Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts.

No abstract is available for this paper.

• Publication year

  1986

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  1986-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/PNAS.83.3.664PMID 3003744PMCID PMC322924
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Actions of insulin-like growth factors.

  1985cited by this paper
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• Growth-stimulatory actions of insulin in vitro and in vivo.

  1984cited by this paper
• Insulin‐like growth factor I/somatomedin‐C (IGF‐I/SM‐C) and glucocorticoids synergistically regulate mitosis in competent human fibroblasts

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• Interrelationships among receptor structures for insulin and peptide growth factors.

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• Antireceptor antibodies as probes of insulinlike growth factor receptor structure.

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• Monoclonal antibodies to receptors for insulin and somatomedin-C.

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  1982cited by this paper
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  1982cited by this paper
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  1982cited by this paper
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  1982cited by this paper
• Fibroblasts from a patient with leprechaunism are resistant to insulin, epidermal growth factor, and somatomedin C.

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• Demonstration of two subtypes of insulin-like growth factor receptors by affinity cross-linking.

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• Stimulation of glucose incorporation and amino acid transport by insulin and an insulin-like growth factor in fibroblasts with defective insulin receptors cultured from a patient with leprechaunism.

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