AID mutates a non-immunoglobulin transgene independent of chromosomal position.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Molecular Immunology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.MOLIMM.2006.02.003PMID 16542725
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Role of genomic instability and p53 in AID-induced c-myc–Igh translocations

  2006cited by this paper
• Biased dA/dT somatic hypermutation as regulated by the heavy chain intronic iEmu enhancer and 3'Ealpha enhancers in human lymphoblastoid B cells.

  2006cited by this paper
• PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells.

  2006cited by this paper
• Episomal vectors to monitor and induce somatic hypermutation in human Burkitt-Lymphoma cell lines.

  2006cited by this paper
• Histone modifications associated with somatic hypermutation.

  2005cited by this paper
• Complex regulation of somatic hypermutation by cis-acting sequences in the endogenous IgH gene in hybridoma cells.

  2005cited by this paper
• The Double-Edged Sword of Activation-Induced Cytidine Deaminase1

  2005cited by this paper
• DNA deamination in immunity

  2005cited by this paper
• Deoxyuridine Is Generated Preferentially in the Nontranscribed Strand of DNA from Cells Expressing Activation-Induced Cytidine Deaminase

  2005cited by this paper
• Elucidation of IgH intronic enhancer functions via germ-line deletion.

  2005cited by this paper
• Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc

  2004cited by this paper
• Replication protein A interacts with AID to promote deamination of somatic hypermutation targets

  2004cited by this paper
• DNA Substrate Length and Surrounding Sequence Affect the Activation-induced Deaminase Activity at Cytidine*

  2004cited by this paper
• The regulation of somatic hypermutation.

  2004cited by this paper
• AID is required for c-myc/IgH chromosome translocations in vivo.

  2004cited by this paper
• Differential regulation of histone acetylation and generation of mutations in switch regions is associated with Ig class switching.

  2004cited by this paper
• Genome-wide somatic hypermutation.

  2004cited by this paper
• Transcription-targeted DNA deamination by the AID antibody diversification enzyme

  2003cited by this paper
• Somatic hypermutation of the B cell receptor genes B29 (Igβ, CD79b) and mb1 (Igα, CD79a)

  2003cited by this paper
• AID Mediates Hypermutation by Deaminating Single Stranded DNA

  2003cited by this paper
• Constitutive Expression of AID Leads to Tumorigenesis

  2003cited by this paper
• What role for AID: mutator, or assembler of the immunoglobulin mutasome?

  2003cited by this paper
• Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

  2003cited by this paper
• Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

  2003cited by this paper
• The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription.

  2003cited by this paper
• Class-switch recombination: after the dawn of AID.

  2003cited by this paper
• Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin.

  2003cited by this paper
• Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

  2003cited by this paper
• Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma.

  2003cited by this paper
• Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a).

  2003cited by this paper
• AID and mismatch repair in antibody diversification

  2002cited by this paper
• Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

  2002cited by this paper
• Somatic immunoglobulin hypermutation.

  2002cited by this paper
• Negative autoregulation of BCL-6 is bypassed by genetic alterations in diffuse large B cell lymphomas

  2002cited by this paper
• Somatic hypermutation of the AID transgene in B and non-B cells

  2002cited by this paper
• AID Enzyme-Induced Hypermutation in an Actively Transcribed Gene in Fibroblasts

  2002cited by this paper
• Clonal instability of V region hypermutation in the Ramos Burkitt's lymphoma cell line.

  2001cited by this paper
• The 3′ Igκ enhancer contains RNA polymerase II promoters: implications for endogenous and transgenic κ gene expression

  2001cited by this paper
• The PU.1 and NF-EM5 binding motifs in the Igkappa 3' enhancer are responsible for directing somatic hypermutations to the intrinsic hotspots in the transgenic Vkappa gene.

  2001cited by this paper
• Increased Transcription Levels Induce Higher Mutation Rates in a Hypermutating Cell Line1

  2001cited by this paper
• Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

  2001cited by this paper
• The 3' Igkappa enhancer contains RNA polymerase II promoters: implications for endogenous and transgenic kappa gene expression.

  2001cited by this paper
• The TATA binding protein, c-Myc and survivin genes are not somatically hypermutated, while Ig and BCL6 genes are hypermutated in human memory B cells.

  2000cited by this paper
• Somatic Mutation of the Cd95 Gene in Human B Cells as a Side-Effect of the Germinal Center Reaction

  2000cited by this paper
• BCL-6 mutations are associated with immunoglobulin variable heavy chain mutations in B-cell chronic lymphocytic leukemia.

  2000cited by this paper
• Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme.

  2000cited by this paper
• Mechanisms involved in targeted gene replacement in mammalian cells.

  2000cited by this paper
• Specific Expression of Activation-induced Cytidine Deaminase (AID), a Novel Member of the RNA-editing Deaminase Family in Germinal Center B Cells*

  1999cited by this paper
• Cis‐acting sequences that affect somatic hypermutation of Ig genes

  1998cited by this paper
• The effects of E mu, 3'alpha (hs 1,2) and 3'kappa enhancers on mutation of an Ig-VDJ-Cgamma2a Ig heavy gene in cultured B cells.

  1998cited by this paper
• BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci.

  1998cited by this paper
• Multiple sequences from downstream of the Jκ cluster can combine to recruit somatic hypermutation to a heterologous, upstream mutation domain

  1998cited by this paper
• Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes.

  1998cited by this paper
• TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line.

  1998cited by this paper
• The Ig mutator is dependent on the presence, position, and orientation of the large intron enhancer.

  1998cited by this paper
• Somatic hypermutation in the heavy chain locus correlates with transcription.

  1998cited by this paper
• The Promotion of  V Region Hypermutation

  1997cited by this paper
• Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice

  1997cited by this paper
• The Transcriptional Promoter Regulates Hypermutation of the Antibody Heavy Chain Locus

  1997cited by this paper
• Cells strongly expressing Igκ transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers

  1997cited by this paper
• Sequence dependent hypermutation of the immunoglobulin heavy chain in cultured B cells.

  1997cited by this paper
• Enhancers of hypermutation

  1996cited by this paper
• Somatic hypermutation of immunoglobulin genes is linked to transcription initiation.

  1996cited by this paper
• Targeting of non-Ig sequences in place of the V segment by somatic hypermutation.

  1995cited by this paper
• BCL6 gene rearrangement and other cytogenetic abnormalities in diffuse large cell lymphoma.

  1995cited by this paper
• Targeting of non-lg sequences in place of the V segment by somatic hyper mutation

  1995cited by this paper
• Elements regulating somatic hypermutation of an immunoglobulin kappa gene: critical role for the intron enhancer/matrix attachment region.

  1994cited by this paper
• Cloning of bcl-6, the locus involved in chromosome translocations affecting band 3q27 in B-cell lymphoma.

  1993cited by this paper
• Evolutionary and somatic selection of the antibody repertoire in the mouse.

  1987cited by this paper
• Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin.

  1984cited by this paper
• Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells.

  1982cited by this paper

• Genetic loss of the ubiquitin ligase RNF126, an AID interacting partner and modifier, affects strand targeting during somatic hypermutation of antibody genes

  2018cites this paper
• Transient AID expression for in situ mutagenesis with improved cellular fitness

  2018cites this paper
• A Novel Regulator of Activation-Induced Cytidine Deaminase/APOBECs in Immunity and Cancer: Schrödinger’s CATalytic Pocket

  2017cites this paper
• Splice Variants of Activation Induced Deaminase (AID) Do Not Affect the Efficiency of Class Switch Recombination in Murine CH12F3 Cells

  2015cites this paper
• Genomic Deoxyuracil: Targeting, Regulation And Repair

  2015cites this paper
• Rôle des protéines AID et Bfl-1 dans les processus d'instabilité génomique et de survie cellulaire induits par l'oncoprotéine Tax au cours de la lymphomagénèse associée à l'infection par HTLV-1

  2014influential citation
• Characterizing the Role of the DNA Damage Response in Class switch recombination

  2014cites this paper
• Investigating the Roles of Follicular Dendritic Cells and Activation-induced Deaminase in Germinal Centers

  2013cites this paper
• Zebrafish AID is capable of deaminating methylated deoxycytidines

  2013cites this paper
• Regulation of Aicda expression and AID activity

  2013cites this paper
• Directed evolution of mammalian anti-apoptosis proteins by somatic hypermutation.

  2012influential citation
• The biochemistry of activation-induced deaminase and its physiological functions.

  2012cites this paper
• Negative Supercoiling Creates Single-Stranded Patches of DNA That Are Substrates for AID–Mediated Mutagenesis

  2012cites this paper
• Investigations into the Targeting and Substrate Specificity of Activation-induced Deaminase

  2012cites this paper
• Confirmation of a Mutation by Multiple Molecular Approaches

  2012cites this paper
• Gene control and remodeling during hematopoiesis

  2011cites this paper
• Repression of human activation induced cytidine deaminase by miR-93 and miR-155

  2011cites this paper
• Assessing somatic hypermutation in Ramos B cells after overexpression or knockdown of specific genes.

  2011cites this paper
• In vIvo BINDING PREFERENCES OF THE MUTATOR PROTEIN AID IN THE GENOME

  2011cites this paper
• Rapid cell division contributes to efficient induction of A/T mutations during Ig gene hypermutation.

  2011cites this paper
• Preferential targeting of somatic hypermutation to hotspot motifs and hypermutable sites and generation of mutational clusters in the IgVH alleles of a rheumatoid factor producing lymphoblastoid cell line.

  2011cites this paper
• The mismatch repair pathway functions normally at a non-AID target in germinal center B cells.

  2011cites this paper
• Mechanism of Mismatch Repair Induced Mutagenesis in Somatic Hypermutation

  2010cites this paper
• Attracting AID to targets of somatic hypermutation

  2010influential citation
• AID constrains germinal center size by rendering B cells susceptible to apoptosis.

  2009cites this paper
• Regulation of activation induced deaminase

  2009cites this paper
• Chromosomal translocations in cancer.

  2008cites this paper
• Two levels of protection for the B cell genome during somatic hypermutation

  2008cites this paper
• The biochemistry of somatic hypermutation.

  2008cites this paper
• Induction of A:T Mutations Is Dependent on Cellular Environment but Independent of Mutation Frequency and Target Gene Location

  2008cites this paper
• Ongoing somatic hypermutation of the rearranged VH but not of the V-lambda gene in EBV-transformed rheumatoid factor-producing lymphoblastoid cell line.

  2008cites this paper
• Targeting of AID-mediated sequence diversification by cis-acting determinants.

  2007cites this paper
• Targeting AID to the Ig genes.

  2007cites this paper
• Immunoglobulin somatic hypermutation.

  2007cites this paper
• Molecular mechanisms of antibody somatic hypermutation.

  2007cites this paper
• Activation‐induced cytidine deaminase induces DNA break repair events more frequently in the Ig switch region than other sites in the mammalian genome

  2007cites this paper
• The role of activation-induced deaminase in antibody diversification and chromosome translocations.

  2007cites this paper
• Targeting of somatic hypermutation

  2006cites this paper