Role of ING4 in human melanoma cell migration, invasion and patient survival.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Carcinogenesis

• Publication date

  2008-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/carcin/bgn086PMID 18375955
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inhibitor of growth 4 suppresses cell spreading and cell migration by interacting with a novel binding partner, liprin alpha1.

  2007cited by this paper
• Prognostic Significance of Nuclear ING3 Expression in Human Cutaneous Melanoma

  2007cited by this paper
• Cancer Statistics, 2007

  2007cited by this paper
• The role of integrin-linked kinase in melanoma cell migration, invasion, and tumor growth

  2007influential reference
• Oncogene-induced senescence: putting the brakes on tumor development.

  2006cited by this paper
• Novel Splice Variants of ING4 and Their Possible Roles in the Regulation of Cell Growth and Motility*

  2006cited by this paper
• The novel tumor suppressor p33ING2 enhances nucleotide excision repair via inducement of histone H4 acetylation and chromatin relaxation.

  2006cited by this paper
• ING3 Promotes UV-induced Apoptosis via Fas/Caspase-8 Pathway in Melanoma Cells*

  2006cited by this paper
• Leucine zipper‐like domain is required for tumor suppressor ING2‐mediated nucleotide excision repair and apoptosis

  2006cited by this paper
• Nuclear ING2 expression is reduced in human cutaneous melanomas

  2006cited by this paper
• Diversity of cytogenetic and pathohistologic profiles in glioblastoma.

  2006cited by this paper
• The novel tumor suppressor p33ING2 enhances UVB-induced apoptosis in human melanoma cells.

  2005cited by this paper
• Meta-analysis of risk factors for cutaneous melanoma: I. Common and atypical naevi.

  2005cited by this paper
• Regulation of HIF by Prolyl hydroxylases: Recruitment of the Candidate Tumor Suppressor Protein ING4

  2005cited by this paper
• Frequent deletion and down-regulation of ING4, a candidate tumor suppressor gene at 12p13, in head and neck squamous cell carcinomas.

  2005cited by this paper
• The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF).

  2005cited by this paper
• Meta-analysis of risk factors for cutaneous melanoma: III. Family history, actinic damage and phenotypic factors.

  2005cited by this paper
• Meta-analysis of risk factors for cutaneous melanoma: II. Sun exposure.

  2005cited by this paper
• Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

  2005cited by this paper
• BRAFE600-associated senescence-like cell cycle arrest of human naevi

  2005cited by this paper
• Prognostic significance of activated Akt expression in melanoma: a clinicopathologic study of 292 cases.

  2005cited by this paper
• Drug Resistance in Melanoma: Mechanisms, Apoptosis, and New Potential Therapeutic Targets

  2004cited by this paper
• The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis

  2004influential reference
• ING4 induces G2/M cell cycle arrest and enhances the chemosensitivity to DNA‐damage agents in HepG2 cells

  2004cited by this paper
• Involvement of Rel/Nuclear Factor-κB Transcription Factors in Keratinocyte Senescence

  2004cited by this paper
• Mutations of the ING1 tumor suppressor gene detected in human melanoma abrogate nucleotide excision repair.

  2004cited by this paper
• A screen for genes that suppress loss of contact inhibition: identification of ING4 as a candidate tumor suppressor gene in human cancer.

  2004cited by this paper
• Adjuvant therapy for high‐risk primary and resected metastatic melanoma

  2003cited by this paper
• p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity.

  2003cited by this paper
• Apoptosis and melanoma chemoresistance

  2003cited by this paper
• Radiation therapy for malignant melanoma.

  2003cited by this paper
• p33(ING1) enhances UVB-induced apoptosis in melanoma cells.

  2002cited by this paper
• Nuclear to cytoplasmic compartment shift of the p33ING1b tumour suppressor protein is associated with malignancy in melanocytic lesions

  2002cited by this paper
• The tumor suppressor candidate p33(ING1) mediates repair of UV-damaged DNA.

  2001cited by this paper
• Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system.

  2001cited by this paper
• Matrix metalloproteinases in human melanoma.

  2000cited by this paper
• Chemotherapy-induced apoptosis in melanoma cells is p53 dependent

  1998cited by this paper
• Expression of gelatinase B and the extracellular matrix metalloproteinase inducer EMMPRIN in benign and malignant pigment cell lesions of the skin.

  1997cited by this paper
• Radiation therapy for malignant melanoma.

  1996cited by this paper
• MATRIX METALLOPROTEINASE‐2 (72 kD TYPE IV COLLAGENASE) EXPRESSION OCCURS IN THE EARLY STAGE OF HUMAN MELANOCYTIC TUMOUR PROGRESSION AND MAY HAVE PROGNOSTIC VALUE

  1996cited by this paper
• Prognosis and treatment of disseminated uveal melanoma

  1993cited by this paper
• [Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue].

  1987cited by this paper

• MicroRNA-650 promotes melanoma metastasis via targeting inhibitor of growth family member 4

  2024cites this paper
• MicroRNAs as the Critical Regulators of Forkhead Box Protein Family in Pancreatic, Thyroid, and Liver Cancers

  2023cites this paper
• Enhanced effect of recombinant adenoviruses co‐expression of ING4 and OSM on anti‐tumour activity of laryngeal cancer

  2022cites this paper
• Inhibitor of Growth 4 (ING4) Plays a Tumor-Repressing Role in Oral Squamous Cell Carcinoma via Nuclear Factor kappa-B (NF-kB)/DNA Methyltransferase 1 (DNMT1) Axis-Mediated Regulation of Aldehyde Dehydrogenase 1A2 (ALDH1A2).

  2022cites this paper
• Tumour Suppressors and ING Splice Variants as Coregulators of the Androgen Receptor Signalling in Prostate

  2021cites this paper
• ING Tumour Suppressors and ING Splice Variants as Coregulators of the Androgen Receptor Signalling in Prostate Cancer

  2021cites this paper
• Roles of the tumor suppressor inhibitor of growth family member 4 (ING4) in cancer.

  2021cites this paper
• CG7379 and ING1 suppress cancer cell invasion by maintaining cell–cell junction integrity

  2020cites this paper
• ING4 Expression Landscape and Association With Clinicopathologic Characteristics in Breast Cancer.

  2020cites this paper
• An Overview of promising Biomarkers in cancer screening and detection.

  2020cites this paper
• Rapamycin-upregulated miR-29b promotes mTORC1-hyperactive cell growth in TSC2-deficient cells by downregulating tumor suppressor retinoic acid receptor β (RARβ)

  2019cites this paper
• The essential role of tumor suppressor gene ING4 in various human cancers and non-neoplastic disorders

  2019cites this paper
• Inhibitor of growth 4 affects hypoxia‐induced migration and angiogenesis regulation in retinal pigment epithelial cells

  2019cites this paper
• ING4 suppresses hepatocellular carcinoma via a NF-κB/miR-155/FOXO3a signaling axis

  2019cites this paper
• Identification of the inhibitor of growth protein 4 (ING4) as a potential target in prostate cancer therapy

  2019cites this paper
• Inhibitor of growth 4 (ING4) inhibits hypoxia-induced EMT by decreasing HIF-1α and snail in HK2 cells.

  2019cites this paper
• NOVA1 acts as an oncogene in melanoma via regulating FOXO3a expression

  2018cites this paper
• MicroRNA-650 targets inhibitor of growth 4 to promote colorectal cancer progression via mitogen activated protein kinase signaling

  2018cites this paper
• Enhanced anti-melanoma efficacy of interferon α-2b via overexpression of ING4 by enhanced Fas/FasL-mediated apoptosis.

  2018cites this paper
• Overexpression of Inhibitor of Growth 4 Enhances Radiosensitivity in Non-Small Cell Lung Cancer Cell Line SPC-A1

  2017cites this paper
• The association of inhibitor of Growth 4 with its prognostic value in osteogenic sarcoma.

  2017cites this paper
• The prognostic significance of ING4 expression on gastric gastrointestinal stromal tumors by immunohistochemistry.

  2017cites this paper
• Role of inhibitor of growth 4 in the suppression of human melanoma cells through the Fas/FasL-mediated apoptosis pathway.

  2017cites this paper
• Melanoma Expression Genes Identified through Genome-Wide Association Study of Breslow Tumor Thickness.

  2017cites this paper
• The prognostic significance of ING4 expression on gastric gastrointestinal stromal tumors by immunohistochemistry.

  2017cites this paper
• Adenovirus-mediated co-expression of ING4 and PTEN cooperatively enhances their antitumor activity in human hepatocellular carcinoma cells.

  2016cites this paper
• Role of Genetics and Epigenetics in Mucosal, Uveal, and Cutaneous Melanomagenesis.

  2016cites this paper
• Adenovirus-mediated p53 and ING4 gene co-transfer elicits synergistic antitumor effects through enhancement of p53 acetylation in breast cancer.

  2016cites this paper
• Inhibitor of growth 4 suppresses colorectal cancer growth and invasion by inducing G1 arrest, inhibiting tumor angiogenesis and reversing epithelial-mesenchymal transition.

  2016cites this paper
• Reduced expression and prognostic implication of inhibitor of growth 4 in human osteosarcoma.

  2016cites this paper
• ING4 suppresses tumor angiogenesis and functions as a prognostic marker in human colorectal cancer

  2016cites this paper
• Co-expression of ING4 and P53 enhances hypopharyngeal cancer chemosensitivity to cisplatin in vivo

  2016cites this paper
• Anti-proliferative constituents from Selaginella pulvinata

  2016cites this paper
• ING4 Inhibits Proliferation and Induces Apoptosis in Human Melanoma A375 Cells via the Fas/Caspase-8 Apoptosis Pathway

  2016cites this paper
• Statins improve survival by inhibiting spontaneous metastasis and tumor growth in a mouse melanoma model.

  2015cites this paper
• Adenovirus-mediated ING4 Gene Transfer in Osteosarcoma Suppresses Tumor Growth via Induction of Apoptosis and Inhibition of Tumor Angiogenesis

  2015influential citation
• Adenovirus-mediated ING 4 / PTEN double tumor suppressor gene co-transfer modified by RGD enhances antitumor activity in human nasopharyngeal carcinoma cells

  2015cites this paper
• MicroRNA-650 in a copy number-variable region regulates the production of interleukin 6 in human osteosarcoma cells.

  2015cites this paper
• Adenovirus-mediated ING4/PTEN double tumor suppressor gene co-transfer modified by RGD enhances antitumor activity in human nasopharyngeal carcinoma cells.

  2015cites this paper
• Personalized Medicine: A Review with Regard to Biomarkers

  2015cites this paper
• ING4 enhances paclitaxel's effect on colorectal cancer growth in vitro and in vivo.

  2015cites this paper
• The Emerging Role of Inhibitor of Growth 4 as a Tumor Suppressor in Multiple Human Cancers

  2015cites this paper
• Synergistic tumor suppression by adenovirus-mediated ING4/PTEN double gene therapy for gastric cancer

  2015cites this paper
• PAQR3: a novel tumor suppressor gene.

  2015cites this paper
• PAQR 3 : a novel tumor suppressor gene

  2015cites this paper
• TRIB2 as a biomarker for diagnosis and progression of melanoma.

  2015cites this paper
• Adenovirus-mediated ING4 Gene Transfer in Osteosarcoma Suppresses Tumor Growth via Induction of Apoptosis and Inhibition of Tumor Angiogenesis

  2015influential citation
• eIF4E is an adverse prognostic marker of melanoma patient survival by increasing melanoma cell invasion.

  2015influential citation
• ING4 regulates a secretory phenotype in primary fibroblasts with dual effects on cell proliferation and tumor growth

  2014cites this paper
• The ING tumor suppressor genes: status in human tumors.

  2014cites this paper
• Delivery of inhibitor of growth 4 (ING4) gene significantly inhibits proliferation and invasion and promotes apoptosis of human osteosarcoma cells

  2014cites this paper
• Tissue prognostic biomarkers in primary cutaneous melanoma

  2014cites this paper
• Reduced ING1 levels in breast cancer promotes metastasis

  2014cites this paper
• Loss of XRCC1 confers a metastatic phenotype to melanoma cells and is associated with poor survival in patients with melanoma

  2014cites this paper
• Prognostic significance of KAI1/CD82 in human melanoma and its role in cell migration and invasion through the regulation of ING4.

  2014cites this paper
• Low ING4 protein expression detected by paraffin-section immunohistochemistry is associated with poor prognosis in untreated patients with gastrointestinal stromal tumors

  2013cites this paper
• RegulatING chromatin regulators: post-translational modification of the ING family of epigenetic regulators.

  2013cites this paper
• Prognostic significance of Fbw7 in human melanoma and its role in cell migration.

  2013cites this paper
• Tumor suppressor ING4 overexpression contributes to proliferation and invasion inhibition in gastric carcinoma by suppressing the NF-κB signaling pathway

  2013cites this paper
• Role of EIF5A2, a downstream target of Akt, in promoting melanoma cell invasion

  2013influential citation
• ING4 regulates JWA in angiogenesis and their prognostic value in melanoma patients

  2013influential citation
• The ING4 Binding with p53 and Induced p53 Acetylation were Attenuated by Human Papillomavirus 16 E6

  2013cites this paper
• Negative Regulation of NF-κB by the ING4 Tumor Suppressor in Breast Cancer

  2012cites this paper
• ING4 is negatively correlated with microvessel density in colon cancer

  2012cites this paper
• Novel Multiple Markers to Distinguish Melanoma from Dysplastic Nevi

  2012cites this paper
• Expression of inhibitor of growth 4 by HSV1716 improves oncolytic potency and enhances efficacy

  2012cites this paper
• Expression of Hypoxia-Inducible Factor (HIF)-1a-Vascular Endothelial Growth Factor (VEGF)-Inhibitory Growth Factor (ING)-4- axis in sarcoidosis patients

  2012cites this paper
• Inhibitor of growth-4 mediates chromatin modification and has a suppressive effect on tumorigenesis and innate immunity

  2012cites this paper
• Enhanced radiosensitivity of non-small-cell lung cancer (NSCLC) by adenovirus-mediated ING4 gene therapy

  2012cites this paper
• Identification of ING4 (Inhibitor of Growth 4) as a Modulator of Docetaxel Sensitivity in Human Lung Adenocarcinoma

  2012cites this paper
• Epigenetic Mechanisms in Commonly Occurring Cancers

  2012cites this paper
• PHF19 and Akt control the switch between proliferative and invasive states in melanoma

  2012cites this paper
• Effect of the tumor suppressor gene ING4 on the proliferation of MCF-7 human breast cancer cells.

  2012cites this paper
• Role of ING Family Genes in Head and Neck Cancer and Their Possible Applications in Cancer Diagnosis and Treatment

  2012influential citation
• Tissue-Based Protein Biomarkers in Melanoma: Immunohistochemistry: (B) Prognostication

  2012cites this paper
• Epigenetic Biomarkers in Melanoma

  2012cites this paper
• Role of Sox4 transcription factor in human cutaneous melanoma

  2012cites this paper
• Klinische Relevanz einer PPFIA1 Amplifikation im humanen Mammakarzinom

  2012cites this paper
• Identification of ING 4 ( Inhibitor of Growth 4 ) as a Modulator of Docetaxel Sensitivity in Human Lung Adenocarcinoma

  2012cites this paper
• Overexpression of α-enolase correlates with poor survival in canine mammary carcinoma

  2011cites this paper
• Enhanced tumor suppression by an ING4/IL-24 bicistronic adenovirus-mediated gene cotransfer in human non-small cell lung cancer cells

  2011cites this paper
• Downregulated Expression of Inhibitor of Growth 4 (ING4) in Advanced Colorectal Cancers: A Non-Randomized Experimental Study

  2011cites this paper
• Synergistic Tumor Suppression by Adenovirus-Mediated Inhibitor of Growth 4 and Interleukin-24 Gene Cotransfer in Hepatocarcinoma Cells

  2011cites this paper
• New Perspectives of “omics” Applications in Melanoma Research

  2011cites this paper
• Regulation of p53 by ING family members in suppression of tumor initiation and progression

  2011cites this paper
• Deletion of the inhibitor of growth 4 (ING4) tumor suppressor gene is prevalent in human epidermal growth factor 2 (HER2)-positive breast cancer.

  2011cites this paper
• Melanoma Prognosis: A REMARK-Based Systematic Review and Bioinformatic Analysis of Immunohistochemical and Gene Microarray Studies

  2011cites this paper
• Elevated Krüppel-like factor 4 transcription factor in canine mammary carcinoma

  2011cites this paper
• Patient outcome prediction using multiple biomarkers in human melanoma: A clinicopathological study of 118 cases.

  2011cites this paper
• Role of ING Family Tumor Suppressors in Breast Cancer

  2011cites this paper
• Is primary melanoma ulceration a factor of good response to adoptive immunotherapy?

  2011cites this paper
• Role of nanomedicine in reversing drug resistance mediated by ATP binding cassette transporters and P-glycoprotein in melanoma.

  2011cites this paper
• Downregulation and translocation of nuclear ING4 is correlated with tumorigenesis and progression of head and neck squamous cell carcinoma.

  2011cites this paper
• Down‐regulation of ING4 is associated with initiation and progression of lung cancer

  2010cites this paper
• Predictive and prognostic molecular markers for cancer medicine

  2010cites this paper
• Cell cycle regulator ING4 is a suppressor of melanoma angiogenesis that is regulated by the metastasis suppressor BRMS1.

  2010cites this paper
• ROLE OF TUMOR SUPPRESSOR ING4 IN HUMAN CUTANEOUS MELANOMA PATHOGENESIS AND PROGRESSION

  2010influential citation
• Inhibitor of growth tumor suppressors in cancer progression

  2010influential citation
• The tumor suppressor ING3 is degraded by SCFSkp2-mediated ubiquitin–proteasome system

  2010cites this paper
• Loss of Inhibitor of Growth (ING‐4) is Implicated in the Pathogenesis and Progression of Human Astrocytomas

  2010cites this paper