Depletion of pre-beta-high density lipoprotein by human chymase impairs ATP-binding cassette transporter A1- but not scavenger receptor class B type I-mediated lipid efflux to high density lipoprotein.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of Biological Chemistry

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 14701812
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Apolipoprotein composition and particle size affect HDL degradation by chymase: effect on cellular cholesterol efflux.

  2003cited by this paper
• Importance of different pathways of cellular cholesterol efflux.

  2003cited by this paper
• Degradation of Phospholipid Transfer Protein (PLTP) and PLTP-generated Pre-β-high Density Lipoprotein by Mast Cell Chymase Impairs High Affinity Efflux of Cholesterol from Macrophage Foam Cells*

  2003cited by this paper
• The Role of Apolipoprotein A-I Helix 10 in Apolipoprotein-mediated Cholesterol Efflux via the ATP-binding Cassette Transporter ABCA1*

  2002cited by this paper
• Cellular cholesterol flux studies: methodological considerations.

  2002cited by this paper
• The C-terminal domain of apolipoprotein A-I is involved in ABCA1-driven phospholipid and cholesterol efflux.

  2002cited by this paper
• Mast Cell Tryptase Degrades HDL and Blocks Its Function as an Acceptor of Cellular Cholesterol

  2002cited by this paper
• Mast Cell Chymase Degrades ApoE and ApoA-II in ApoA-I–Knockout Mouse Plasma and Reduces Its Ability to Promote Cellular Cholesterol Efflux

  2002cited by this paper
• Delineation of the role of pre-beta 1-HDL in cholesterol efflux using isolated pre-beta 1-HDL.

  2002cited by this paper
• The Zinc Finger Protein 202 (ZNF202) Is a Transcriptional Repressor of ATP Binding Cassette Transporter A1 (ABCA1) and ABCG1 Gene Expression and a Modulator of Cellular Lipid Efflux*

  2001cited by this paper
• Chymase bound to heparin is resistant to its natural inhibitors and capable of proteolyzing high density lipoproteins in aortic intimal fluid.

  2001cited by this paper
• Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis.

  2001cited by this paper
• Apolipoprotein specificity for lipid efflux by the human ABCAI transporter.

  2001cited by this paper
• Cellular cholesterol efflux.

  2001cited by this paper
• ATP-binding Cassette Transporter A1 (ABCA1) Functions as a Cholesterol Efflux Regulatory Protein*

  2001cited by this paper
• Specific Binding of ApoA-I, Enhanced Cholesterol Efflux, and Altered Plasma Membrane Morphology in Cells Expressing ABC1*

  2000cited by this paper
• ABCA1 Is the cAMP-inducible Apolipoprotein Receptor That Mediates Cholesterol Secretion from Macrophages*

  2000cited by this paper
• Human ApoA-IV overexpression in transgenic mice induces cAMP-stimulated cholesterol efflux from J774 macrophages to whole serum.

  2000cited by this paper
• Identification of domains in apoA-I susceptible to proteolysis by mast cell chymase. Implications for HDL function.

  2000cited by this paper
• A two-step mechanism for free cholesterol and phospholipid efflux from human vascular cells to apolipoprotein A-1.

  2000cited by this paper
• Plasmin and kallikrein reduce HDL-induced cholesterol efflux from foam cells.

  2000cited by this paper
• High Density Lipoprotein Phospholipid Composition Is a Major Determinant of the Bi-directional Flux and Net Movement of Cellular Free Cholesterol Mediated by Scavenger Receptor BI*

  2000cited by this paper
• The Correlation of ATP-binding Cassette 1 mRNA Levels with Cholesterol Efflux from Various Cell Lines*

  2000cited by this paper
• Induction of cellular cholesterol efflux to lipid-free apolipoprotein A-I by cAMP.

  1999cited by this paper
• Depletion of pre beta 1LpA1 and LpA4 particles by mast cell chymase reduces cholesterol efflux from macrophage foam cells induced by plasma.

  1999cited by this paper
• Matrix Metalloproteinases-3, -7, and -12, but Not -9, Reduce High Density Lipoprotein-induced Cholesterol Efflux from Human Macrophage Foam Cells by Truncation of the Carboxyl Terminus of Apolipoprotein A-I

  1999cited by this paper
• Apolipoprotein-mediated cellular cholesterol efflux.

  1998cited by this paper
• Scavenger Receptor Class B Type I as a Mediator of Cellular Cholesterol Efflux to Lipoproteins and Phospholipid Acceptors*

  1998cited by this paper
• Limited proteolysis of high density lipoprotein abolishes its interaction with cell-surface binding sites that promote cholesterol efflux.

  1997cited by this paper
• Decreased reverse cholesterol transport from Tangier disease fibroblasts. Acceptor specificity and effect of brefeldin on lipid efflux.

  1997cited by this paper
• The molecular structure of apolipoprotein A-II modulates the capacity of HDL to promote cell cholesterol efflux.

  1996cited by this paper
• Chymase in exocytosed rat mast cell granules effectively proteolyzes apolipoprotein AI-containing lipoproteins, so reducing the cholesterol efflux-inducing ability of serum and aortic intimal fluid.

  1996cited by this paper
• Selective inhibition of free apolipoprotein-mediated cellular lipid efflux by probucol.

  1996cited by this paper
• Mast cells in human fatty streaks and atheromas: implications for intimal lipid accumulation

  1996cited by this paper
• Apolipoprotein AIV of human interstitial fluid is associated with apolipoprotein AI-containing but not with AII-containing particles

  1996cited by this paper
• Efflux of cellular cholesterol and phospholipid to lipid-free apolipoproteins and class A amphipathic peptides.

  1995cited by this paper
• Molecular physiology of reverse cholesterol transport.

  1995cited by this paper
• Mast cells of two types differing in neutral protease composition in the human aortic intima. Demonstration of tryptase- and tryptase/chymase-containing mast cells in normal intimas, fatty streaks, and the shoulder region of atheromas.

  1994cited by this paper
• Cell-derived unesterified cholesterol cycles between different HDLs and LDL for its effective esterification in plasma.

  1993cited by this paper
• Human plasma phospholipid transfer protein causes high density lipoprotein conversion.

  1993cited by this paper
• Comparison of apo A-I-containing subpopulations of dog plasma and prenodal peripheral lymph: evidence for alteration in subpopulations in the interstitial space.

  1993cited by this paper
• Lecithin-cholesterol acyltransferase in the metabolism of high-density lipoproteins.

  1991cited by this paper
• Cholesterol transport between cells and high-density lipoproteins.

  1991cited by this paper
• Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa.

  1987cited by this paper
• Interstitial fluid lipoproteins.

  1987cited by this paper
• Low density lipoprotein degradation by secretory granules of rat mast cells. Sequential degradation of apolipoprotein B by granule chymase and carboxypeptidase A.

  1986cited by this paper
• Apolipoprotein AIMilano. Accelerated binding and dissociation from lipids of a human apolipoprotein variant.

  1985cited by this paper
• Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis.

  1983cited by this paper

• High-density lipoprotein in cardiovascular diseases: From high quantity to high quality.

  2025cites this paper
• Understanding the heterogeneity and dysfunction of HDL in chronic kidney disease: insights from recent reviews

  2024influential citation
• TNFα Activates the Liver X Receptor Signaling Pathway and Promotes Cholesterol Efflux from Human Brain Pericytes Independently of ABCA1

  2023cites this paper
• HDL metabolism and functions impacting on cell cholesterol homeostasis are specifically altered in patients with abdominal aortic aneurysm

  2022cites this paper
• Neutrophil proteinase 3 - An LDL- and HDL-proteolyzing enzyme with a potential to contribute to cholesterol accumulation in human atherosclerotic lesions.

  2022cites this paper
• The role of HDL- and non-HDL-related parameters in cell-cholesterol efflux capacity.

  2022cites this paper
• High Density Lipoprotein Cholesterol Efflux Capacity and Atherosclerosis in Cardiovascular Disease: Pathophysiological Aspects and Pharmacological Perspectives

  2021cites this paper
• Atherosclerosis Regression and Cholesterol Efflux in Hypertriglyceridemic Mice.

  2021cites this paper
• Cholesterol efflux capacity and its association with prevalent metabolic syndrome in a multi-ethnic population (Dallas Heart Study)

  2021cites this paper
• Probucol treatment is associated with an ABCA1-independent mechanism of cholesterol efflux to lipid poor apolipoproteins from foam cell macrophages.

  2021cites this paper
• The effect of transgender hormonal treatment on high density lipoprotein cholesterol efflux capacity.

  2021cites this paper
• The Difference Between High Density Lipoprotein Subfractions and Subspecies: an Evolving Model in Cardiovascular Disease and Diabetes

  2021cites this paper
• 7Intracoronary monocyte expression pattern and HDL subfractions after non-ST elevation myocardial infarction.

  2021cites this paper
• Cholesterol efflux promoting function of high-density lipoproteins in calcific aortic valve stenosis

  2021cites this paper
• Lipid efflux mechanisms, relation to disease and potential therapeutic aspects.

  2020cites this paper
• HDL particle size is increased and HDL-cholesterol efflux is enhanced in type 1 diabetes: a cross-sectional study

  2020cites this paper
• HDL-Mediated Cholesterol Efflux and Plasma Loading Capacities Are Altered in Subjects with Metabolically- but Not Genetically Driven Non-Alcoholic Fatty Liver Disease (NAFLD)

  2020cites this paper
• The PPAR pan-agonist tetradecylthioacetic acid promotes redistribution of plasma cholesterol towards large HDL

  2020cites this paper
• The Extent of Human Apolipoprotein A-I Lipidation Strongly Affects the β-Amyloid Efflux Across the Blood-Brain Barrier in vitro

  2019cites this paper
• Analysis of Low Molecular Weight Substances and Related Processes Influencing Cellular Cholesterol Efflux

  2019cites this paper
• A proteomic approach to identify novel disease biomarkers in LCAT deficiency.

  2019cites this paper
• Ambient Air Pollution Is Associated With HDL (High-Density Lipoprotein) Dysfunction in Healthy Adults

  2019cites this paper
• HDL cholesterol is associated with PBMC expression of genes involved in HDL metabolism and atherogenesis

  2019cites this paper
• Atheroinflammatory Properties of LDL and HDL Particles Modified by Human Mast Cell Neutral Proteases

  2018cites this paper
• High-Density Lipoprotein Particles, Cell-Cholesterol Efflux, and Coronary Heart Disease Risk: The Pre&bgr;-1 Paradox

  2018cites this paper
• Vitamin D replacement ameliorates serum lipoprotein functions, adipokine profile and subclinical atherosclerosis in pre-menopausal women.

  2018cites this paper
• Depletion in LpA-I:A-II particles enhances HDL-mediated endothelial protection in familial LCAT deficiency patient-oriented and epidemiological research

  2017cites this paper
• effect of a novel nutraceutical combination on serum lipoprotein functional profile and circulating PCsK9

  2017cites this paper
• Depletion in LpA-I:A-II particles enhances HDL-mediated endothelial protection in familial LCAT deficiency[S]

  2017cites this paper
• Effect of a novel nutraceutical combination on serum lipoprotein functional profile and circulating PCSK9

  2017cites this paper
• ApoA-IMilano phospholipid complex (ETC-216) infusion in human volunteers. Insights into the phenotypic characteristics of ApoA-IMilano carriers.

  2016cites this paper
• HDL function and subclinical atherosclerosis in juvenile idiopathic arthritis.

  2016cites this paper
• Plasma-derived and synthetic high-density lipoprotein inhibit tissue factor in endothelial cells and monocytes.

  2016cites this paper
• Carboxyl-Terminal Cleavage of Apolipoprotein A-I by Human Mast Cell Chymase Impairs Its Anti-Inflammatory Properties

  2016cites this paper
• Paraoxonase 1‐treated oxLDL promotes cholesterol efflux from macrophages by stimulating the PPARγ–LXRα–ABCA1 pathway

  2016cites this paper
• Role of LCAT in Atherosclerosis.

  2016cites this paper
• Supplemental Information An Essential Role for Liver ERa in Coupling Hepatic Metabolism to the Reproductive Cycle

  2016cites this paper
• Effect of chronic kidney disease on macrophage cholesterol efflux.

  2015cites this paper
• Cholesterol trafficking-related serum lipoprotein functions in children with cholesteryl ester storage disease.

  2015cites this paper
• What does procollagen C-endopeptidase enhancer protein 2 have to do with HDL-cholesteryl ester uptake? Or how I learned to stop worrying and love reverse cholesterol transport?

  2015cites this paper
• Cholesterol Efflux Capacity and Pre-Beta-1 HDL Concentrations Are Increased in Dyslipidemic Patients Treated With Evacetrapib.

  2015cites this paper
• Regulation of Hepatic Cholesteryl Ester Transfer Protein Expression and Reverse Cholesterol Transport by Inhibition of DNA Topoisomerase II*

  2015cites this paper
• Mast Cells and HDL : Studies on Cholesterol Efflux and Reverse Cholesterol Transport

  2015cites this paper
• Structure of HDL: particle subclasses and molecular components.

  2015cites this paper
• Cholesterol efflux and reverse cholesterol transport.

  2015cites this paper
• Acquired lecithin:cholesterol acyltransferase deficiency as a major factor in lowering plasma HDL levels in chronic kidney disease

  2015cites this paper
• The mast cell as a pluripotent HDL-modifying effector in atherogenesis: from in vitro to in vivo significance

  2015cites this paper
• ROLE OF ABNORMAL LIPOPROTEINS IN ATHEROSCLEROSIS AND RENAL DISEASE IN LCAT DEFICIENCY

  2014cites this paper
• Hepatic ACAT2 Knock Down Increases ABCA1 and Modifies HDL Metabolism in Mice

  2014cites this paper
• Enhanced cholesterol efflux to HDL through the ABCA1 transporter in hypertriglyceridemia of type 2 diabetes.

  2014cites this paper
• HDL function and cardiovascular risk: debate continues...

  2013cites this paper
• ABCA1-dependent serum cholesterol efflux capacity inversely correlates with pulse wave velocity in healthy subjects[S]

  2013cites this paper
• Paradoxical Association of Enhanced Cholesterol Efflux With Increased Incident Cardiovascular Risks

  2013cites this paper
• Pharmaceutical stabilization of mast cells attenuates experimental atherogenesis in low-density lipoprotein receptor-deficient mice.

  2013cites this paper
• Assessing the functional properties of high-density lipoproteins: an emerging concept in cardiovascular research.

  2013cites this paper
• Mechanisms of hexosamine-induced cholesterol accumulation and therapeutic actions of chromium

  2013influential citation
• Carotid intima media thickness is related positively to plasma pre ß-high density lipoproteins in non-diabetic subjects.

  2012cites this paper
• Emerging role of mast cells and macrophages in cardiovascular and metabolic diseases.

  2012cites this paper
• Purified human paraoxonase-1 interacts with plasma membrane lipid rafts and mediates cholesterol efflux from macrophages.

  2012cites this paper
• Cellular cholesterol efflux and cholesterol loading capacity of serum: effects of LDL-apheresis[S]

  2012cites this paper
• Extra-virgin olive oil consumption improves the capacity of HDL to mediate cholesterol efflux and increases ABCA1 and ABCG1 expression in human macrophages

  2012cites this paper
• Genetic lecithin:cholesterol acyltransferase deficiency and cardiovascular disease.

  2012cites this paper
• Cardiovascular disease risk reduction by raising HDL cholesterol – current therapies and future opportunities

  2012cites this paper
• Brain Pericytes ABCA1 Expression Mediates Cholesterol Efflux but not Cellular Amyloid-β Peptide Accumulation

  2012cites this paper
• Impairment of the ABCA1 and SR-BI-mediated cholesterol efflux pathways and HDL anti-inflammatory activity in Alzheimer's disease.

  2012cites this paper
• Spontaneous remodeling of HDL particles at acidic pH enhances their capacity to induce cholesterol efflux from human macrophage foam cells[S]

  2012cites this paper
• Effect of the amyloidogenic L75P apolipoprotein A-I variant on HDL subpopulations

  2011cites this paper
• Extracellular modifications of HDL in vivo and the emerging concept of proteolytic inactivation of pre&bgr;-HDL

  2011cites this paper
• Cellular cholesterol efflux pathways: impact on intracellular lipid trafficking and methodological considerations.

  2011cites this paper
• Macrophage, But Not Systemic, Apolipoprotein E Is Necessary for Macrophage Reverse Cholesterol Transport In Vivo

  2011cites this paper
• An integrated approach for the mechanisms responsible for atherosclerotic plaque regression.

  2011cites this paper
• Detection of chymase-digested C-terminally truncated apolipoprotein A-I in normal human serum.

  2011cites this paper
• High-density lipoprotein quantity or quality for cardiovascular prevention?

  2010cites this paper
• Mast cell-dependent proteolytic modification of HDL particles during anaphylactic shock in the mouse reduces their ability to induce cholesterol efflux from macrophage foam cells ex vivo.

  2010cites this paper
• Acidic Extracellular Environments Strongly Impair ABCA1-Mediated Cholesterol Efflux From Human Macrophage Foam Cells

  2010cites this paper
• The Ability to Promote Efflux Via ABCA1 Determines the Capacity of Serum Specimens With Similar High-Density Lipoprotein Cholesterol to Remove Cholesterol From Macrophages

  2010cites this paper
• Impact of android overweight or obesity and insulin resistance on basal and postprandial SR-BI and ABCA1-mediated serum cholesterol efflux capacities.

  2010cites this paper
• High-density lipoprotein metabolism and the human embryo.

  2010cites this paper
• Functional LCAT is not required for macrophage cholesterol efflux to human serum.

  2009cites this paper
• Dysfunctional high-density lipoprotein

  2009cites this paper
• Recent advances on the antiatherogenic effects of HDL-derived proteins and mimetic peptides.

  2009cites this paper
• The puzzle of high-density lipoprotein in cardiovascular prevention

  2009cites this paper
• Improving cardiovascular disease prevention : from risk assessment to novel therapy

  2009cites this paper
• Understanding the molecular mechanisms behind lipid homeostasis: the role of apoE and hepatic ACAT 2 in atherogenesis

  2009cites this paper
• A novel homozygous mutation in CETP gene as a cause of CETP deficiency in a Caucasian kindred.

  2009cites this paper
• Reduced Expression of ATP-Binding Cassette Transporter G1 Increases Cholesterol Accumulation in Macrophages of Patients With Type 2 Diabetes Mellitus

  2008cites this paper
• In Situ Mouse Carotid Perfusion Model: Glucose and Cholesterol Transport in the Eye and Brain

  2008cites this paper
• The LXR agonist T0901317 promotes the reverse cholesterol transport from macrophages by increasing plasma efflux potential Published, JLR Papers in Press, February 5, 2008.

  2008influential citation
• Enhanced removal of cholesterol from macrophage foam cells to serum from type IV hypertriglyceridemic subjects.

  2008cites this paper
• Synthetic HDL as a new treatment for atherosclerosis regression: has the time come?

  2008cites this paper
• Fibroblast cholesterol efflux to plasma from metabolic syndrome subjects is not defective despite low high-density lipoprotein cholesterol.

  2008cites this paper
• Cellular cholesterol efflux to serum is impaired in diabetic nephropathy

  2008cites this paper
• Association of cholesteryl ester transfer protein with HDL particles reduces its proteolytic inactivation by mast cell chymase Published, JLR Papers in Press, November 8, 2007.

  2008cites this paper
• Increased cholesterol efflux from cultured fibroblasts to plasma from hypertriglyceridemic type 2 diabetic patients: roles of pre beta-HDL, phospholipid transfer protein and cholesterol esterification.

  2008cites this paper
• CETP inhibition in cardiovascular risk management: a critical appraisal

  2007cites this paper
• Effects of fenofibrate and simvastatin on HDL-related biomarkers in low-HDL patients.

  2007cites this paper
• A Unique Protease-sensitive High Density Lipoprotein Particle Containing the Apolipoprotein A-IMilano Dimer Effectively Promotes ATP-binding Cassette A1-mediated Cell Cholesterol Efflux*

  2007cites this paper
• ApoA-I cleaved by transthyretin has reduced ability to promote cholesterol efflux and increased amyloidogenicity Published, JLR Papers in Press, August 10, 2007.

  2007cites this paper
• Apolipoprotein A‐I breakdown is induced by thrombolysis in coronary patients

  2007cites this paper
• Mast cells: multipotent local effector cells in atherothrombosis

  2007cites this paper