Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression.

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Psychiatry Research

• Publication date

  1993-10-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/0165-1781(93)90027-EPMID 7511248
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Coexisting dysregulations of both the sympathoadrenal system and hypothalamic-pituitary-adrenal-axis in melancholia

  2005cited by this paper
• The cytokine handbook

  1994cited by this paper
• Interleukin-1 beta: a putative mediator of HPA axis hyperactivity in major depression?

  1993cited by this paper
• Psychomotor retardation, anorexia, weight loss, sleep disturbances, and loss of energy: psychopathological correlates of hyperhaptoglobinemia during major depression.

  1993cited by this paper
• Autoimmunity in depression: increased antiphospholipid autoantibodies

  1993cited by this paper
• Significantly increased expression of T-cell activation markers (interleukin-2 and HLA-DR) in depression: further evidence for an inflammatory process during that illness.

  1993cited by this paper
• Leukocytosis, monocytosis and neutrophilia: hallmarks of severe depression.

  1992cited by this paper
• A study on the blunted natural killer cell activity in severely depressed patients.

  1992cited by this paper
• Immune disorders in depression: higher T helper/T suppressor‐cytotoxic cell ratio

  1992cited by this paper
• Disturbances in acute phase plasma proteins during melancholia: additional evidence for the presence of an inflammatory process during that illness.

  1992cited by this paper
• Higher alpha 1-antitrypsin, haptoglobin, ceruloplasmin and lower retinol binding protein plasma levels during depression: further evidence for the existence of an inflammatory response during that illness.

  1992cited by this paper
• A significantly increased number and percentage of B cells in depressed subjects: results of flow cytometric measurements.

  1992cited by this paper
• Evidence for a systemic immune activation during depression: results of leukocyte enumeration by flow cytometry in conjunction with monoclonal antibody staining

  1992cited by this paper
• Time-dependent variations of central norepinephrine and dopamine following antigen administration.

  1991cited by this paper
• Anthropometric and biochemical assessment of the nutritional state in depression: evidence for lower visceral protein plasma levels in depression.

  1991cited by this paper
• L‐5‐hydroxytryptophan stimulated cortisol escape from dexamethasone suppression in melancholic patients

  1991cited by this paper
• A further exploration of the relationships between immune parameters and the HPA-axis activity in depressed patients

  1991cited by this paper
• Antiphospholipid, antinuclear, Epstein-Barr and cytomegalovirus antibodies, and soluble interleukin-2 receptors in depressive patients.

  1991cited by this paper
• Release of interleukin-6 from anterior pituitary cell aggregates: developmental pattern and modulation by glucocorticoids and forskolin.

  1991cited by this paper
• Prostaglandin-dependent in vitro stimulation of adrenocortical steroidogenesis by interleukins.

  1991cited by this paper
• Sleep in diabetic rats: effects of interleukin 1.

  1991cited by this paper
• Modulation of IL-1 inflammatory and immunomodulatory properties by IL-6.

  1991cited by this paper
• Role of prostaglandins in the behavioral changes induced by murine interleukin 1 alpha in the rat.

  1991cited by this paper
• Interleukin-1 augments gamma-aminobutyric acidA receptor function in brain.

  1991cited by this paper
• Reduction of exploratory behavior by intraperitoneal injection of interleukin-1 involves brain corticotropin-releasing factor.

  1991cited by this paper
• A multivariate study of simultaneous escape from suppression by dexamethasone of urinary free cortisol, plasma cortisol, adrenocorticotropic hormone and β‐endorphin in melancholic patients

  1991cited by this paper
• Recombinant human interleukin 6 is a potent inducer of the acute phase response and elevates the blood platelets in nonhuman primates.

  1991cited by this paper
• Abrogation of glucocorticoid-mediated inhibition of T cell proliferation by the synergistic action of IL-1, IL-6, and IFN-gamma.

  1991cited by this paper
• Decreased serum dipeptidyl peptidase IV activity in major depression.

  1991cited by this paper
• Induction of cytotoxic T lymphocyte development from murine thymocytes by IL-1 and IL-6.

  1991cited by this paper
• Signal transduction mechanism of interleukin 6 in cultured rat mesangial cells

  1991cited by this paper
• Depression‐related disturbances in mitogen‐induced lymphocyte responses and interleukin‐1β and soluble interleukin‐2 receptor production

  1991cited by this paper
• Role of prostaglandins in the behavioral changes induced by murine interleukin 1α in the rat

  1991cited by this paper
• Stress‐and Endotoxin‐Induced Increases in Brain Tryptophan and Serotonin Metabolism Depend on Sympathetic Nervous System Activity

  1991cited by this paper
• Interleukin-1 stimulates the release of dopamine and dihydroxyphenylacetic acid from the hypothalamus in vivo.

  1991cited by this paper
• Interleukin 1 alters rat sleep: temporal and dose-related effects.

  1991cited by this paper
• Interleukins-1 and -6 stimulate the release of corticotropin-releasing hormone-41 from rat hypothalamus in vitro via the eicosanoid cyclooxygenase pathway.

  1991cited by this paper
• Growth-promoting activity of IL-1 alpha, IL-6, and tumor necrosis factor-alpha in combination with IL-2, IL-4, or IL-7 on murine thymocytes. Differential effects on CD4/CD8 subsets and on CD3+/CD3- double-negative thymocytes.

  1990cited by this paper
• IL-2 dependence of the promotion of human B cell differentiation by IL-6 (BSF-2).

  1990cited by this paper
• Interleukin 1 receptor blockade attenuates the host inflammatory response.

  1990cited by this paper
• The effects of psychological stress on plasma interleukin-6 activity in rats.

  1990cited by this paper
• Glucocorticoids inhibit the production of IL 6 from monocytes, endothelial cells and fibroblasts

  1990cited by this paper
• [Regulation of antibody production by monokines and glucocorticoids].

  1990cited by this paper
• Evidence that glucocorticosteroids block expression of the human interleukin-6 gene by accessory cells.

  1990cited by this paper
• The adrenocorticotropin response to interleukin-1 beta instilled into the rat median eminence depends on the local release of catecholamines.

  1990cited by this paper
• Interleukin-6 and the acute phase response.

  1990cited by this paper
• Accessory factors involved in murine T cell activation. Distinct roles of interleukin 6, interleukin 1 and tumor necrosis factor

  1990cited by this paper
• Interleukin-6: historical background, genetics and biological significance.

  1990cited by this paper
• IL-6 is an accessory signal in the alternative CD2-mediated pathway of T cell activation.

  1990cited by this paper
• Major depressive disorder, alcoholism, and reduced natural killer cell cytotoxicity. Role of severity of depressive symptoms and alcohol consumption.

  1990cited by this paper
• Interleukin‐1 and Interleukin‐6 Stimulate Acute‐Phase Protein Production in Primary Mouse Hepatocytes

  1989cited by this paper
• Natural killer cell activity in depressive illness: preliminary report.

  1989cited by this paper
• Lymphokine regulation of CD45R expression on human T cell clones

  1989cited by this paper
• Stress and immunity: an integrated view of relationships between the brain and the immune system.

  1989cited by this paper
• Impaired Lymphocyte Stimulation by Mitogens in Severely Depressed Patients

  1989cited by this paper
• Recombinant interleukin (IL) 2‐induced human B cell differentiation is mediated by autocrine IL6

  1989cited by this paper
• Lymphocyte mitogenesis, immunoglobulin and complement levels in depressed patients and normal controls

  1989cited by this paper
• Evidence for the involvement of the central adrenergic system in interleukin 1-induced adrenocortical response.

  1989cited by this paper
• Virus infection as a stressor: influenza virus elevates plasma concentrations of corticosterone, and brain concentrations of MHPG and tryptophan.

  1989cited by this paper
• IL-6 modulates the synthesis of a specific set of acute phase plasma proteins in vivo.

  1989cited by this paper
• Effects of purified human interleukin-1 on sleep and febrile response of cats.

  1989cited by this paper
• In the rat, interleukin-1 alpha and -beta stimulate adrenocorticotropin and catecholamine release.

  1989cited by this paper
• Effects of recombinant human interleukin-1 alpha, -1 beta, 2 and 6 on ACTH synthesis and release in the mouse pituitary tumour cell line AtT-20.

  1989cited by this paper
• Interleukin‐6 is the major regulator of acute phase protein synthesis in adult human hepatocytes

  1989cited by this paper
• Effects of recombinant human interleukin-1α, -1β, 2 and 6 on ACTH synthesis and release in the mouse pituitary tumour cell line AtT-20

  1989cited by this paper
• In the Rat, Interleukin- lα and -β Stimulate Adrenocorticotropin and Catecholamine Release*

  1989cited by this paper
• Systemic interleukin-1 administration stimulates hypothalamic norepinephrine metabolism parallelling the increased plasma corticosterone.

  1988cited by this paper
• Nutritional aspects of leukocytic cytokines.

  1988cited by this paper
• Interleukin-6 stimulates the secretion of adrenocorticotropic hormone in conscious, freely-moving rats.

  1988cited by this paper
• B cell stimulatory factor-2 is involved in the differentiation of cytotoxic T lymphocytes.

  1988cited by this paper
• Fever and acute phase reactants in the rat.

  1988cited by this paper
• Cellular immunity and the hypothalamic-pituitary axis in major affective disorder: a preliminary study.

  1988cited by this paper
• Activation and proliferation of normal resting human T lymphocytes in serum-free culture: role of IL-4 and IL-6.

  1988cited by this paper
• Recombinant human interleukin‐6 (IL‐6/BSF‐2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes

  1988cited by this paper
• Interleukin-1 immunoreactive innervation of the human hypothalamus.

  1988cited by this paper
• Glucocorticosteroid‐dependent synergy between interleukin 1 and interleukin 6 for human B lymphocyte differentiation

  1988cited by this paper
• Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor.

  1987cited by this paper
• Glucocorticoid receptor function in depression

  1987cited by this paper
• Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1.

  1987cited by this paper
• Low natural killer cytotoxicity in major depression.

  1987cited by this paper
• Interleukin 1 and interleukin 2 enhance proopiomelanocortin gene expression in pituitary cells.

  1987cited by this paper
• Depression, immunocompetence, and prostaglandins of the E series.

  1986cited by this paper
• Induction of interleukin 2 responsiveness in thymocytes by synergistic action of interleukin 1 and interleukin 2.

  1985cited by this paper
• Corticotropin-releasing activity of monokines.

  1985cited by this paper
• Lymphocyte function in major depressive disorder.

  1984cited by this paper
• Impaired lymphocyte function in depressive illness.

  1983cited by this paper
• Research diagnostic criteria and DSM-III: an annotated comparison.

  1982cited by this paper
• A RATING SCALE FOR DEPRESSION

  1960cited by this paper

• Association Between Plasma SITH‐1 Antibody Titers and Treatment Trajectory of Treatment‐Resistant Depression

  2025cites this paper
• Cytokine Blockade Attenuates Inflammation and Improves Depressive Psychopathology After COVID-19: A Naturalistic Observational Study

  2025cites this paper
• Effect of esketamine on postoperative pain relief and depressive status in patients with traumatic fractures

  2025cites this paper
• Differential associations of serum globulin and albumin-globulin ratio with depression in cancer and non-cancer populations: a cross-sectional study

  2025cites this paper
• Immune-neuroendocrine crosstalk in mood and psychotic disorders: A meta-analysis and systematic review

  2025cites this paper
• Serum Levels of Zinc, Albumin, Interleukin-6 and CRP in Patients with Unipolar and Bipolar Depression: Cross Sectional Study

  2024cites this paper
• Cytokine dysregulation in amnestic mild cognitive impairment

  2024cites this paper
• P2X7 receptors from the perspective of NLRP3 inflammasome pathway in depression: Potential role of cannabidiol

  2024cites this paper
• The inflammatory underpinning of depression: An historical perspective.

  2024cites this paper
• The association between triglyceride glucose index and suicidal ideation in American adults: Results from NHANES 2005 to 2018

  2024cites this paper
• Whole-Genome Metagenomic Analysis of the Oral Microbiota in Patients with Obstructive Sleep Apnea Comorbid with Major Depressive Disorder

  2024influential citation
• Association between serum copper, zinc, and selenium concentrations and depressive symptoms in the US adult population, NHANES (2011–2016)

  2023cites this paper
• Potential Inflammatory Biomarkers for Major Depressive Disorder Related to Suicidal Behaviors: A Systematic Review

  2023cites this paper
• Role of Tyrosine Nitrosylation in Stress-Induced Major Depressive Disorder: Mechanisms and Implications

  2023cites this paper
• Mechanistic insights into the anti-depressant effect of curcumin based on network pharmacology and experimental validation

  2023cites this paper
• Unlocking the Secrets: Exploring the Biochemical Correlates of Suicidal Thoughts and Behaviors in Adults with Autism Spectrum Conditions

  2023cites this paper
• Graves’ disease as a driver of depression: a mechanistic insight

  2023cites this paper
• Differentiating melancholic and non-melancholic depression via biological markers: A review

  2023cites this paper
• Association between depression and macrovascular disease: a mini review

  2023cites this paper
• T helper-1 activation via interleukin-16 is a key phenomenon in the acute phase of severe, first-episode major depressive disorder and suicidal behaviors

  2023cites this paper
• Effect of subanesthetic dose of esketamine on postoperative rehabilitation in elderly patients undergoing hip arthroplasty

  2023cites this paper
• Kynurenine monooxygenase inhibition and associated reduced quinolinic acid reverses depression-like behaviour by upregulating Nrf2/ARE pathway in mouse model of depression: In-vivo and In-silico studies.

  2022cites this paper
• Intricate role of sleep deprivation in modulating depression: focusing on BDNF, VEGF, serotonin, cortisol, and TNF-α

  2022cites this paper
• The Impact of Cognitive Behavioral Therapy on Peripheral Interleukin-6 Levels in Depression: A Systematic Review and Meta-Analysis

  2022cites this paper
• Lipopolysaccharide-induced changes in effort-related motivational function: Interactions with 2-deoxyglucose.

  2022cites this paper
• Mechanisms of Xiong-Pi-Fang in treating coronary heart disease associated with depression: A systematic pharmacology strategy and in vivo pharmacological validation.

  2022cites this paper
• Rice Germ Ameliorated Chronic Unpredictable Mild Stress-Induced Depressive-like Behavior by Reducing Neuroinflammation

  2022cites this paper
• Effects of cannabidiol on activated immune-inflammatory pathways in major depressive patients and healthy controls.

  2022influential citation
• Molecular Biomarkers for Pediatric Depressive Disorders: A Narrative Review

  2021cites this paper
• Intersections between pneumonia, lowered oxygen saturation percentage and immune activation mediate depression, anxiety, and chronic fatigue syndrome-like symptoms due to COVID-19: A nomothetic network approach

  2021cites this paper
• Inflammation and Cognition in Depression: A Narrative Review

  2021cites this paper
• Insights into interplay of immunopathophysiological events and molecular mechanistic cascades in psoriasis and its associated comorbidities.

  2021cites this paper
• Suicide: An Immunological Disorder?

  2021cites this paper
• SSRIs: Applications in inflammatory lung disease and implications for COVID‐19

  2021cites this paper
• Linking interleukin-6 and depression

  2021cites this paper
• Dysregulation of the gut-brain-skin axis and key overlapping inflammatory and immune mechanisms of psoriasis and depression.

  2021cites this paper
• Molecular pathology associated with altered synaptic transcriptome in the dorsolateral prefrontal cortex of depressed subjects

  2021cites this paper
• On inflammatory hypothesis of depression: what is the role of IL-6 in the middle of the chaos?

  2021cites this paper
• Persistent pain induces mood problems and memory loss by the involvement of cytokines, growth factors, and supraspinal glial cells

  2020cites this paper
• Differential modulation of GR signaling and HDACs in the development of resilient/vulnerable phenotype and antidepressant-like response of vorinostat.

  2020cites this paper
• Appetite change profiles in depression exhibit differential relationships between systemic inflammation and activity in reward and interoceptive neurocircuitry.

  2020cites this paper
• Depression and inflammation: implications for cardiovascular disease

  2020influential citation
• Changes of Serum Melatonin, Interleukin-6, Homocysteine, and Complement C3 and C4 Levels in Patients With Depression

  2020cites this paper
• Preclinical Considerations about Affective Disorders and Pain: A Broadly Intertwined, yet Often Under-Explored, Relationship Having Major Clinical Implications

  2020cites this paper
• Is there a relationship between morphological and functional platelet changes and depressive disorder?

  2020cites this paper
• β-Catenin and TCFs/LEF signaling discordantly regulate IL-6 expression in astrocytes

  2020cites this paper
• The secret behind peripheral inflammation and depression: The hypothalamus

  2020cites this paper
• Role of Interleukin-6 in Depressive Disorder

  2020cites this paper
• „Old Friends“, Immunregulation und Stressresilienz

  2020cites this paper
• „Old Friends“, Immunregulation und Stressresilienz

  2020cites this paper
• The Emerging Field of Nutritional Mental Health: Inflammation, the Microbiome, Oxidative Stress, and Mitochondrial Function

  2020cites this paper
• Peripheral Markers of Depression

  2020cites this paper
• Serum interferon-gamma level is associated with drug-naïve major depressive disorder

  2020cites this paper
• An Overview of the Heterogeneity of Major Depressive Disorder: Current Knowledge and Future Prospective

  2020cites this paper
• Hypothalamic Glutamine-Glutamate Metabolites and Peripheral Pro-Inflammatory Cytokines in Participants with Depression: A Case-Control Study

  2020cites this paper
• Inflammation, depression, and anxiety disorder: A population-based study examining the association between Interleukin-6 and the experiencing of depressive and anxiety symptoms.

  2020cites this paper
• Treatment-resistant depression: Neurobiological correlates and the effect of sleep deprivation with sleep phase advance for the augmentation of pharmacotherapy

  2020cites this paper
• Subcutaneous tocilizumab: recent advances for the treatment of rheumatoid arthritis

  2019cites this paper
• IL-10 is associated with increased mu-opioid receptor levels in major depressive disorder

  2019cites this paper
• Psychophysiological Responses in People Living with Dementia after an Art Gallery Intervention: An Exploratory Study

  2019cites this paper
• SCI and depression: Does inflammation commandeer the brain?

  2019cites this paper
• Repeated social defeat in female mice induces anxiety-like behavior associated with enhanced myelopoiesis and increased monocyte accumulation in the brain.

  2019influential citation
• Quinolinic Acid and Nuclear Factor Erythroid 2-Related Factor 2 in Depression: Role in Neuroprogression

  2019cites this paper
• Glucocorticoid Resistance: Is It a Requisite for Increased Cytokine Production in Depression? A Systematic Review and Meta-Analysis

  2019cites this paper
• IL-6 inhibitor for the treatment of rheumatoid arthritis: A comprehensive review

  2019cites this paper
• Expression of serotonin 2A, 2C, 6 and 7 receptor and IL-6 mRNA in experimental toxoplasmic encephalitis in mice

  2019cites this paper
• Maternal Dietary Fiber Composition during Gestation Induces Changes in Offspring Antioxidative Capacity, Inflammatory Response, and Gut Microbiota in a Sow Model

  2019cites this paper
• DETAILED STUDY PROTOCOL TITLE: Omega-3 Fatty Acids for MDD with High Inflammation: A Personalized Approach

  2019cites this paper
• Glucocorticoids and Dehydroepiandrosterone: A Role in Immunosenescence?

  2019cites this paper
• Elevated tumor necrosis factor-alpha receptor subtype 1 and the association with abnormal brain function in treatment-resistant depression.

  2018cites this paper
• The VITamin D and OmegA-3 TriaL-Depression Endpoint Prevention (VITAL-DEP): Rationale and design of a large-scale ancillary study evaluating vitamin D and marine omega-3 fatty acid supplements for prevention of late-life depression.

  2018cites this paper
• Antidepressant and anti-inflammatory effects of a combined fluoxetine and celecoxib treatment in a rat model of depression

  2018cites this paper
• Higher concentration of interleukin 6 - A possible link between major depressive disorder and childhood abuse.

  2018cites this paper
• IL-1β, IL-6, TNF- α and CRP in Elderly Patients with Depression or Alzheimer’s disease: Systematic Review and Meta-Analysis

  2018cites this paper
• Inflaming sex differences in mood disorders

  2018cites this paper
• Interleukins and Acute Phase Proteins of Bovine Sera during Natural Helminth Burden in Ibadan Nigeria

  2018cites this paper
• The Compensatory Immune-Regulatory Reflex System (CIRS) in Depression and Bipolar Disorder

  2018cites this paper
• Proteomic Studies of Psychiatric Disorders.

  2018cites this paper
• Less immune activation following social stress in rural vs. urban participants raised with regular or no animal contact, respectively

  2018cites this paper
• Old Friends, immunoregulation, and stress resilience

  2018cites this paper
• Tryptophan catabolites along the indoleamine 2,3-dioxygenase pathway as a biological link between depression and cancer

  2018cites this paper
• Rural participants raised in the presence of farm animals show less immune activation following acute psychosocial stress

  2018cites this paper
• Pancreatic Cancer–Associated Depression: A Case Report and Review of the Literature

  2018cites this paper
• Major depression model induced by repeated and intermittent lipopolysaccharide administration: Long-lasting behavioral, neuroimmune and neuroprogressive alterations.

  2018cites this paper
• ASSOCIATION BETWEEN THE MAGNITUDE OF THE IMMUNE RESPONSE AND RECURRENT MAJOR DEPRESSION DISORDER IN HUMANS AND DEPRESSION-LIKE BEHAVIOR IN ANIMALS

  2018cites this paper
• Major Depressive Disorder Following Dermatomyositis: A Case Linking Depression with Inflammation.

  2018cites this paper
• Distinct inflammatory response patterns are evident among men and women with higher depressive symptoms.

  2018cites this paper
• The brain-adipocyte-gut network: Linking obesity and depression subtypes

  2018cites this paper
• Effects of Mind-Body Training on Cytokines and Their Interactions with Catecholamines

  2017cites this paper
• IL-6 roles - Molecular pathway and clinical implication in pancreatic cancer - A systemic review.

  2017cites this paper
• Immune System Modulators with Antidepressant Effects: Evidence from Animal Models.

  2017cites this paper
• An investigation of kynurenine pathway metabolism, the hypothalamic-pituitary-adrenal axis, and inflammatory markers in Major Depressive Disorder

  2017cites this paper
• The role of immune abnormality in depression and cardiovascular disease

  2017cites this paper
• Inflammatory markers in late pregnancy in association with postpartum depression-A nested case-control study.

  2017cites this paper
• Psychoneuroimmunology of mental disorders.

  2017cites this paper
• Peripheral Immune Alterations in Major Depression: The Role of Subtypes and Pathogenetic Characteristics

  2017cites this paper
• Inflammatory Mechanisms of Depression and Suicidal Behavior

  2017cites this paper
• Effects of confinement duration and parity on stereotypic behavioral and physiological responses of pregnant sows.

  2017cites this paper
• The psychoneuroimmunology of pregnancy.

  2017cites this paper
• Effort-related motivational effects of the pro-inflammatory cytokine interleukin-6: pharmacological and neurochemical characterization

  2016cites this paper