Neuronal release of proBDNF

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Nature Neuroscience

• Publication date

  2009-02-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1038/nn.2244PMID 19136973PMCID PMC2737352
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF

  2008cited by this paper
• Neuroscience

  2008cited by this paper
• Postsynaptic Secretion of BDNF and NT-3 from Hippocampal Neurons Depends on Calcium–Calmodulin Kinase II Signaling and Proceeds via Delayed Fusion Pore Opening

  2007cited by this paper
• Brain-Derived Neurotrophic Factor Promotes Long-Term Potentiation-Related Cytoskeletal Changes in Adult Hippocampus

  2007cited by this paper
• Practice makes perfect: the neural substrates of tactile discrimination by Mah-Jong experts include the primary visual cortex

  2006cited by this paper
• Difference in trafficking of brain-derived neurotrophic factor between axons and dendrites of cortical neurons, revealed by live-cell imaging

  2005cited by this paper
• Sortilin Controls Intracellular Sorting of Brain-Derived Neurotrophic Factor to the Regulated Secretory Pathway

  2005cited by this paper
• ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75NTR and Sortilin

  2005cited by this paper
• Activation of p75NTR by proBDNF facilitates hippocampal long-term depression

  2005cited by this paper
• Nerve growth factor, brain‐derived neurotrophic factor, and neurotrophin‐3 are sorted to dense‐core vesicles and released via the regulated pathway in primary rat cortical neurons

  2004cited by this paper
• Biosynthesis and Post-translational Processing of the Precursor to Brain-derived Neurotrophic Factor*

  2001cited by this paper
• Neurotrophins: roles in neuronal development and function.

  2001cited by this paper
• Expression of brain-derived neurotrophic factor protein in the adult rat central nervous system.

  1997cited by this paper
• Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator

  1995cited by this paper
• The developmental expression in rat of proteases furin, PC1, PC2, and carboxypeptidase E: implications for early maturation of proteolytic processing capacity

  1994cited by this paper
• Nature Neuroscience

  year unknowncited by this paper

• Molecular sabotage of hippocampal synaptic plasticity by amyloid-β in Alzheimer's disease: A narrative review

  2026cites this paper
• Disruption of BDNF signalling in neuropathologies.

  2026cites this paper
• Differential expression of long-term depression, and synaptic tagging and capture in mouse hippocampal area CA2 synapses

  2025cites this paper
• BDNF-driven synaptic plasticity requires autocrine matrix metalloproteinase–9 activity

  2025cites this paper
• Role of brain-derived neurotrophic factor in frailty: From mechanisms to interventions.

  2025cites this paper
• Tmprss3 is expressed in several cell types of the inner ear including type II but hardly in type I spiral ganglion neurons

  2025cites this paper
• Chronic stress leads to earlier cognitive decline in an Alzheimer's mouse model: The role of neuroinflammation and TrkB.

  2025cites this paper
• Peripheral neuronal sensitization and neurovascular remodelling in osteoarthritis pain

  2025cites this paper
• Changes in proBDNF and Mature BDNF Levels After Medium-Intensity Functional Motor Rehabilitation Program in Patients with Parkinson’s Disease

  2025cites this paper
• Dual Functions of Mature and Immature Brain Neurotrophins in Regulating Neuroplasticity and Their Modification by Glucocorticoids

  2025cites this paper
• Sortilin and L-type Calcium Channels May be Involved in the Unusual Mechanism of proBDNF Signaling in Regenerating Mouse Neuromuscular Junctions

  2025cites this paper
• Probiotics and undernourishment impact on brain 5-Hydroxytryptamine system and neurotrophin BDNF in rats: Risk of depression and anxiety?

  2024cites this paper
• Expression of Pro- and Mature Brain-Derived Neurotrophic Factor and Bcl-xL in the Hippocampus of Neonatal Rats under Dexamethasone Treatment

  2024cites this paper
• Expression of pro- and mature brain neurotrophic factor and Bcl-xL in the hippocampus of neonatal rats under dexamethasone treatment

  2024cites this paper
• Dopamine receptors and key elements of the neurotrophins (BDNF, CDNF) expression patterns during critical periods of ontogenesis in the brain structures of mice with autism-like behavior (BTBR) or its absence (С57BL/6 J)

  2024cites this paper
• Impact and Mechanisms of Action of BDNF on Neurological Disorders, Cancer, and Cardiovascular Diseases

  2024cites this paper
• The chronic unpredictable mild stress (CUMS) Paradigm: Bridging the gap in depression research from bench to bedside.

  2024cites this paper
• Fluoxetine and ketamine trigger the p75NTR proteolytic pathway and enhance extinction memory and brain plasticity through p75NTR.

  2024cites this paper
• Brain-Derived Neurotrophic Factor, Nociception, and Pain

  2024cites this paper
• Localized release of muscle-generated BDNF regulates the initial formation of postsynaptic apparatus at neuromuscular synapses

  2024cites this paper
• Precise genome-editing in human diseases: mechanisms, strategies and applications

  2024cites this paper
• Neural Influences on Tumor Progression Within the Central Nervous System

  2024cites this paper
• Inhibiting proBDNF to mature BDNF conversion leads to ASD-like phenotypes in vivo

  2024cites this paper
• BDNF-TrkB Signaling in Mitochondria: Implications for Neurodegenerative Diseases

  2024cites this paper
• Connecting the Emotional-Cognitive Puzzle: The Role of Tyrosine Kinase (TrkB) Receptor Isoform Imbalance in Age-Related Emotional and Cognitive impairments.

  2024cites this paper
• Hippocampal exosomes from stroke aggravate post-stroke depression by regulating the expression of proBDNF and p75NTR and altering spine density

  2024cites this paper
• Seasonal fluctuations in BDNF regulate hibernation and torpor in golden-mantled ground squirrels.

  2024cites this paper
• Enhanced peripheral levels of BDNF and proBDNF: elucidating neurotrophin dynamics in cocaine use disorder

  2024cites this paper
• The effects of peripheral hormone responses to exercise on adult hippocampal neurogenesis

  2023cites this paper
• A new perspective on hippocampal synaptic plasticity and post‐stroke depression

  2023cites this paper
• Environmental Enrichment Engages Vesicular Zinc Signaling to Enhance Hippocampal Neurogenesis

  2023cites this paper
• Neural stem/progenitor cell‐derived extracellular vesicles: A novel therapy for neurological diseases and beyond

  2023cites this paper
• Serum BDNF predicts increases in telomere length during a month-long residential meditation retreat

  2023cites this paper
• ProBDNF and its receptors in immune-mediated inflammatory diseases: novel insights into the regulation of metabolism and mitochondria

  2023cites this paper
• Molecular mechanisms of rapid-acting antidepressants: new perspectives for developing antidepressants.

  2023cites this paper
• Mechanisms Controlling the Expression and Secretion of BDNF

  2023cites this paper
• The dendritic engram

  2023cites this paper
• Brain-derived neurotrophic factor – a key player in the gastrointestinal system

  2023cites this paper
• Discovering the Potential Mechanisms of Medicinal Mushrooms Antidepressant Activity: A Review

  2023cites this paper
• Brain-derived neurotrophic factor interplay with oxidative stress: neuropathology approach in potential biomarker of Alzheimer’s disease

  2023cites this paper
• Increased levels of brain-derived neurotrophic factor in cultures of nervous cells treated with a selective serotonin reuptake inhibitor

  2023cites this paper
• Delayed Outgrowth in Response to the BDNF and Altered Synaptic Proteins in Neurons From SHR Rats

  2023cites this paper
• Interaction of Brain-derived Neurotrophic Factor, Exercise, and Fear Extinction: Implications for Post-traumatic Stress Disorder

  2023cites this paper
• The Role of BDNF in Multiple Sclerosis Neuroinflammation

  2023cites this paper
• Changes in Plasma TPH2, GDNF, Trk-b, BDNF, and proBDNF in People Who Died by Suicide

  2023cites this paper
• ProBDNF signaling is involved in periodontitis-induced depression-like behavior in mouse hippocampus.

  2023cites this paper
• The Role of BDNF as a Biomarker in Cognitive and Sensory Neurodegeneration

  2023cites this paper
• TrkB/BDNF signaling pathway and its small molecular agonists in CNS injury.

  2023cites this paper
• An Ultra-Low Dose of ∆9-Tetrahydrocannabinol Alleviates Alzheimer’s Disease-Related Cognitive Impairments and Modulates TrkB Receptor Expression in a 5XFAD Mouse Model

  2022cites this paper
• New Frontiers in Neurodegeneration and Regeneration Associated with Brain-Derived Neurotrophic Factor and the rs6265 Single Nucleotide Polymorphism

  2022cites this paper
• The role of brain derived neurotrophic factor in central nervous system

  2022cites this paper
• A Common Human Brain-Derived Neurotrophic Factor Polymorphism Leads to Prolonged Depression of Excitatory Synaptic Transmission by Isoflurane in Hippocampal Cultures

  2022cites this paper
• Impact of sleep disorders and disease duration on neurotrophins levels in cocaine use disorder.

  2022cites this paper
• Consequences of the rs6265 (Val66Met) polymorphism in the BDNF gene in selected mental disorders and sport

  2022cites this paper
• signaling in and structural in the developing system

  2022cites this paper
• Prelimbic proBDNF Facilitates Retrieval-Dependent Fear Memory Destabilization by Regulation of Synaptic and Neural Functions in Juvenile Rats

  2022cites this paper
• Imbalance in Sirt1 Alternative Splicing in Response to Chronic Stress during the Adolescence Period in Female Mice

  2022cites this paper
• Role of BDNF/ProBDNF Imbalance in Postoperative Cognitive Dysfunction by Modulating Synaptic Plasticity in Aged Mice

  2022cites this paper
• Molecular mechanisms of synaptogenesis

  2022cites this paper
• IL-33 in the basolateral amygdala integrates neuroinflammation into anxiogenic circuits via modulating BDNF expression.

  2022cites this paper
• Engineering a switchable single‐chain TEV protease to control protein maturation in living neurons

  2022cites this paper
• BDNF Therapeutic Mechanisms in Neuropsychiatric Disorders

  2022cites this paper
• Prelimbic proBDNF facilitates memory destabilization by regulation of neuronal function in juveniles

  2022influential citation
• Brain-derived neurotrophic factor in Alzheimer’s disease and its pharmaceutical potential

  2022cites this paper
• A common human brain-derived neurotrophic factor polymorphism leads to sustained depression of excitatory synaptic transmission by isoflurane in hippocampus

  2022cites this paper
• BDNF as a potential predictive biomarker for patients with pediatric cerebral palsy

  2022cites this paper
• Systemic blockade of proBDNF inhibited the expansion and altered the transcriptomic expression in CD3+B220+ cells in MRL/lpr lupus mice

  2022cites this paper
• Up-regulation of proBDNF/p75NTR signaling in antibody-secreting cells drives systemic lupus erythematosus

  2022cites this paper
• An ultra-low dose of Δ9-tetrahydrocannabinol improves Alzheimer’s Disease-related cognitive deficits

  2021cites this paper
• Intervention of Brain-Derived Neurotrophic Factor and Other Neurotrophins in Adult Neurogenesis.

  2021cites this paper
• Chronic In ammatory Pain Management by BDNF Modulation: A Comparative Study of Gabapentin, Indomethacin and Their Combination on Arthritis Rat Model

  2021cites this paper
• Moderators of gene-outcome associations following traumatic brain injury.

  2021cites this paper
• Chronic Stress Weakens Connectivity in the Prefrontal Cortex: Architectural and Molecular Changes

  2021cites this paper
• Recent advancements in CRISPR-Cas toolbox for imaging applications

  2021cites this paper
• Requirements of Postnatal proBDNF in the Hippocampus for Spatial Memory Consolidation and Neural Function

  2021cites this paper
• Effects of General Anesthetics on Synaptic Transmission and Plasticity

  2021cites this paper
• Brain-Derived Neurotrophic Factor and Its Role in Stress-Related Disorders

  2021cites this paper
• Deletion of TrkB in parvalbumin interneurons alters cortical neural dynamics

  2021cites this paper
• Involvement of Denervated Midbrain-Derived Factors in the Formation of Ectopic Cortico-Mesencephalic Projection after Hemispherectomy

  2021cites this paper
• Synucleinopathy-associated pathogenesis in Parkinson’s disease and the potential for brain-derived neurotrophic factor

  2021cites this paper
• Long-term depression at hippocampal mossy fiber-CA3 synapses involves BDNF but is not mediated by p75NTR signaling

  2021cites this paper
• Concepts of Neuroinflammation and Their Relationship With Impaired Mitochondrial Functions in Bipolar Disorder

  2021cites this paper
• Increased Serum Levels of Brain-Derived Neurotrophic Factor Contribute to Inflammatory Responses in Patients with Rheumatoid Arthritis

  2021cites this paper
• Age Related Response of Neonatal Rat Retinal Ganglion Cells to Reduced TrkB Signaling in vitro and in vivo

  2021cites this paper
• Emergence of synaptic organization and computation in dendrites

  2021cites this paper
• ProBDNF induces sustained elevation of intracellular Ca2+ possibly mediated by TRPM7 channels in rodent microglial cells

  2021cites this paper
• Robustly High Hippocampal BDNF levels under Acute Stress in Mice Lacking the Full-length p75 Neurotrophin Receptor

  2021cites this paper
• Cryptotanshinone ameliorates CUS-induced depressive-like behaviors in mice

  2021cites this paper
• Alcohol and Brain-Derived Neurotrophic Factor (BDNF)

  2021cites this paper
• MMP2 and MMP9 Activity Is Crucial for Adult Visual Cortex Plasticity in Healthy and Stroke-Affected Mice

  2021influential citation
• Synucleinopathy-associated pathogenesis in Parkinson’s disease and the potential for brain-derived neurotrophic factor

  2021cites this paper
• Comparative Genomics of the BDNF Gene, Non-Canonical Modes of Transcriptional Regulation, and Neurological Disease

  2021cites this paper
• The Association of Brain-Derived Neurotrophic Factor with Long-Term Potentiation

  2021cites this paper
• The Pleiotropic Potential of BDNF beyond Neurons: Implication for a Healthy Mind in a Healthy Body

  2021cites this paper
• Brain-derived neurotrophic factor precursor in the immune system is a novel target for treating multiple sclerosis

  2021cites this paper
• Protriptyline improves spatial memory and reduces oxidative damage by regulating NFκB-BDNF/CREB signaling axis in streptozotocin-induced rat model of Alzheimer's disease.

  2021cites this paper
• Brain-Derived Neurotrophic Factor (BDNF) Depression and Subjective Sleep Quality in the First Trimester of Pregnancy Among Migrant Workers in Thailand

  2021cites this paper
• BDNF signaling in correlation-dependent structural plasticity in the developing visual system

  2021cites this paper
• The postnatal GABA shift: a developmental perspective.

  2021cites this paper
• Emergence of local and global synaptic organization on cortical dendrites

  2021cites this paper