Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Biochemical Pharmacology

• Publication date

  2004-04-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.BCP.2003.11.009PMID 15013846
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Promoting Effect of Kaempferol on the Differentiation and Mineralization of Murine Pre-osteoblastic Cell Line MC3T3-E1

  2003cited by this paper
• Potent inhibitory effect of naturally occurring flavonoids quercetin and kaempferol on in vitro osteoclastic bone resorption.

  2003cited by this paper
• Reversal of bone loss in mice by nongenotropic signaling of sex steroids.

  2003cited by this paper
• Reversal of Bone Loss in Mice by Nongenotropic Signaling of Sex Steroids

  2002cited by this paper
• Membrane association of estrogen receptor alpha mediates estrogen effect on MAPK activation.

  2002cited by this paper
• Effects of Genistein and Hormone‐Replacement Therapy on Bone Loss in Early Postmenopausal Women: A Randomized Double‐Blind Placebo‐Controlled Study

  2002cited by this paper
• The ligand binding profiles of estrogen receptors alpha and beta are species dependent.

  2002cited by this paper
• Estrogen Receptor-mediated Activation of the Serum Response Element in MCF-7 Cells through MAPK-dependent Phosphorylation of Elk-1*

  2001cited by this paper
• Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity.

  2001cited by this paper
• Stretch-mediated Activation of Selective MAPK Subtypes and Potentiation of AP-1 Binding in Human Osteoblastic Cells

  2001cited by this paper
• Intracellular signaling pathways: nongenomic actions of estrogens and ligand-independent activation of estrogen receptors.

  2001cited by this paper
• Intracellular signaling pathways: nongenomic actions of estrogens and ligand-independent activation of estrogen receptors.

  2001cited by this paper
• Erk Is Essential for Growth, Differentiation, Integrin Expression, and Cell Function in Human Osteoblastic Cells*

  2001cited by this paper
• Stimulatory effect of Daidzein in osteoblastic MC3T3-E1 cells.

  2000cited by this paper
• Estrogen stimulates protein tyrosine phosphorylation and Src kinase activity in avian osteoclasts

  2000cited by this paper
• Estrogen receptor pathways to AP-1.

  2000cited by this paper
• Human vascular endothelial cells contain membrane binding sites for estradiol, which mediate rapid intracellular signaling.

  2000cited by this paper
• Rutin Inhibits Ovariectomy‐Induced Osteopenia in Rats

  2000cited by this paper
• Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ERalpha and ERbeta expressed in Chinese hamster ovary cells.

  1999cited by this paper
• Alternatives to the use of estrogen in postmenopausal women.

  1999cited by this paper
• Bone-sparing effect of soy protein in ovarian hormone-deficient rats is related to its isoflavone content.

  1998cited by this paper
• Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.

  1998cited by this paper
• Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β.

  1998cited by this paper
• Differential expression of estrogen receptors alpha and beta mRNA during differentiation of human osteoblast SV-HFO cells.

  1997cited by this paper
• Rapid activation of MAP kinase by estrogen in the bone cell line.

  1997cited by this paper
• Differential Expression of Estrogen Receptors α and β mRNA During Differentiation of Human Osteoblast SV-HFO Cells.

  1997cited by this paper
• Tyrosine kinase/p21ras/MAP‐kinase pathway activation by estradiol‐receptor complex in MCF‐7 cells.

  1996cited by this paper
• Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis.

  1996cited by this paper
• Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis.

  1995cited by this paper
• Membrane estrogen receptors identified by multiple antibody labeling and impeded‐ligand binding

  1995cited by this paper
• A rapid, quantitative assay for measuring alkaline phosphatase activity in osteoblastic cells in vitro.

  1994cited by this paper
• Pathogenesis of osteoporosis.

  1993cited by this paper
• Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis.

  1993cited by this paper
• Comparison of Osteoporosis and Calcium Intake between Japan and the United States

  1992cited by this paper
• A comparison of hip fracture incidence among native Japanese, Japanese Americans, and American Caucasians.

  1991cited by this paper
• A potent specific pure antiestrogen with clinical potential.

  1991cited by this paper
• Estrogens, bone loss and preservation

  1990cited by this paper
• Briefe an die Redaktion

  1989cited by this paper
• Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability.

  1986cited by this paper

• Innovative synergy of bone xenograft and quercetin in the alveolar bone socket: Histological and immunohistochemical assessment of healing.

  2026cites this paper
• Polyphenols and Bone Health: A Comprehensive Review of Their Role in Osteoporosis Prevention and Treatment

  2025cites this paper
• Unlocking the mechanistic insights of clinically proven natural products against osteoporosis

  2025cites this paper
• Cissus quadrangularis: A comprehensive review as an emerging biomaterial for periodontal regeneration

  2025cites this paper
• Network pharmacology and experimental validation uncover how Shoutai Pills improve ovarian function in postpartum depression following a secondary birth.

  2025cites this paper
• KAEMPFEROL, A WIDELY INGESTED DIETARY FLAVONOID AND SUPPLEMENT, ENHANCES BIOLOGICAL PERFORMANCE VIA HORMESIS, ESPECIALLY FOR AGEING-RELATED PROCESSES.

  2025cites this paper
• Quercetin-calcium hydroxide scaffolds modulate dental pulp stem cell response in vitro under a simulated inflammatory environment.

  2025cites this paper
• Using network pharmacology and molecular docking technology, proteomics and experiments were used to verify the effect of Yigu decoction (YGD) on the expression of key genes in osteoporotic mice

  2025cites this paper
• Comparison of dose and time effects of flavonoids, alone or in combination, on the induction of mineralization markers in human osteoblast-like cells.

  2025cites this paper
• EGCG and Taxifolin Modulate Secretory Activity and Expression of Dentinogenesis Markers in Odontoblast-Like Cells

  2025influential citation
• Silk fibroin/chitosan thiourea hydrogel scaffold with vancomycin and quercetin-loaded PLGA nanoparticles for treating chronic MRSA osteomyelitis in rats.

  2024cites this paper
• Pharmacological and mechanistic aspects of quercetin in osteoporosis

  2024cites this paper
• Extrusion 3D-printed tricalcium phosphate-polycaprolactone biocomposites for quercetin-KCl delivery in bone tissue engineering

  2024cites this paper
• Quercetin in Osteoporosis Treatment: A Comprehensive Review of Its Mechanisms and Therapeutic Potential

  2024cites this paper
• The Role of Traditional Chinese Medicines in the Treatment of Osteoporosis.

  2024cites this paper
• 3D printed scaffolds with quercetin and vitamin D3 nanocarriers: In vitro cellular evaluation.

  2024cites this paper
• Sea buckthorn and its flavonoids isorhamnetin, quercetin, and kaempferol favorably influence bone and breast tissue health

  2024cites this paper
• Overcoming Skin Barrier with Transfersomes: Opportunities, Challenges, and Applications.

  2024cites this paper
• Exploring the role and mechanism of Fuzi decoction in the treatment of osteoporosis by integrating network pharmacology and experimental verification

  2023cites this paper
• Isolation of Pro-Osteogenic Compounds from Euptelea polyandra That Reciprocally Regulate Osteoblast and Osteoclast Differentiation

  2023cites this paper
• Controlled release of kaempferol from porous scaffolds augments in-vitro osteogenesis in human osteoblasts

  2023cites this paper
• Kaempferol prevents aseptic loosening via enhance the Wnt/β-catenin signaling pathway in vitro and in vivo

  2023cites this paper
• Exploring the potential therapeutic effect of Eucommia ulmoides–Dipsaci Radix herbal pair on osteoporosis based on network pharmacology and molecular docking technology

  2022cites this paper
• Equisetum arvense Inhibits Alveolar Bone Destruction in a Rat Model with Lipopolysaccharide (LPS)-Induced Periodontitis

  2022cites this paper
• Estrogenic flavonoids and their molecular mechanisms of action.

  2022cites this paper
• Investigation on characterization of novel anti-bacterial chitosan/gelatin composite membranes loaded with quercetin via electrophoretic deposition

  2022cites this paper
• Traditional Chinese Medicine Compound-Loaded Materials in Bone Regeneration

  2022cites this paper
• Ethanolic extract from the root and leaf of Sida cordifolia promotes osteoblast activity and prevents ovariectomy-induced bone loss in mice.

  2022cites this paper
• The Role of Macronutrients, Micronutrients and Flavonoid Polyphenols in the Prevention and Treatment of Osteoporosis

  2022cites this paper
• Investigation of the effects of quercetin and xenograft on the healing of bone defects: An experimental study

  2022cites this paper
• In vitro biomineralization and osteogenesis of Cissus quadrangularis stem extracts: An osteogenic regulator for bone tissue engineering

  2021cites this paper
• Artematrolide A inhibited cervical cancer cell proliferation via ROS/ERK/mTOR pathway and metabolic shift.

  2021cites this paper
• Osteoprotective Effects of ‘Anti-Diabetic’ Polyherbal Mixture in Type 1 Diabetic Rats

  2021cites this paper
• Pathophysiological effects of cadmium(II) on human health-a critical review

  2021cites this paper
• Functionalization with a Polyphenol-Rich Pomace Extract Empowers a Ceramic Bone Filler with In Vitro Antioxidant, Anti-Inflammatory, and Pro-Osteogenic Properties

  2021cites this paper
• Flavonoids: Classification, Function, and Molecular Mechanisms Involved in Bone Remodelling

  2021cites this paper
• Design and Synthesis of Water-Soluble and Potent MMP-13 Inhibitors with Activity in Human Osteosarcoma Cells

  2021cites this paper
• Bioactive Herbal Extracts of Traditional Chinese Medicine Applied with the Biomaterials: For the Current Applications and Advances in the Musculoskeletal System

  2021cites this paper
• Role of Polyphenols in the Metabolism of the Skeletal System in Humans and Animals – A Review

  2021cites this paper
• Salvia officinalis mitigates uterus and liver damages induced by an estrogen deficiency in ovariectomized rats.

  2020cites this paper
• Quercetin-Based Nanocomposites as a Tool to Improve Dental Disease Management

  2020cites this paper
• Oral Administration of Quercetin or Its Derivatives Inhibit Bone Loss in Animal Model of Osteoporosis

  2020cites this paper
• Evaluation of Bone Regeneration Efficacy in a Rabbit Model of Femoral Condyles Defect by Polyphenols-Containing Bone Filler

  2020cites this paper
• Bacillus subtilis Fermentation of Malva verticillata Leaves Enhances Antioxidant Activity and Osteoblast Differentiation

  2020cites this paper
• Effects of the Non-Alcoholic Fraction of Beer on Abdominal Fat, Osteoporosis, and Body Hydration in Women

  2020cites this paper
• Quercetin as an Agent for Protecting the Bone: A Review of the Current Evidence

  2020influential citation
• A chitosan film containing quercetin-loaded transfersomes for treatment of secondary osteoporosis

  2020cites this paper
• Bioflavonoids as Promising Antiosteoporotic Agents

  2020cites this paper
• Superparamagnetic iron oxide nanoparticles combined with NGF and quercetin promote neuronal branching morphogenesis of PC12 cells

  2019cites this paper
• An investigation into osteogenic differentiation effects of silk fibroin-nettle (Urtica dioica L.) nanofibers.

  2019cites this paper
• DDDT_A_227738 3497..3514

  2019cites this paper
• Improvement of the Physical Properties of Guided Bone Regeneration Membrane from Porcine Pericardium by Polyphenols-Rich Pomace Extract

  2019cites this paper
• Kaempferol stimulates WNT/β-catenin signaling pathway to induce differentiation of osteoblasts.

  2019cites this paper
• The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies

  2019cites this paper
• Poly(vinylidene fluoride) Composite Nanofibers Containing Polyhedral Oligomeric Silsesquioxane–Epigallocatechin Gallate Conjugate for Bone Tissue Regeneration

  2019cites this paper
• Dietary quercetin improved the growth, antioxidation, and flesh quality of grass carp ( Ctenopharyngodon idella )

  2019cites this paper
• Citrus aurantium Ameliorates Cisplatin-Induced Nephrotoxicity

  2019cites this paper
• Mimicking growth factors: role of small molecule scaffold additives in promoting tissue regeneration and repair

  2019cites this paper
• Quinoa Secondary Metabolites and Their Biological Activities or Functions

  2019cites this paper
• Unraveling the Role of Melatonin/Quercetin in Attenuating the Metabolic and Bone Turnover Alternations in Iron Treated-Ovariectomized Female Rats

  2019cites this paper
• µCT analysis reveals that Cissus quadrangularis L. stem and Trigonella foenum-graecum L. seed extracts prevent diabetic osteopathy

  2018cites this paper
• Kaempferol-immobilized titanium dioxide promotes formation of new bone: effects of loading methods on bone marrow stromal cell differentiation in vivo and in vitro

  2018cites this paper
• Clinical Pharmacology of Citrus aurantium and Citrus sinensis for the Treatment of Anxiety

  2018cites this paper
• On Impact

  2018cites this paper
• Isoquercitrin promotes the osteogenic differentiation of osteoblasts and BMSCs via the RUNX2 or BMP pathway

  2018cites this paper
• Chemo‐preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review

  2018cites this paper
• Effects of 17β-Estradiol on Mitophagy in the Murine MC3T3-E1 Osteoblast Cell Line is Mediated via G Protein-Coupled Estrogen Receptor and the ERK1/2 Signaling Pathway

  2018cites this paper
• The Effects of Kaempferol-Inhibited Autophagy on Osteoclast Formation

  2018cites this paper
• Ethyl acetate and n‐butanol fraction of Cissus quadrangularis promotes the mineralization potential of murine pre‐osteoblast cell line MC3T3‐E1 (sub‐clone 4)

  2018cites this paper
• Effect of Quercetin on Bone Mineral Status and Markers of Bone Turnover in Retinoic Acid-Induced Osteoporosis

  2018cites this paper
• Dietary flavonoid kaempferol inhibits glucocorticoid-induced bone loss by promoting osteoblast survival.

  2018cites this paper
• Evaluation of the anti-osteoporotic effect of Ginkgo biloba L. in Wistar rats with glucocorticoid-induced-osteoporosis by bone densitometry using dual-energy x-ray absorptiometry (DEXA) and mechanical testing.

  2017cites this paper
• Kaempferol – A dietary anticancer molecule with multiple mechanisms of action: Recent trends and advancements

  2017cites this paper
• A study on the osteogenic activity of Trigonellafoenum-graecum L . seed extract on osteoblast like cells

  2017cites this paper
• Therapeutic Potential and Outlook of Alternative Medicine for Osteoporosis.

  2017cites this paper
• Effects of flavonoids incorporated biological macromolecules based scaffolds in bone tissue engineering.

  2017cites this paper
• Oral administration of kaempferol inhibits bone loss in rat model of ovariectomy-induced osteopenia

  2017cites this paper
• Ethanol Extract of Cissus quadrangularis Enhances Osteoblast Differentiation and Mineralization of Murine Pre‐Osteoblastic MC3T3‐E1 Cells

  2017cites this paper
• Emerging Importance of Phytochemicals in Regulation of Stem Cells Fate via Signaling Pathways

  2017cites this paper
• New Target Sites for Treatment of Osteoporosis.

  2017cites this paper
• Protective Effects of Pretreatment with Quercetin Against Lipopolysaccharide-Induced Apoptosis and the Inhibition of Osteoblast Differentiation via the MAPK and Wnt/β-Catenin Pathways in MC3T3-E1 Cells

  2017cites this paper
• Quercetin nanoparticles attenuates scopolamine induced spatial memory deficits and pathological damages in rats

  2017cites this paper
• To Study the Regulation of Bone Markers in Osteoporosis

  2017cites this paper
• Biocomposite Scaffolds Derived from Renewable Resources for Bone Tissue Repair

  2017cites this paper
• Flavonoid Composition of Tarocco (Citrus sinensis L. Osbeck) Clone "Lempso" and Fast Antioxidant Activity Screening by DPPH-UHPLC-PDA-IT-TOF.

  2017cites this paper
• Herbal Supplement in a Buffer for Dry Eye Syndrome Treatment

  2017cites this paper
• The In Vitro and In Vivo Biological Activities of the Leaf of Cape Myrtle, Myrsine africana L.

  2017cites this paper
• Quercetin and alendronate multi-functionalized materials as tools to hinder oxidative stress damage.

  2017cites this paper
• The effect of quercetin delivery system on osteogenesis and angiogenesis under osteoporotic conditions.

  2017cites this paper
• Molecular signaling mechanisms behind polyphenol-induced bone anabolism

  2017cites this paper
• Protuoksidativna i protuupalna učinkovitost flavonoida u osteoporozi izazvanoj retinoičnom kiselinom u štakora

  2016cites this paper
• Kaempferol stimulates gene expression of low-density lipoprotein receptor through activation of Sp1 in cultured hepatocytes

  2016cites this paper
• Cysteine Prevents Menopausal Syndromes in Ovariectomized Mouse

  2016cites this paper
• Antioxidant and bone repair properties of quercetin-functionalized hydroxyapatite: An in vitro osteoblast-osteoclast-endothelial cell co-culture study.

  2016cites this paper
• Quercetin-induced changes in femoral bone microstructure of adult male rabbits

  2016cites this paper
• Effects of the extract of Ginkgo biloba on the differentiation of bone marrow mesenchymal stem cells in vitro.

  2016cites this paper
• The phenolic acids of Agen prunes (dried plums) or Agen prune juice concentrates do not account for the protective action on bone in a rat model of postmenopausal osteoporosis.

  2016cites this paper
• Enhanced healing process of fracture by treatment of Kaempferol.

  2016cites this paper
• Preclinical studies and clinical evaluation of compounds from the genus Epimedium for osteoporosis and bone health.

  2016cites this paper
• Tissue engineering of the liver

  2016cites this paper