Deficiency of tenascin‐C attenuates liver fibrosis in immune‐mediated chronic hepatitis in mice

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Pathology

• Publication date

  2007-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/path.2099PMID 17121418
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sirius red histophotometry and spectrophotometry of sections in the assessment of the collagen content of liver tissue and its application in growing rat liver.

  2008cited by this paper
• Tenascin expression in human chronic liver disease and in hepatocellular carcinoma.

  2008cited by this paper
• Deficiency of tenascin C attenuates allergen‐induced bronchial asthma in the mouse

  2006cited by this paper
• Therapeutic strategies against TGF-beta signaling pathway in hepatic fibrosis.

  2006cited by this paper
• Circulating level of large splice variants of tenascin‐C is a marker of piecemeal necrosis activity in patients with chronic hepatitis C

  2006cited by this paper
• Tenascin-C regulates recruitment of myofibroblasts during tissue repair after myocardial injury.

  2005cited by this paper
• Tenascin-C-coated platinum coils for acceleration of organization of cavities and reduction of lumen size in a rat aneurysm model.

  2005cited by this paper
• Tenascin-C is an essential factor for neointimal hyperplasia after aortotomy in mice.

  2005cited by this paper
• Liver fibrosis.

  2005cited by this paper
• Co‐stimulation of human breast cancer cells with transforming growth factor‐β and tenascin‐C enhances matrix metalloproteinase‐9 expression and cancer cell invasion

  2004cited by this paper
• Liver fibrosis

  2004cited by this paper
• Tenascin‐C upregulates matrix metalloproteinase‐9 in breast cancer cells: Direct and synergistic effects with transforming growth factor β1

  2003cited by this paper
• Tenascins: regulation and putative functions during pathological stress

  2003cited by this paper
• Cytokine expression in three mouse models of experimental hepatitis.

  2002cited by this paper
• Rat liver myofibroblasts and hepatic stellate cells differ in CD95-mediated apoptosis and response to TNF-alpha.

  2002cited by this paper
• Mesenchymal cells in the liver--one cell type or two?

  2002cited by this paper
• Transforming growth factor beta and the liver.

  2001cited by this paper
• Hepatic Stellate Cells as a Target for the Treatment of Liver Fibrosis

  2001influential reference
• The tenascin family of ECM glycoproteins: Structure, function, and regulation during embryonic development and tissue remodeling

  2000cited by this paper
• Essential pathogenetic role for interferon (IFN-)gamma in concanavalin A-induced T cell-dependent hepatitis: exacerbation by exogenous IFN-gamma and prevention by IFN-gamma receptor-immunoglobulin fusion protein.

  2000cited by this paper
• Repeated concanavalin a challenge in mice induces an interleukin 10–producing phenotype and liver fibrosis

  2000cited by this paper
• Hepatic stellate cells: a target for the treatment of liver fibrosis

  2000cited by this paper
• Tenascin-C in development and disease: gene regulation and cell function.

  2000cited by this paper
• ESSENTIAL PATHOGENETIC ROLE FOR INTERFERON (IFN-)γ IN CONCANAVALIN A-INDUCED T CELL-DEPENDENT HEPATITIS: EXACERBATION BY EXOGENOUS IFN-γ AND PREVENTION BY IFN-γ RECEPTOR-IMMUNOGLOBULIN FUSION PROTEIN

  2000cited by this paper
• Immunopathogenesis of hepatic fibrosis in chronic liver injury induced by repeatedly administered concanavalin A.

  1999cited by this paper
• Rat liver myofibroblasts and hepatic stellate cells: different cell populations of the fibroblast lineage with fibrogenic potential.

  1999cited by this paper
• In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: a potential new therapy for hepatic fibrosis.

  1999cited by this paper
• Tenascin-C promotes healing of Habu-snake venom-induced glomerulonephritis: studies in knockout congenic mice and in culture.

  1998cited by this paper
• Effect of tenascin-C deficiency on chemically induced dermatitis in the mouse.

  1998cited by this paper
• The peripheral nerve and the neuromuscular junction are affected in the tenascin-C-deficient mouse.

  1998cited by this paper
• Integrin-mediated intracellular Ca2+ signaling in Jurkat T lymphocytes.

  1997cited by this paper
• Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses.

  1997cited by this paper
• Analysis of tenascin mRNA expression in the murine mammary gland from embryogenesis to carcinogenesis: an in situ hybridization study.

  1997cited by this paper
• Bystander Activation by Cytokines of Intrahepatic T Cells in Chronic Viral Hepatitis

  1997cited by this paper
• Tenascin Supports Lymphocyte Rolling

  1997cited by this paper
• Preprotachykinin A and cholecystokinin mRNAs in tenascin-gene knockout mouse brain.

  1997cited by this paper
• Abnormal behavior and neurotransmissions of tenascin gene knockout mouse.

  1996cited by this paper
• Critical involvement of interferon γ in the pathogenesis of T‐cell activation‐associated hepatitis and regulatory mechanisms of interleukin‐6 for the manifestations of hepatitis

  1996cited by this paper
• Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A.

  1996cited by this paper
• Activation of human lymphomononuclear cells by peptides derived from extracellular matrix proteins.

  1995cited by this paper
• Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation.

  1995cited by this paper
• Regulation of the α2(I) collagen gene transcription in fat‐storing cells derived from a cirrhotic liver

  1995cited by this paper
• T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin 6

  1994cited by this paper
• Increased intrahepatic messenger RNA expression of interleukins 2, 6, and 8 in human cirrhosis.

  1994cited by this paper
• Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis.

  1994cited by this paper
• Compartmentalization of T lymphocytes to the site of disease: intrahepatic CD4+ T cells specific for the protein NS4 of hepatitis C virus in patients with chronic hepatitis C

  1993cited by this paper
• The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies

  1993influential reference
• Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies.

  1993cited by this paper
• Book Review Ethical Problems in Dialysis and Transplantation (Developments in Nephrology. Vol. 33.) Edited by Carl M. Kjellstrand and John B. Dossetor. 235 pp., illustrated. Boston, Kluwer Academic, 1992. $108.50. 0-7923-1625-8

  1993cited by this paper
• A T cell-dependent experimental liver injury in mice inducible by concanavalin A.

  1992cited by this paper
• Mice develop normally without tenascin.

  1992cited by this paper
• Extracellular proteins that modulate cell-matrix interactions. SPARC, tenascin, and thrombospondin.

  1991cited by this paper
• Procollagen expression by nonparenchymal rat liver cells in experimental biliary fibrosis.

  1990cited by this paper
• Expression of the novel extracellular matrix component tenascin in normal and diseased human liver. An immunohistochemical study.

  1990cited by this paper
• In situ hybridization for procollagen types I, III and IV mRNA in normal and fibrotic rat liver: Evidence for predominant expression in nonparenchymal liver cells

  1989cited by this paper
• Tenascin: cDNA cloning and induction by TGF‐beta.

  1988cited by this paper
• Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis

  1981cited by this paper
• Experimental hepatic fibrosis without hepatocellular regeneration. A kinetic study.

  1968cited by this paper
• Transforming Growth Factor (cid:1) and the Liver

  year unknowncited by this paper

• Identifying key pathways and genes in the progression of wooden breast across multiple broiler lines using weighted gene co-expression network analysis.

  2026cites this paper
• The functional role of the extracellular matrix in inflammatory bowel disease associated gut fibrosis.

  2025cites this paper
• Hepatic stellate cells: balancing homeostasis, hepatoprotection and fibrogenesis in health and disease

  2025cites this paper
• TNC-targeted CAR-macrophage therapy alleviates liver fibrosis in mice

  2025cites this paper
• The Role of Tenascin-C in the Physiopathology of Familial Mediterranean Fever

  2024cites this paper
• Cell-type specific effects of mineralocorticoid receptor gene expression suggest intercellular communication regulating fibrosis in skeletal muscle disease

  2024cites this paper
• Singular Value Decomposition-Driven Non-negative Matrix Factorization with Application to Identify the Association Patterns of Sarcoma Recurrence

  2024cites this paper
• Serum proteomic profiling of patients with compensated advanced chronic liver disease with and without clinically significant portal hypertension

  2024cites this paper
• Targeting myocardial inflammation: investigating the therapeutic potential of atrial natriuretic peptide in atrial fibrosis

  2024cites this paper
• Biology of Tenascin C and its role in physiology and pathology.

  2023cites this paper
• Proteomic quantification of native and ECM-enriched mouse ovaries reveals an age-dependent fibro-inflammatory signature

  2023cites this paper
• Plasma exosome proteomics reveals the pathogenesis mechanism of post-stroke cognitive impairment

  2023cites this paper
• Matrix protein Tenascin-C promotes kidney fibrosis via STAT3 activation in response to tubular injury

  2022cites this paper
• LOXL-2 and TNC-C are markers of liver fibrogenesis in HCV/HIV-, HIV- and HCV-infected patients.

  2022cites this paper
• COL1A1 expression induced by overexpression of both a 15-amino acid peptide from the fibrinogen domain of tenascin-X and integrin α11 in LX-2 cells

  2022cites this paper
• Tenascin-C in fibrosis in multiple organs: Translational implications.

  2022cites this paper
• Elevated Serum Tenascin-C Predicts Mortality in Critically Ill Patients With Multiple Organ Dysfunction

  2021cites this paper
• Tenascin C Has a Modest Protective Effect on Acute Lung Pathology during Methicillin-Resistant Staphylococcus aureus-Induced Pneumonia in Mice

  2021cites this paper
• Validation strategies for identifying drug targets in dermal fibrotic disorders.

  2021cites this paper
• Structure-function specialisation of the interfascicular matrix in the human achilles tendon

  2021cites this paper
• Tenascin-C Deficiency Is Associated With Reduced Bacterial Outgrowth During Klebsiella pneumoniae-Evoked Pneumosepsis in Mice

  2021cites this paper
• Extracellular Vesicles: An Emerging Mechanism Governing the Secretion and Biological Roles of Tenascin-C

  2021cites this paper
• Tumor Microenvironment in Pancreatic Intraepithelial Neoplasia

  2021cites this paper
• Upregulation of Fibrinogen-Like 1 Expression Contributes to Reducing the Progression of Preeclampsia

  2021cites this paper
• Inhibition of AMPA (α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionate) Receptor Reduces Acute Blood–Brain Barrier Disruption After Subarachnoid Hemorrhage in Mice

  2021cites this paper
• Tenascin-C induces phenotypic changes in fibroblasts to myofibroblasts with high contractility through the integrin αvβ1/TGF-β/SMAD signaling axis in human breast cancer.

  2020cites this paper
• Tumor Microenvironment: Extracellular Matrix Components – Part B

  2020cites this paper
• The Growing World of DAMPs

  2020cites this paper
• Tenascin-C Function in Glioma: Immunomodulation and Beyond.

  2020cites this paper
• A bioengineered living cell construct activates metallothionein/zinc/MMP8 and inhibits TGFβ to stimulate remodeling of fibrotic venous leg ulcers

  2020cites this paper
• DAMP-Promoted Efferent Innate Immune Responses in Human Diseases: Fibrosis

  2020cites this paper
• The Roles of Tenascins in Cardiovascular, Inflammatory, and Heritable Connective Tissue Diseases

  2020cites this paper
• Effects of Tenascin C on the Integrity of Extracellular Matrix and Skin Aging

  2020cites this paper
• Immunomodulatory Role of the Extracellular Matrix Within the Liver Disease Microenvironment

  2020cites this paper
• Tubulointerstitial nephritis antigen‐like 1 deficiency alleviates age‐dependent depressed ovulation associated with ovarian collagen deposition in mice

  2019cites this paper
• iNOS Gene Ablation Prevents Liver Fibrosis in Leptin-Deficient ob/ob Mice

  2019cites this paper
• Molecular characterization of a precision-cut rat liver slice model for the evaluation of antifibrotic compounds.

  2019cites this paper
• Unraveling reno-protective effects of SGLT2 inhibition in human proximal tubular cells.

  2019cites this paper
• Nanoparticle mediated silencing of tenascin C in hepatic stellate cells: effect on inflammatory gene expression and cell migration.

  2019cites this paper
• Effect of exposure to Asian sand dust-Particulate matter on liver Tenascin-C expression in human cancer cell and mouse hepatic tissue.

  2019cites this paper
• PAI1 mediates fibroblast–mast cell interactions in skin fibrosis

  2018cites this paper
• Lhx8 ablation leads to massive autophagy of mouse oocytes associated with DNA damage†

  2018cites this paper
• Multiple Roles of Tenascins in Homeostasis and Pathophysiology of Aorta

  2018cites this paper
• Internal Affairs: Tenascin-C as a Clinically Relevant, Endogenous Driver of Innate Immunity

  2018cites this paper
• Targeted disruption of the iNOS gene improves adipose tissue inflammation and fibrosis in leptin-deficient ob/ob mice: role of tenascin C

  2018cites this paper
• Preventive effects of cilostazol against the development of shunt-dependent hydrocephalus after subarachnoid hemorrhage.

  2017cites this paper
• Suppression of hepatic dysfunction in tenascin-X-deficient mice fed a high-fat diet

  2017influential citation
• Tenascin-C Is a Major Component of the Fibrogenic Niche in Kidney Fibrosis.

  2017cites this paper
• The use of induced pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSCs) to study the genetic basis of human diseases

  2017cites this paper
• Bone Marrow Stem Cells Anti-liver Fibrosis Potency: Inhibition of Hepatic Stellate Cells Activity and Extracellular Matrix Deposition

  2017cites this paper
• Periostin promotes hepatic fibrosis in mice by modulating hepatic stellate cell activation via αv integrin interaction

  2016cites this paper
• Epidermal growth factor-like repeats of tenascin-C-induced constriction of cerebral arteries via activation of epidermal growth factor receptors in rats.

  2016cites this paper
• Hepatoprotective and Anti-fibrotic Agents: It's Time to Take the Next Step

  2016cites this paper
• Aneurysm Organization Effects of Gellan Sulfate Core Platinum Coil with Tenascin-C in a Simulated Clinical Setting and the Possible Mechanism.

  2016cites this paper
• Diet-Induced Obesity Enhances Progression of Hepatocellular Carcinoma through Tenascin-C/Toll-Like Receptor 4 Signaling.

  2016cites this paper
• Tenascin-C drives persistence of organ fibrosis

  2016cites this paper
• Tenascin-C and integrins in cancer

  2015cites this paper
• Tenascin-C May Accelerate Cardiac Fibrosis by Activating Macrophages via the Integrin &agr;V&bgr;3/Nuclear Factor–&kgr;B/Interleukin-6 Axis

  2015cites this paper
• Tenascins in fibrotic disorders—from bench to bedside

  2015cites this paper
• Tenascin C in metastasis: A view from the invasive front

  2015cites this paper
• Chapter 105 – Ischemia-Reperfusion Injury in Liver Transplantation

  2015cites this paper
• Matricellular protein periostin contributes to hepatic inflammation and fibrosis.

  2015cites this paper
• Inhibition of Fibrous Adhesion Formation in the Temporomandibular Joint of Tenascin-C Knockout Mice

  2014cites this paper
• The wound healing, chronic fibrosis, and cancer progression triad.

  2014cites this paper
• Tenascin‐C Aggravates Autoimmune Myocarditis via Dendritic Cell Activation and Th17 Cell Differentiation

  2014cites this paper
• Gellan Sulfate Core Platinum Coil with Tenascin-C Promotes Intra-Aneurysmal Organization in Rats

  2014cites this paper
• Tenascin-C Causes Neuronal Apoptosis After Subarachnoid Hemorrhage in Rats

  2014cites this paper
• Tenascin-C: Form versus function

  2014cites this paper
• Cloning and expression analysis of the gene encoding fibrinogen-like protein A, a novel regeneration-related protein from Apostichopus japonicus

  2014cites this paper
• PDGF and TGF‐β promote tenascin‐C expression in subepithelial myofibroblasts and contribute to intestinal mucosal protection in mice

  2014cites this paper
• Mechanotransduction and extracellular matrix homeostasis

  2014cites this paper
• Tenascins in stem cell niches.

  2014cites this paper
• Availability of TGF-1 in the Myofibroblast Matrix: A Matter of Strain and Fibronectin

  2014cites this paper
• The myofibroblast matrix: implications for tissue repair and fibrosis

  2013cites this paper
• Leukotriene C4 aggravates bleomycin‐induced pulmonary fibrosis in mice

  2013cites this paper
• Role of Reactive Stroma in Prostate Cancer

  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013influential citation
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
• Tenascin-C in cardiovascular tissue remodeling: from development to inflammation and repair.

  2012cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
• Tenascins and the importance of adhesion modulation.

  2011cites this paper
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  2011cites this paper
• Modulation of Tumor Cell Survival, Proliferation, and Differentiation by the Peptide Derived from Tenascin-C: Implication of β1-Integrin Activation

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  2011influential citation