IL-17-Producing Alveolar Macrophages Mediate Allergic Lung Inflammation Related to Asthma1

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Immunology

• Publication date

  2008-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.181.9.6117PMID 18941201
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mast cell-derived tumour necrosis factor is essential for allergic airway disease

  2008cited by this paper
• IgEb immune complexes activate macrophages through FcgammaRIV binding.

  2007cited by this paper
• Allergen-induced CD11b+ CD11c(int) CCR3+ macrophages in the lung promote eosinophilic airway inflammation in a mouse asthma model.

  2007cited by this paper
• TH17 cells in the big picture of immunology.

  2007cited by this paper
• Mast cell-derived TNF contributes to airway hyperreactivity, inflammation, and TH2 cytokine production in an asthma model in mice.

  2007cited by this paper
• IgEb immune complexes activate macrophages through FcγRIV binding

  2007cited by this paper
• T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-γ and IL-13 production

  2007cited by this paper
• IL-17 family cytokines and the expanding diversity of effector T cell lineages.

  2007cited by this paper
• Th17: an effector CD4 T cell lineage with regulatory T cell ties.

  2006cited by this paper
• Interleukin-17 is a negative regulator of established allergic asthma

  2006cited by this paper
• INFLUENCE OF DEPLETION OF ALVEOLAR MACROPHAGES ON APOPTOSIS IN CANDIDA-INDUCED ACUTE LUNG INJURY

  2005cited by this paper
• Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17.

  2005cited by this paper
• Macrophage polarization comes of age.

  2005cited by this paper
• A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

  2005cited by this paper
• Up-Regulation of CC Chemokine Ligand 20 Expression in Human Airway Epithelium by IL-17 through a JAK-Independent but MEK/NF-κB-Dependent Signaling Pathway1

  2005cited by this paper
• Macrophages induce an allergen-specific and long-term suppression in a mouse asthma model

  2005cited by this paper
• Adoptive transfer of alveolar macrophages abrogates bronchial hyperresponsiveness.

  2004cited by this paper
• IL-17 Markedly Up-Regulates β-Defensin-2 Expression in Human Airway Epithelium via JAK and NF-κB Signaling Pathways1

  2004cited by this paper
• The alveolar macrophage: the forgotten cell in asthma.

  2004cited by this paper
• Interleukin-17 signal transduction pathways implicated in inducing matrix metalloproteinase-3, -13 and aggrecanase-1 genes in articular chondrocytes.

  2004cited by this paper
• IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways.

  2004cited by this paper
• Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine.

  2003cited by this paper
• Cutting Edge: Roles of Toll-Like Receptor 4 and IL-23 in IL-17 Expression in Response to Klebsiella pneumoniae Infection1

  2003cited by this paper
• The role of T lymphocytes in the pathogenesis of asthma.

  2003cited by this paper
• Interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma.

  2003cited by this paper
• Alternative activation of macrophages

  2003cited by this paper
• IL-17, Produced by Lymphocytes and Neutrophils, Is Necessary for Lipopolysaccharide-Induced Airway Neutrophilia: IL-15 as a Possible Trigger

  2003cited by this paper
• Alveolar macrophage activation by myeloperoxidase: a model for exacerbation of lung inflammation.

  2002cited by this paper
• Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses.

  2002cited by this paper
• IgE-Dependent Mast Cell Activation Potentiates Airway Responses in Murine Asthma Models1

  2002cited by this paper
• IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines.

  2001cited by this paper
• Functional heterogeneity in liver and lung macrophages

  2001cited by this paper
• Anti-inflammatory cytokines in asthma and allergy: interleukin-10, interleukin-12, interferon-gamma.

  2001cited by this paper
• Th Type 1-Stimulating Activity of Lung Macrophages Inhibits Th2-Mediated Allergic Airway Inflammation by an IFN-γ-Dependent Mechanism1

  2001cited by this paper
• Mast Cells Can Amplify Airway Reactivity and Features of Chronic Inflammation in an Asthma Model in Mice

  2000cited by this paper
• Innate immunity and pulmonary host defense

  2000cited by this paper
• An Essential Role of Mast Cells in the Development of Airway Hyperresponsiveness in a Murine Asthma Model

  2000cited by this paper
• Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways.

  1999cited by this paper
• Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation.

  1999cited by this paper
• Immunologic basis of antigen-induced airway hyperresponsiveness.

  1999cited by this paper
• Interleukin-17.

  1998cited by this paper
• IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages.

  1998cited by this paper
• Inhaled corticosteroids increase interleukin-10 but reduce macrophage inflammatory protein-1alpha, granulocyte-macrophage colony-stimulating factor, and interferon-gamma release from alveolar macrophages in asthma.

  1998cited by this paper
• IL-17 Stimulates the Production and Expression of Proinflammatory Cytokines, IL-β and TNF-α, by Human Macrophages

  1998cited by this paper
• Development of Eosinophilic Airway Inflammation and Airway Hyperresponsiveness in Mast Cell–deficient Mice

  1997cited by this paper
• Interleukin-10 regulation in normal subjects and patients with asthma.

  1996cited by this paper
• Pulmonary macrophages.

  1994cited by this paper
• Interferon gamma regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4+ T cells

  1993cited by this paper
• [Pulmonary alveolar macrophage].

  1983cited by this paper
• The Pulmonary-Alveolar Macrophage

  1979cited by this paper

• Characterization of the Cellular Immune Response to Group B Streptococcal Vaginal Colonization

  2025cites this paper
• Immunoregulatory macrophages induced by mycobacterial nonpolar lipids.

  2025cites this paper
• Airborne fine particulate matter exposure induces transcriptomic alterations resembling asthmatic signatures: insights from integrated omics analysis

  2025cites this paper
• Redox-dependent suppression of ATF3 impairs steroid sensitivity in asthma through MKP-1/p38 MAPK signaling.

  2025cites this paper
• Effects of Etanercept on Experimental Osteoarthritis in Rats: Role of Histone Deacetylases.

  2024cites this paper
• RORγt inverse agonist TF-S14 inhibits Th17 cytokines and prolongs skin allograft survival in sensitized mice

  2024cites this paper
• The Presence and Pathogenic Roles of M(IL‐33 + IL‐2) Macrophages in Allergic Airway Inflammation

  2024cites this paper
• Distinct trajectories distinguish Antigen-specific T cells in peanut-allergic individuals undergoing oral immunotherapy.

  2023cites this paper
• Macrophages Orchestrate Airway Inflammation, Remodeling, and Resolution in Asthma

  2023cites this paper
• Echinochrome exhibits anti-asthmatic activity through the suppression of airway inflammation, oxidative stress, and histopathological alterations in ovalbumin-induced asthma in BALB/c mice

  2023cites this paper
• Inhibition of non-receptor tyrosine kinase LCK partially mitigates mixed granulocytic airway inflammation in a murine model of asthma.

  2023cites this paper
• The role of IL-17 in acute kidney injury.

  2023cites this paper
• Tuberous Sclerosis Complex 1 Deficiency in Macrophages Promotes Unclassical Inflammatory Response to Lipopolysaccharide In Vitro and Dextran Sodium Sulfate-Induced Colitis in Mice

  2022cites this paper
• Glaesserella parasuis induces IL-17 production might through PKC-ERK/MAPK and IκB/NF-κB signaling pathways.

  2022cites this paper
• MiR-365-3p is a negative regulator in IL-17-mediated asthmatic inflammation

  2022cites this paper
• Role of Macrophages in Air Pollution Exposure Related Asthma

  2022cites this paper
• Fungal-mediated lung allergic airway disease: The critical role of macrophages and dendritic cells

  2022influential citation
• Interleukin-17 contributes to Ross River virus-induced arthritis and myositis

  2022cites this paper
• Contribution of Interleukin-17A to Retinal Degenerative Diseases

  2022cites this paper
• HDAC6-specific inhibitor alleviates hashimoto's thyroiditis through inhibition of Th17 cell differentiation.

  2022cites this paper
• Nontypeable Haemophilus influenzae infection of pulmonary macrophages drives neutrophilic inflammation in severe asthma

  2022cites this paper
• Allergic airway inflammation induces upregulation of the expression of IL-23R by macrophages and not in CD3 + T cells and CD11c+F4/80− dendritic cells of the lung

  2022cites this paper
• Tendon Immune Regeneration: Insights on the Synergetic Role of Stem and Immune Cells during Tendon Regeneration

  2022cites this paper
• Dual RNASeq Reveals NTHi-Macrophage Transcriptomic Changes During Intracellular Persistence

  2021cites this paper
• MicroRNA-mediated calcineurin signaling activation induces CCL2, CCL3, CCL5, IL8, and chemotactic activities in 4,4′-methylene diphenyl diisocyanate exposed macrophages

  2021cites this paper
• Arf6 exacerbates allergic asthma through cell-to-cell transmission of ASC inflammasomes

  2021cites this paper
• IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice.

  2021cites this paper
• Thyme oil alleviates Ova-induced bronchial asthma through modulating Th2 cytokines, IgE, TSLP and ROS.

  2021cites this paper
• Requirement of Gαi1 and Gαi3 in interleukin-4-induced signaling, macrophage M2 polarization and allergic asthma response

  2021cites this paper
• IRAK-M knockout promotes allergic airway inflammation, but not airway hyperresponsiveness, in house dust mite-induced experimental asthma model

  2021influential citation
• Leukocytes in Critical Patients With Asthma Exacerbation

  2021cites this paper
• Exploring IL-17 in spondyloarthritis for development of novel treatments and biomarkers.

  2021cites this paper
• Cellular and molecular mechanisms of allergic asthma.

  2021cites this paper
• Unexpected connections of the IL-23/IL-17 and IL-4/IL-13 cytokine axes in inflammatory arthritis and enthesitis.

  2021cites this paper
• Inflammation in Asthma Pathogenesis: Role of T cells, Macrophages, Epithelial Cells and Type 2 Inflammation.

  2021cites this paper
• Scavenger Receptor BI Attenuates IL-17A-dependent Neutrophilic Inflammation in Asthma.

  2021cites this paper
• Targeting Molecular and Cellular Mechanisms in Asthma

  2021cites this paper
• Interleukin-17A serum levels in young patients with atopic dermatitis and food allergy

  2021cites this paper
• Toxicological Evaluations in Macrophages and Mice Acutely and Chronically Exposed to Halloysite Clay Nanotubes Functionalized with Polystyrene

  2021cites this paper
• The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis

  2020cites this paper
• Role of IL-17 and IL-23 in the Pathogenesis of Neutrophilic Asthma

  2020cites this paper
• Lung Tissue Damage Associated with Allergic Asthma in BALB/c Mice Could Be Controlled with a Single Injection of Mesenchymal Stem Cells from Human Bone Marrow up to 14 d After Transplantation

  2020cites this paper
• The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk

  2020cites this paper
• PPARγ Deficiency in Carbon Nanotube-elicited Granulomatous Inflammation Promotes a Th17 Response to a Microbial Antigen

  2020cites this paper
• Arginine metabolic control of airway inflammation.

  2020cites this paper
• Proteomics analysis revealed the importance of inflammation mediated downstream pathways and the protective role of curcumin during bleomycin-induced pulmonary fibrosis in C57BL/6 mice.

  2020cites this paper
• Is There An Explanation for How An Irriant Causes A Non-Allergic Asthmatic Disorder Such as Reactive Airways Dysfunction Syndrome (Rads)?

  2020cites this paper
• Role of IL-17 in asthma pathogenesis and its implications for the clinic

  2019cites this paper
• Acute 4,4'-Methylene Diphenyl Diisocyanate Exposure-Mediated Downregulation of miR-206-3p and miR-381-3p Activates Inducible Nitric Oxide Synthase Transcription by Targeting Calcineurin/NFAT Signaling in Macrophages.

  2019cites this paper
• Concise Details of RADS

  2019cites this paper
• Targeting interleukin-17 in chronic inflammatory disease: A clinical perspective

  2019cites this paper
• The Relationship Between Serum IL-17 Level and Viral Load in Chronic Hepatitis B

  2019cites this paper
• Therapeutic suppression of pulmonary neutrophilia and allergic airway hyperresponsiveness by a RORγt inverse agonist.

  2019cites this paper
• Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Induces Interleukin-17 Production via Activation of the IRAK1-PI3K-p38MAPK-C/EBPβ/CREB Pathways

  2019cites this paper
• Mast cell degranulation impairs pneumococcus clearance in mice via IL-6 dependent and TNF-α independent mechanisms

  2019cites this paper
• Effect of the anti-IL-17 antibody on allergic inflammation in an obesity-related asthma model

  2018cites this paper
• Integrin CD11b negatively regulates Mincle-induced signaling via the Lyn–SIRPα–SHP1 complex

  2018cites this paper
• Aspergillus fumigatus conidia stimulate lung epithelial cells (TC-1 JHU-1) to produce IL-12, IFNγ, IL-13 and IL-17 cytokines: Modulatory effect of propolis extract.

  2018cites this paper
• NLRP3 regulates macrophage M2 polarization through up-regulation of IL-4 in asthma.

  2018cites this paper
• Soluble mucus component CLCA1 modulates expression of leukotactic cytokines and BPIFA1 in murine alveolar macrophages but not in bone marrow-derived macrophages

  2018cites this paper
• Complement C3 Produced by Macrophages Promotes Renal Fibrosis via IL-17A Secretion

  2018cites this paper
• Upregulated IGF‑1 in the lungs of asthmatic mice originates from alveolar macrophages.

  2018cites this paper
• Effect of Anti-IL17 Antibody Treatment Alone and in Combination With Rho-Kinase Inhibitor in a Murine Model of Asthma

  2018cites this paper
• The role of hypodermic injection with low dose of adrenaline in emergency treatment of severe asthma

  2018cites this paper
• IL-23-induced macrophage polarization and its pathological roles in mice with imiquimod-induced psoriasis

  2018cites this paper
• Circulating Tumor Microparticles Promote Lung Metastasis by Reprogramming Inflammatory and Mechanical Niches via a Macrophage-Dependent Pathway

  2018cites this paper
• Enterovirus D68 infection induces IL-17-dependent neutrophilic airway inflammation and hyperresponsiveness.

  2018cites this paper
• Rhinovirus infection induces distinct transcriptome profiles in polarized human macrophages.

  2018cites this paper
• Distinguishing rheumatoid arthritis from psoriatic arthritis

  2018cites this paper
• Inhibition of airway inflammation , hyperresponsiveness by the fructus schisandrae ( wu wei zi ) extract in a murine model of allergic asthma

  2018cites this paper
• Mouse &bgr;‐defensin‐14 for inducing the maturation of dendritic cells

  2018cites this paper
• attenuates lipopolysaccharide-induced acute lung injury by regulating the e ff ects of anti-oxidation and anti-in fl ammation both in vitro and in vivo †

  2018cites this paper
• Crosstalk Between Alveolar Epithelial Cells and Macrophages in Asthma

  2018cites this paper
• Alpinumisoflavone attenuates lipopolysaccharide-induced acute lung injury by regulating the effects of anti-oxidation and anti-inflammation both in vitro and in vivo

  2018cites this paper
• Study of integrin CD11b's regulation on mincle signaling

  2017cites this paper
• IL‐17 contributes to the pathogenesis of obliterative bronchiolitis via regulation of M1 macrophages polarization in murine heterotopic trachea transplantation models

  2017cites this paper
• Modulation of effector functions of bovine mononuclear phagocytes by γδ T lymphocytes during in vitro Mycobacterium avium subspecies paratuberculosis infection

  2017influential citation
• Semaphorin 3E Deficiency Exacerbates Airway Inflammation, Hyperresponsiveness, and Remodeling in a Mouse Model of Allergic Asthma

  2017cites this paper
• Characterization and biological significance of IL-23-induced neutrophil polarization

  2017cites this paper
• Immunopathology alters Th17 cell glucocorticoid sensitivity

  2017cites this paper
• Role of C/EBP homologous protein and endoplasmic reticulum stress in asthma exacerbation by regulating the IL‐4/signal transducer and activator of transcription 6/transcription factor EC/IL‐4 receptor &agr; positive feedback loop in M2 macrophages

  2017cites this paper
• Methanosphaera stadtmanae induces a type IV hypersensitivity response in a mouse model of airway inflammation

  2017cites this paper
• Interleukin‐17 acts as double‐edged sword in anti‐tumor immunity and tumorigenesis

  2017cites this paper
• IL-17: overview and role in oral immunity and microbiome.

  2017cites this paper
• Central Role of IL-23 and IL-17 Producing Eosinophils as Immunomodulatory Effector Cells in Acute Pulmonary Aspergillosis and Allergic Asthma

  2017influential citation
• Macrophage dysfunction in the pathogenesis and treatment of asthma

  2017cites this paper
• IL-17 axis accelerates the inflammatory progression of obese in mice via TBK1 and IKBKE pathway.

  2017cites this paper
• Meta-Analysis of Risk Association Between Interleukin-17A and F Gene Polymorphisms and Inflammatory Diseases

  2017cites this paper
• Mouse Model of IL-17-Dominant Rhinitis Using Polyinosinic-Polycytidylic Acid

  2017cites this paper
• IBBJ Spring 2015 , Vol 1 , No 2 Biology of TH 17 Cells and Their Role in Inflammatory Diseases

  2017cites this paper
• Mechanisms regulating airway responses to the fungal allergen Alternaria alternata

  2016cites this paper
• Allergen-Induced IL-6 Regulates IL-9/IL-17A Balance in CD4+ T Cells in Allergic Airway Inflammation

  2016cites this paper
• This information is current as Inflammation T Cells in Allergic Airway + Balance in CD 4 Allergen-Induced IL-6 Regulates IL-9 / IL-17 A Polte

  2016cites this paper
• Origin, Localization, and Immunoregulatory Properties of Pulmonary Phagocytes in Allergic Asthma

  2016cites this paper
• MyD88 modulates eosinophil and neutrophil recruitment as well as IL-17A production during allergic inflammation.

  2016cites this paper
• Effects of Angelicin on Ovalbumin (OVA)-Induced Airway Inflammation in a Mouse Model of Asthma

  2016cites this paper
• Eosinophils as Drivers of the IL-23/IL-17 Axis: Implications for Acute Aspergillosis and Allergic Asthma: A Dissertation

  2016cites this paper
• FoxO1 regulates allergic asthmatic inflammation through regulating polarization of the macrophage inflammatory phenotype

  2016cites this paper
• IL-17A mediates inflammatory and tissue remodelling events in early human tendinopathy

  2016cites this paper
• IL-17A-mediated expression of epithelial IL-17C promotes inflammation during acute Pseudomonas aeruginosa pneumonia

  2016cites this paper