Repression of Clostridium difficile toxin gene expression by CodY

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Molecular Microbiology

• Publication date

  2007-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1365-2958.2007.05906.xPMID 17725558
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Clostridium difficile

  2018cited by this paper
• Clostridium difficile toxin expression is inhibited by the novel regulator TcdC

  2007cited by this paper
• Characterization of relA and codY mutants of Listeria monocytogenes: identification of the CodY regulon and its role in virulence

  2007cited by this paper
• tcdC Genotypes Associated with Severe TcdC Truncation in an Epidemic Clone and Other Strains of Clostridium difficile

  2006cited by this paper
• Construction and analysis of chromosomal Clostridium difficile mutants

  2006cited by this paper
• The Structure of CodY, a GTP- and Isoleucine-responsive Regulator of Stationary Phase and Virulence in Gram-positive Bacteria*

  2006cited by this paper
• Identification of Clostridium difficile toxin B cardiotoxicity using a zebrafish embryo model of intoxication

  2006cited by this paper
• Regulation of Glutamine and Glutamate Metabolism by GlnR and GlnA in Streptococcus pneumoniae*

  2006cited by this paper
• Linking the nutritional status of Streptococcus pyogenes to alteration of transcriptional gene expression: the action of CodY and RelA.

  2006cited by this paper
• The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome

  2006cited by this paper
• Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe.

  2005cited by this paper
• Clostridium difficile Toxins: Mechanism of Action and Role in Disease

  2005cited by this paper
• A Region of Bacillus subtilis CodY Protein Required for Interaction with DNA

  2005cited by this paper
• Construction and Analysis

  2005cited by this paper
• CodY, a global regulator of stationary phase and virulence in Gram-positive bacteria.

  2005cited by this paper
• The Lactococcus lactis CodY Regulon

  2005cited by this paper
• Overall control of nitrogen metabolism in Lactococcus lactis by CodY, and possible models for CodY regulation in Firmicutes.

  2005cited by this paper
• Activation of the Bacillus subtilis global regulator CodY by direct interaction with branched‐chain amino acids

  2004influential reference
• Expression of Clostridium difficile Toxins A and B and Their Sigma Factor TcdD Is Controlled by Temperature

  2003cited by this paper
• CodY-Regulated Aminotransferases AraT and BcaT Play a Major Role in the Growth of Lactococcus lactis in Milk by Regulating the Intracellular Pool of Amino Acids

  2003cited by this paper
• Complex Regulation of the Bacillus subtilis Aconitase Gene

  2003influential reference
• Additional Targets of the Bacillus subtilis Global Regulator CodY Identified by Chromatin Immunoprecipitation and Genome-Wide Transcript Analysis

  2003cited by this paper
• Environmental Response and Autoregulation of Clostridium difficile TxeR, a Sigma Factor for Toxin Gene Expression

  2002cited by this paper
• Direct and indirect roles of CcpA in regulation of Bacillus subtilis Krebs cycle genes

  2002cited by this paper
• Bacillus subtilis CodY represses early-stationary-phase genes by sensing GTP levels.

  2001influential reference
• Regulation of toxin synthesis in Clostridium difficile by an alternative RNA polymerase sigma factor

  2001cited by this paper
• Molecular Cloning: A Laboratory Manual

  2001cited by this paper
• Evidence for holin function of tcdE gene in the pathogenicity of Clostridium difficile.

  2001cited by this paper
• Toxins, Butyric Acid, and Other Short-Chain Fatty Acids Are Coordinately Expressed and Down-Regulated by Cysteine in Clostridium difficile

  2000cited by this paper
• Suppression of toxin production in Clostridium difficile VPI 10463 by amino acids.

  1999influential reference
• Clostridium difficile infection.

  1998cited by this paper
• Conjugative transfer of RP4-oriT shuttle vectors from Escherichia coli to Clostridium perfringens.

  1998cited by this paper
• Inhibition of enhanced toxin production by Clostridium difficile in biotin-limited conditions.

  1998cited by this paper
• Effect of isoleucine on toxin production by Clostridium difficile in a defined medium.

  1998cited by this paper
• Regulated transcription of Clostridium difficile toxin genes

  1998influential reference
• Effect of Arginine on Toxin Production by Clostridium difficile in Defined Medium

  1997cited by this paper
• Transcription analysis of the genes tcdA-E of the pathogenicity locus of Clostridium difficile.

  1997influential reference
• Transcriptional analysis of the toxigenic element of Clostridium difficile.

  1997influential reference
• Large clostridial cytotoxins--a family of glycosyltransferases modifying small GTP-binding proteins.

  1996cited by this paper
• Definition of the single integration site of the pathogenicity locus in Clostridium difficile.

  1996influential reference
• Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter

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• Glucosylation of Rho proteins by Clostridium difficile toxin B

  1995cited by this paper
• A gene required for nutritional repression of the Bacillus subtilis dipeptide permease operon

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• The toxigenic element of Clostridium difficile strain VPI 10463.

  1995influential reference
• The Enterotoxin from Clostridium difficile (ToxA) Monoglucosylates the Rho Proteins(*)

  1995cited by this paper
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• The toxigenic element of Clostridium difficile strain 10463 and its transcriptional analysis in strains which differ in toxigenicity

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• Transferable Resistance to Clindamycin, Erythromycin, and Tetracycline in Clostridium difficile

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• Effect of Clindamycin on Cytotoxin Production by Clostridium difficile

  1982cited by this paper
• Transferable tetracycline resistance in Clostridium difficile

  1981influential reference
• Effect of environmental stress on Clostridium difficile toxin levels during continuous cultivation

  1979cited by this paper

• Naturally occurring CodY variants alter ligand binding, DNA target affinity, and virulence in Clostridioides difficile

  2025cites this paper
• Analysis of essential genes in Clostridioides difficile by CRISPRi and Tn-seq

  2025cites this paper
• Proline Stickland fermentation supports C. difficile spore maturation

  2025cites this paper
• Advances in Understanding the Pathogenesis of Clostridioides difficile Infection.

  2025cites this paper
• Analysis of Essential Genes in Clostridioides difficile by CRISPRi and Tn-seq

  2025cites this paper
• Deciphering strain differences in codY regulation of Clostridioides difficiles sporulation

  2025influential citation
• In vitro and in Vivo Models for Understanding Clostridioides difficile.

  2025cites this paper
• Development of a high-throughput screening platform for C. difficile toxin synthesis inhibitors unveils meclizine as an antivirulence agent

  2025cites this paper
• Identification of a family of peptidoglycan transpeptidases reveals that Clostridioides difficile requires noncanonical cross-links for viability

  2024cites this paper
• Theophylline-based control of repA on a Clostridioides difficile plasmid for use in allelic exchange.

  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
• Identification of a new family of peptidoglycan transpeptidases reveals atypical crosslinking is essential for viability in Clostridioides difficile

  2024cites this paper
• Influence of microbiota on the growth and gene expression of Clostridioides difficile in an in vitro coculture model

  2024cites this paper
• Regulatory Networks: Linking Toxin Production and Sporulation in Clostridioides difficile.

  2024cites this paper
• The microbial metabolite Urolithin A reduces C. difficile toxin expression and repairs toxin-induced epithelial damage

  2023cites this paper
• Butyrate enhances Clostridioides difficile sporulation in vitro

  2023cites this paper
• Regulation of Clostridial Toxin Gene Expression: A Pasteurian Tradition

  2023cites this paper
• Glycine fermentation by C. difficile promotes virulence, spore formation, and is induced by host cathelicidin

  2023cites this paper
• Glycine fermentation by C. difficile promotes virulence and spore formation, and is induced by host cathelicidin

  2023cites this paper
• One size does not fit all – Trehalose metabolism by Clostridioides difficile is variable across the five phylogenetic lineages

  2023cites this paper
• Food for thought—The link between Clostridioides difficile metabolism and pathogenesis

  2023cites this paper
• Butyrate enhances Clostridioides difficile sporulation in vitro

  2023influential citation
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  2023cites this paper
• Low-toxin Clostridioides difficile RT027 strains exhibit robust virulence

  2022cites this paper
• CodY Is a Global Transcriptional Regulator Required for Virulence in Group B Streptococcus

  2022cites this paper
• Regulatory transcription factors of Clostridioides difficile pathogenesis with a focus on toxin regulation

  2022influential citation
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  2022cites this paper
• Strain Variation in Clostridioides difficile Cytotoxicity Associated with Genomic Variation at Both Pathogenic and Nonpathogenic Loci

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  2022cites this paper
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• Genetic mechanisms governing sporulation initiation in Clostridioides difficile.

  2021cites this paper
• What’s a Biofilm?—How the Choice of the Biofilm Model Impacts the Protein Inventory of Clostridioides difficile

  2021cites this paper
• Influence of L-lactate and low glucose concentrations on the metabolism and the toxin formation of Clostridioides difficile

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• c-di-GMP Inhibits Early Sporulation in Clostridioides difficile

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