Research resource: nuclear receptors as transcriptome: discriminant and prognostic value in breast cancer.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Molecular Endocrinology

• Publication date

  2013-01-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/me.2012-1265PMID 23292282PMCID PMC5417325
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2012influential reference
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