Diacylglycerol accumulation and microvascular abnormalities induced by elevated glucose levels.

No abstract is available for this paper.

• Publication year

  1991

• Venue

  Journal of Clinical Investigation

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI114988PMID 1985103PMCID PMC294984
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Increased endothelial albumin permeability mediated by protein kinase C activation.

  1990cited by this paper
• Glucose-induced microvascular functional changes in nondiabetic rats are stereospecific and are prevented by an aldose reductase inhibitor.

  1990cited by this paper
• Diacylglycerol synthesis de novo from glucose by pancreatic islets isolated from rats and humans.

  1990cited by this paper
• Mechanisms Underlying Atriopeptin‐Induced Increases in Hematocrit and Vascular Permeation in Rats

  1989cited by this paper
• Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. Possible mediation by glucose.

  1989cited by this paper
• The diacylglycerol analogue, 1,2-sn-dioctanoylglycerol, induces an increase in cytosolic free Ca2+ and cytosolic acidification of T lymphocytes through a protein kinase C-independent process.

  1989cited by this paper
• Comparison of effects of phorbol esters and glucose on protein kinase C activation and insulin secretion in pancreatic islets.

  1989cited by this paper
• Effects of diacylglycerols on the structure of phosphatidylcholine bilayers: a 2H and 31P NMR study.

  1989cited by this paper
• Na+-K+-ATPase is an effector protein for protein kinase C in renal proximal tubule cells.

  1989cited by this paper
• Differential regulation of protein kinase C and (Na,K)-adenosine triphosphatase activities by elevated glucose levels in retinal capillary endothelial cells.

  1989cited by this paper
• Prevention of Hemodynamic and Vascular Albumin Filtration Changes in Diabetic Rats by Aldose Reductase Inhibitors

  1989cited by this paper
• Secretagogue-induced diacylglycerol accumulation in isolated pancreatic islets. Mass spectrometric characterization of the fatty acyl content indicates multiple mechanisms of generation.

  1989cited by this paper
• In vitro correction of impaired Na+-K+-ATPase in diabetic nerve by protein kinase C agonists.

  1989cited by this paper
• Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications.

  1989cited by this paper
• Effects of hypothyroidism on vascular 125I-albumin permeation and blood flow in rats.

  1989cited by this paper
• Biochemical manifestations of diabetes mellitus in microscopic layers of the cornea and retina.

  1989cited by this paper
• The protein kinase C family: heterogeneity and its implications.

  1989cited by this paper
• Rapid analysis of sorbitol, galactitol, mannitol and myoinositol mixtures from biological sources.

  1989cited by this paper
• Influence of alpha 1-adrenergic receptor stimulation and phorbol esters on hepatic Na+/K+-ATPase activity.

  1988cited by this paper
• Influence of α1-Adrenergic Receptor Stimulation and Phorbol Esters on Hepatic Na+/K+-ATPase Activity

  1988cited by this paper
• Pathogenesis and prevention of diabetic neuropathy.

  1988cited by this paper
• The antiproliferative effects of staurosporine are not exclusively mediated by inhibition of protein kinase C.

  1988cited by this paper
• Phorbol esters and diacylglycerols amplify bradykinin-stimulated prostaglandin synthesis in Swiss 3T3 fibroblasts. Possible independence from protein kinase C.

  1988cited by this paper
• Comparison of the HPLC-separated species patterns of phosphatidic acid, CDP-diacylglycerol and diacylglycerol synthesized de novo in rat liver microsomes (a new method).

  1988cited by this paper
• Glutathione depletion in the lens of galactosemic and diabetic rats.

  1988cited by this paper
• Basement membrane abnormalities in diabetes mellitus: relationship to clinical microangiopathy.

  1988cited by this paper
• Alteration of 1,2-Diacylglycerol Content in Myocardium From Diabetic Rats

  1988cited by this paper
• Mechanisms whereby insulin increases diacylglycerol in BC3H-1 myocytes.

  1988cited by this paper
• Reduced Na++K+-ATPase activity in peripheral nerve of streptozotocin-diabetic rats: a role for protein kinase C?

  1988cited by this paper
• Glucose and carbachol generate 1,2-diacylglycerols by different mechanisms in pancreatic islets.

  1988cited by this paper
• Increased Vascular Permeability in Spontaneously Diabetic BB/W Rats and in Rats With Mild Versus Severe Streptozocin-Induced Diabetes: Prevention by Aldose Reductase Inhibitors and Castration

  1987cited by this paper
• Banting Lecture 1986: Does a Common Mechanism Induce the Diverse Complications of Diabetes?

  1987cited by this paper
• Quantitative measurement of sn-1,2-diacylglycerols.

  1987cited by this paper
• Differential regulation of phosphatidylcholine biosynthesis by 12-O-tetradecanoylphorbol-13-acetate and diacylglycerol in NG108-15 neuroblastoma x glioma hybrid cells.

  1987cited by this paper
• 1,2-Diacylglycerols but not phorbol esters stimulate sphingomyelin hydrolysis in GH3 pituitary cells.

  1987cited by this paper
• Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase.

  1986cited by this paper
• Attenuation of sn-1,2-diacylglycerol second messengers. Metabolism of exogenous diacylglycerols by human platelets.

  1986cited by this paper
• Measurement of protein using bicinchoninic acid.

  1985cited by this paper
• Albumin Permeation of New Vessels Is Increased in Diabetic Rats

  1985cited by this paper
• Diacylglycerols, lysolecithin, or hydrocarbons markedly alter the bilayer to hexagonal phase transition temperature of phosphatidylethanolamines.

  1985cited by this paper
• Pancreatic islets synthesize phospholipids de novo from glucose via acyl-dihydroxyacetone phosphate.

  1985cited by this paper
• The inflammatory reaction in an experimental model of open wounds in the rat. The effect of arachidonic acid metabolites.

  1984cited by this paper
• Albumin catabolism in diabetic rats.

  1983cited by this paper
• Metabolic alterations in the human erythrocyte produced by increases in glucose concentration. The role of the polyol pathway.

  1971cited by this paper

• Acute Hyperglycemia-Induced Injury in Myocardial Infarction

  2024cites this paper
• Role of pyruvate in maintaining cell viability and energy production under high-glucose conditions

  2021cites this paper
• Glucose and diabetic asciib disease1

  2020cites this paper
• Perturbed Biochemical Pathways and Associated Oxidative Stress Lead to Vascular Dysfunctions in Diabetic Retinopathy

  2019cites this paper
• In vitro analysis of drugs that improve hyperglycemia-induced blood-brain barrier dysfunction.

  2018cites this paper
• Review Article: Molecular mechanisms underlying microvascular complications in diabetes mellitus

  2016cites this paper
• Molecular mechanisms underlying diabetic microvascular complications

  2016cites this paper
• Diabetic complications within the context of aging: Nicotinamide adenine dinucleotide redox, insulin C‐peptide, sirtuin 1–liver kinase B1–adenosine monophosphate‐activated protein kinase positive feedback and forkhead box O3

  2016cites this paper
• Molecular mechanisms underlying microvascular complications in diabetes mellitus

  2016cites this paper
• The possible link between high glucose-induced PKCβ expression and the appearance of GLP-1 resistance in endothelial cells

  2015cites this paper
• Endothelial dysfunction as a predictor of cardiovascular disease in type 1 diabetes.

  2015cites this paper
• experimental diabetes cardiovascular tissues during early stages of Upregulation of PKC genes and isozymes in

  2015cites this paper
• PREDICTORS OF PROLONGED MECHANICAL VENTILATION AFTER ISOLATED CORONARY ARTERY BYPASS GRAFT SURGERY

  2015cites this paper
• Diabetes Mellitus: Alterations in Vessel Wall Properties

  2015cites this paper
• Roles of PKC Isoforms in Development of Diabetes-Induced Cardiovascular Complications

  2014cites this paper
• Inhibition of PKC‐θ preserves cardiac function and reduces fibrosis in streptozotocin‐induced diabetic cardiomyopathy

  2014influential citation
• The effects of HIV Protease Inhibitors (Lopinavir/Ritonavir) on the non-oxidative pathways of glucose metabolism

  2014cites this paper
• To determine the association of risk factors in type 2 diabetic patients with diabetic macular ischemia

  2014cites this paper
• Cerebrovascular Disease in Type 1 Diabetes: Role of Oxidative Stress

  2014cites this paper
• The effect of vascular endothelial growth factor in the progression of bladder cancer and diabetic retinopathy.

  2013cites this paper
• Étude des mécanismes cellulaires activés par l'Angiopoïétine-1 et le VEGF régulant la perméabilité et la migration endothéliales

  2013cites this paper
• Endocrinology of the Vasculature

  2013cites this paper
• Review Article The effect of vascular endothelial growth factor in the progression of bladder cancer and diabetic retinopathy

  2013cites this paper
• Is Fluid Overload More Important than Diabetes in Renal Progression in Late Chronic Kidney Disease?

  2013cites this paper
• Selective inhibition of PKCβ2 preserves cardiac function after myocardial infarction and is associated with improved angiogenesis of ischemic myocardium in diabetic rats.

  2013cites this paper
• An Insight in to the Pathogenesis of Diabetic Vascular Diseases: Role ofOxidative Stress and Antioxidants

  2013cites this paper
• Regulation and Maintenance of Vascular Tone and Patency in Cardiovascular Health and Disease

  2012cites this paper
• Hyperglycemia and Endothelial Dysfunction in Atherosclerosis: Lessons from Type 1 Diabetes

  2012cites this paper
• Mechanisms underlying the abnormal inositol metabolisms in diabetes mellitus

  2011cites this paper
• Regulation of Endothelial Barrier Function

  2011cites this paper
• Update on the management of diabetic polyneuropathies

  2011cites this paper
• Toxicidade de aminoacetona e células produtoras de insulina

  2010cites this paper
• Activation of protein kinase C isoforms and its impact on diabetic complications.

  2010cites this paper
• Cilostazol ameliorates nephropathy in type 1 diabetic rats involving improvement in oxidative stress and regulation of TGF-Beta and NF-kappaB.

  2010cites this paper
• Cilostazol Ameliorates Nephropathy in Type 1 Diabetic Rats Involving Improvement in Oxidative Stress and Regulation of TGF-β and NF-κB

  2010cites this paper
• Early Neural and Vascular Dysfunctions in Diabetic Rats Are Largely Sequelae of Increased Sorbitol Oxidation

  2010influential citation
• The effect of folate and vitamin B6 on endothelial function in children with Type 1 diabetes.

  2010cites this paper
• The Impact of Macrophage Insulin Resistance on Advanced Atherosclerotic Plaque Progression [2010;106:58–67] The RAGE Axis: A Fundamental Mechanism Signaling Danger to the Vulnerable Vasculature [2010;106:842–853] The Promise of Cell-Based Therapies for Diabetic Complications: Challenges and Solution

  2010cites this paper
• Aortic vasoreactivity during a postnatal critical window of the pancreas in rats

  2010cites this paper
• Role of protein kinase C in diabetic complications

  2010cites this paper
• Selective Inhibition of Protein Kinase C β2 Attenuates Inducible Nitric Oxide Synthase–Mediated Cardiovascular Abnormalities in Streptozotocin-Induced Diabetic Rats

  2009cites this paper
• Activation of human platelet protein kinase C-ß2 in vivo in response to acute hyperglycemia

  2009cites this paper
• Review article Disturbances in mitochondrial biosynthesis of acetyl-CoA and their role in the prevention of ischemic heart disease

  2008cites this paper
• [Disturbances in mitochondrial biosynthesis of acetyl-CoA and their role in the prevention of ischemic heart disease].

  2008cites this paper
• The Role of Protein Kinase C in Diabetic Retinal Vascular Abnormalities

  2008cites this paper
• Nonproliferative Diabetic Retinopathy

  2008cites this paper
• Diacylglycerol kinases as emerging potential drug targets for a variety of diseases.

  2008cites this paper
• Disfunção Endotelial no Diabetes Melito Tipo 1 revisão

  2008cites this paper
• Disfunção endotelial no diabetes melito tipo 1

  2008cites this paper
• Zaburzenia mitochondrialnej biosyntezy acetylokoenzymu A i ich znaczenie w prewencji choroby niedokrwiennej serca Disturbances in mitochondrial biosynthesis of acetyl-CoA and their role in the prevention of ischemic heart disease

  2008cites this paper
• [Endothelial dysfunction in type 1 diabetes].

  2008cites this paper
• Microvascular Permeability in Diabetes and Insulin Resistance

  2007cites this paper
• Understanding the pathology and mechanisms of type I diabetic bone loss

  2007cites this paper
• Glucose Regulates Diacylglycerol Intracellular Levels and Protein Kinase C Activity by Modulating Diacylglycerol Kinase Subcellular Localization*

  2007cites this paper
• Stroke and the Blood‐Brain Interface

  2007cites this paper
• The role of protein kinase C activation and the vascular complications of diabetes.

  2007cites this paper
• Rottlerin causes pulmonary edema in vivo: a possible role for PKCdelta.

  2007cites this paper
• Diabetes-induced cerebrovascular dysfunction: role of poly(ADP-ribose) polymerase.

  2007cites this paper
• Induction of reactive oxygen species from isolated rat glomeruli by protein kinase C activation and TNF-alpha stimulation, and effects of a phosphodiesterase inhibitor.

  2007influential citation
• Perspectives in Diabetes Hyperglycemic Pseudohypoxia and Diabetic Complications

  2006cites this paper
• Early onset of subclinical atherosclerosis in women with gestational diabetes mellitus

  2006cites this paper
• Palmitic acid-induced activation of human T-lymphocytes and aortic endothelial cells with production of insulin receptors, reactive oxygen species, cytokines, and lipid peroxidation.

  2006cites this paper
• Coronary vascular dysfunction in obese type 2 diabetic mice.

  2006cites this paper
• High glucose enhances inducible nitric oxide synthase expression. Role of protein kinase C-betaII.

  2006cites this paper
• Inhibition of PKC beta by oral administration of ruboxistaurin is well tolerated and ameliorates diabetes-induced retinal hemodynamic abnormalities in patients.

  2006cites this paper
• Perspectives in Diabetes Activation of Protein Kinase C in Glomerular Cells in Diabetes

  2006cites this paper
• Chronic hyperglycemia modulates osteoblast gene expression through osmotic and non‐osmotic pathways

  2006influential citation
• Aldose reductase in diabetic microvascular complications.

  2005cites this paper
• Errata

  2005cites this paper
• Nephrology Dialysis Transplantation Interactions between the sorbitol pathway , non-enzymatic glycation , and diabetic vascular dysfunction

  2005cites this paper
• Ruboxistaurin, a Protein Kinase C β Inhibitor, as an Emerging Treatment for Diabetes Microvascular Complications

  2005cites this paper
• Effects of Diabetes and Insulin Resistance on Endothelial Functions

  2005cites this paper
• NITRIC OXIDE-CYCLIC GMP CONTRIBUTES TO ABNORMAL ACTIVATION OF NA+-K+-ATPASE IN THE AORTA FROM RATS WITH ENDOTOXIC SHOCK

  2005cites this paper
• Regulators of vascular permeability: potential sites for intervention in the treatment of macular edema

  2004cites this paper
• Aspectos moleculares del daño tisular inducido por la hiperglucemia crónica

  2004cites this paper
• Interactions between hyperglycemia and hypoxia: implications for diabetic retinopathy.

  2004cites this paper
• Sorbitol dehydrogenase: structure, function and ligand design.

  2004cites this paper
• Altered endothelin-1 induced contraction and second messenger generation in bovine retinal microvascular pericytes cultured in high glucose medium

  2004cites this paper
• A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli.

  2004influential citation
• Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1358 Diabetes-induced Alterations in Renal Microcirculation and Metabolism

  2004cites this paper
• The role of endothelium in the pathogenesis of diabetic microangiopathy

  2004cites this paper
• Review: Endothelial dysfunction and pre-symptomatic atherosclerosis in type 1 diabetes — pathogenesis and identification

  2003cites this paper
• Protein kinase C-dependent increase in reactive oxygen species (ROS) production in vascular tissues of diabetes: role of vascular NAD(P)H oxidase.

  2003cites this paper
• High glucose potentiates mitogenic responses of cultured ovine coronary smooth muscle cells to platelet derived growth factor and transforming growth factor-beta1.

  2003cites this paper
• Upregulation of PKC genes and isozymes in cardiovascular tissues during early stages of experimental diabetes.

  2003cites this paper
• Effects of protein kinase C inhibition and activation on proliferation and apoptosis of bovine retinal pericytes

  2003influential citation
• The Microcirculation in Diabetes Mellitus

  2003cites this paper
• Diabetes mellitus and endothelial dysfunction: a central role for oxidative stress

  2003cites this paper
• Obesity lowers hyperglycemic threshold for impaired in vivo endothelial nitric oxide function.

  2002cites this paper
• Effect of Aldose Reductase Inhibition on Interleukin-1β-Induced Nitric Oxide (NO) Synthesis in Vascular Tissue

  2002cites this paper
• Diacylglycerol production and protein kinase C activity are increased in a mouse model of diabetic embryopathy.

  2002cites this paper
• Coronary Artery Function in Diabetes Mellitus

  2002cites this paper
• Lessons Learned Since the Last Renal-Retinal Conference

  2002cites this paper
• Mechanisms of amelioration of glucose-induced endothelial dysfunction following inhibition of protein kinase C in vivo.

  2002cites this paper
• Coronary and femoral arterial contraction with high glucose, insulin, and glucose-insulin-potassium solution: effects of hypoxia

  2002cites this paper
• Modification of the fenvalerate-induced nociceptive response in mice by diabetes.

  2002cites this paper
• Nonsynaptic Noradrenaline Release in Neuro-Immune Responses

  2002cites this paper
• Diabetic vascular dysfunction: Links to glucose‐induced reductive stress and VEGF

  2002cites this paper
• Insulin-induced up-regulation of histamine H1-receptors

  2002cites this paper
• Relationship between thromboxane/prostacyclin ratio and diabetic vascular complications.

  2001cites this paper