Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms.

No abstract is available for this paper.

• Publication year

  1991

• Venue

  Journal of Neurophysiology

• Publication date

  1991-07-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1152/JN.1991.66.1.190PMID 1919666
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1960cited by this paper
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