SnoN as a novel negative regulator of TGF-β/Smad signaling: a target for tailoring organ fibrosis.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  American Journal of Physiology. Heart and Circulatory Physiology

• Publication date

  2015-01-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/ajpheart.00453.2014PMID 25380815
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2011cited by this paper
• Antifibrotic properties of c-Ski and its regulation of cardiac myofibroblast phenotype and contractility.

  2011influential reference
• Migration of fibrocytes in fibrogenic liver injury.

  2011cited by this paper
• The Ski proto-oncogene regulates body composition and suppresses lipogenesis

  2010cited by this paper
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  2010cited by this paper
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  2010influential reference
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  2010cited by this paper
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  2009cited by this paper
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  2008cited by this paper
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  2006influential reference
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  2006cited by this paper
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  2006influential reference
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  2006cited by this paper
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  2005cited by this paper
• Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteins.

  2005cited by this paper
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  2005cited by this paper
• Fine tuning and cross-talking of TGF-beta signal by inhibitory Smads.

  2005cited by this paper
• Crystal structure of the dachshund homology domain of human SKI.

  2004cited by this paper
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  2004influential reference
• Ski and SnoN: negative regulators of TGF-beta signaling.

  2004influential reference
• Ski and SnoN: negative regulators of TGF-β signaling

  2004cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
• Defective T-Cell Activation Is Associated with Augmented Transforming Growth Factor β Sensitivity in Mice with Mutations in the Sno Gene

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• The Transforming Activity of Ski and SnoN Is Dependent on Their Ability to Repress the Activity of Smad Proteins*

  2003cited by this paper
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  2003influential reference
• DACH1 Inhibits Transforming Growth Factor-β Signaling through Binding Smad4*

  2003cited by this paper
• Transforming growth factor signal transduction

  2002cited by this paper
• Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling.

  2002influential reference
• The Ski Protein Family Is Required for MeCP2-mediated Transcriptional Repression*

  2001cited by this paper
• Regulation of Smad activity.

  2000cited by this paper
• Molecular basis of renal fibrosis

  2000cited by this paper
• The sno gene, which encodes a component of the histone deacetylase complex, acts as a tumor suppressor in mice

  2000cited by this paper
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  1999cited by this paper
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  1999influential reference
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  1999influential reference
• Negative Feedback Regulation of TGF-β Signaling by the SnoN Oncoprotein

  1999cited by this paper
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  1998cited by this paper
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  1997influential reference
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  1996influential reference
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• The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

  1994cited by this paper
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  1994influential reference
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  1994cited by this paper
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  1990cited by this paper
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  1989cited by this paper
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  year unknowncited by this paper

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