Substance P reduces tail‐flick latency: Implications for chronic pain syndromes

No abstract is available for this paper.

• Publication year

  1982

• Venue

  Pain

• Publication date

  1982-10-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/0304-3959(82)90096-3PMID 6184663
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Elevated csf level of substance p in arachnoiditis is reduced by systemic administration of morphine

  1981cited by this paper
• Diurnal rhythm in sensitivity of a nociceptive spinal reflex.

  1981cited by this paper
• Design for an inexpensive unit for measuring tail flick latencies.

  1981cited by this paper
• Diurnal variation in excitation of dorsal horn units by naloxone in the spinal cat suggests a circulating opioid factor.

  1981cited by this paper
• A re-evaluation of the neurochemical and antinociceptive effects of intrathecal capsaicin in the rat.

  1981cited by this paper
• Behavioral evidence that substance P may be a spinal cord sensory neurotransmitter.

  1981cited by this paper
• Substance P: does it produce analgesia or hyperalgesia?

  1980cited by this paper
• Neurotoxic action of capsaicin on spinal substance P neurons.

  1980cited by this paper
• Substance P and pain: an updating

  1980cited by this paper
• Effects of capsaicin on nociceptive heat, pressure and chemical thresholds and on substance P levels in the rat.

  1980cited by this paper
• Effects of substance P on nociceptive and non‐nociceptive trigeminal brain stem neurons

  1980cited by this paper
• Morphine does not antagonize the substance P mediated excitation of dorsal horn neurons.

  1980cited by this paper
• Responses of spinal neurones to a substance P analogue, noxious pinch and bradykinin.

  1980cited by this paper
• Supersensitivity to substance P after dorsal root section.

  1979cited by this paper
• Substance P-induced analgesia in the rat.

  1979cited by this paper
• Self-mutilation after dorsal rhizotomy in rats: effects of prior pain and pattern of root lesions.

  1979cited by this paper
• Failure of substance P to produce analgesia in the mouse [proceedings].

  1979cited by this paper
• Lack of analgesic activity of substance P following intraperitoneal administration.

  1979cited by this paper
• The production and prevention of experimental anesthesia dolorosa

  1979cited by this paper
• Nociceptive threshold after neonatal capsaicin treatment.

  1979cited by this paper
• Effects of intrathecal and intracerebroventricular injections of substance P on nociception in the rat and mouse [proceedings].

  1979cited by this paper
• Substance P effects on spinal nociceptive neurones.

  1979cited by this paper
• Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia.

  1979cited by this paper
• The Action of Substance P on Motoneurons of the Isolated Rat Spinal Cord

  1979cited by this paper
• Analgesic activity of substance P following intracerebral administration in rats.

  1978cited by this paper
• Behavioural depressant and antinociceptive properties of substance P in the mouse: possible implication of brain monoamines.

  1978cited by this paper
• Modulation of acetylcholine metabolism in the hippocampal cholinergic pathway by intraseptally injected substance P.

  1978cited by this paper
• Enkephalin and substance P effects related to trigeminal pain.

  1978cited by this paper
• Elimination of substance P from the circulation of the rat and its inhibition by bacitracin

  1978cited by this paper
• Supersensitivity to a substance P analogue following dorsal root section.

  1978cited by this paper
• Functional identification of units in the rat dorsal horn responding to a substance P analogue [proceedings].

  1978cited by this paper
• Diurnal variation in sensory and pain thresholds correlated with mood states.

  1978cited by this paper
• Capsaicin-induced depletion of substance P from primary sensory neurones.

  1978cited by this paper
• Diurnal changes in serotonin content of frontal pole and pain sensitivity in the rat.

  1978cited by this paper
• Dual actions of substance P on nociception: possible role of endogenous opioids.

  1978cited by this paper
• 312 – A STUDY OF THE RESPONSE OF GUINEA PIG ILEUM TO SUBSTANCE P, ENKEPHALIN AND MORPHINE

  1978cited by this paper
• 311 – MECHANISM OF ACTION OF SUBSTANCE P IN MYENTERIC NEURONES

  1978cited by this paper
• Functional identification of units in the rat dorsal horn responding to a substance P analogue [proceedings].

  1978cited by this paper
• Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones

  1977cited by this paper
• Opiate analgesics inhibit substance P release from rat trigeminal nucleus

  1977cited by this paper
• Effect of substance P in cat dorsal horn neurones activated by noxious stimuli.

  1977cited by this paper
• Substance P and analgesia

  1976cited by this paper
• Release of substance P-like immunoreactivity from isolated spinal cord of newborn rat

  1976cited by this paper
• Chronic catheterization of the spinal subarachnoid space.

  1976cited by this paper
• Effects of substance P on functionally identified units in cat spinal cord.

  1976cited by this paper
• Effect of peptides and amino acids on dihydromorphine binding to the opiate receptor

  1975cited by this paper
• Experimental immunohistochemical studies on the localization and distribution of substance P in cat primary sensory neurons.

  1975cited by this paper
• Effects of central lesions on disorders produced by multiple dorsal rhizotomy in rats.

  1974cited by this paper
• The effects of substance P and other peptides on spinal neurons of the frog.

  1974cited by this paper
• Pharmacological analysis of central actions of synthetic substance P.

  1973cited by this paper
• Studies on the cutaneous pricking pain threshold in man. Circadian and circatrigintan changes.

  1970cited by this paper
• Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin.

  1967cited by this paper
• CONTRIBUTION TO THE THEORY THAT SUBSTANCE P HAS A TRANSMITTER ROLE IN SENSITIVE PATHWAY.

  1964cited by this paper
• Tranquilizing Effect of “Substance P”

  1959cited by this paper

• Chronic Migraine Pathophysiology and Treatment: A Review of Current Perspectives

  2021cites this paper
• Mice with neuropathic pain exhibit morphine tolerance due to a decrease in the morphine concentration in the brain.

  2016cites this paper
• Cerebrolysin improves sciatic nerve dysfunction in a mouse model of diabetic peripheral neuropathy

  2016cites this paper
• Differences in electrophysiological properties of functionally identified nociceptive sensory neurons in an animal model of cancer-induced bone pain

  2016cites this paper
• Evaluation of the Neurokinin-1 receptor knockout mouse model of Attention Deficit Hyperactivity Disorder

  2013cites this paper
• Schwann Cell Proliferation and Macrophage Infiltration Are Evident at Day 14 after Painful Cervical Nerve Root Compression in the Rat

  2011cites this paper
• Models and mechanisms of hyperalgesia and allodynia.

  2009cites this paper
• Intrathecal substance P augments morphine-induced antinociception: possible relevance in the production of substance P N-terminal fragments.

  2009cites this paper
• Pregabalin and gabapentin inhibit substance P‐induced NF‐κB activation in neuroblastoma and glioma cells

  2008cites this paper
• The intracerebroventricular kainic acid-induced damage affects animal nociceptive behavior.

  2007cites this paper
• Contribution of Substance P and Neurokinin A to the Differential Injury-Induced Thermal and Mechanical Responsiveness of Lamina I and V Neurons

  2007cites this paper
• Central pharmacology of nociceptive transmission

  2006cites this paper
• Farmacología central de la transmisión nociceptiva

  2006cites this paper
• Role of Heteromeric GPCR Interactions in Pain/Analgesia

  2005cites this paper
• Mechanisms of nociception evoked by intrathecal high-dose morphine.

  2005cites this paper
• Attenuation of nociception in a model of acute pancreatitis by an NK-1 antagonist.

  2004cites this paper
• Pregabalin and gabapentin reduce release of substance P and CGRP from rat spinal tissues only after inflammation or activation of protein kinase C

  2003cites this paper
• Functional role of exogenous administration of substance P in chronic constriction injury model of neuropathic pain in gerbils.

  2003cites this paper
• Excitatory amino acid receptors implicated in neuropathic pain: the role of receptor phosphorylation and adapter proteins

  2002cites this paper
• The relationship between resting blood pressure and acute pain sensitivity in healthy normotensives and chronic back pain sufferers: the effects of opioid blockade

  2002cites this paper
• Antinociceptive effect following dietary-induced thiamine deficiency in mice: involvement of substance P and somatostatin.

  2001cites this paper
• Antinociceptive profiles of aspirin and acetaminophen in formalin, substance P and glutamate pain models.

  2001cites this paper
• Differential roles of spinal cholera toxin- and pertussis toxin-sensitive G proteins in nociceptive responses caused by formalin, capsaicin, and substance P in mice.

  2001cites this paper
• Elevated substance-P-like immunoreactivity levels in spinal dialysates during the formalin test in normal and diabetic rats.

  2000cites this paper
• In vitro prostanoid release from spinal cord following peripheral inflammation: effects of substance P, NMDA and capsaicin

  1999influential citation
• Spinal neurokin3 receptors facilitate the nociceptive flexor reflex via a pathway involving nitric oxide.

  1999cites this paper
• Transgenic mice over-expressing substance P exhibit allodynia and hyperalgesia which are reversed by substance P and N-methyl-D-aspartate receptor antagonists.

  1999cites this paper
• Vanilloid (Capsaicin) receptors and mechanisms.

  1999cites this paper
• Cyclic AMP Regulates the Expression of Neurokinin1 Receptors by Neonatal Rat Spinal Neurons in Culture

  1999cites this paper
• Evidence for Tonic Activation of NK-1 Receptors during the Second Phase of the Formalin Test in the Rat

  1999cites this paper
• Intrathecal substance P-induced thermal hyperalgesia and spinal release of prostaglandin E2 and amino acids.

  1999cites this paper
• The role of VIP/PACAP receptor subtypes in spinal somatosensory processing in rats with an experimental peripheral mononeuropathy.

  1999cites this paper
• Involvement of tachykinin NK1 receptors in nociceptin-induced hyperalgesia in mice.

  1999cites this paper
• Sensitization of pain pathways in the spinal cord: cellular mechanisms.

  1998cites this paper
• The effects of SDZ NKT 343, a potent NK1 receptor antagonist, on cutaneous responses of primate spinothalamic tract neurones sensitized by intradermal capsaicin injection

  1998cites this paper
• Spinal Neurokinin NK1 Receptor Down‐Regulation and Antinociception: Effects of Spinal NK1 Receptor Antisense Oligonucleotides and NK1 Receptor Occupancy

  1998cites this paper
• Mechanism of action of nonsteroidal anti-inflammatory drugs.

  1998cites this paper
• Substance P transmitter or regulator in spinal sensory mechanisms

  1998cites this paper
• The nonpeptide NK-1 receptor antagonists LY303870 and LY306740 block the responses of spinal dorsal horn neurons to substance P and to peripheral noxious stimuli.

  1998cites this paper
• Substance P release in the rat periaqueductal gray and preoptic anterior hypothalamus after noxious cold stimulation: effect of selective mu and kappa opioid agonists.

  1997cites this paper
• LY303870, a centrally active neurokinin-1 antagonist with a long duration of action.

  1997cites this paper
• Differential roles of neurokinin 1 and neurokinin 2 receptors in the development and maintenance of heat hyperalgesia induced by acute inflammation

  1997cites this paper
• Antinociceptive involvement of substance P in the spinal cord of mice: dose effects of substance P on the behavior elicited by intrathecally administered NMDA.

  1997cites this paper
• Neurokinin Receptor Antagonists

  1997cites this paper
• Tachykinins: Central and Peripheral Effects

  1997cites this paper
• Thermal hyperalgesia in rat evoked by intrathecal substance P at multiple stimulus intensities reflects an increase in the gain of nociceptive processing.

  1996cites this paper
• The role of adenosine in spinal opioid antinociception.

  1996cites this paper
• Spinally-mediated behavioural responses evoked by intrathecal high-dose morphine: possible involvement of substance P in the mouse spinal cord.

  1996cites this paper
• SR 48968 specifically depresses neurokinin A- vs. substance P-induced hyperalgesia in a nociceptive withdrawal reflex.

  1996cites this paper
• Zusammenfassung: Spinale Schmerzverarbeitung

  1996cites this paper
• Kappa-opioid receptor modulation of the release of substance P in the dorsal horn.

  1996cites this paper
• Neurokinin actions on substantia gelatinosa neurones in an adult longitudinal spinal cord preparation.

  1995cites this paper
• Plasticity in the synthesis and storage of substance P and calcitonin gene-related peptide in primary afferent neurons during peripheral inflammation.

  1995cites this paper
• Antagonism of nociceptive responses of cat spinal dorsal horn neurons in vivo by the NK-1 receptor antagonists CP-96,345 and CP-99,994, but not by CP-96,344.

  1995cites this paper
• Central antinociceptive effects of non‐steroidal anti‐inflammatory drugs and paracetarmol

  1995cites this paper
• Noxious peripheral stimulation produces antinociception mediated via substance P and opioid mechanisms in the rat tail-flick test.

  1995cites this paper
• Physiological and pharmacological characterization of the spinal tachykinin NK2 receptor.

  1994cites this paper
• Cellular Mechanisms of Sensory Processing

  1994cites this paper
• Hyperalgesia Following Noxious Thermal, Mechanical, or Chemical Stimulation Involves Overlapping Spinal Mechanisms and Interactive Participation of Excitatory Amino Acids and Neuropeptides

  1994cites this paper
• Illness-induced hyperalgesia is mediated by spinal neuropeptides and excitatory amino acids.

  1994cites this paper
• Synaptic Activation by the Release of Peptides

  1994cites this paper
• Physiological roles for adenosine and ATP in synaptic transmission in the spinal dorsal horn.

  1993cites this paper
• Antinociception induced by CP 96,345, a non-peptide NK-1 receptor antagonist, in the mouse formalin and capsaicin tests.

  1993cites this paper
• Antinociceptive effects in the formalin and capsaicin tests after intrathecal administration of substance P analogues in mice.

  1993cites this paper
• Substance P markedly potentiates the antinociceptive effects of morphine sulfate administered at the spinal level.

  1993cites this paper
• Neural mediation of the cardiovascular responses to intrathecal administration of substance P in the rat: slowing of the cardioacceleration by an adrenal opioid factor.

  1993cites this paper
• CP-96,345, but not its stereoisomer, CP-96,344, blocks the nociceptive responses to intrathecally administered substance P and to noxious thermal and chemical stimuli in the rat.

  1993cites this paper
• Substance P-like Immunoreactivity and Analgesic Effects of Vibratory Stimulation on Patients Suffering From Chronic Pain

  1993cites this paper
• Spinal mediators of nociceptive neurotransmission and hyperalgesia

  1993cites this paper
• Antinociceptive activity of NK1 receptor antagonists: non‐specific effects of racemic RP67580

  1993cites this paper
• Substance P receptor desensitization in the dorsal horn: possible involvement of receptor-G protein complexes.

  1993cites this paper
• Intrathecal CP-96,345 blocks reflex facilitation induced in rats by substance P and C-fiber-conditioning stimulation.

  1992cites this paper
• Autoradiographic analysis of 125I-substance P binding in rat spinal cord following chronic constriction injury of the sciatic nerve.

  1992cites this paper
• Adenosine receptor link in an adrenal opioid-induced antinociception in the rat tail-flick test.

  1992cites this paper
• Participation of substance P in spinal physiological responses to peripheral aversive stimulation.

  1992cites this paper
• Bombesin, neuromedin C and neuromedin B given intrathecally facilitate the tail flick reflex in the rat.

  1992cites this paper
• Administration of AP5, a glutamate antagonist, unmasks glycine analgesic actions in the rat.

  1992cites this paper
• Effects of dorsal rhizotomy on neurokinin receptor sub-types in the rat spinal cord: a quantitative autoradiographic study.

  1991cites this paper
• Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model

  1991cites this paper
• Opioid and neurokinin activities of substance P fragments and their analogs.

  1991cites this paper
• Responses of functionally identified neurones in the dorsal horn of the cat spinal cord to substance P, neurokinin A and physalaemin.

  1991cites this paper
• Pharmacology of spinal peptides affecting sensory and motor functions: dynorphins, somatostatins and tachykinins.

  1991cites this paper
• Stereospecific effects of a nonpeptidic NK1 selective antagonist, CP-96,345: antinociception in the absence of motor dysfunction.

  1991cites this paper
• On the role of NK-2 tachykinin receptors in the mediation of spinal reflex excitability in the rat.

  1991cites this paper
• NMDA receptor antagonist blocks the facilitation of the tail flick reflex in the rat induced by intrathecal administration of substance P and by noxious cutaneous stimulation.

  1991cites this paper
• Novel substance P antagonist, CP-96,345, blocks responses of cat spinal dorsal horn neurons to noxious cutaneous stimulation and to substance P.

  1991cites this paper
• Streptozotocin-induced diabetes in mice reduces the nociceptive threshold, as recognized after application of noxious mechanical stimuli but not of thermal stimuli.

  1991cites this paper
• Differential effects of substance P analogs on neurokinin 1 receptor agonists in the mouse spinal cord.

  1991cites this paper
• Correlation of substance P-induced desensitization with substance P amino terminal metabolites in the mouse spinal cord.

  1990cites this paper
• The involvement of neurokinin receptor subtypes in somatosensory processing in the superficial dorsal horn of the cat.

  1990cites this paper
• The effects of substance P analogues on the scratching, biting and licking response induced by intrathecal injection of N‐methyl‐d‐aspartate in mice

  1990cites this paper
• Roles of substance P and somatostatin on transmission of nociceptive information induced by formalin in spinal cord.

  1990cites this paper
• Quantitative autoradiographic distribution of multiple neurokinin binding sites in rat spinal cord.

  1990cites this paper
• Effects of intrathecal substance P and a substance P antagonist on a reflex to noxious heat are independent of changes in tail skin temperature.

  1990cites this paper
• Evidence that substance P selectively modulates C-fiber-evoked discharges of dorsal horn nociceptive neurons.

  1990cites this paper
• Substance P and peripheral inflammatory hyperalgesia

  1989cites this paper
• Intrathecal administration of CGRP in the rat attenuates a facilitation of the tail flick reflex induced by either substance P or noxious cutaneous stimulation.

  1989cites this paper
• Algesia and local responses induced by neurokinin A and substance P in human skin and temporal muscle.

  1989cites this paper
• Thyrotropin-Releasing Hormone Given Intrathecally to the Rat Increases Arterial Pressure and Heart Rate

  1989cites this paper
• Subsensitivity to substance P in SART-stressed mice.

  1989cites this paper