Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Nature Immunology

• Publication date

  2004-10-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ni1127PMID 15489857
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The generation of antibody diversity through somatic hypermutation and class switch recombination.

  2004cited by this paper
• AID: how does it aid antibody diversity?

  2004cited by this paper
• AID is required for c-myc/IgH chromosome translocations in vivo.

  2004cited by this paper
• Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

  2004cited by this paper
• Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA.

  2004cited by this paper
• Genome-wide somatic hypermutation.

  2004cited by this paper
• Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to S mu in Ig class switch recombination.

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• Constitutive Expression of AID Leads to Tumorigenesis

  2003cited by this paper
• Somatic hypermutation of the B cell receptor genes B29 (Igβ, CD79b) and mb1 (Igα, CD79a)

  2003cited by this paper
• The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice.

  2003cited by this paper
• Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma.

  2003cited by this paper
• Neoplastic development in plasma cells

  2003cited by this paper
• Transcription-targeted DNA deamination by the AID antibody diversification enzyme

  2003cited by this paper
• Transcription-Coupled Events Associating with Immunoglobulin Switch Region Chromatin

  2003cited by this paper
• R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells

  2003cited by this paper
• The Block in Immunoglobulin Class Switch Recombination Caused by Activation-Induced Cytidine Deaminase Deficiency Occurs Prior to the Generation of DNA Double Strand Breaks in Switch μ Region 1

  2003cited by this paper
• The role of DNA breaks in genomic instability and tumorigenesis

  2003cited by this paper
• AID-dependent generation of resected double-strand DNA breaks and recruitment of Rad52/Rad51 in somatic hypermutation.

  2003cited by this paper
• The influence of transcriptional orientation on endogenous switch region function

  2003cited by this paper
• Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a).

  2003cited by this paper
• Internal IgH class switch region deletions are position-independent and enhanced by AID expression

  2002cited by this paper
• Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations.

  2002cited by this paper
• The Activation-induced Deaminase Functions in a Postcleavage Step of the Somatic Hypermutation Process

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• Critical Roles of Activation-Induced Cytidine Deaminase in the Homeostasis of Gut Flora

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• DNA Double-Strand Breaks

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• Evidence for Replicative Repair of DNA Double-Strand Breaks Leading to Oncogenic Translocation and Gene Amplification

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• A human nuclease specific for G4 DNA

  2001cited by this paper
• Mechanisms of chromosomal translocations in B cell lymphomas

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• AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching

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• Chromosome translocations in multiple myeloma

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• DNA double strand break repair and chromosomal translocation: Lessons from animal models

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• Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

  2001cited by this paper
• Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme.

  2000cited by this paper
• Cell-cycle-regulated DNA double-strand breaks in somatic hypermutation of immunoglobulin genes

  2000cited by this paper
• The role of immunoglobulin translocations in the pathogenesis of B-cell malignancies.

  2000cited by this paper
• Transcription-induced Cleavage of Immunoglobulin Switch Regions by Nucleotide Excision Repair Nucleases in Vitro*

  2000cited by this paper
• Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2).

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• Increased Frequency of Surface IgA-Positive Plasma Cells in the Intestinal Lamina Propria and Decreased IgA Excretion in Hyper IgA (HIGA) Mice, a Murine Model of IgA Nephropathy with Hyperserum IgA1

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• Recurrent chromosome aberrations in cancer.

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• Recombinase-activating gene (RAG) 2-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice.

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• DNA double-strand breaks in immunoglobulin genes undergoing somatic hypermutation.

  2000cited by this paper
• Increased frequency of surface IgA-Positive Plasma cells in the intestinal lamina propria and decreased IgA excretion in hyper IgA(HIGA)mice,a murine model of IgA nephropathy with hyperserum IgA

  2000cited by this paper
• Immunoglobulin Switch Recombination May Occur by a DNA End‐Joining Mechanism a

  1999cited by this paper
• Specific Expression of Activation-induced Cytidine Deaminase (AID), a Novel Member of the RNA-editing Deaminase Family in Germinal Center B Cells*

  1999cited by this paper
• Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase.

  1999cited by this paper
• Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes.

  1998cited by this paper
• Pathological and Physiological Double-Strand Breaks: Roles in Cancer, Aging, and the Immune System

  1998cited by this paper
• Warner-Lambert/Parke-Davis Award Lecture. Pathological and physiological double-strand breaks: roles in cancer, aging, and the immune system.

  1998cited by this paper
• A matter of life and cell death.

  1998cited by this paper
• BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci.

  1998cited by this paper
• Experimental plasmacytomagenesis in mice.

  1997cited by this paper
• Ig Sgamma3 DNA-specifc double strand breaks are induced in mitogen-activated B cells and are implicated in switch recombination.

  1997cited by this paper
• Migration of cells with immunoglobulin/c-myc recombinations in lymphoid tissues of mice.

  1997cited by this paper
• Chromosomal translocations deregulating c-myc are associated with normal immune responses

  1997cited by this paper
• Detection of immunoglobulin/c-myc recombinations in mice that are resistant to plasmacytoma induction.

  1996cited by this paper
• Immunoglobulin class switching.

  1996cited by this paper
• Elevated interleukin 6 is induced by prostaglandin E2 in a murine model of inflammation: possible role of cyclooxygenase-2.

  1996cited by this paper
• The Ig heavy chain switch region is a hotspot for insertion of transfected DNA.

  1995cited by this paper
• The role of c-myc in cell growth.

  1993cited by this paper
• Detection of recombinations between c-myc and immunoglobulin switch alpha in murine plasma cell tumors and preneoplastic lesions by polymerase chain reaction.

  1993cited by this paper
• Elevation of interleukin-6 in response to a chronic inflammatory stimulus in mice: inhibition by indomethacin.

  1992cited by this paper
• Plasmacytomagenesis in mice: model of neoplastic development dependent upon chromosomal translocations.

  1992cited by this paper
• Immunoglobulin class switching.

  1984cited by this paper
• Escherichia coli extract-catalyzed recombination in switch regions of mouse immunoglobulin genes.

  1983cited by this paper
• HISTOLOGY OF DEVELOPING PLASMA CELL NEOPLASIA INDUCED BY MINERAL OIL IN BALB/C MICE.

  1964cited by this paper

• The uncharacterized SANT and BTB domain-containing protein SANBR inhibits class switch recombination

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• chronic lymphocytic leukemia patients expression in tissue samples from mantle cell lymphoma and B-cell Quantitative RT-PCR analysis of activation-induced cytidine deaminase

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• The APOBEC3 family of retroelement restriction factors.

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• Gene Conversion-Like Events in the Diversification of Human Rearranged IGHV3-23*01 Gene Sequences

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• Translocation of an antibody transgene requires AID and occurs by interchromosomal switching to all switch regions except the mu switch region

  2011cites this paper
• Assessment of therapeutic targets in experimental models of Myc-induced lymphoma

  2011cites this paper
• Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions.

  2011cites this paper
• Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells.

  2011cites this paper
• How does DNA break during chromosomal translocations?

  2011cites this paper
• Controlling somatic hypermutation in immunoglobulin variable and switch regions

  2010cites this paper
• Parp 1 facilitates alternative NHEJ , whereas Parp 2 suppresses IgH / c-myc translocations during immunoglobulin class switch recombination

  2009cites this paper
• AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations.

  2009cites this paper
• Epstein-Barr virus and its role in the pathogenesis of Burkitt's lymphoma: an unresolved issue.

  2009cites this paper
• Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: Concurrent upregulation of somatic hypermutation and class switch DNA recombination

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• Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination

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• Molecular characterization of hybridoma subclones spontaneously switching at high frequencies in vitro.

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• Reduced immunoglobulin class switch recombination in the absence of Artemis.

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• Blimp1 is limiting for transformation in a mouse plasmacytoma model.

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• Switching on chromosomal translocations.

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• Antibody diversification

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