influential reference
• Type-specific epitope locations revealed by X-ray crystallographic study of adenovirus type 5 hexon.

  2000influential reference
• Circumvention of vector-specific neutralizing antibody response by alternating use of human and non-human adenoviruses: implications in gene therapy.

  2000cited by this paper
• Immune Response to Recombinant Capsid Proteins of Adenovirus in Humans: Antifiber and Anti-Penton Base Antibodies Have a Synergistic Effect on Neutralizing Activity

  1998cited by this paper
• Circumvention of Immunity to the Adenovirus Major Coat Protein Hexon

  1998cited by this paper
• Development of replication-defective herpes simplex virus vectors.

  1997cited by this paper
• Circumvention of Anti-Adenovirus Neutralizing Immunity by Administration of an Adenoviral Vector of an Alternate Serotype

  1997cited by this paper
• SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modeling

  1997cited by this paper
• Splicing by overlap extension by PCR using asymmetric amplification: an improved technique for the generation of hybrid proteins of immunological interest.

  1997cited by this paper
• Adenovirus type 5 and 7 capsid chimera: fiber replacement alters receptor tropism without affecting primary immune neutralization epitopes

  1996cited by this paper
• “Sero-Switch” Adenovirus-Mediated In Vivo Gene Transfer: Circumvention of Anti-Adenovirus Humoral Immune Defenses Against Repeat Adenovirus Vector Administration by Changing the Adenovirus Serotype

  1996cited by this paper
• The refined crystal structure of hexon, the major coat protein of adenovirus type 2, at 2.9 A resolution.

  1994influential reference
• Electrophoretic migration of adenovirus hexon under non-denaturing conditions.

  1994cited by this paper
• Spectroscopic evidence that monoclonal antibodies recognize the dominant conformation of medium-sized synthetic peptides.

  1994cited by this paper
• Difference imaging of adenovirus: bridging the resolution gap between X‐ray crystallography and electron microscopy.

  1993cited by this paper
• Antipeptide antisera define neutralizing epitopes on the adenovirus hexon.

  1992cited by this paper
• Antibodies with specificities against a dispase-produced 15-kilodalton hexon fragment neutralize adenovirus type 2 infectivity

  1990cited by this paper
• Neutralization of adenoviruses: kinetics, stoichiometry, and mechanisms

  1988cited by this paper
• Interaction between HeLa cells and adenovirus type 2 virions neutralized by different antisera

  1985cited by this paper
• Continuous cultures of fused cells secreting antibody of predefined specificity

  1975cited by this paper
• Neutralization of Adenoviruses: Kinetics, Stoichiometry, and Mechanisms

  year unknowncited by this paper

• Molecular characteristics of human adenovirus isolated from the 2024 influenza-like illness outbreaks in Suzhou City, China

  2025cites this paper
• Genomic characteristics and phylogenetic analysis of human adenovirus 14 in China during 2010-2016.

  2025cites this paper
• Molecular characterization and evolutionary analysis of human adenovirus type 55, related to febrile respiratory illness in the South Korean military

  2025cites this paper
• The seroprevalence of adenoviruses since 20001

  2025cites this paper
• Adenovirus‐Specific T Cells in Adults Are Frequent, Cross‐Reactive to Common Childhood Adenovirus Infections and Boosted by Adenovirus‐Vectored Vaccines

  2024cites this paper
• Molecular Characterization of Hydropericardium Hepatitis Syndrome in Broiler Chickens

  2024cites this paper
• A recombinant virus-like particle vaccine against adenovirus-7 induces a potent humoral response

  2023cites this paper
• Seroprevalence of neutralizing antibodies to human mastadenovirus serotypes 3 and 7 in healthy children from guangdong province

  2023cites this paper
• Evidence of vertical transmission of fowl adenovirus 8b in ducks.

  2023cites this paper
• Hsp70 Inhibits the Replication of Fowl Adenovirus Serotype 4 by Suppressing Viral Hexon with the Assistance of DnaJC7

  2022cites this paper
• New p35 (H3L) Epitope Involved in Vaccinia Virus Neutralization and Its Deimmunization

  2022cites this paper
• Identification of Recombinant Chimpanzee Adenovirus C68 Degradation Products Detected by AEX-HPLC

  2022cites this paper
• A multi-epitopes tandem antigen for five types of human adenoviruses and its application in development of multivalent IgM immunochromatographic strip test.

  2022cites this paper
• Significance of Preexisting Vector Immunity and Activation of Innate Responses for Adenoviral Vector-Based Therapy

  2022cites this paper
• Icosahedral gold nanoparticles decorated with hexon protein: a surrogate for adenovirus serotype 5

  2022cites this paper
• Epidemiological and molecular analysis of circulating fowl adenoviruses and emerging of serotypes 1, 3, and 8b in Egypt

  2021influential citation
• A recent perspective on fiber and hexon genes proteins analyses of fowl adenovirus toward virus infectivity—A review

  2021cites this paper
• Immunological Study of Reconstructed Common Ancestral Sequence of Adenovirus Hexon Protein

  2021cites this paper
• In Silico Designing of a Multi-Epitope Based Vaccine Candidate Against Human Adenovirus Type B3 Respiratory Infections by Utilising Various Immunoinformatics Approaches

  2021cites this paper
• Sequencing Coding Region and in Silico Structural Analysis of Protein Hexon of HAdV-3 Causing Conjunctivitis in Vietnam

  2021cites this paper
• Design and Engineering of Deimmunized Vaccinia Viral Vectors

  2020cites this paper
• PCR Based Detection and Phylogenetic Analysis of Fowl Adenovirus Strains Isolated from 2019 Epidemic from Punjab and Sindh, Pakistan

  2020cites this paper
• Bioinformatics analysis reveals four major hexon variants of human adenovirus type-3 (HAdV-3) as the potential strains for development of vaccine and siRNA-based therapeutics against HAdV-3 respiratory infections

  2020cites this paper
• Construction and Characterization of a Novel Recombinant Attenuated and Replication-Deficient Candidate Human Adenovirus Type 3 Vaccine: “Adenovirus Vaccine Within an Adenovirus Vector”

  2020cites this paper
• Prevalence and characteristics of a novel bovine adenovirus type 3 with a natural deletion fiber gene.

  2020cites this paper
• Molecular retargeting of antibodies converts immune defense against oncolytic viruses into cancer immunotherapy

  2019cites this paper
• Molecular evolution of human adenovirus type 16 through multiple recombination events

  2019cites this paper
• A novel human monoclonal antibody potently neutralizes human adenovirus serotype 7 by primarily targeting the adenovirus hexon protein.

  2019cites this paper
• Immunology of Adenoviral Vectors in Cancer Therapy

  2019cites this paper
• Genetic characterization of fowl adenovirus serotype 4 isolates in Southern China reveals potential cross-species transmission.

  2019cites this paper
• A Murine Monoclonal Antibody With Potent Neutralization Ability Against Human Adenovirus 7

  2019cites this paper
• Seroprevalence of Neutralizing Antibodies to Human Adenovirus Type 4 and 7 in Healthy Populations From Southern China

  2018cites this paper
• Deep analysis of Loop L1 HVRs1-4 region of the hexon gene of adenovirus field strains isolated in Poland

  2018cites this paper
• Identification of adenovirus neutralizing antigens using capsid chimeric viruses.

  2018cites this paper
• Interaction of Human Enterochromaffin Cells with Human Enteric Adenovirus 41 Leads to Serotonin Release and Subsequent Activation of Enteric Glia Cells

  2018cites this paper
• Worldwide increased prevalence of human adenovirus type 3 (HAdV-3) respiratory infections is well correlated with heterogeneous hypervariable regions (HVRs) of hexon

  2018cites this paper
• Correction: Worldwide increased prevalence of human adenovirus type 3 (HAdV-3) respiratory infections is well correlated with heterogeneous hypervariable regions (HVRs) of hexon

  2018cites this paper
• Hexon and fiber of adenovirus type 14 and 55 are major targets of neutralizing antibody but only fiber-specific antibody contributes to cross-neutralizing activity.

  2018cites this paper
• Adenoviruses and Their Diversity in Poultry Adenoviruses and Their Diversity in Poultry

  2018influential citation
• Oncolytic adenovirus Ad657 for systemic virotherapy against prostate cancer

  2018influential citation
• Oncolytic adenovirus Ad 657 for systemic virotherapy against prostate cancer

  2018influential citation
• Adenoviruses and Their Diversity in Poultry

  2018influential citation
• Broadly neutralizing monoclonal antibodies against human adenovirus types 55, 14p, 7, and 11 generated with recombinant type 11 fiber knob

  2018cites this paper
• Small-size recombinant adenoviral hexon protein fragments for the production of virus-type specific antibodies

  2017influential citation
• Fowl adenovirus serotype 4: Epidemiology, pathogenesis, diagnostic detection, and vaccine strategies

  2017cites this paper
• Identification of a Critical and Conformational Neutralizing Epitope in Human Adenovirus Type 4 Hexon

  2017cites this paper
• Identification and molecular characteristic of fowl adenovirus serotype 4 isolated from a live Newcastle disease virus vaccine

  2017cites this paper
• Molecular characterisation of fowl adenovirus type 7 isolated from poultry associated with inclusion body hepatitis in Poland

  2017cites this paper
• Development of a prototype immunochromatographic test for rapid diagnosis of respiratory adenovirus infection

  2017cites this paper
• Interaction between hexon and L4-100K determines virus rescue and growth of hexon-chimeric recombinant Ad5 vectors

  2016cites this paper
• Molecular epidemiology of hydropericardium syndrome outbreak-associated serotype 4 fowl adenovirus isolates in central China

  2016cites this paper
• Adenoviral vector-based strategies against infectious disease and cancer

  2016cites this paper
• Fowl adenovirus species C serotype 4 is attributed to the emergence of hepatitis-hydropericardium syndrome in chickens in China.

  2016cites this paper
• Adenoviral Vector Vaccines Antigen Transgene

  2016cites this paper
• Antibodies against Adenoviruses

  2016cites this paper
• Methods to Mitigate Immune Responses to Adenoviral Vectors

  2016cites this paper
• Adenovirus-host interactions : implications for tropism and therapy

  2016cites this paper
• Upstream Bioprocess for Adenovirus Vectors

  2016cites this paper
• Hexon-modified recombinant E1-deleted adenoviral vectors as bivalent vaccine carriers for Coxsackievirus A16 and Enterovirus 71.

  2015cites this paper
• Identification and Application of Neutralizing Epitopes of Human Adenovirus Type 55 Hexon Protein

  2015cites this paper
• Early host cell interactions and antivirals against ocular adenoviruses

  2015cites this paper
• Neutralizing epitopes mapping of human adenovirus type 14 hexon.

  2015cites this paper
• Phylogenetic and geographic analysis of fowl adenovirus field strains isolated from poultry in Poland

  2015influential citation
• Chimpanzee adenovirus and MVA-vectored respiratory syncytial virus vaccine is safe and expands humoral and cellular immunity in adults

  2015cites this paper
• Chimpanzee adenovirus– and MVA-vectored respiratory syncytial virus vaccine is safe and immunogenic in adults

  2015cites this paper
• Pre-existing immunity against Ad vectors

  2014cites this paper
• Human Adenovirus-Specific γ/δ and CD8+ T Cells Generated by T-Cell Receptor Transfection to Treat Adenovirus Infection after Allogeneic Stem Cell Transplantation

  2014cites this paper
• Adenovirus-Based Vaccines for Fighting Infectious Diseases and Cancer: Progress in the Field

  2014cites this paper
• Human adenovirus type 8: the major agent of epidemic keratoconjunctivitis (EKC).

  2014cites this paper
• TransferAdenovirus Serotype 5 Gene Effect of Neutralizing Sera on Factor

  2014cites this paper
• Circumventing Antivector Immunity: Potential Use of Nonhuman Adenoviral Vectors

  2014cites this paper
• Consequences of Adenovirus Vector Vaccination on T Cell Activation and SIV Susceptibility in Rhesus Macaques

  2014cites this paper
• Molecular and serological characterization of species B2 adenovirus strains isolated from children hospitalized with acute respiratory disease in Buenos Aires, Argentina.

  2013cites this paper
• Hydropericardium syndrome: current state and future developments

  2013cites this paper
• Automatic comparison and classification of protein structures.

  2013cites this paper
• Structural studies on adenovirus: the human adenovirus packaging motor, and characterization of two reptilian adenoviruses

  2013cites this paper
• Hexon-modified recombinant E1-deleted adenovirus vectors as dual specificity vaccine carriers for influenza virus.

  2013cites this paper
• Directed Evolution of Mutator Adenoviruses Resistant to Antibody Neutralization

  2013cites this paper
• Epitope mapping and characterization of a neutralizing monoclonal antibody against human adenovirus type 3.

  2013cites this paper
• Adenovirus Species B interactions with CD46

  2012cites this paper
• Latest Insights on Adenovirus Structure and Assembly

  2012cites this paper
• Serotype-Specific Neutralizing Antibody Epitopes of Human Adenovirus Type 3 (HAdV-3) and HAdV-7 Reside in Multiple Hexon Hypervariable Regions

  2012influential citation
• Protection against Enterovirus 71 with Neutralizing Epitope Incorporation within Adenovirus Type 3 Hexon

  2012influential citation
• Structure-Based High-Throughput Epitope Analysis of Hexon Proteins in B and C Species Human Adenoviruses (HAdVs)

  2012cites this paper
• Latest Insights on Adenovirus Structure and Assembly

  2012cites this paper
• Characterization of malleability and immunological properties of human adenovirus type 3 hexon hypervariable region 1

  2012cites this paper
• Chimeric hexon HVRs protein reflects partial function of adenovirus.

  2012cites this paper
• transfer serotype 5 hexon: effect of mutagenesis on FX interactions and gene Identification of coagulation factor (F)X binding sites on the adenovirus

  2011cites this paper
• Molecular analysis of adenoviruses from clinical samples

  2011cites this paper
• Characterization of variant strains of respiratory adenoviruses isolated in Egypt from 2003 to 2010

  2011cites this paper
• Isolation, Cloning and In silico Study of Hexon Gene of Fowl Adenovirus 4(FAV4) Isolates Associated with Hydro Pericardium Syndrome in DomesticFowl

  2011cites this paper
• Genetic engineering of adenoviral vectors for improved therapeutic applications

  2011cites this paper
• Switching the fiber knob of oncolytic adenoviruses to avoid neutralizing antibodies in human cancer patients

  2011cites this paper
• Development of adenovirus hybrid vectors for Sleeping Beauty transposition in large mammals.

  2011cites this paper
• Construction and characterization of human adenovirus serotype 3 packaged by serotype 7 hexon.

  2011cites this paper
• Anti-adenovirus activities of shikonin, a component of Chinese herbal medicine in vitro.

  2011cites this paper
• Isolation, Cloning and In silico Study of Hexon Gene of Fowl Adenovirus 4 (FAV4) Isolates Associated with Hydro Pericardium Syndrome in Domestic Fowl

  2011cites this paper
• Advances and Future Challenges in Adenoviral Vector Pharmacology and Targeting

  2011cites this paper
• Adenovirus specific T-cell responses in humans following natural infection and vaccination

  2010cites this paper
• Replacing adenoviral vector HVR1 with a malaria B cell epitope improves immunogenicity and circumvents preexisting immunity to adenovirus in mice.

  2010cites this paper