Mechano-oxidative coupling by mitochondria induces proinflammatory responses in lung venular capillaries.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Journal of Clinical Investigation

• Publication date

  2003-03-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1172/JCI17271PMID 12618523PMCID PMC151903
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Role of ecNOS-derived NO in mediating TNF-induced endothelial barrier dysfunction.

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• Mitochondrial Ca 2 1 Uptake Depends on the Spatial and Temporal Profile of Cytosolic Ca 2 1 Signals*

  2001influential reference
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  2000cited by this paper
• Hypoxia/Reoxygenation Stimulates Intracellular Calcium Oscillations in Human Aortic Endothelial Cells

  2000cited by this paper
• Inositol 1,4,5-trisphosphate-induced Ca2+ release is inhibited by mitochondrial depolarization.

  2000cited by this paper
• Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin.

  2000cited by this paper
• AMPA Exposures Induce Mitochondrial Ca2+ Overload and ROS Generation in Spinal Motor Neurons In Vitro

  2000cited by this paper
• A novel signaling mechanism between gas and blood compartments of the lung

  2000cited by this paper
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  2000cited by this paper
• Mitochondrial calcium transients in adult rabbit cardiac myocytes: inhibition by ruthenium red and artifacts caused by lysosomal loading of Ca(2+)-indicating fluorophores.

  2000cited by this paper
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  1999influential reference
• Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis

  1999cited by this paper
• Mitochondria Exert a Negative Feedback on the Propagation of Intracellular Ca2+ Waves in Rat Cortical Astrocytes

  1999influential reference
• Ca2+-induced increased lipid packing and domain formation in submitochondrial particles. A possible early step in the mechanism of Ca2+-stimulated generation of reactive oxygen species by the respiratory chain.

  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
• Detection and imaging of nitric oxide with novel fluorescent indicators: diaminofluoresceins.

  1998cited by this paper
• Calcium sensors in regulated exocytosis.

  1998cited by this paper
• Ca2+-stimulated mitochondrial reactive oxygen species generation and permeability transition are inhibited by dibucaine or Mg2+.

  1998cited by this paper
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  1998cited by this paper
• Pulsatile stretch stimulates superoxide production in human aortic endothelial cells.

  1997cited by this paper
• Cyclic strain induces an oxidative stress in endothelial cells.

  1997cited by this paper
• Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor.

  1997cited by this paper
• Delayed autoregulation of the Ca2+ signals resulting from capacitative Ca2+ entry in bovine pulmonary artery endothelial cells.

  1997influential reference
• High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria

  1997cited by this paper
• Mitochondrial Regulation of Store-operated Calcium Signaling in T Lymphocytes

  1997cited by this paper
• Fluorescence-based measurement of nitric oxide synthase activity in activated rat macrophages using dichlorofluorescin.

  1997influential reference
• Ca2+ waves in lung capillary endothelium.

  1996cited by this paper
• Activation of Fyn tyrosine kinase upon secretagogue stimulation of bovine chromaffin cells

  1996cited by this paper
• Sequential contribution of L- and P-selectin to leukocyte rolling in vivo

  1995cited by this paper
• Decoding of cytosolic calcium oscillations in the mitochondria.

  1995cited by this paper
• Adhesion molecules contribute to ischemia and reperfusion-induced injury in the isolated rat lung.

  1995cited by this paper
• Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation

  1995cited by this paper
• Prolonged peak elevations in cytoplasmic free calcium ions, derived from intracellular stores, correlate with the extent of thrombin‐stimulated exocytosis in single human umbilical vein endothelial cells

  1994cited by this paper
• Evaluation of 2',7'-dichlorofluorescin and dihydrorhodamine 123 as fluorescent probes for intracellular H2O2 in cultured endothelial cells.

  1993cited by this paper
• Neutrophil-dependent acute lung injury. Requirement for P-selectin (GMP-140).

  1992cited by this paper
• A microplate assay for the detection of oxidative products using 2',7'-dichlorofluorescin-diacetate.

  1992cited by this paper
• Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

  1990cited by this paper
• Flow-cytometric characterization of stimulation, free radical formation, peroxidase activity and phagocytosis of human granulocytes with 2,7-dichlorofluorescein (DCF).

  1987influential reference
• Mitochondrial and plasma membrane potentials cause unusual accumulation and retention of rhodamine 123 by human breast adenocarcinoma-derived MCF-7 cells.

  1985cited by this paper

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  2008cites this paper
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