A thermodynamic model for receptor clustering.

Intracellular signaling often arises from ligand-induced oligomerization of cell surface receptors. This oligomerization or clustering process is fundamentally a cooperative behavior between near-neighbor receptor molecules; the properties of this cooperative process clearly affect the signal transduction. Recent investigations have revealed the molecular basis of receptor-receptor interactions, but a simple theoretical framework for using these data to predict cluster formation has been lacking. Here, we propose a simple, coarse-grained, phenomenological model for ligand-modulated receptor interactions and discuss its equilibrium properties via mean-field theory. The existence of a first-order transition for this model has immediate implications for the robustness of the cellular signaling response.

• Publication year

  1999

• Venue

  Biophysical Journal

• Publication date

  1999-08-06

• Fields of study

  Biology, Medicine, Physics, Chemistry

• Identifiers
  DOI 10.1016/S0006-3495(99)77073-6arXiv cond-mat/9908106PMID 10545339PMCID PMC1300513
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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