Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Free Radical Biology & Medicine

• Publication date

  2012-07-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.freeradbiomed.2012.05.007PMID 22618020PMCID PMC3392471
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase

  2012cited by this paper
• Pathogenesis of liver fibrosis.

  2011cited by this paper
• Control of Hepatic Nuclear Superoxide Production by Glucose 6-Phosphate Dehydrogenase and NADPH Oxidase-4*

  2011cited by this paper
• NOX1/nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase promotes proliferation of stellate cells and aggravates liver fibrosis induced by bile duct ligation

  2011cited by this paper
• Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors.

  2011cited by this paper
• The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91phox mediate hepatic fibrosis in mice

  2011cited by this paper
• Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases.

  2011cited by this paper
• First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis.

  2010influential reference
• Cell Death and Fibrogenesis

  2010cited by this paper
• Adenosine inhibits chemotaxis and induces hepatocyte‐specific genes in bone marrow mesenchymal stem cells

  2010cited by this paper
• Hepatocyte NAD(P)H oxidases as an endogenous source of reactive oxygen species during hepatitis C virus infection

  2010cited by this paper
• Reduced nicotinamide adenine dinucleotide phosphate oxidase 2 plays a key role in stellate cell activation and liver fibrogenesis in vivo.

  2010cited by this paper
• NADPH Oxidase-4 Mediates Myofibroblast Activation and Fibrogenic Responses to Lung Injury

  2009cited by this paper
• Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-kappaB-dependent pathways.

  2009cited by this paper
• The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-beta-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms.

  2009cited by this paper
• Mechanisms of hepatic fibrogenesis.

  2008cited by this paper
• Oxidative and nitrosative stress and fibrogenic response.

  2008cited by this paper
• Mechanisms of disease progression in nonalcoholic fatty liver disease.

  2008cited by this paper
• Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity.

  2008cited by this paper
• Gene expression profiles during hepatic stellate cell activation in culture and in vivo.

  2007cited by this paper
• Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas‐induced murine liver injury by altering Bcl‐2 proteins

  2006cited by this paper
• Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo

  2006cited by this paper
• Involvement of NADPH Oxidase Isoforms and Src Family Kinases in CD95-dependent Hepatocyte Apoptosis*

  2005cited by this paper
• Cytochrome P450 2E1-derived Reactive Oxygen Species Mediate Paracrine Stimulation of Collagen I Protein Synthesis by Hepatic Stellate Cells*

  2002cited by this paper
• [Mechanisms of hepatic fibrogenesis].

  2002cited by this paper
• Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c.

  2000influential reference
• Purification of rat hepatic stellate cells by side scatter–activated cell sorting

  1998cited by this paper
• Pathogenesis of liver fibrosis.

  1997cited by this paper

• NOX1/4 drives hepatic iron and lipid dysregulation, redox imbalance, and inflammation in ethanol-fed mice.

  2026cites this paper
• Reactive Oxygen Species-Mediated Mitochondrial-Targeted Therapeutics in Hepatic Disorders: Current Progress and Future Opportunities.

  2025cites this paper
• Mechanism-guided drug development and treatment for liver fibrosis: a clinical perspective

  2025cites this paper
• Targeting oxidative stress-mediated regulated cell death as a vulnerability in cancer

  2025cites this paper
• Nicotinamide Adenine Dinucleotide Phosphate Oxidases and Metabolic Dysfunction-Associated Steatotic Liver Disease

  2025cites this paper
• NOX4 mediates the renoprotection of remote ischemic preconditioning against acute kidney injury by inhibiting NF-κB signaling and tubular apoptosis.

  2025cites this paper
• Redox Modulation in Hepatic Fibrosis: Translating NOX1/4 Inhibition to Therapy

  2025cites this paper
• Basal release of 6-cyanodopamine in human vas deferens, a new endogenous catecholamine that enhances smooth muscle contractility.

  2025cites this paper
• 6-Cyanodopamine as an endogenous modulator of heart chronotropism and inotropism.

  2025cites this paper
• NADPH Oxidases: Redox Regulation of Cell Homeostasis & Disease.

  2025cites this paper
• NADPH Oxidase: A Potential Therapeutic Target to Reduce Primary Sclerosis Cholangitis Following Liver Transplantation.

  2025cites this paper
• Primary biliary cholangitis and the narrowing gap towards optimal disease control.

  2025cites this paper
• Mesenchymal stem cell and exosome-based therapy for liver diseases: can it overcome conventional therapeutic inconsistencies?

  2025cites this paper
• Molecular mechanisms of lncRNA NEAT1 in the pathogenesis of liver-related diseases, with special focus on therapeutic approaches.

  2025cites this paper
• Deciphering the role of LncRNA in alcoholic liver disease: Mechanisms and therapeutic potential

  2024cites this paper
• Ferroptosis in age-related vascular diseases: Molecular mechanisms and innovative therapeutic strategies.

  2024cites this paper
• Cannabidiol regulates the activation of hepatic stellate cells by modulating the NOX4 and NF-κB pathways.

  2024cites this paper
• NADPH oxidase 4 is dispensable for skin myofibroblast differentiation and wound healing

  2023cites this paper
• Setanaxib mitigates oxidative damage following retinal ischemia-reperfusion via NOX1 and NOX4 inhibition in retinal ganglion cells.

  2023cites this paper
• A Cyclodiaryliodonium NOX Inhibitor for the Treatment of Pancreatic Cancer via Enzyme‐Activatable Targeted Delivery by Sulfated Glycosaminoglycan Derivatives

  2023cites this paper
• Pre‐clinical evidence of a dual NADPH oxidase 1/4 inhibitor (setanaxib) in liver, kidney and lung fibrosis

  2023cites this paper
• Cellular heterogeneity and plasticity during NAFLD progression

  2023cites this paper
• Exosome-associated miRNA-99a-5p targeting BMPR2 promotes hepatocyte apoptosis during the process of hepatic fibrosis

  2023cites this paper
• Fibroblast growth factor 18 alleviates stress-induced pathological cardiac hypertrophy in male mice

  2023cites this paper
• Oxidative Stress in Liver Pathophysiology and Disease

  2023cites this paper
• Mitochondria- and NOX4-dependent antioxidant defense mitigates progression to nonalcoholic steatohepatitis in obesity

  2023cites this paper
• Novel Therapeutic Approaches to Liver Fibrosis Based on Targeting Oxidative Stress

  2023cites this paper
• A predicted structure of NADPH Oxidase 1 identifies key components of ROS generation and strategies for inhibition

  2023cites this paper
• Oxidative stress in Wernicke’s encephalopathy

  2023cites this paper
• Calcitriol Inhibits NaAsO2 Triggered Hepatic Stellate Cells Activation and Extracellular Matrix Oversecretion by Activating Nrf2 Signaling Pathway Through Vitamin D Receptor

  2023cites this paper
• Extracellular matrix remodelling in obesity and metabolic disorders

  2023cites this paper
• Role of Nox4 in Mitigating Inflammation and Fibrosis in Dextran Sulfate Sodium–Induced Colitis

  2023cites this paper
• Current investigations for liver fibrosis treatment: between repurposing the FDA-approved drugs and the other emerging approaches

  2023cites this paper
• Effects and potential mechanisms of IGF1/IGF1R in the liver fibrosis: A review.

  2023cites this paper
• Bacterial protease alleviate chronic liver fibrosis induced by thioacetamide through suppression of hepatic stellate cells consequently decrease its proliferative index.

  2023cites this paper
• Redox Biology and Liver Fibrosis

  2023cites this paper
• Setanaxib, a first‐in‐class selective NADPH oxidase 1/4 inhibitor for primary biliary cholangitis: A randomized, placebo‐controlled, phase 2 trial

  2023cites this paper
• Synergistic effects of combined treatment of 1,2-dichloroethane and high-dose ethanol on liver damage in mice and the related mechanisms.

  2023cites this paper
• Molecular Mechanism Pathways of Natural Compounds for the Treatment of Non-Alcoholic Fatty Liver Disease

  2023cites this paper
• S100A8-Mediated NLRP3 Inflammasome-Dependent Pyroptosis in Macrophages Facilitates Liver Fibrosis Progression

  2022cites this paper
• Isolation of biomedically important bioactive compounds from Debregeasia salicifolia with extraordinary antioxidant potential hepato-protectivity

  2022cites this paper
• NOX as a Therapeutic Target in Liver Disease

  2022influential citation
• Evaluate the benefit effects of Dodonaea viscosa in kidney of infected rats with Staphylococcus aureus

  2022cites this paper
• Aucubin ameliorates liver fibrosis and hepatic stellate cells activation in diabetic mice via inhibiting ER stress-mediated IRE1α/TXNIP/NLRP3 inflammasome through NOX4/ROS pathway.

  2022cites this paper
• Primary biliary cholangitis as a roadmap for the development of novel treatments of cholestatic liver diseases.

  2022cites this paper
• When healing turns into killing – the pathophysiology of pancreatic and hepatic fibrosis

  2022cites this paper
• Established new compound IMB16-4 self-emulsifying drug delivery systems for increasing oral bioavailability and enhancing anti-hepatic fibrosis effect.

  2022cites this paper
• Targeting Oxidative Stress as a Therapeutic Approach for Idiopathic Pulmonary Fibrosis

  2022cites this paper
• NOX4 inhibition promotes the remodeling of dystrophic muscle

  2022cites this paper
• Novel Insights into Alcoholic Liver Disease: Iron Overload, Iron Sensing and Hemolysis

  2022cites this paper
• Label-free and non-destructive identification of naïve and primed embryonic stem cells based on differences in cellular metabolism.

  2022cites this paper
• Pathways Linking Nicotinamide Adenine Dinucleotide Phosphate Production to Endoplasmic Reticulum Protein Oxidation and Stress

  2022cites this paper
• Integrative transcriptomic and proteomic analysis reveals mechanisms of silica-induced pulmonary fibrosis in rats

  2022cites this paper
• Forsythiaside A Regulates Activation of Hepatic Stellate Cells by Inhibiting NOX4-Dependent ROS

  2022cites this paper
• Oxidative Stress Induced by Reactive Oxygen Species (ROS) and NADPH Oxidase 4 (NOX4) in the Pathogenesis of the Fibrotic Process in Systemic Sclerosis: A Promising Therapeutic Target

  2021cites this paper
• Novel Therapeutic Targets in Liver Fibrosis

  2021cites this paper
• Liver Fibrosis: Therapeutic Targets and Advances in Drug Therapy

  2021cites this paper
• The TGF-β/NADPH Oxidases Axis in the Regulation of Liver Cell Biology in Health and Disease

  2021cites this paper
• Determination of in vivo biological activities of Dodonaea viscosa flowers against CCL4 toxicity in albino mice with bioactive compound detection

  2021cites this paper
• Inflammasome as an Effective Platform for Fibrosis Therapy

  2021cites this paper
• The pathogenesis, models and therapeutic advances of primary biliary cholangitis.

  2021cites this paper
• Schisandrin B Protects against Acute Ethanol-Induced Cardiac Injury by Downregulating Autophagy via the NOX4/ROS Pathway

  2021cites this paper
• NAMPT-mediated NAD+ biosynthesis suppresses activation of hepatic stellate cells and protects against CCl4-induced liver fibrosis in mice

  2021cites this paper
• Pathophysiology and Therapeutic Potential of NADPH Oxidases in Ischemic Stroke-Induced Oxidative Stress

  2021cites this paper
• Backstage players of fibrosis: NOX4, mTOR, HDAC, and S1P; companions of TGF-β.

  2021cites this paper
• NOX4: a potential therapeutic target for pancreatic cancer and its mechanism

  2021cites this paper
• Oxidative Stress Is a Key Modulator in the Development of Nonalcoholic Fatty Liver Disease

  2021cites this paper
• CMAR_A_240719 3915..3925

  2020cites this paper
• NOX1 inhibition attenuates the development of a pro‐tumorigenic environment in experimental hepatocellular carcinoma

  2020cites this paper
• NADPH oxidase 4 (Nox4) deletion accelerates liver regeneration in mice

  2020cites this paper
• NADPH oxidase 1 inhibition attenuates platelet activation and thrombosis in vivo without affecting haemostasis

  2020cites this paper
• The Apelin–Apelin Receptor Axis Triggers Cholangiocyte Proliferation and Liver Fibrosis During Mouse Models of Cholestasis

  2020cites this paper
• NADPH oxidase 1 is a novel pharmacological target for the development of an antiplatelet drug without bleeding side effects

  2020cites this paper
• Liver fibrosis: Pathophysiology and clinical implications

  2020cites this paper
• NADPH oxidase 4 is protective and not fibrogenic in intestinal inflammation

  2020cites this paper
• Ursolic acid reverses liver fibrosis by inhibiting interactive NOX4/ROS and RhoA/ROCK1 signalling pathways

  2020cites this paper
• miR‐322 treatment rescues cell apoptosis and neural tube defect formation through silencing NADPH oxidase 4

  2020cites this paper
• SIRT1–NOX4 signaling axis regulates cancer cachexia

  2020cites this paper
• A comparative analysis of interferons and direct‐acting antivirals on the expression of genes involved in hepatitis C pathogenesis

  2020cites this paper
• Fibroproliferative disorders and diabetes: Understanding the pathophysiologic relationship between Peyronie’s disease, Dupuytren disease and diabetes

  2020cites this paper
• Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives

  2020cites this paper
• Mechanisms of liver fibrosis and its role in liver cancer

  2020cites this paper
• Redox distress in organ fibrosis: The role of noncoding RNAs

  2020cites this paper
• Inhibiting the Activity of NADPH Oxidase in Cancer

  2020cites this paper
• Anti-fibrotic treatments for chronic liver diseases: The present and the future

  2020cites this paper
• Mechanism of the Regulatory Effect of Overexpression of circMTO1 on Proliferation and Apoptosis of Hepatoma Cells via miR-9-5p/NOX4 Axis

  2020cites this paper
• CSF‐1 in Osteocytes Inhibits Nox4‐mediated Oxidative Stress and Promotes Normal Bone Homeostasis

  2020cites this paper
• New Therapeutic Targets in Autoimmune Cholangiopathies

  2020cites this paper
• NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets

  2019cites this paper
• Resveratrol slows cell growth by targeting the Warburg effect and stimulating mitochondria metabolism

  2019cites this paper
• NADPH Oxidases and Aging Models of Lung Fibrosis.

  2019cites this paper
• Plumbagin ameliorates liver fibrosis via a ROS-mediated NF-кB signaling pathway in vitro and in vivo.

  2019cites this paper
• NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice.

  2019cites this paper
• Long non-coding RNA H19, a negative regulator of microRNA-148b-3p, participates in hypoxia stress in human hepatic sinusoidal endothelial cells via NOX4 and eNOS/NO signaling.

  2019cites this paper
• Inhibitory Effect of Sestrin 2 on Hepatic Stellate Cell Activation and Liver Fibrosis

  2019cites this paper
• Protein tyrosine phosphatase 1b deficiency protects against hepatic fibrosis by modulating nadph oxidases

  2019cites this paper
• Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis

  2019cites this paper
• Acute Changes in NADPH Oxidase 4 in Early Post‐Traumatic Osteoarthritis

  2019cites this paper
• Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation

  2019cites this paper
• Interaction Mechanisms Between the NOX4/ROS and RhoA/ROCK1 Signaling Pathways as New Anti- fibrosis Targets of Ursolic Acid in Hepatic Stellate Cells

  2019cites this paper