Uncommon mutation, but common amplifications, of the PIK3CA gene in thyroid tumors.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Clinical Endocrinology and Metabolism

• Publication date

  2005-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/JC.2004-2281PMID 15928251
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• BRAF mutation in thyroid cancer.

  2005cited by this paper
• It ain't over 'til it's over.

  2005cited by this paper
• The PIK3CA gene is mutated with high frequency in human breast cancers

  2004influential reference
• Akt activation and localisation correlate with tumour invasion and oncogene expression in thyroid cancer

  2004influential reference
• PI3K/Akt signalling pathway and cancer.

  2004cited by this paper
• Chronic expression of RET/PTC 3 enhances basal and insulin‐stimulated PI3 kinase/AKT signaling and increases IRS‐2 expression in FRTL‐5 thyroid cells

  2004cited by this paper
• High Frequency of Mutations of the PIK3CA Gene in Human Cancers

  2004influential reference
• Phosphoinositide 3-Kinase Signalling Pathways in Tumor Progression, Invasion and Angiogenesis

  2004cited by this paper
• Akt: a potential target for thyroid cancer therapy.

  2004cited by this paper
• BRAF T1796A transversion mutation in various thyroid neoplasms.

  2004cited by this paper
• Increased expression of phosphorylated p70S6 kinase and Akt in papillary thyroid cancer tissues.

  2003influential reference
• BRAF mutation in papillary thyroid carcinoma.

  2003cited by this paper
• Gene amplification in esophageal adenocarcinomas and Barrett's with high-grade dysplasia.

  2003cited by this paper
• Electrophile and oxidant damage of mitochondrial DNA leading to rapid evolution of homoplasmic mutations

  2003cited by this paper
• Specific pattern of RAS oncogene mutations in follicular thyroid tumors.

  2003cited by this paper
• Frequent monoallelic deletion of PTEN and its reciprocal associatioin with PIK3CA amplification in gastric carcinoma

  2003cited by this paper
• RET/PTC (rearranged in transformation/papillary thyroid carcinomas) tyrosine kinase phosphorylates and activates phosphoinositide-dependent kinase 1 (PDK1): an alternative phosphatidylinositol 3-kinase-independent pathway to activate PDK1.

  2003cited by this paper
• Genomic gain of PIK3CA and increased expression of p110alpha are associated with progression of dysplasia into invasive squamous cell carcinoma

  2002cited by this paper
• RET/PTC rearrangement in thyroid tumors

  2002cited by this paper
• Carcinoma Overexpression and Overactivation of Akt in Thyroid Updated

  2001cited by this paper
• Enhanced sensitivity to apoptosis in Ras-transformed thyroid cells

  2001cited by this paper
• Understanding Ras: 'it ain't over 'til it's over'.

  2000influential reference
• PIK3CA as an oncogene in cervical cancer

  2000cited by this paper
• PI-3-kinase is an essential anti-apoptotic effector in the proliferative response of primary human epithelial cells to mutant RAS

  2000cited by this paper
• PIK3CA is implicated as an oncogene in ovarian cancer

  1999cited by this paper
• Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

  1997cited by this paper

• Papillary Thyroid Carcinoma With 5 Unique Point Mutations and Typical Behavior

  2025cites this paper
• The Role of Inositols in Endocrine and Neuroendocrine Tumors

  2024cites this paper
• Systemic treatments for radioiodine-refractory thyroid cancers

  2024cites this paper
• Multi-view progression diagnosis of thyroid cancer by integrating platelet transcriptomes and blood routine tests

  2023cites this paper
• Progress in Thyroid Cancer Genomics: A 40-Year Journey

  2023cites this paper
• Nanotechnological Advancements For The Theranostic Intervention In Anaplastic Thyroid Cancer: Current Perspectives And Future Direction.

  2023cites this paper
• Genetica del carcinoma anaplastico della tiroide

  2022cites this paper
• PIK3CA mutations in the endocrine organs

  2022cites this paper
• Relationship between TSHR, BRAF and PIK3CA gene copy number variations and thyroid nodules

  2021cites this paper
• Targeting the PI3K/Akt/mTOR pathway in non‐small cell lung cancer (NSCLC)

  2020cites this paper
• New Therapies for Advanced Thyroid Cancer

  2020cites this paper
• DNA FISH Diagnostic Assay on Cytological Samples of Thyroid Follicular Neoplasms †

  2020cites this paper
• Molecular Determinants of Thyroid Nodules with Indeterminate Cytology and RAS Mutations

  2020cites this paper
• PGPM_A_181520 235..245

  2019cites this paper
• Thyroid tumors with follicular architecture.

  2019cites this paper
• Molecular Alterations in Thyroid Cancer: From Bench to Clinical Practice

  2019cites this paper
• PTPN1 promotes the progression of glioma by activating the MAPK/ERK and PI3K/AKT pathways and is associated with poor patient survival.

  2019cites this paper
• Molecular aberrations and signaling cascades implicated in the pathogenesis of anaplastic thyroid cancer.

  2019cites this paper
• Personalized treatment options for thyroid cancer: current perspectives

  2019cites this paper
• Differentiated Thyroid Carcinoma in Pediatric Age: Genetic and Clinical Scenario

  2019cites this paper
• The signaling pathways that mediate the anti-cancer effects of caloric restriction.

  2019cites this paper
• Positive PIK3CA (P.H1047R) Mutation in a Benign Thyroid Nodule of a Patient With Men-1 Syndrome

  2018cites this paper
• Gender-related differences in the association between concomitant amplification of AIB1 and HER2 and clinical outcomes in glioma patients.

  2018cites this paper
• Application of microarray and quantitative real-time PCR methods in oncology

  2018cites this paper
• Study on PIK3CA Gene Mutations in Oral Squamous Cell Carcinoma among South Indian populations

  2018cites this paper
• Systemic Therapy for Advanced Metastatic Thyroid Cancer

  2017cites this paper
• Key signaling pathways in thyroid cancer.

  2017cites this paper
• Combined MEK and Pi3′-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo

  2017cites this paper
• TGX-221 inhibits proliferation and induces apoptosis in human glioblastoma cells

  2017cites this paper
• Molecular Genetics of Thyroid Cancer

  2017cites this paper
• Molecular Markers in Thyroid Fine-Needle Aspiration Biopsies

  2016cites this paper
• AIB1 Genomic Amplification Predicts Poor Clinical Outcomes in Female Glioma Patients

  2016cites this paper
• Does Molecular Genotype Provide Useful Information in the Management of Radioiodine Refractory Thyroid Cancers? Results of a Retrospective Study

  2016cites this paper
• The chromosome 3q26 OncCassette: A multigenic driver of human cancer.

  2016cites this paper
• Chapter 92 – Thyroid Neoplasia

  2016cites this paper
• Targeted therapies in thyroid cancer: an extensive review of the literature

  2016cites this paper
• Sirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular Effects

  2016cites this paper
• Targeted treatments of radio-iodine refractory differentiated thyroid cancer.

  2015cites this paper
• Modulation of inflammation by autophagy: Consequences for human disease

  2015cites this paper
• PI3K/AKT Pathway and Its Mediators in Thyroid Carcinomas

  2015cites this paper
• RAS proto-oncogene in medullary thyroid carcinoma.

  2015cites this paper
• Rolle der Molekularpathologie beim Schilddrüsenkarzinom

  2015cites this paper
• PI3K/Akt/mTOR: A promising therapeutic target for non-medullary thyroid carcinoma.

  2015cites this paper
• Rolle der Molekularpathologie beim Schilddrüsenkarzinom Tumordiagnostik, Zytologie und zielgerichtete Therapie

  2015cites this paper
• PI3K regulatory subunit p85alpha plays a tumor suppressive role in the transformation of mammary epithelial cells

  2015cites this paper
• Thyroid Follicular Cell Neoplasms in Multistep Carcinogenesis

  2015influential citation
• Molekularpathogenese von Schilddrüsentumoren

  2015cites this paper
• Genetic profiling of advanced radioactive iodine-resistant differentiated thyroid cancer and correlation with axitinib efficacy.

  2015cites this paper
• Thyroid Cancer: Molecular Characteristics of Radiation-Associated Papillary Thyroid Cancer, with a Special Reference to of Atomic Radiation Exposure

  2015cites this paper
• Oncogenic PIK3CA Mutation and Dysregulation in Human Salivary Duct Carcinoma

  2014cites this paper
• Advances in subunits of PI3K class I in cancer.

  2014cites this paper
• An update on molecular biology of thyroid cancers.

  2014influential citation
• Concomitant PIK3CA amplification and RASSF1A or PAX6 hypermethylation predict worse survival in gastric cancer.

  2014cites this paper
• Autophagy: A potential target for thyroid cancer therapy (Review).

  2014cites this paper
• Update on the Cytologic and Molecular Features of Medullary Thyroid Carcinoma

  2014cites this paper
• Imaging, genetic testing, and biomarker assessment of follicular cell-derived thyroid cancer

  2014cites this paper
• Concomitant BRAFV600E Mutation and RET/PTC Rearrangement Is a Frequent Occurrence in Papillary Thyroid Carcinoma

  2014cites this paper
• Molecular Testing in Thyroid Cancer

  2014cites this paper
• Autophagy and thyroid carcinogenesis: genetic and epigenetic links.

  2013cites this paper
• Exomic sequencing of medullary thyroid cancer reveals dominant and mutually exclusive oncogenic mutations in RET and RAS.

  2013cites this paper
• Carcinogenesis of PIK3CA

  2013cites this paper
• Molecular pathogenesis and mechanisms of thyroid cancer

  2013cites this paper
• PIK3CA Gene Mutations and Amplifications in Chinese Patients With Ovarian Clear Cell Carcinoma

  2013cites this paper
• Concomitant PIK3CA amplification and RASSF1A or PAX6 hypermethylation predict worse survival in gastric cancer.

  2013cites this paper
• Targeting the Akt kinase to modulate survival, invasiveness and drug resistance of cancer cells.

  2013cites this paper
• Search for mutations in signaling pathways in head and neck squamous cell carcinoma.

  2013cites this paper
• Usefulness of Molecular Biology in Follicular-Derived Thyroid Tumors: From Translational Research to Clinical Practice

  2013cites this paper
• Usefulness of ancillary methods for diagnosis, prognosis and targeted therapy in thyroid pathology.

  2013cites this paper
• of mantle cell lymphoma Constitutive activation of Akt contributes to the pathogenesis and survival

  2013cites this paper
• survival of mantle cell lymphoma Constitutive activation of Akt contributes to the pathogenesis and

  2013cites this paper
• Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer

  2012influential citation
• mTOR pathway overactivation in BRAF mutated papillary thyroid carcinoma.

  2012cites this paper
• Frequent Gene Amplification Predicts Poor Prognosis in Gastric Cancer

  2012cites this paper
• Utility of a PI3K/mTOR Inhibitor (NVP-BEZ235) for Thyroid Cancer Therapy

  2012cites this paper
• Single Nucleotide Polymorphism rs17849071 G/T in the PIK3CA Gene Is Inversely Associated with Follicular Thyroid Cancer and PIK3CA Amplification

  2012cites this paper
• Radioactive iodine-refractory differentiated thyroid cancer: unmet needs and future directions

  2012cites this paper
• Signaling Networks Associated with AKT Activation in Non-Small Cell Lung Cancer (NSCLC): New Insights on the Role of Phosphatydil-Inositol-3 kinase

  2012cites this paper
• Role of genes differentially expressed in thyroid carcinogenesis

  2012cites this paper
• Targeting the PI3K pathway for cancer therapy.

  2012cites this paper
• Target therapies for radioiodine refractory advanced thyroid tumors.

  2012cites this paper
• Superoxide dismutase 3-mediated cell survival and proliferation

  2012cites this paper
• Molecular Diagnostics in the Evaluation of Thyroid Samples

  2012cites this paper
• Cytologic and molecular diagnosis of thyroid cancers

  2012cites this paper
• Identificação de alterações moleculares envolvidas na progressão e desdiferenciação dos carcinomas da tiróide

  2012cites this paper
• Small molecules targeting phosphoinositide 3-kinases

  2012cites this paper
• COMPARATIVE ANALYSIS OF HUMAN THYROID CARCINOMA CELL LINES

  2012cites this paper
• Thyroid Function and Growth Regulation under Normal and Abnormal Conditions

  2012cites this paper
• FOXM1 is a molecular determinant of the mitogenic and invasive phenotype of anaplastic thyroid carcinoma.

  2012cites this paper
• New phosphatidylinositol 3-kinase inhibitors for cancer

  2011cites this paper
• 2 Links Between the PI 3 K Pathway and Cancer

  2011cites this paper
• Novel insights into FOXOlogy: FOXOs and their putative role in thyroid carcinogenesis

  2011cites this paper
• Is the PIK3CA gene expression level in FNAB washouts equivalent to that in postoperative tissue specimens of papillary thyroid carcinoma?

  2011cites this paper
• The frequent co-expression of the oncogenes PIK3CA and PAK1 in oral carcinomas.

  2011cites this paper
• Follicular adenoma and carcinoma of the thyroid gland.

  2011cites this paper
• Prise en charge des cancers réfractaires de la thyroïde

  2011cites this paper
• TWIST1 plays a pleiotropic role in determining the anaplastic thyroid cancer phenotype.

  2011cites this paper
• Phosphatidylinositol 3-kinase isoforms as novel drug targets.

  2011cites this paper
• [Management of refractory thyroid cancers].

  2011cites this paper
• A minireview: the role of MAPK/ERK and PI3K/Akt pathways in thyroid follicular cell-derived neoplasm.

  2011cites this paper
• Recent Advances in Molecular Diagnosis of Thyroid Cancer

  2011cites this paper