Increased Coupled Gating of L-Type Ca2+ Channels During Hypertension and Timothy Syndrome

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Circulation Research

• Publication date

  2010-03-05

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/CIRCRESAHA.109.213363PMID 20110531PMCID PMC2834417
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Robust approaches to quantitative ratiometric FRET imaging of CFP/YFP fluorophores under confocal microscopy

  2009cited by this paper
• L-type voltage-dependent Ca2+ channels mediate expression of presynaptic LTP in amygdala

  2009cited by this paper
• Crystal structure of dimeric cardiac L-type calcium channel regulatory domains bridged by Ca2+·calmodulins

  2009cited by this paper
• The control of Ca2+ influx and NFATc3 signaling in arterial smooth muscle during hypertension

  2008cited by this paper
• Partners in crime: how two Sox proteins cooperate to specify arterial fate.

  2008cited by this paper
• AKAP150 Is Required for Stuttering Persistent Ca2+ Sparklets and Angiotensin II–Induced Hypertension

  2008cited by this paper
• AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling.

  2007cited by this paper
• Calcium Green FlAsH as a genetically targeted small-molecule calcium indicator.

  2007cited by this paper
• Cav1.3 channels produce persistent calcium sparklets, but Cav1.2 channels are responsible for sparklets in mouse arterial smooth muscle

  2007cited by this paper
• Ca(v)1.3 channels produce persistent calcium sparklets, but Ca(v)1.2 channels are responsible for sparklets in mouse arterial smooth muscle.

  2007cited by this paper
• Rapid Chemically Induced Changes of PtdIns(4,5)P2 Gate KCNQ Ion Channels

  2006cited by this paper
• Mechanisms Underlying Heterogeneous Ca2+ Sparklet Activity in Arterial Smooth Muscle

  2006cited by this paper
• The C terminus of the L-type voltage-gated calcium channel Ca(V)1.2 encodes a transcription factor.

  2006cited by this paper
• Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices.

  2006cited by this paper
• Constitutively active L-type Ca2+ channels.

  2005cited by this paper
• “Optical Patch-clamping”: Single-channel Recording by Imaging Ca 2 (cid:1) Flux through Individual Muscle Acetylcholine Receptor Channels

  2005cited by this paper
• “Optical Patch-clamping”

  2005cited by this paper
• High Blood Pressure Upregulates Arterial L-Type Ca2+ Channels Is Membrane Depolarization the Signal?

  2004cited by this paper
• Imaging the activity and localization of single voltage-gated Ca(2+) channels by total internal reflection fluorescence microscopy.

  2004cited by this paper
• Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism.

  2004cited by this paper
• Ca 2 + Currents in Cerebral Artery Smooth Muscle Cells of Rat at Physiological Ca 2 + Concentrations

  2003cited by this paper
• Imaging the localized protein interactions between Pit-1 and the CCAAT/enhancer binding protein alpha in the living pituitary cell nucleus.

  2003cited by this paper
• Measurement of cytoplasmic calcium concentration in the rods of wild‐type and transducin knock‐out mice

  2002cited by this paper
• Ca2+ signalling between single L-type Ca2+ channels and ryanodine receptors in heart cells

  2001cited by this paper
• Coupled Gating Between Cardiac Calcium Release Channels (Ryanodine Receptors)

  2001cited by this paper
• Preassociation of calmodulin with voltage-gated Ca(2+) channels revealed by FRET in single living cells.

  2001cited by this paper
• β-Adrenergic Receptor Subtype-Specific Signaling in Cardiac Myocytes from β1 and β2 Adrenoceptor Knockout Mice

  2001cited by this paper
• Beta-adrenergic receptor subtype-specific signaling in cardiac myocytes from beta(1) and beta(2) adrenoceptor knockout mice.

  2001cited by this paper
• Estimating intracellular calcium concentrations and buffering without wavelength ratioing.

  2000cited by this paper
• Amplitude distribution of calcium sparks in confocal images: theory and studies with an automatic detection method.

  1999cited by this paper
• Calmodulin supports both inactivation and facilitation of L-type calcium channels

  1999cited by this paper
• Shape, size, and distribution of Ca(2+) release units and couplons in skeletal and cardiac muscles.

  1999cited by this paper
• Selective activation of Ca2+-activated K+ channels by co-localized Ca2+ channels in hippocampal neurons

  1998cited by this paper
• cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits.

  1997cited by this paper
• Inducible gene expression and protein translocation using nontoxic ligands identified by a mammalian three-hybrid screen.

  1997cited by this paper
• Relation between the sarcolemmal Ca2+ current and Ca2+ sparks and local control theories for cardiac excitation-contraction coupling.

  1996cited by this paper
• Coordination of Three Signaling Enzymes by AKAP79, a Mammalian Scaffold Protein

  1996cited by this paper
• Coupled Markov chain model: characterization of membrane channel currents with multiple conductance sublevels as partially coupled elementary pores.

  1996cited by this paper
• Ca2+ currents in cerebral artery smooth muscle cells of rat at physiological Ca2+ concentrations

  1996cited by this paper
• Fluorescence resonance energy transfer.

  1995cited by this paper
• Mechanism of Ca(2+)-sensitive inactivation of L-type Ca2+ channels.

  1994cited by this paper
• Effect of membrane potential changes on the calcium transient in single rat cardiac muscle cells.

  1987cited by this paper
• Ca 2 + signalling between single L-type Ca 2 + channels and ryanodine receptors in heart cells

  year unknowncited by this paper

• Allosteric coupling of RyR calcium channels: Is it relevant to the [patho]physiology of heart and muscle?

  2026cites this paper
• Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights.

  2026cites this paper
• Blood Pressure Regulates Functional Coupling of L-Type Ca2+ Channels: Reimaging the Foundation of Cerebral Blood Flow Control

  2026cites this paper
• 14-3-3 promotes sarcolemmal expression of cardiac CaV1.2 and nucleates isoproterenol-triggered channel superclustering

  2025cites this paper
• Amyloid β alters vascular CaV1.2 channel spatiotemporal properties.

  2025cites this paper
• Disrupted Binding Dynamics of the CaMD130G Mutant to Cav1.2 Channels: Implications for Long QT Syndrome Pathogenesis.

  2025cites this paper
• Blood pressure variability compromises vascular function in middle-aged mice

  2025cites this paper
• Ca2+ microdomain-based excitation-transcription coupling in cardiac myocytes and vascular smooth muscle cells

  2025influential citation
• Long AKAP18 isoforms anchor ubiquitin specific proteinases and coordinate calcium reuptake at the sarcoplasmic reticulum

  2025cites this paper
• Ventricular ion channels and arrhythmias: an overview of physiology, pathophysiology and pharmacology

  2025cites this paper
• Anchored PKA synchronizes adrenergic phosphoregulation of cardiac Cav1.2 channels

  2024cites this paper
• 14-3-3 promotes sarcolemmal expression of cardiac CaV1.2 and nucleates isoproterenol-triggered channel super-clustering

  2024cites this paper
• α1C S1928 Phosphorylation of CaV1.2 Channel Controls Vascular Reactivity and Blood Pressure

  2024influential citation
• Blood pressure variability compromises vascular function in middle-aged mice

  2024cites this paper
• A computational model predicts sex-specific responses to calcium channel blockers in mammalian mesenteric vascular smooth muscle

  2024influential citation
• Channels, Transporters, and Receptors at Membrane Contact Sites

  2024cites this paper
• Calcium signaling in endothelial and vascular smooth muscle cells; sex differences and the influence of estrogens and androgens.

  2024cites this paper
• Milestone Papers in Signal Transduction Mechanisms of Hypertension and Its Complications.

  2024cites this paper
• Sorbs2 Deficiency and Vascular BK Channelopathy in Diabetes

  2024cites this paper
• Pacemaking in the lymphatic system.

  2024cites this paper
• The life cycle of a capillary: Mechanisms of angiogenesis and rarefaction in microvascular physiology and pathologies

  2024influential citation
• Kinesin-1 mediates proper ER folding of the CaV1.2 channel and maintains mouse glucose homeostasis

  2024influential citation
• The formation of KV2.1 macro-clusters is required for sex-specific differences in L-type CaV1.2 clustering and function in arterial myocytes

  2023cites this paper
• A computational model predicts sex-specific responses to calcium 1 channel blockers in mesenteric vascular smooth muscle 2 3 4

  2023cites this paper
• The formation of KV2.1 macro-clusters is required for sex-specific differences in L-type CaV1.2 clustering and function in arterial myocytes

  2023cites this paper
• The formation of KV2.1 macro-clusters is required for sex-specific differences in L-type CaV1.2 clustering and function in arterial myocytes

  2023cites this paper
• NPC1-dependent alterations in KV2.1–CaV1.2 nanodomains drive neuronal death in models of Niemann-Pick Type C disease

  2023cites this paper
• A computational model predicts sex-specific responses to calcium channel blockers in mammalian mesenteric vascular smooth muscle

  2023cites this paper
• Regulation of Cardiac Cav1.2 Channels by Calmodulin

  2023cites this paper
• Diversity of cells and signals in the cardiovascular system

  2023cites this paper
• The CaV1.2 G406R mutation decreases synaptic inhibition and alters L-type Ca2+ channel-dependent LTP at hippocampal synapses in a mouse model of Timothy Syndrome

  2022cites this paper
• Ion channel molecular complexes in vascular smooth muscle

  2022cites this paper
• Functional tuning of Vascular L-type Ca2+ channels

  2022cites this paper
• Vascular CaV1.2 channels in diabetes.

  2022cites this paper
• Biological noise is a key determinant of the reproducibility and adaptability of cardiac pacemaking and EC coupling

  2022cites this paper
• SARS-CoV-2 Envelope Protein Forms Clustered Pentamers in Lipid Bilayers

  2022cites this paper
• Spatiotemporal Control of Vascular CaV1.2 by α1C S1928 Phosphorylation

  2022cites this paper
• Journal Pre-proof The CaV1.2 G406R mutation decreases synaptic inhibition and alters L-type Ca2+ channel-dependent LTP at hippocampal synapses in a mouse model of Timothy

  2022cites this paper
• L-type channel inactivation balances the increased peak calcium current due to absence of Rad in cardiomyocytes

  2021cites this paper
• Secondhand Smoke Exposure Impairs Ion Channel Function and Contractility of Mesenteric Arteries

  2021cites this paper
• Antenatal Hypoxia Affects Pulmonary Artery Contractile Functions via Downregulating L‐type Ca2+ Channels Subunit Alpha1 C in Adult Male Offspring

  2021cites this paper
• Rad Modulation of the L-type Calcium Channel Confers Systolic Advantage in the Heart

  2021cites this paper
• Three novel genetic variants in the FAM110D, CACNA1A and NLRP12 genes are associated with susceptibility to hypertension among Dai people.

  2021cites this paper
• Mechanisms and Regulation of Cardiac CaV1.2 Trafficking

  2021cites this paper
• Sensitivity Analysis of a Smooth Muscle Cell Electrophysiological Model

  2021cites this paper
• The Molecular Basis for the Calcium-Dependent Slow Afterhyperpolarization in CA1 Hippocampal Pyramidal Neurons

  2021cites this paper
• Microsoft Word-zqab031.docx

  2021cites this paper
• Mechanisms and Physiological Implications of Cooperative Gating of Ion Channels Clusters.

  2021cites this paper
• The Organization of the Sinoatrial Node Microvasculature Varies Regionally to Match Local Myocyte Excitability

  2021cites this paper
• Modulation of Function, Structure and Clustering of K+ Channels by Lipids: Lessons Learnt from KcsA

  2020cites this paper
• Kv2.1 channels play opposing roles in regulating membrane potential, Ca2+ channel function, and myogenic tone in arterial smooth muscle

  2020cites this paper
• Cellular and molecular effects of hyperglycemia on ion channels in vascular smooth muscle

  2020cites this paper
• Cardiac Transmembrane Ion Channels and Action Potentials: Cellular Physiology and Arrhythmogenic Behavior.

  2020cites this paper
• Drugs that Regulate Local Cell Signaling: AKAP Targeting as a Therapeutic Option.

  2020cites this paper
• Elevated basal transcription can underlie timothy channel association with autism related disorders.

  2020cites this paper
• Clusters of cooperative ion channels enable a membrane-potential-based mechanism for short-term memory

  2020cites this paper
• Calcium signals that determine vascular resistance

  2019cites this paper
• Ion Channels and Their Regulation in Vascular Smooth Muscle

  2019cites this paper
• Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons

  2019cites this paper
• Highlight article: Dysfunctional Cav1.2 channel in Timothy syndrome, from cell to bedside

  2019cites this paper
• Exercise and Ion-Channel Remodeling in Vascular Smooth Muscle During Hypertension: Therapeutic Implications

  2019cites this paper
• Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in neurons

  2019cites this paper
• A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia

  2019cites this paper
• β‐adrenergic‐mediated dynamic augmentation of sarcolemmal CaV1.2 clustering and co‐operativity in ventricular myocytes

  2019cites this paper
• Channel surfing: new insights into plasticity of excitation‐contraction coupling

  2019cites this paper
• Sulfur‐containing gaseous signal molecules, ion channels and cardiovascular diseases

  2018cites this paper
• Calcium dependence of spontaneous neurotransmitter release

  2018cites this paper
• Dynamic L-type CaV1.2 channel trafficking facilitates CaV1.2 clustering and cooperative gating

  2018cites this paper
• Mutant voltage-gated Na+ channels can exert a dominant negative effect through coupled gating.

  2018cites this paper
• An African loss-of-function CACNA1C variant p.T1787M associated with a risk of ventricular fibrillation

  2018cites this paper
• Effects of Perfusate Solution Composition on the Relationship between Cardiac Conduction Velocity and Gap Junction Coupling

  2018cites this paper
• Roles of A-Kinase Anchoring Proteins and Phosphodiesterases in the Cardiovascular System

  2018cites this paper
• A model for cooperative gating of L-type Ca2+ channels and its effects on cardiac alternans dynamics

  2018cites this paper
• Dyadic Plasticity in Cardiomyocytes

  2018cites this paper
• Supramolekulare Organisation und funktionale Auswirkungen von Ballungen von K+‐Kanälen in Membranen

  2017cites this paper
• Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.

  2017cites this paper
• JGP_201611709 639..660

  2017cites this paper
• Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes

  2017cites this paper
• on TRPV4 channels by AKAP150-bound PKCα in arterial

  2017cites this paper
• Nitric Oxide–Dependent Feedback Loop Regulates Transient Receptor Potential Vanilloid 4 (TRPV4) Channel Cooperativity and Endothelial Function in Small Pulmonary Arteries

  2017cites this paper
• Cardiac T-Tubule Microanatomy and Function.

  2017cites this paper
• Calcium Channels in Vascular Smooth Muscle.

  2017cites this paper
• Supramolecular Organization and Functional Implications of K+ Channel Clusters in Membranes

  2017cites this paper
• A 2 A-Kinase Anchoring Protein ( AKAP )

  2017cites this paper
• Characterization of CaV1.2 exon 33 heterozygous knockout mice and negative correlation between Rbfox1 and CaV1.2 exon 33 expressions in human heart failure

  2017cites this paper
• Calmodulin limits pathogenic Na+ channel persistent current

  2017cites this paper
• Endoplasmic Reticulum-Plasma Membrane Contacts Regulate Cellular Excitability.

  2017cites this paper
• Neurostructural Organization and Neocortical Projecting Neuron Distribution in a Mouse Model of Timothy Syndrome-Mediated Autism Spectrum Disorder

  2017cites this paper
• Distance constraints on activation of TRPV4 channels by AKAP150-bound PKCα in arterial myocytes

  2017cites this paper
• Three lenses into the cardiac dyad: calcium signaling, microtubule trafficking, and junctional sarcoplasmic reticular mobility

  2016cites this paper
• Molecular and Functional Characterization of Rare CACNA1C Variants in Sudden Unexplained Death in the Young.

  2016cites this paper
• Corrigendum: Sustained Contraction in Vascular Smooth Muscle by Activation of L-type Ca2+ Channels Does Not Involve Ca2+ Sensitization or Caldesmon

  2016cites this paper
• Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders

  2016influential citation
• Associations of Variants in the CACNA1A and CACNA1C Genes With Longitudinal Blood Pressure Changes and Hypertension Incidence: The GenSalt Study.

  2016cites this paper
• Ca2+ entry into neurons is facilitated by cooperative gating of clustered CaV1.3 channels

  2016cites this paper
• Sustained Contraction in Vascular Smooth Muscle by Activation of L-type Ca2+ Channels Does Not Involve Ca2+ Sensitization or Caldesmon

  2016cites this paper
• Emerging roles of A-kinase anchoring proteins in cardiovascular pathophysiology.

  2016cites this paper
• Mechanisms and dynamics of AKAP79/150‐orchestrated multi‐protein signalling complexes in brain and peripheral nerve

  2016cites this paper
• BIN1 regulates dynamic t-tubule membrane.

  2016cites this paper
• Calcium regulation of inhibitory synaptic transmission

  2016cites this paper