Regulation of HIF by Prolyl hydroxylases: Recruitment of the Candidate Tumor Suppressor Protein ING4

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Cell Cycle

• Publication date

  2005-07-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4161/cc.4.9.2040PMID 16096374
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Activation of HIF-prolyl Hydroxylases by R59949, an Inhibitor of the Diacylglycerol Kinase*

  2005cited by this paper
• The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF).

  2005cited by this paper
• OS-9 Interacts with Hypoxia-Inducible Factor 1α and Prolyl Hydroxylases to Promote Oxygen-Dependent Degradation of HIF-1α

  2005cited by this paper
• Proline hydroxylation and gene expression.

  2005cited by this paper
• OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.

  2005cited by this paper
• Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia.

  2004cited by this paper
• The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis

  2004cited by this paper
• ING4 induces G2/M cell cycle arrest and enhances the chemosensitivity to DNA‐damage agents in HepG2 cells

  2004cited by this paper
• Structural and Functional Conservation of the NuA4 Histone Acetyltransferase Complex from Yeast to Humans

  2004cited by this paper
• A screen for genes that suppress loss of contact inhibition: identification of ING4 as a candidate tumor suppressor gene in human cancer.

  2004cited by this paper
• Biological functions of the ING family tumor suppressors

  2004cited by this paper
• Drosophila cyclin D/Cdk4 requires Hif-1 prolyl hydroxylase to drive cell growth.

  2004cited by this paper
• p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity.

  2003cited by this paper
• Characterization of the Human Prolyl 4-Hydroxylases That Modify the Hypoxia-inducible Factor*

  2003cited by this paper
• Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor.

  2003cited by this paper
• von Hippel–Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination

  2003cited by this paper
• Hypoxia Up-regulates Prolyl Hydroxylase Activity

  2003cited by this paper
• Targeting HIF-1 for cancer therapy

  2003cited by this paper
• Intracellular localisation of human HIF-1α hydroxylases: implications for oxygen sensing

  2003cited by this paper
• Different HATS of the ING1 gene family.

  2002cited by this paper
• Role of Prolyl Hydroxylation in Oncogenically Stabilized Hypoxia-inducible Factor-1α*

  2002cited by this paper
• Role of the Sin3-Histone Deacetylase Complex in Growth Regulation by the Candidate Tumor Suppressor p33ING1

  2002cited by this paper
• Hypoxic but not anoxic stabilization of HIF-1alpha requires mitochondrial reactive oxygen species.

  2002cited by this paper
• HIF-1 and human disease: one highly involved factor.

  2000cited by this paper
• The metabolic implications of intracellular circulation.

  1999cited by this paper
• Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1α

  1997cited by this paper
• Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit*

  1997cited by this paper
• The PHD finger: implications for chromatin-mediated transcriptional regulation.

  1995cited by this paper

• The relativity analysis of hypoxia inducible factor-1α in pulmonary arterial hypertension (ascites syndrome) in broilers: a review

  2024cites this paper
• Role of liver sinusoidal endothelial cells in non-alcoholic fatty liver disease.

  2019cites this paper
• Inhibitor of growth 4 (ING4) inhibits hypoxia-induced EMT by decreasing HIF-1α and snail in HK2 cells.

  2019cites this paper
• The pro-oncogenic adaptor CIN85 acts as an inhibitory binding partner of hypoxia-inducible factor prolyl hydroxylase 2.

  2019cites this paper
• The pro-oncogenic adaptor CIN85 inhibits hypoxia-inducible factor prolyl hydroxylase-2

  2018cites this paper
• INGs are potential drug targets for cancer

  2017cites this paper
• Inhibitor of growth-4 is a potential target for cancer therapy

  2016cites this paper
• The expression of inhibitor of growth 4 is reduced in cervical cancer tissues.

  2016cites this paper
• Reduced expression and prognostic implication of inhibitor of growth 4 in human osteosarcoma.

  2016cites this paper
• Adenovirus-mediated ING4 Gene Transfer in Osteosarcoma Suppresses Tumor Growth via Induction of Apoptosis and Inhibition of Tumor Angiogenesis

  2015cites this paper
• Adenovirus-mediated ING4 Gene Transfer in Osteosarcoma Suppresses Tumor Growth via Induction of Apoptosis and Inhibition of Tumor Angiogenesis

  2015cites this paper
• Reduced ING4 Expression Is Associated with the Malignancy of Human Bladder

  2015cites this paper
• The Emerging Role of Inhibitor of Growth 4 as a Tumor Suppressor in Multiple Human Cancers

  2015cites this paper
• Keep‐ING balance: Tumor suppression by epigenetic regulation

  2014cites this paper
• Experimental Studies on the Inhibition of Adenovirus-ING4-OSM Therapy on Nasopharyngeal Carcinoma Proliferation In Vitro and In Vivo

  2014cites this paper
• ING4 regulates JWA in angiogenesis and their prognostic value in melanoma patients

  2013cites this paper
• Pathogenic mechanisms behind dysregulated angiogenesis with focus on HIF and IGF-I signaling

  2013cites this paper
• RegulatING chromatin regulators: post-translational modification of the ING family of epigenetic regulators.

  2013cites this paper
• The Dual Role of HIF Hydroxylase PHD3 in Cancer Cell Survival

  2012cites this paper
• ING4 is negatively correlated with microvessel density in colon cancer

  2012cites this paper
• Expression of tumor suppressor gene ING4 in ovarian carcinoma is correlated with microvessel density

  2012cites this paper
• Oxygen sensing by the prolyl-4-hydroxylase PHD2 within the nuclear compartment and the influence of compartmentalisation on HIF-1 signalling

  2012cites this paper
• Expression of Hypoxia-Inducible Factor (HIF)-1a-Vascular Endothelial Growth Factor (VEGF)-Inhibitory Growth Factor (ING)-4- axis in sarcoidosis patients

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• Inhibitor of growth-4 mediates chromatin modification and has a suppressive effect on tumorigenesis and innate immunity

  2012cites this paper
• ING4 (inhibitor of growth family, member 4)

  2012cites this paper
• Role of ING Family Tumor Suppressors in Breast Cancer

  2011cites this paper
• Impact of pEGFP mediated ING4 gene on growth of glioma U251 cells and its potential molecular mechanism

  2011cites this paper
• Attenuates the Function of p 53 through Interaction with Inhibitor of Growth Family Proteins 4 and 5

  2011influential citation
• Prolyl hydroxylase and hypoxia inducible factor: potential targets for cancer therapy

  2011cites this paper
• Downregulated Expression of Inhibitor of Growth 4 (ING4) in Advanced Colorectal Cancers: A Non-Randomized Experimental Study

  2011cites this paper
• Cell Cycle Regulator ING4 Is a Suppressor of Melanoma Angiogenesis that Is Regulated by the Metastasis Suppressor BRMS1

  2010cites this paper
• EBNA3C Attenuates the Function of p53 through Interaction with Inhibitor of Growth Family Proteins 4 and 5

  2010influential citation
• Functional impact of cancer-associated mutations in the tumor suppressor protein ING4.

  2010cites this paper
• ROLE OF TUMOR SUPPRESSOR ING4 IN HUMAN CUTANEOUS MELANOMA PATHOGENESIS AND PROGRESSION

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• Cell cycle regulator ING4 is a suppressor of melanoma angiogenesis that is regulated by the metastasis suppressor BRMS1.

  2010cites this paper
• Inhibitor of growth tumor suppressors in cancer progression

  2010influential citation
• Down‐regulation of ING4 is associated with initiation and progression of lung cancer

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• Down-regulation of the inhibitor of growth family member 4 (ING4) in different forms of pulmonary fibrosis

  2009cites this paper
• ING4 mediates crosstalk between histone H3 K4 trimethylation and H3 acetylation to attenuate cellular transformation.

  2009cites this paper
• Potential usage of ING family members in cancer diagnostics and molecular therapy.

  2009cites this paper
• The return of the INGs, histone mark sensors and phospholipid signaling effectors.

  2009cites this paper
• Role of tumour suppressor ING3 in melanoma pathogenesis

  2009cites this paper
• Decreased Expression of Inhibitor of Growth 4 Correlated with Poor Prognosis of Hepatocellular Carcinoma

  2009influential citation
• Reviewing the current classification of inhibitor of growth family proteins

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  2007cites this paper
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• THE NEW TUMOR SUPPRESSOR GENE INHIBITOR OF GROWTH FAMILY MEMBER 4 (ING4) REGULATES THE PRODUCTION OF PRO-ANGIOGENIC MOLECULES BY MYELOMA CELLS AND SUPPRESSES HYPOXIA INDUCIBLE FACTOR (HIF)-1 α ACTIVITY BEING INVOLVED IN MYELOMA-INDUCED ANGIOGENESIS.

  2007influential citation
• Grow-ING, Age-ING and Die-ING: ING proteins link cancer, senescence and apoptosis.

  2006cites this paper