Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Oncogene

• Publication date

  2004-09-23

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.onc.1207995PMID 15286701
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways

  2004cited by this paper
• Roscovitine sensitizes glioma cells to TRAIL-mediated apoptosis by downregulation of survivin and XIAP

  2004cited by this paper
• Apo2L/TRAIL and its death and decoy receptors

  2003cited by this paper
• Multistep Carcinogenesis: A Chain Reaction of Aneuploidizations

  2003cited by this paper
• A JNK-dependent pathway is required for TNFalpha-induced apoptosis.

  2003influential reference
• JNK-dependent Release of Mitochondrial Protein, Smac, during Apoptosis in Multiple Myeloma (MM) Cells*

  2003cited by this paper
• Translation Inhibitors Sensitize Prostate Cancer Cells to Apoptosis Induced by Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) by Activating c-Jun N-terminal Kinase*

  2003cited by this paper
• Binding Specificity and Regulation of the Serine Protease and PDZ Domains of HtrA2/Omi*

  2003cited by this paper
• The epidermal growth factor receptor-tyrosine kinase: a promising therapeutic target in solid tumors.

  2003cited by this paper
• JunD mediates survival signaling by the JNK signal transduction pathway.

  2003cited by this paper
• Activation of the JNK signaling pathway: Breaking the brake on apoptosis

  2003cited by this paper
• Death receptors leave a caspase footprint that Smacs of XIAP

  2003cited by this paper
• c-Jun N-terminal Kinase Contributes to Apoptotic Synergy Induced by Tumor Necrosis Factor-related Apoptosis-inducing Ligand plus DNA Damage in Chemoresistant, p53 Inactive Mesothelioma Cells*

  2003cited by this paper
• Substrate cleavage by caspases generates protein fragments with Smac/Diablo-like activities

  2003cited by this paper
• JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

  2003cited by this paper
• Cell surface Death Receptor signaling in normal and cancer cells.

  2003cited by this paper
• Role of JNK in Tumor Development

  2003cited by this paper
• Cell Cycle Effects and Caspase-Dependent and Independent Death of HL-60 and Jurkat Cells Treated with the Inhibitor of NF-6B Parthenolide

  2003cited by this paper
• NF‐κB inhibitor sesquiterpene parthenolide induces concurrently atypical apoptosis and cell necrosis: Difficulties in identification of dead cells in such cultures

  2003influential reference
• Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound

  2002cited by this paper
• Oxidative Stress-mediated Apoptosis

  2002cited by this paper
• Synergy is achieved by complementation with Apo2L/TRAIL and actinomycin D in Apo2L/TRAIL‐mediated apoptosis of prostate cancer cells: Role of XIAP in resistance

  2002cited by this paper
• Apoptosis A Link between Cancer Genetics and Chemotherapy

  2002cited by this paper
• NF-κB in cancer: from innocent bystander to major culprit

  2002cited by this paper
• Reduced response of prostate cancer cells to TRAIL is modulated by NFkappaB-mediated inhibition of caspases and Bid activation.

  2002cited by this paper
• The Absence of NF-κB-Mediated Inhibition of c-Jun N-Terminal Kinase Activation Contributes to Tumor Necrosis Factor Alpha-Induced Apoptosis

  2002cited by this paper
• AP-1 as a regulator of cell life and death

  2002cited by this paper
• NF-kappaB in cancer: from innocent bystander to major culprit.

  2002cited by this paper
• NF-kappaB and breast cancer.

  2002cited by this paper
• The p65/RelA Subunit of NF-κB Suppresses the Sustained, Antiapoptotic Activity of Jun Kinase Induced by Tumor Necrosis Factor

  2002cited by this paper
• NF-?B and breast cancer

  2002cited by this paper
• Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions

  2001cited by this paper
• Modulation of epidermal growth factor receptor in endocrine-resistant, oestrogen receptor-positive breast cancer.

  2001cited by this paper
• Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.

  2001cited by this paper
• A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death.

  2001cited by this paper
• NF-κB activation results in rapid inactivation of JNK in TNFα-treated Ewing sarcoma cells: a mechanism for the anti-apoptotic effect of NF-κB

  2001cited by this paper
• Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of human melanoma is regulated by smac/DIABLO release from mitochondria.

  2001cited by this paper
• Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling.

  2001cited by this paper
• The kiss of death: promises and failures of death receptors and ligands in cancer therapy

  2001cited by this paper
• Inhibition of JNK activation through NF-kappaB target genes.

  2001cited by this paper
• Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8.

  2001cited by this paper
• NF-kappa B activation results in rapid inactivation of JNK in TNF alpha-treated Ewing sarcoma cells: a mechanism for the anti-apoptotic effect of NF-kappa B.

  2001cited by this paper
• Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling

  2001cited by this paper
• Rel/NF-κB Transcription Factors Protect against Tumor Necrosis Factor (TNF)-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis by Up-regulating the TRAIL Decoy Receptor DcR1*

  2001cited by this paper
• Inhibition of JNK activation through NF-κB target genes

  2001cited by this paper
• Epidermal growth factor-induced nuclear factor κB activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells

  2000cited by this paper
• Signal transduction by the JNK group of MAP kinases.

  2000cited by this paper
• Epidermal growth factor-induced nuclear factor kappa B activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells.

  2000cited by this paper
• Cancer cell-derived interleukin 1alpha contributes to autocrine and paracrine induction of pro-metastatic genes in breast cancer.

  2000cited by this paper
• Radiation and the Apo2L/TRAIL apoptotic pathway preferentially inhibit the colonization of premalignant human breast cells overexpressing cyclin D1.

  2000cited by this paper
• Parthenolide inhibits activation of signal transducers and activators of transcription (STATs) induced by cytokines of the IL-6 family.

  2000cited by this paper
• Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide.

  2000cited by this paper
• Paclitaxel sensitivity of breast cancer cells with constitutively active NF-κB is enhanced by IκBα super-repressor and parthenolide

  2000influential reference
• Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy.

  2000cited by this paper
• Mechanisms of resistance of normal cells to TRAIL induced apoptosis vary between different cell types

  2000cited by this paper
• Complete sequencing of TP53 predicts poor response to systemic therapy of advanced breast cancer.

  2000cited by this paper
• Negative Regulation of Transactivation Function but Not DNA Binding of NF-κB and AP-1 by IκBβ1 in Breast Cancer Cells*

  1999cited by this paper
• Tumoricidal activity of tumor necrosis factor–related apoptosis–inducing ligand in vivo

  1999cited by this paper
• Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

  1999cited by this paper
• Negative regulation of transactivation function but not DNA binding of NF-kappaB and AP-1 by IkappaBbeta1 in breast cancer cells.

  1999cited by this paper
• JNK/SAPK activity contributes to TRAIL-induced apoptosis

  1999cited by this paper
• Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB

  1999cited by this paper
• NF-kappaB activation and interleukin 6 production in fibroblasts by estrogen receptor-negative breast cancer cell-derived interleukin 1alpha.

  1998cited by this paper
• Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors.

  1998cited by this paper
• NF-κB activation and interleukin 6 production in fibroblasts by estrogen receptor-negative breast cancer cell-derived interleukin 1α

  1998cited by this paper
• Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta.

  1998cited by this paper
• Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth

  1997cited by this paper
• Artemisinin enhances heme-catalysed oxidation of lipid membranes.

  1997cited by this paper
• Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-alpha) translation: glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK

  1997cited by this paper
• Protein phosphatase 2A is a critical regulator of protein kinase C zeta signaling targeted by SV40 small t to promote cell growth and NF-kappaB activation.

  1997cited by this paper
• An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

  1996cited by this paper
• An essential role for NF-kappaB in preventing TNF-alpha-induced cell death.

  1996cited by this paper
• Transforming activity of the human mammary line HBL100 DNA is associated with SV40 large T antigen genetic information integrated in its genome.

  1988cited by this paper

• Bioinformatics approach reveals the modulatory role of JUN in atorvastatin-mediated anti-breast cancer effects

  2025cites this paper
• Parthenolide Inhibits Tumor Cell Growth and Metastasis in Melanoma A2058 Cells.

  2024cites this paper
• Green nanotech paradigm for enhancing sesquiterpene lactone therapeutics in cancer.

  2024cites this paper
• A metabolomics approach reveals metabolic disturbance of human cholangiocarcinoma cells after parthenolide treatment.

  2024cites this paper
• Inhibitory effect of parthenolide on peripheral nerve degeneration

  2023cites this paper
• Study on antitumor activity of parthenolide C ‐14 derivatives

  2023cites this paper
• DDDT_A_355059 1255..1272

  2022cites this paper
• Recent advances on the structural modification of parthenolide and its derivatives as anticancer agents.

  2022cites this paper
• Exploring the recent trends in perturbing the cellular signaling pathways in cancer by natural products

  2022cites this paper
• Traditional Medicinal Plants as a Source of Inspiration for Osteosarcoma Therapy

  2022cites this paper
• Parthenolide and Its Soluble Analogues: Multitasking Compounds with Antitumor Properties

  2022influential citation
• Design, Synthesis, and Antileukemic Evaluation of a Novel Mikanolide Derivative Through the Ras/Raf/MEK/ERK Pathway

  2022cites this paper
• The Emerging Potential of Parthenolide Nanoformulations in Tumor Therapy

  2022cites this paper
• Parthenolide as Cooperating Agent for Anti-Cancer Treatment of Various Malignancies

  2020influential citation
• Applications of Sesquiterpene Lactones: A Review of Some Potential Success Cases

  2020cites this paper
• Advances in chemistry and bioactivity of parthenolide.

  2019cites this paper
• Sesquiterpenes in Fresh Food

  2019cites this paper
• Drug Repurposing Approach Identifies a Synergistic Drug Combination of an Antifungal Agent and an Experimental Organometallic Drug for Melanoma Treatment.

  2018cites this paper
• Parthenolide reduces metastasis by inhibition of vimentin expression and induces apoptosis by suppression elongation factor α - 1 expression.

  2018cites this paper
• Parthenolide promotes apoptotic cell death and inhibits the migration and invasion of SW620 cells

  2017cites this paper
• Parthenolide attenuates cerebral ischemia/reperfusion injury via Akt/GSK-3β pathway in PC12 cells.

  2017cites this paper
• Synthesis, characterization and anticancer evaluation of phosphinogold(I) thiocarbohydrate complexes

  2017cites this paper
• N-[11CH3]Dimethylaminoparthenolide (DMAPT) uptake into orthotopic 9LSF glioblastoma tumors in the rat.

  2016cites this paper
• Parthenolide induces MITF-M downregulation and senescence in patient-derived MITF-Mhigh melanoma cell populations

  2016cites this paper
• Synthetic Modification of 9α- and 9β-Hydroxyparthenolide by Heck or Acylation Reactions and Evaluation of Cytotoxic Activities

  2016cites this paper
• Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches

  2016cites this paper
• Chemoenzymatic synthesis and antileukemic activity of novel C9- and C14-functionalized parthenolide analogs.

  2016cites this paper
• Synthesis and anticancer evaluation of novel 9α-substituted-13-(1,2,3-triazolo)-parthenolides

  2016cites this paper
• Anti-inflammatory and Anti-tumor Activities of Parthenolide: An Update

  2016cites this paper
• Nanodelivery of Parthenolide Using Functionalized Nanographene Enhances its Anticancer Activity.

  2015cites this paper
• NF-κB in cancer therapy

  2015influential citation
• The role of oxidative stress in anticancer activity of sesquiterpene lactones

  2015cites this paper
• Parthenolide enhances sensitivity of colorectal cancer cells to TRAIL by inducing death receptor 5 and promotes TRAIL-induced apoptosis.

  2015cites this paper
• NF-κB-dependent and -independent epigenetic modulation using the novel anti-cancer agent DMAPT

  2015cites this paper
• Dimers of Melampomagnolide B Exhibit Potent Anticancer Activity against Hematological and Solid Tumor Cells.

  2015cites this paper
• Induction of survivin inhibition, G₂/M cell cycle arrest and autophagic on cell death in human malignant glioblastoma cells.

  2015cites this paper
• Characterization and target identification of non-toxic IKKβ inhibitors for anticancer therapy

  2015cites this paper
• Organ-specific adaptive signaling pathway activation in metastatic breast cancer cells

  2015cites this paper
• Sesquiterpene lactones of Moquiniastrum polymorphum subsp. floccosum have antineoplastic effects in Walker-256 tumor-bearing rats.

  2015cites this paper
• Micheliolide, a new sesquiterpene lactone that inhibits intestinal inflammation and colitis-associated cancer

  2014cites this paper
• Anisomycin, an Inhibitor of Protein Synthesis, Overcomes TRAIL Resistance in Human Hepatocarcinoma Cells via Caspases Activation and Bid Downregulation

  2014cites this paper
• Emetine enhances the tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of pancreatic cancer cells by downregulation of myeloid cell leukemia sequence-1 protein.

  2014cites this paper
• CGP74514A Enhances TRAIL-induced Apoptosis in Breast

  2014cites this paper
• Targeting Apoptosis Pathways in Cancer and Perspectives with Natural Compounds from Mother Nature

  2014cites this paper
• Parthenolide Sensitizes Human Colorectal Cancer Cells to Tumor Necrosis Factor-related Apoptosis-inducing Ligand through Mitochondrial and Caspase Dependent Pathway

  2014cites this paper
• CCT 327 enhances TRAIL-induced apoptosis through the induction of death receptors and downregulation of cell survival proteins in TRAIL-resistant human leukemia cells

  2014cites this paper
• CGP74514A enhances TRAIL-induced apoptosis in breast cancer cells by reducing X-linked inhibitor of apoptosis protein.

  2014cites this paper
• CCT327 enhances TRAIL-induced apoptosis through the induction of death receptors and downregulation of cell survival proteins in TRAIL-resistant human leukemia cells.

  2014cites this paper
• Parthenolide exerts inhibitory effects on angiogenesis through the downregulation of VEGF/VEGFRs in colorectal cancer.

  2014cites this paper
• Hedyotis diffusa Willd extract inhibits the growth of human glioblastoma cells by inducing mitochondrial apoptosis via AKT/ERK pathways.

  2014cites this paper
• Age Sensitivity of NFκB Abundance and Programmed Cell Death in Erythrocytes Induced by NFκB Inhibitors

  2013cites this paper
• Sesquiterpenoids Lactones: Benefits to Plants and People

  2013influential citation
• Curcumin enhances TRAIL-induced apoptosis of breast cancer cells by regulating apoptosis-related proteins

  2013cites this paper
• Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibition

  2013cites this paper
• Bioinformatics analysis reveals potential candidate drugs for cervical cancer

  2013cites this paper
• Parthenolide induces caspase‐independent and AIF‐mediated cell death in human osteosarcoma and melanoma cells

  2013influential citation
• Parthenolide reduces the frequency of ABCB5-positive cells and clonogenic capacity of melanoma cells from anchorage independent melanospheres

  2013cites this paper
• Parthenolide enhances dacarbazine activity against melanoma cells

  2013cites this paper
• Expression of NFkB1, GADD45A and JNK1 in salivary gland carcinomas of different histotypes.

  2013cites this paper
• SYNTHESIS AND EVALUATION OF PARTHENOLIDE ANALOGUES: CHEMICAL PROBES AND THERAPEUTIC AGENTS

  2013cites this paper
• Sub-toxic dose of apigenin sensitizes HepG2 cells to TRAIL through ERK-dependent up-regulation of TRAIL receptor DR5

  2013cites this paper
• Parthenolide complements the cell death-inducing activity of doxorubicin in melanoma cells.

  2013cites this paper
• Antimutagenic and antioxidant activities of some bioflavours from wine.

  2013cites this paper
• Sesquiterpene lactones: Adverse health effects and toxicity mechanisms

  2013cites this paper
• Synergistic induction of TRAIL-mediated apoptosis by anisomycin in human hepatoma cells via the BH3-only protein Bid and c-Jun/AP-1 signaling pathway.

  2013cites this paper
• Parthenolide generates reactive oxygen species and autophagy in MDA-MB231 cells. A soluble parthenolide analogue inhibits tumour growth and metastasis in a xenograft model of breast cancer

  2013cites this paper
• Apoptotic Regulators and Its Clinical Implications in Mammary Carcinoma

  2012cites this paper
• Parthenolide suppresses tumor growth in a xenograft model of colorectal cancer cells by inducing mitochondrial dysfunction and apoptosis.

  2012cites this paper
• Parthenolide induces apoptosis and lytic cytotoxicity in Epstein-Barr virus-positive Burkitt lymphoma

  2012cites this paper
• Oxidative Stress and Lipid Peroxidation Products in Cancer Progression and Therapy

  2012cites this paper
• Sesquiterpene lactones as drugs with multiple targets in cancer treatment: focus on parthenolide

  2012cites this paper
• Downregulation of Mcl-1 by daunorubicin pretreatment reverses resistance of breast cancer cells to TNF-related apoptosis-inducing ligand.

  2012cites this paper
• AW00179 potentiates TRAIL-mediated death of human lung cancer H1299 cells through ROS-JNK-c-Jun-mediated up-regulation of DR5 and down-regulation of anti-apoptotic molecules

  2012cites this paper
• Parthenolide, an inhibitor of the nuclear factor-κB pathway, ameliorates dextran sulfate sodium-induced colitis in mice.

  2012cites this paper
• Natural and synthetic α-methylenelactones and α-methylenelactams with anticancer potential.

  2012cites this paper
• Novel Apoptotic Regulators in Carcinogenesis

  2012cites this paper
• The natural products parthenolide and andrographolide exhibit anti-cancer stem cell activity in multiple myeloma

  2011cites this paper
• Parthenolide inhibits TRIF-dependent signaling pathway of toll-like receptors in RAW264.7 macrophages

  2011cites this paper
• Parthenolide augments the anticancer effects of 5- fluorouracil on cell apoptosis and decreased NF-κB activity in a gastric cancer cell line

  2011cites this paper
• Parthenolide sensitizes HL-60 cells to aclarubicin- induced apoptosis by inhibiting NF-kappa band COX-2 activation

  2011cites this paper
• Parthenolide sensitizes hepatocellular carcinoma cells to trail by inducing the expression of death receptors through inhibition of STAT3 activation

  2011cites this paper
• Parthenolide, a Sesquiterpene Lactone, Expresses Multiple Anti-cancer and Anti-inflammatory Activities

  2011cites this paper
• A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco‐associated cancers, lung and bladder cancer, by targeting NF‐κB and generating reactive oxygen species

  2011cites this paper
• Parthenolide inhibits STAT3 signaling and attenuates angiotensin II-induced left ventricular hypertrophy via modulation of fibroblast activity.

  2011cites this paper
• Perspectives on sesquiterpene lactones in inflammation and cancer.

  2011cites this paper
• Estudio de los mecanismos que regulan la expresión y función del ligando de muerte TRAIL en células T normales y leucémicas

  2011cites this paper
• Oxaliplatin sensitizes human colon cancer cells to TRAIL through JNK-dependent phosphorylation of Bcl-xL.

  2011cites this paper
• TRAILing death in cancer.

  2010cites this paper
• BCL2 and CASP8 regulation by NF‐κB differentially affect mitochondrial function and cell fate in antiestrogen‐sensitive and ‐resistant breast cancer cells

  2010cites this paper
• Cell context‐dependent activities of parthenolide in primary and metastatic melanoma cells

  2010cites this paper
• Sustained c-Jun-NH2-Kinase Activity Promotes Epithelial-Mesenchymal Transition, Invasion, and Survival of Breast Cancer Cells by Regulating Extracellular Signal-Regulated Kinase Activation

  2010cites this paper
• Tailored α-methylene-γ-butyrolactones and their effects on growth suppression in pancreatic carcinoma cells.

  2010cites this paper
• Myeloperoxidase Expression as a Potential Determinant of Parthenolide-Induced Apoptosis in Leukemia Bulk and Leukemia Stem Cells

  2010cites this paper
• Parthenolide induces proliferation inhibition and apoptosis of pancreatic cancer cells in vitro

  2010cites this paper
• Independent component analysis: Mining microarray data for fundamental human gene expression modules

  2010cites this paper
• A water‐soluble parthenolide analogue suppresses in vivo prostate cancer growth by targeting NFκB and generating reactive oxygen species

  2010cites this paper
• Paclitaxel efficacy is increased by parthenolide via nuclear factor-kappaB pathways in in vitro and in vivo human non-small cell lung cancer models.

  2010cites this paper
• Inhibition of NF-kappaB by combination therapy with parthenolide and hyperthermia and kinetics of apoptosis induction and cell cycle arrest in human lung adenocarcinoma cells.

  2010cites this paper
• Pentoxifylline augments TRAIL/Apo2L mediated apoptosis in cutaneous T cell lymphoma (HuT-78 and MyLa) by modulating the expression of antiapoptotic proteins and death receptors.

  2010cites this paper
• [Molecular mechanisms of parthenolide's action: Old drug with a new face].

  2010influential citation