Direct Evidence from Single-Cell Analysis that Human α-Defensins Block Adenovirus Uncoating To Neutralize Infection

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Virology

• Publication date

  2010-02-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.02471-09PMID 20130047PMCID PMC2849482
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Year : 2008 Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo

  2009cited by this paper
• Genetic reconstitution of the human Adenovirus type 2 temperature-sensitive 1 mutant defective in endosomal escape

  2009cited by this paper
• Structure and uncoating of immature adenovirus.

  2009cited by this paper
• Cryo-Electron Microscopy Structure of Adenovirus Type 2 Temperature-Sensitive Mutant 1 Reveals Insight into the Cell Entry Defect

  2009cited by this paper
• Adenovirus receptors: implications for tropism, treatment and targeting

  2009cited by this paper
• Human α-Defensins Inhibit BK Virus Infection by Aggregating Virions and Blocking Binding to Host Cells*

  2008cited by this paper
• The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

  2008cited by this paper
• Key Role of Splenic Myeloid DCs in the IFN-αβ Response to Adenoviruses In Vivo

  2008cited by this paper
• Neutralizing Antibody Blocks Adenovirus Infection by Arresting Microtubule-Dependent Cytoplasmic Transport

  2008cited by this paper
• Mechanism of adenovirus neutralization by Human alpha-defensins.

  2008cited by this paper
• Intracellular trafficking of adenovirus: many means to many ends.

  2007cited by this paper
• Toll-like receptor 9 triggers an innate immune response to helper-dependent adenoviral vectors.

  2007cited by this paper
• Innate Immune Response to Adenoviral Vectors Is Mediated by both Toll-Like Receptor-Dependent and -Independent Pathways

  2007cited by this paper
• Sensing Infection by Adenovirus: Toll-Like Receptor-Independent Viral DNA Recognition Signals Activation of the Interferon Regulatory Factor 3 Master Regulator

  2007cited by this paper
• Preferential Activation of Toll-Like Receptor Nine by CD46-Utilizing Adenoviruses

  2006cited by this paper
• Stepwise D ismantling of Adenovirus 2 durhg Entry into Cek llrs

  2006cited by this paper
• Simple and highly efficient BAC recombineering using galK selection

  2005cited by this paper
• Nuclear targeting of adenovirus type 2 requires CRM1-mediated nuclear export.

  2005influential reference
• Adenovirus Protein VI Mediates Membrane Disruption following Capsid Disassembly

  2005cited by this paper
• Bromodeoxyuridine-Labeled Viral Particles as a Tool for Visualization of the Immediate-Early Events of Human Cytomegalovirus Infection

  2004cited by this paper
• Development of stable liquid formulations for adenovirus-based vaccines.

  2004cited by this paper
• Association of Adenovirus with the Microtubule Organizing Center

  2003influential reference
• Association of Adenovirus with the MicrotubuleOrganizingCenter

  2003cited by this paper
• The First Step of Adenovirus Type 2 Disassembly Occurs at the Cell Surface, Independently of Endocytosis and Escape to the Cytosol

  2000cited by this paper
• Stepwise dismantling of adenovirus 2 during entry into cells.

  1993cited by this paper
• Neutralization of adenoviruses: kinetics, stoichiometry, and mechanisms

  1988cited by this paper
• Entry of adenovirus 2 into HeLa cells

  1984cited by this paper
• Uncoating of adenovirus type 2

  1979cited by this paper
• Separation of Two Types of Adeno-Associated Virus Particles Containing Complementary Polynucleotide Chains

  1972cited by this paper
• Structural proteins of adenoviruses

  1971cited by this paper
• Early events in the interaction of adenoviruses with HeLa cells. II. Comparative observations on the penetration of types 1, 5, 7, and 12.

  1970cited by this paper
• Structural proteins of adenoviruses. IV. Sequential degradation of the adenovirus type 2 virion.

  1970cited by this paper
• Early events in the interaction of adenoviruses with HeLa cells. I. Penetration of type 5 and intracellular release of the DNA genome.

  1970cited by this paper
• Evidence for a Single-Stranded Adenovirus-Associated Virus Genome: Isolation and Separation of Complementary Single Strands

  1970cited by this paper
• Early Events of Virus-Cell Interaction in an Adenovirus System

  1969cited by this paper
• Intracellular Uncoating of Type 5 Adenovirus Deoxyribonucleic Acid

  1967influential reference
• The effect of heat on the anatomy of the adenovirus.

  1967cited by this paper
• Early events in the infection process of adenovirus type 5 in HeLa cells.

  1967influential reference
• An Analysis of Adenovirus Particles and Soluble Antigens produced in the Presence of 5-Bromodeoxyuridine

  1963cited by this paper
• Neutralization of Adenoviruses: Kinetics, Stoichiometry, and Mechanisms

  year unknowncited by this paper

• Vitamin D-Induced Antimicrobial Peptides in Combating Viral Infections.

  2026cites this paper
• Advances in the discovery, mechanism of action, optimization of activity and potential for clinical application of antimicrobial peptides

  2025cites this paper
• Post-translational modifications on protein VII are important during the early stages of adenovirus infection

  2024cites this paper
• Human coronaviruses: activation and antagonism of innate immune responses

  2024cites this paper
• The antimicrobial protein RNase 7 directly restricts herpes simplex virus infection of human keratinocytes

  2024cites this paper
• Mechanisms of AAV neutralization by human alpha-defensins

  2024cites this paper
• Uncovering the Potent Antiviral Activity of the Sesterterpenoids from the Sponge Ircinia Felix Against Human Adenoviruses: from the Natural Source to the Total Synthesis

  2024cites this paper
• Alpha-defensin binding expands human adenovirus tropism

  2024cites this paper
• Alpha-defensin binding expands human adenovirus tropism

  2024cites this paper
• Heteroleptic (S^C)-cyclometallated gold(III) complexes as novel antiviral agents

  2024cites this paper
• Inhibition of adenovirus transport from the endosome to the cell nucleus by rotenone

  2024cites this paper
• Corrected and republished from: “VP4 Is a Determinant of Alpha-Defensin Modulation of Rotaviral Infection”

  2023cites this paper
• Pathogenicity and virulence of human adenovirus F41: Possible links to severe hepatitis in children

  2023cites this paper
• Fowl adenovirus serotype 4 enters leghorn male hepatocellular cells via the clathrin-mediated endocytosis pathway

  2023cites this paper
• The Function and Modification of Human Defensin 5.

  2023cites this paper
• Antimicrobial Mechanisms and Clinical Application Prospects of Antimicrobial Peptides

  2022cites this paper
• Adenovirus receptors on antigen‐presenting cells of the skin

  2022cites this paper
• VP4 Is a Determinant of Alpha-Defensin Modulation of Rotaviral Infection

  2022cites this paper
• Adenovirus-α-Defensin Complexes Induce NLRP3-Associated Maturation of Human Phagocytes via Toll-Like Receptor 4 Engagement

  2022cites this paper
• Theta-Defensins to Counter COVID-19 as Furin Inhibitors: In Silico Efficiency Prediction and Novel Compound Design

  2022cites this paper
• Discovery of a Small Molecule Inhibitor of Human Adenovirus Capable of Preventing Escape from the Endosome

  2021cites this paper
• Adenovirus-α-defensin complexes induce NLRP3-associated maturation of human phagocytes via TLR4 engagement

  2021cites this paper
• Bromodeoxyuridine Labelling to Determine Viral DNA Localization in Fluorescence and Electron Microscopy: The Case of Adenovirus

  2021cites this paper
• Natural antimicrobial peptides as a source of new antiviral agents.

  2021cites this paper
• Are Host Defense Peptides and Their Derivatives Ready to be Part of the Treatment of the Next Coronavirus Pandemic?

  2021cites this paper
• Understanding Post Entry Sorting of Adenovirus Capsids; A Chance to Change Vaccine Vector Properties

  2021cites this paper
• The antimicrobial potentialities of (Nk-lysin peptides of chicken, bovine, and human) against bacteria and rotavirus

  2021cites this paper
• Emerging Antiviral Therapeutics for Human Adenovirus Infection: Recent Developments and Novel Strategies.

  2021cites this paper
• STING is dispensable during KSHV infection of primary endothelial cells.

  2020cites this paper
• Membrane disrupting peptides: mechanistic elucidation of antimicrobial activity

  2020cites this paper
• Serinol-Based Benzoic Acid Esters as New Scaffolds for the Development of Adenovirus Infection Inhibitors: Design, Synthesis, and In Vitro Biological Evaluation.

  2020cites this paper
• Atomic force microscopy to elucidate how peptides disrupt membranes.

  2020cites this paper
• Antiviral and Antiproliferative Potential of Marine Organisms From the Yucatan Peninsula, Mexico

  2020cites this paper
• Defensin-driven viral evolution

  2020influential citation
• Defensins: A Double-Edged Sword in Host Immunity

  2020cites this paper
• Salmonella enterica Infection of Murine and Human Enteroid-Derived Monolayers Elicits Differential Activation of Epithelium-Intrinsic Inflammasomes

  2020cites this paper
• Penaeidins restrict white spot syndrome virus infection by antagonizing the envelope proteins to block viral entry

  2020cites this paper
• Antiviral Activities of Human Host Defense Peptides.

  2020cites this paper
• Antimicrobial host defence peptides: functions and clinical potential

  2020cites this paper
• Adenovirus—Extracellular Protein Interactions and Their Impact on Innate Immune Responses by Human Mononuclear Phagocytes

  2020cites this paper
• Discovery of Novel Substituted N-(4-Amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide Analogues as Potent Human Adenovirus Inhibitors.

  2020cites this paper
• Lessons learned from adenovirus (1970–2019)

  2019cites this paper
• Imaging the adenovirus infection cycle

  2019cites this paper
• Optimization of piperazine-derived ureas privileged structures for effective -antiadenovirus agents.

  2019cites this paper
• Repositioning salicylanilide anthelmintic drugs to treat adenovirus infections

  2019cites this paper
• α-Defensin HD5 Stabilizes Human Papillomavirus 16 Capsid/Core Interactions

  2019cites this paper
• Antiviral Activity of Synthetic Peptides Derived from Physiological Proteins

  2019cites this paper
• Murine adenoviruses: tools for studying adenovirus pathogenesis in a natural host

  2019cites this paper
• Human Antimicrobial Peptides as Therapeutics for Viral Infections

  2019cites this paper
• How non-enveloped viruses hijack host machineries to cause infection.

  2019cites this paper
• Pathogenesis and management of adenoviral keratoconjunctivitis

  2018cites this paper
• Adenovirus Infection of Human Enteroids Reveals Interferon Sensitivity and Preferential Infection of Goblet Cells

  2018cites this paper
• Towards the Application of Human Defensins as Antivirals

  2018cites this paper
• Bacterial RecA Protein Promotes Adenoviral Recombination during In Vitro Infection

  2018cites this paper
• Human Neutrophil Defensin-1, -3, and -4 Are Elevated in Nasal Aspirates from Children with Naturally Occurring Adenovirus Infection

  2018cites this paper
• Inhibition of adenovirus infection by mifepristone

  2018cites this paper
• α-Defensin HD5 Inhibits Human Papillomavirus 16 Infection via Capsid Stabilization and Redirection to the Lysosome

  2017cites this paper
• Deciphering the Multifactorial Susceptibility of Mucosal Junction Cells to HPV Infection and Related Carcinogenesis

  2017cites this paper
• Defensins in Viral Infection and Pathogenesis.

  2017cites this paper
• A Single Maturation Cleavage Site in Adenovirus Impacts Cell Entry and Capsid Assembly

  2016cites this paper
• Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host Immunity

  2016cites this paper
• New 4-Acyl-1-phenylaminocarbonyl-2-phenylpiperazine Derivatives as Potential Inhibitors of Adenovirus Infection. Synthesis, Biological Evaluation, and Structure-activity Relationships.

  2016cites this paper
• Defensins Potentiate a Neutralizing Antibody Response to Enteric Viral Infection

  2016cites this paper
• Directed Evolution of Adenoviruses.

  2016cites this paper
• Antimicrobial and antiviral effects of human defensins: pathogenetic value and prospective application to medicinal therapy

  2016cites this paper
• Antiviral Host Defence Peptides

  2016cites this paper
• Adenovirus membrane penetration: Tickling the tail of a sleeping dragon.

  2015cites this paper
• Human defensins and innate immune control of JC Polyomavirus infection

  2015cites this paper
• Host-defense peptides enhance enteric viral infection in a small intestinal organoid model and in vivo

  2015cites this paper
• Coronavirus and Influenza Virus Proteolytic Priming Takes Place in Tetraspanin-Enriched Membrane Microdomains

  2015cites this paper
• Adenovirus Tales: From the Cell Surface to the Nuclear Pore Complex

  2015cites this paper
• A Single Maturation Cleavage Site in Adenovirus Impacts Cell Entry and Capsid Assembly

  2015cites this paper
• Coat as a Dagger: The Use of Capsid Proteins to Perforate Membranes during Non-Enveloped DNA Viruses Trafficking

  2014cites this paper
• Alpha-Defensin HD5 Inhibits Furin Cleavage of Human Papillomavirus 16 L2 To Block Infection

  2014cites this paper
• Inhibition of adenovirus replication by a trisubstituted piperazin-2-one derivative.

  2014cites this paper
• Viruses and the Microbiota.

  2014cites this paper
• Delineation of Interfaces on Human Alpha-Defensins Critical for Human Adenovirus and Human Papillomavirus Inhibition

  2014cites this paper
• CXC chemokines and antimicrobial peptides in rhinovirus‐induced experimental asthma exacerbations

  2014cites this paper
• The Human Alpha Defensin HD5 Neutralizes JC Polyomavirus Infection by Reducing Endoplasmic Reticulum Traffic and Stabilizing the Viral Capsid

  2013cites this paper
• Host defense peptides: general overview and an update on their activity against Chlamydia spp.

  2013cites this paper
• An Intrinsically Disordered Region of the Adenovirus Capsid Is Implicated in Neutralization by Human Alpha Defensin 5

  2013cites this paper
• Tracking viral genomes in host cells at single-molecule resolution.

  2013cites this paper
• Cationic Host Defence Peptides: Potential as Antiviral Therapeutics

  2013cites this paper
• Antiviral Mechanisms of Human Defensins

  2013cites this paper
• STRUCTURAL DETERMINATION AND COMPUTATIONAL PREDICTION OF ADENOVIRAL SURFACE EPITOPES PROVIDE INSIGHT INTO THE MECHANISMS OF ADENOVIRAL INACTIVATION BY HUMAN DEFENSIN 5 By

  2012cites this paper
• Latest Insights on Adenovirus Structure and Assembly

  2012cites this paper
• Development of chemiluminescent assays for the quantitative detection and imaging of 5-bromo-2′deoxyuridine-labeled DNA in parvovirus B19-infected cells

  2012cites this paper
• Critical Determinants of Human α-Defensin 5 Activity against Non-enveloped Viruses*

  2012cites this paper
• α‐Defensins in human innate immunity

  2012cites this paper
• Latest Insights on Adenovirus Structure and Assembly

  2012influential citation
• The papillomavirus virion: a machine built to hide molecular Achilles' heels.

  2012cites this paper
• Eicosanoids and Respiratory Viral Infection: Coordinators of Inflammation and Potential Therapeutic Targets

  2012cites this paper
• Regulation of Virus Neutralization and the Persistent Fraction by TRIM21

  2012cites this paper
• Persistent Fraction by TRIM 21 Regulation of Virus Neutralization and the

  2012cites this paper
• Integrin and Defensin Modulate the Mechanical Properties of Adenovirus

  2012cites this paper
• Functional Genetic and Biophysical Analyses of Membrane Disruption by Human Adenovirus

  2011cites this paper
• Human Adenovirus Analyses of Membrane Disruption by Functional Genetic and Biophysical

  2011cites this paper
• Functional characterization of two defensin isoforms of the hard tick Ixodes ricinus

  2011cites this paper
• Implications of the innate immune response to adenovirus and adenoviral vectors.

  2011cites this paper
• Properties associated with filoviral-glycoprotein-mediated entry events in permissive cells

  2010cites this paper