Quinoline-resistance reversing agents for the malaria parasite Plasmodium falciparum.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Drug resistance updates

• Publication date

  2006-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.DRUP.2006.09.002PMID 17064951
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A chloroquine-like molecule designed to reverse resistance in Plasmodium falciparum.

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  2004influential reference
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  2004cited by this paper
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• Variations in the sequence and expression of the Plasmodium falciparum chloroquine resistance transporter (Pfcrt) and their relationship to chloroquine resistance in vitro.

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• The antimalarial drug resistance protein Plasmodium falciparum chloroquine resistance transporter binds chloroquine.

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• Levels of chloroquine resistance in Plasmodium falciparum are determined by loci other than pfcrt and pfmdr1.

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  2002influential reference
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• Structural Analysis of Chloroquine Resistance Reversal by Imipramine Analogs

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• Allelic modifications of the cg2 and cg1 genes do not alter the chloroquine response of drug-resistant Plasmodium falciparum.

  2000influential reference
• Structure-function relationships in aminoquinolines: effect of amino and chloro groups on quinoline-hematin complex formation, inhibition of beta-hematin formation, and antiplasmodial activity.

  2000cited by this paper
• Nonylphenolethoxylates as Malarial Chloroquine Resistance Reversal Agents

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• Potent Enhancement of the Sensitivity of Plasmodium falciparum to Chloroquine by the Bisbenzylisoquinoline Alkaloid Cepharanthin

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  2000influential reference
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  1993influential reference
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• Treatment of chloroquine-resistant malaria in monkeys with a drug combination that reverses resistance in vitro.

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• Vacuolar acidification and chloroquine sensitivity in Plasmodium falciparum.

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