A comprehensive review of interventions in the NOD mouse and implications for translation.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Immunity

• Publication date

  2005-08-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/J.IMMUNI.2005.08.002PMID 16111631
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A Single Course of Anti-CD3 Monoclonal Antibody hOKT3γ1(Ala-Ala) Results in Improvement in C-Peptide Responses and Clinical Parameters for at Least 2 Years after Onset of Type 1 Diabetes

  2005cited by this paper
• The NOD mouse: a model of immune dysregulation.

  2005cited by this paper
• Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial--Type 1.

  2005cited by this paper
• Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes.

  2005cited by this paper
• Pancreatic β-Cell Function and Immune Responses to Insulin After Administration of Intranasal Insulin to Humans At Risk for Type 1 Diabetes

  2004cited by this paper
• In Vitro–expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes

  2004cited by this paper
• Extrapancreatic insulin-producing cells in multiple organs in diabetes.

  2004cited by this paper
• ROLE OF THE THYMUS IN TRANSPLANTATION TOLERANCE IN MINIATURE SWINE: IV. THE THYMUS IS REQUIRED DURING THE INDUCTION PHASE, BUT NOT THE MAINTENANCE PHASE, OF RENAL ALLOGRAFT TOLERANCE1

  2004cited by this paper
• Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease.

  2004cited by this paper
• Pancreatic beta-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes.

  2004cited by this paper
• Rat models of type 1 diabetes: genetics, environment, and autoimmunity.

  2004cited by this paper
• Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes

  2004cited by this paper
• Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells.

  2004cited by this paper
• Recombinant adeno-associated virus-mediated alpha-1 antitrypsin gene therapy prevents type I diabetes in NOD mice

  2004cited by this paper
• Cytokine profile and insulin antibody IgG subclasses in patients with recent onset Type 1 diabetes treated with oral insulin

  2004cited by this paper
• Perturbed Homeostasis of Peripheral T Cells Elicits Decreased Susceptibility to Anti-CD3-Induced Apoptosis in Prediabetic Nonobese Diabetic Mice1

  2004cited by this paper
• Of Mice and Not Men: Differences between Mouse and Human Immunology

  2004cited by this paper
• Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells 1

  2003cited by this paper
• The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens

  2003cited by this paper
• Systemic Overexpression of IL-10 Induces CD4+CD25+ Cell Populations In Vivo and Ameliorates Type 1 Diabetes in Nonobese Diabetic Mice in a Dose-Dependent Fashion 1

  2003cited by this paper
• Dendritic Cells Transduced to Express Interleukin-4 Prevent Diabetes in Nonobese Diabetic Mice with Advanced Insulitis

  2003cited by this paper
• TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes

  2003cited by this paper
• Schistosoma mansoni antigens modulate the activity of the innate immune response and prevent onset of type 1 diabetes

  2003cited by this paper
• The Programmed Death-1 (PD-1) Pathway Regulates Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice

  2003cited by this paper
• Suppression of Autoimmune Diabetes by Viral IL-10 Gene Transfer1

  2002cited by this paper
• Tumor necrosis factor-alpha regulation of CD4+CD25+ T cell levels in NOD mice.

  2002cited by this paper
• Remission and pancreas isograft survival in recent onset diabetic NOD mice after treatment with low-dose anti-CD3 monoclonal antibodies.

  2002cited by this paper
• Gene Transfer of Ig-Fusion Proteins Into B Cells Prevents and Treats Autoimmune Diseases1

  2002cited by this paper
• The anti-inflammatory compound lisofylline prevents Type I diabetes in non-obese diabetic mice

  2002cited by this paper
• Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus.

  2002cited by this paper
• Cytokines and autoimmunity

  2002cited by this paper
• Tumor necrosis factor-α regulation of CD4+C25+ T cell levels in NOD mice

  2002cited by this paper
• Tolerance to islet autoantigens in type 1 diabetes.

  2001cited by this paper
• Efficacy of inhaled human insulin in type 1 diabetes mellitus: a randomised proof-of-concept study.

  2001cited by this paper
• Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation.

  2001cited by this paper
• Therapeutic Alteration of Insulin-Dependent Diabetes Mellitus Progression by T Cell Tolerance to Glutamic Acid Decarboxylase 65 Peptides In Vitro and In Vivo1

  2001cited by this paper
• Mucosal administration of IL-10 enhances oral tolerance in autoimmune encephalomyelitis and diabetes.

  2001cited by this paper
• Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice

  2001cited by this paper
• Induction of Diabetes in Nonobese Diabetic Mice by Th2 T Cell Clones from a TCR Transgenic Mouse1

  2000cited by this paper
• Immunotherapy of spontaneous type 1 diabetes in nonobese diabetic mice by systemic interleukin-4 treatment employing adenovirus vector-mediated gene transfer

  2000cited by this paper
• B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes.

  2000cited by this paper
• No effect of oral insulin on residual beta-cell function in recent-onset Type I diabetes (the IMDIAB VII)

  2000cited by this paper
• Suppression and acceleration of autoimmune diabetes by neutralization of endogenous interleukin-12 in NOD mice.

  2000cited by this paper
• Early Th1 Response in Unprimed Nonobese Diabetic Mice to the Tyrosine Phosphatase-Like Insulinoma-Associated Protein 2, an Autoantigen in Type 1 Diabetes

  2000cited by this paper
• Therapeutic controversy: prevention and treatment of diabetes in children.

  2000cited by this paper
• Oral insulin administration and residual beta-cell function in recent-onset type 1 diabetes: a multicentre randomised controlled trial. Diabète Insuline Orale group.

  2000cited by this paper
• Prevention of Type I Diabetes by Low-Dose Gamma Irradiation in NOD Mice

  2000cited by this paper
• Oral insulin administration and residual (β-cell function in recent-onset type 1 diabetes: a multicentre randomised controlled trial

  2000cited by this paper
• Prevention of Type 1 Diabetes: Perspectives

  2000cited by this paper
• Therapeutic controversy: prevention and treatment of diabetes in children.

  2000cited by this paper
• Early prophylaxis with recombinant human interleukin-11 prevents spontaneous diabetes in NOD mice.

  1999cited by this paper
• Endogenous interleukin‐12 only plays a key pathogenetic role in non‐obese diabetic mouse diabetes during the very early stages of the disease

  1999cited by this paper
• Allometric issues in drug development.

  1999cited by this paper
• Insulin in oral immune "tolerance": a one-amino acid change in the B chain makes the difference.

  1999cited by this paper
• Intramuscular administration of expression plasmids encoding interferon‐γ receptor/IgG1 or IL‐4/IgG1 chimeric proteins protects from autoimmunity

  1999cited by this paper
• Transfer of dendritic cells (DC) ex vivo stimulated with interferon‐gamma (IFN‐γ) down‐modulates autoimmune diabetes in non‐obese diabetic (NOD) mice

  1999cited by this paper
• Anti-GAD Monoclonal Antibody Delays the Onset of Diabetes Mellitus in NOD Mice

  1999cited by this paper
• Effect of intrathymic administration of mycobacterial heat shock protein 65 and peptide p277 on the development of diabetes in NOD mice: caution required in vaccination studies

  1998cited by this paper
• Systemic Delivery of Interleukin 10 by Intramuscular Injection of Expression Plasmid DNA Prevents Autoimmune Diabetes in Nonobese Diabetic Mice

  1998cited by this paper
• Administration of IL-4 prevents autoimmune diabetes but enhances pancreatic insulitis in NOD mice.

  1998cited by this paper
• Retardation or Acceleration of Diabetes in NOD/Lt Mice Mediated by Intrathymic Administration of Candidate β-Cell Antigens

  1997cited by this paper
• A cholera toxoid-insulin conjugate as an oral vaccine against spontaneous autoimmune diabetes.

  1997cited by this paper
• CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice.

  1997cited by this paper
• T Helper 2 (Th2) T Cells Induce Acute Pancreatitis and Diabetes in Immune-compromised Nonobese Diabetic (NOD) Mice

  1997cited by this paper
• A noncytolytic IL-10/Fc fusion protein prevents diabetes, blocks autoimmunity, and promotes suppressor phenomena in NOD mice.

  1997cited by this paper
• Dapsone Decreases the Cumulative Incidence of Diabetes in Non-Obese Diabetic Female Mice

  1997cited by this paper
• Regulation of autoimmune diabetes by interleukin 3-dependent bone marrow-derived cells in NOD mice.

  1997cited by this paper
• Oral insulin for diabetes prevention in NOD mice: potentiation by enhancing Th2 cytokine expression in the gut through bacterial adjuvant

  1997cited by this paper
• Inhibition of diabetes in non-obese diabetic mice by nicotinamide treatment for 5 weeks at the early age.

  1997cited by this paper
• CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice.

  1997cited by this paper
• Effect of oral and intravenous insulin and glutamic acid decarboxylase in NOD mice.

  1997cited by this paper
• Metabolically inactive insulin analog prevents type I diabetes in prediabetic NOD mice.

  1997cited by this paper
• The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD.

  1997cited by this paper
• Deviation of pancreas‐infiltrating cells to Th2 by interleukin‐12 antagonist administration inhibits autoimmune diabetes

  1997cited by this paper
• Aerosol Insulin Induces Regulatory CD8 γδ T Cells That Prevent Murine Insulin-dependent Diabetes

  1996cited by this paper
• The timing of immunization affects the development of diabetes in rodents.

  1996cited by this paper
• A new type of CD4+ suppressor T cell completely prevents spontaneous autoimmune diabetes and recurrent diabetes in syngeneic islet-transplanted NOD mice.

  1996cited by this paper
• Active Suppression of Diabetes after Oral Administration of Insulin Is Determined by Antigen Dosage

  1996cited by this paper
• Prevention of a Thl Disease by a Thl, Cytokine: IL‐12 and Diabetes in, NOD Mice

  1996cited by this paper
• Prevention of a Th1 disease by a Th1 cytokine: IL-12 and diabetes in NOD mice.

  1996cited by this paper
• Standardizing experiments with NOD mice.

  1996cited by this paper
• Oral Insulin Does Not Prevent Insulin‐dependent Diabetes Melltus in BB Rats

  1996cited by this paper
• Transfer of Diabetes in the NOD-scid Mouse by CD4 T-Cell Clones: Differential Requirement for CD8 T-Cells

  1996cited by this paper
• T helper cell subsets in insulin-dependent diabetes.

  1995cited by this paper
• Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice

  1995cited by this paper
• CD4+ beta islet cell-reactive T cell clones that suppress autoimmune diabetes in nonobese diabetic mice

  1995cited by this paper
• In vivo activity and in vitro specificity of CD4+ Th1 and Th2 cells derived from the spleens of diabetic NOD mice.

  1995cited by this paper
• Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription.

  1995cited by this paper
• Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse

  1995cited by this paper
• Administration of monoclonal antibodies against vascular cell adhesion molecule-1/very late antigen-4 abrogates predisposing autoimmune diabetes in NOD mice.

  1995cited by this paper
• Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin

  1994cited by this paper
• Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process

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• Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice.

  1994cited by this paper
• Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse.

  1994cited by this paper
• Tolbutamide reduces the incidence of diabetes mellitus, but not insulitis, in the non-obese-diabetic mouse

  1993cited by this paper
• Reduced incidence of insulitis in NOD mice following anti-CD3 injection: requirement for neonatal injection.

  1992cited by this paper
• Long-term abrogation of autoimmune diabetes in nonobese diabetic mice by immunotherapy with anti-lymphocyte serum.

  1992cited by this paper
• Rapamycin prevents the onset of insulin‐dependent diabetes mellitus (IDDM) in NOD mice

  1992cited by this paper
• Homeostasis as regulated by activated macrophage. V. Suppression of diabetes mellitus in non-obese diabetic mice by LPSw (a lipopolysaccharide from wheat flour).

  1992cited by this paper
• [Remission of established disease in diabetic NOD mice induced by anti-CD3 monoclonal antibody].

  1992cited by this paper

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• Lymph node sharing between pancreas, gut, and liver leads to immune crosstalk and regulation of pancreatic autoimmunity.

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• Footprint of pancreas infiltrating and circulating immune cells throughout type 1 diabetes development

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• RANKL/RANK is required for cytokine-induced beta cell death; osteoprotegerin, a RANKL inhibitor, reverses rodent type 1 diabetes

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• Formation of pancreatic β-cells from precursor cells contributes to the reversal of established type 1 diabetes.

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• Autoantigen Treatment in Type 1 Diabetes: Unsolved Questions on How to Select Autoantigen and Administration Route

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  2016cites this paper
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• Exposure to DDT metabolite p,p′-DDE increases autoimmune type 1 diabetes incidence in NOD mouse model

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