Immune outcomes in the liver: Is CD8 T cell fate determined by the environment?

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Journal of Hepatology

• Publication date

  2015-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.jhep.2015.05.033PMID 26103545
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2014influential reference
• Dysfunctional CD8+ T cells in hepatitis B and C are characterized by a lack of antigen-specific T-bet induction

  2014cited by this paper
• IL-21 Restricts Virus-driven Treg Cell Expansion in Chronic LCMV Infection

  2013cited by this paper
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  2013cited by this paper
• The Depletion of NK Cells Prevents T Cell Exhaustion to Efficiently Control Disseminating Virus Infection

  2013cited by this paper
• References Subscriptions Permissions

  2013cited by this paper
• Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell–mediated deletion

  2013cited by this paper
• Molecular mechanisms of T cell co-stimulation and co-inhibition

  2013cited by this paper
• Rapid Deletion and Inactivation of CTLs upon Recognition of a Number of Target Cells over a Critical Threshold

  2013cited by this paper
• The Third Signal Cytokine IL-12 Rescues the Anti-Viral Function of Exhausted HBV-Specific CD8 T Cells

  2013cited by this paper
• CD40 Activation Rescues Antiviral CD8+ T Cells from PD-1-Mediated Exhaustion

  2013cited by this paper
• Gene Therapy for Tolerance: High-Level Expression of Donor Major Histocompatibility Complex in the Liver Overcomes Naive and Memory Alloresponses to Skin Grafts

  2013cited by this paper
• Pathways of antigen processing.

  2013cited by this paper
• A Randomized, Double-Blind, Placebo-Controlled Assessment of BMS-936558, a Fully Human Monoclonal Antibody to Programmed Death-1 (PD-1), in Patients with Chronic Hepatitis C Virus Infection

  2013cited by this paper
• Antigen cross-presentation by dendritic cell subsets: one general or all sergeants?

  2013cited by this paper
• Intrahepatic myeloid-cell aggregates enable local proliferation of CD8+ T cells and successful immunotherapy against chronic viral liver infection

  2013cited by this paper
• Liver sinusoidal endothelial cells contribute to CD8 T cell tolerance toward circulating carcinoembryonic antigen in mice

  2012cited by this paper
• Foxp3+ regulatory T cells protect the liver from immune damage and compromise virus control during acute experimental hepatitis B virus infection in mice

  2012cited by this paper
• Combined blockade of programmed death-1 and activation of CD137 increase responses of human liver T cells against HBV, but not HCV.

  2012cited by this paper
• IL-10–Producing Regulatory B Cells in the Pathogenesis of Chronic Hepatitis B Virus Infection

  2012cited by this paper
• Antigen amount dictates CD8+ T‐cell exhaustion during chronic viral infection irrespective of the type of antigen presenting cell

  2012cited by this paper
• Inhibitory Receptors on Lymphocytes: Insights from Infections

  2012cited by this paper
• TNF-induced target cell killing by CTL activated through cross-presentation.

  2012cited by this paper
• Liver Restores Immune Homeostasis after Local Inflammation despite the Presence of Autoreactive T Cells

  2012cited by this paper
• Failure of CD4 T-Cells to Respond to Liver-Derived Antigen and to Provide Help to CD8 T-Cells

  2011cited by this paper
• Early IL‐10 predominant responses are associated with progression to chronic hepatitis C virus infection in injecting drug users

  2011cited by this paper
• Natural killer cells act as rheostats modulating antiviral T cells

  2011cited by this paper
• Liver antigen-presenting cells.

  2011cited by this paper
• Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity

  2011cited by this paper
• Role of the coinhibitory receptor cytotoxic T lymphocyte antigen‐4 on apoptosis‐Prone CD8 T cells in persistent hepatitis B virus infection

  2011cited by this paper
• The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses

  2011cited by this paper
• Hepatocyte entry leads to degradation of autoreactive CD8 T cells

  2011cited by this paper
• Affinity Thresholds for Naive CD8+ CTL Activation by Peptides and Engineered Influenza A Viruses

  2011cited by this paper
• Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection

  2011cited by this paper
• Ineffective CD8(+) T-cell immunity to adeno-associated virus can result in prolonged liver injury and fibrogenesis.

  2011cited by this paper
• A Crucial Role for Kupffer Cell-Derived Galectin-9 in Regulation of T Cell Immunity in Hepatitis C Infection

  2010cited by this paper
• Targeting Toll-like receptors: emerging therapeutics?

  2010cited by this paper
• Direct, help‐independent priming of CD8+ T cells by adeno‐associated virus–transduced hepatocytes

  2010cited by this paper
• Intrahepatic levels of PD-1/PD-L correlate with liver inflammation in chronic hepatitis B

  2010cited by this paper
• Dynamic Regulation of CD8 T Cell Tolerance Induction by Liver Sinusoidal Endothelial Cells

  2010cited by this paper
• HBcAg induces interleukin‐10 production, inhibiting HBcAg‐specific Th17 responses in chronic hepatitis B patients

  2010cited by this paper
• Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

  2010cited by this paper
• Antigen-presenting cell function in the tolerogenic liver environment

  2010cited by this paper
• Distinct Roles for CCR4 and CXCR3 in the Recruitment and Positioning of Regulatory T Cells in the Inflamed Human Liver

  2010cited by this paper
• Abundant numbers of regulatory T cells localize to the liver of chronic hepatitis C infected patients and limit the extent of fibrosis.

  2010cited by this paper
• A Vital Role for Interleukin-21 in the Control of a Chronic Viral Infection

  2009cited by this paper
• IL-21 Is Required to Control Chronic Viral Infection

  2009cited by this paper
• Complete but curtailed T cell response to very low affinity antigen

  2009cited by this paper
• IL-21R on T Cells Is Critical for Sustained Functionality and Control of Chronic Viral Infection

  2009cited by this paper
• Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade

  2009cited by this paper
• High antigen levels are the cause of T cell exhaustion during chronic viral infection

  2009cited by this paper
• T cell activation.

  2009cited by this paper
• Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

  2009cited by this paper
• The Size of the Viral Inoculum Contributes to the Outcome of Hepatitis B Virus Infection

  2009cited by this paper
• Chronic Antigen Stimulation Alone Is Sufficient to Drive CD8+ T Cell Exhaustion1

  2009cited by this paper
• Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization.

  2008cited by this paper
• Intrahepatic murine CD8 T-cell activation associates with a distinct phenotype leading to Bim-dependent death.

  2008cited by this paper
• Enhancing SIV-Specific Immunity In Vivo by PD-1 Blockade

  2008cited by this paper
• Selective expansion of a subset of exhausted CD8 T cells by αPD-L1 blockade

  2008cited by this paper
• Mechanism of T cell tolerance induction by murine hepatic Kupffer cells

  2008cited by this paper
• Natural killer cell and hepatic cell interaction via NKG2A leads to dendritic cell‐mediated induction of CD4+ CD25+ T cells with PD‐1‐dependent regulatory activities

  2007cited by this paper
• Dysfunction and functional restoration of HCV‐specific CD8 responses in chronic hepatitis C virus infection

  2007cited by this paper
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  2007cited by this paper
• The liver: a special case in transplantation tolerance.

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• Effector and memory CTL differentiation.

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• Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling.

  2006cited by this paper
• Interleukin-10 determines viral clearance or persistence in vivo

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• Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection

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• Hepatocytes Express Abundant Surface Class I MHC and Efficiently Use Transporter Associated with Antigen Processing, Tapasin, and Low Molecular Weight Polypeptide Proteasome Subunit Components of Antigen Processing and Presentation Pathway1

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• Mechanisms of suppression by suppressor T cells

  2005cited by this paper
• Adaptive immune responses in acute and chronic hepatitis C virus infection

  2005cited by this paper
• Oscillating CD8(+) T cell effector functions after antigen recognition in the liver.

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• Cutting Edge: Type I IFNs Provide a Third Signal to CD8 T Cells to Stimulate Clonal Expansion and Differentiation1

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• Mechanisms of suppression by suppressor T cells

  2005cited by this paper
• Inhibition of T‐cell responses by hepatic stellate cells via B7‐H1–mediated T‐cell apoptosis in mice

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• Liver Sinusoidal Endothelial Cells Are Insufficient to Activate T Cells

  2004cited by this paper
• The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity.

  2004cited by this paper
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