The diverse functions of osteoglycin: a deceitful dwarf, or a master regulator of disease?

No abstract is available for this paper.

• Publication year

  2016

• Venue

  The FASEB Journal

• Publication date

  2016-04-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1096/fj.201500096RPMID 27080639
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling

  2015cited by this paper
• Osteoglycin Prevents Cardiac Dilatation and Dysfunction After Myocardial Infarction Through Infarct Collagen Strengthening

  2015cited by this paper
• Novel extracellular matrix biomarkers as predictors of adverse outcome in chronic heart failure: association between biglycan and response to statin therapy in the CORONA trial.

  2015cited by this paper
• Interactions Between Muscle Tissues and Bone Metabolism

  2015cited by this paper
• Aortic wall proteomic analysis in spontaneously hypertensive rats with a blood pressure decrease induced by 6-week load-free swimming.

  2015cited by this paper
• Brief Report: Distinct Dysregulation of the Small Leucine‐Rich Repeat Protein Family in Osteoarthritic Acetabular Labrum Compared to Articular Cartilage

  2015cited by this paper
• Circulating Osteoglycin and NGAL/MMP9 Complex Concentrations Predict 1-Year Major Adverse Cardiovascular Events After Coronary Angiography

  2014cited by this paper
• Proteomic analysis of human osteoarthritis synovial fluid

  2014cited by this paper
• Measurement of Novel Biomarkers to Predict Chronic Heart Failure Outcomes and Left Ventricular Remodeling

  2014cited by this paper
• Osteoglycin deficiency does not affect atherosclerosis in mice.

  2014cited by this paper
• Local carotid atherosclerotic plaque proteins for the identification of circulating biomarkers in coronary patients.

  2014cited by this paper
• Myocardial Extracellular Matrix: An Ever-Changing and Diverse Entity

  2014cited by this paper
• Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology.

  2014cited by this paper
• Deciphering the role of the ADAM17-dependent secretome in cell signaling.

  2014cited by this paper
• Characterization of spinal cord glial cells in a model of hindlimb unloading in mice.

  2014cited by this paper
• Active vitamin D possesses beneficial effects on the interaction between muscle and bone.

  2014cited by this paper
• Panel of emerging cardiac biomarkers contributes for prognosis rather than diagnosis in chronic heart failure.

  2014cited by this paper
• Quantitative Proteomics Approach to Screening of Potential Diagnostic and Therapeutic Targets for Laryngeal Carcinoma

  2014cited by this paper
• The regulatory roles of small leucine‐rich proteoglycans in extracellular matrix assembly

  2013cited by this paper
• Molecular differences between human thyroid follicular adenoma and carcinoma revealed by analysis of a murine model of thyroid cancer.

  2013cited by this paper
• Enhancement of IGF-2-induced neurite outgrowth by IGF-binding protein-2 and osteoglycin in SH-SY5Y human neuroblastoma cells.

  2013cited by this paper
• Isolation of bovine corneal keratan sulfate and its growth factor and morphogen binding

  2013cited by this paper
• Specific Requirement of Gli Transcription Factors in Hedgehog-mediated Intestinal Development*

  2013cited by this paper
• Proteomic analysis of calcified abdominal and thoracic aortic aneurysms.

  2012cited by this paper
• Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid, and sclera.

  2012cited by this paper
• Bone as an endocrine organ.

  2012cited by this paper
• Autoimmunoreactive IgGs from patients with postural orthostatic tachycardia syndrome

  2012cited by this paper
• Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation

  2012cited by this paper
• Small leucine rich proteoglycan family regulates multiple signalling pathways in neural development and maintenance

  2012cited by this paper
• Role of Osteoglycin in the Linkage between Muscle and Bone*

  2012cited by this paper
• Developmental changes and regional localization of Dspp, Mepe, Mimecan and Versican in postnatal developing mouse teeth

  2012cited by this paper
• MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart

  2012influential reference
• Decreased expression of extracellular matrix proteins and trophic factors in the amygdala complex of depressed mice after chronic immobilization stress

  2012cited by this paper
• A nontargeted proteomic approach to the study of visceral and subcutaneous adipose tissue in human obesity.

  2012cited by this paper
• Canine tissue-specific expression of multiple small leucine rich proteoglycans.

  2012cited by this paper
• Gene expression profiling of connective tissue growth factor (CTGF) stimulated primary human tenon fibroblasts reveals an inflammatory and wound healing response in vitro

  2011cited by this paper
• Levels of Circulating MMCN-151, a Degradation Product of Mimecan, Reflect Pathological Extracellular Matrix Remodeling in Apolipoprotein E Knockout Mice

  2011cited by this paper
• Ex Vivo Soft-Laser Treatment Inhibits the Synovial Expression of Vimentin and α-Enolase, Potential Autoantigens in Rheumatoid Arthritis

  2011cited by this paper
• Effects of Ultraviolet-A and Riboflavin on the Interaction of Collagen and Proteoglycans during Corneal Cross-linking*

  2011cited by this paper
• Keratocan is Expressed by Osteoblasts and Can Modulate Osteogenic Differentiation

  2011cited by this paper
• Toponostics of invasive ductal breast carcinoma: combination of spatial protein expression imaging and quantitative proteome signature analysis.

  2011cited by this paper
• Mimecan is involved in aortic hypertrophy induced by sinoaortic denervation in rats

  2011cited by this paper
• Metabolomics in premature labor: a novel approach to identify patients at risk for preterm delivery

  2010cited by this paper
• Candidate gene study to investigate the genetic determinants of normal variation in central corneal thickness

  2010cited by this paper
• lucocorticoid upregulates mimecan expression in corticotroph cells in -

  2010cited by this paper
• Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine‐rich proteoglycans

  2010cited by this paper
• Expression of Small Leucine-Rich Proteoglycans During Experimental Fungal Keratitis

  2010cited by this paper
• Molecular Markers of Preterm Labor in the Choriodecidua

  2010cited by this paper
• Use of rat genomics for investigating the metabolic syndrome.

  2010cited by this paper
• Diagnostic protein marker patterns in squamous cervical cancer

  2010cited by this paper
• The molecular basis of corneal transparency.

  2010cited by this paper
• Water sorption and dynamic mechanical properties of dentin adhesives with a urethane-based multifunctional methacrylate monomer.

  2009cited by this paper
• Different expression of mimecan as a marker for differential diagnosis between NSCLC and SCLC.

  2009cited by this paper
• Proteomic analysis of the LPS-induced stress response in rat chondrocytes reveals induction of innate immune response components in articular cartilage.

  2008cited by this paper
• Biological Functions of the Small Leucine-rich Proteoglycans: From Genetics to Signal Transduction*

  2008cited by this paper
• The proteoglycan osteoglycin/mimecan is correlated with arteriogenesis

  2008cited by this paper
• High expression of osteoglycin decreases the metastatic capability of mouse hepatocarcinoma Hca-F cells to lymph nodes.

  2008cited by this paper
• Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass

  2008cited by this paper
• Characterization of metalloprotease cleavage products of human articular cartilage.

  2008cited by this paper
• Expression studies of osteoglycin/mimecan (OGN) in the cochlea and auditory phenotype of Ogn-deficient mice.

  2008cited by this paper
• Differential Expression of Mimecan and Thioredoxin Domain–Containing Protein 5 in Colorectal Adenoma and Cancer: A Proteomic Study

  2007cited by this paper
• Activation of genes for growth factor and cytokine pathways late in chondrogenic differentiation of ATDC5 cells.

  2006cited by this paper
• Porcine OGN and ASPN: mapping, polymorphisms and use for quantitative trait loci identification for growth and carcass traits in a Meishan x Piétrain intercross.

  2006cited by this paper
• Detection of differentially expressed glycogenes in trabecular meshwork of eyes with primary open-angle glaucoma.

  2006cited by this paper
• Global gene expression analysis in the bones reveals involvement of several novel genes and pathways in mediating an anabolic response of mechanical loading in mice

  2005cited by this paper
• The mimecan gene expressed in human pituitary and regulated by pituitary transcription factor-1 as a marker for diagnosing pituitary tumors.

  2005cited by this paper
• Assessment of some tools for the characterization of the human osteoarthritic cartilage proteome.

  2005cited by this paper
• Influence of aging on glycosaminoglycans and small leucine-rich proteoglycans production by skin fibroblasts

  2005cited by this paper
• An x-ray diffraction study of corneal structure in mimecan-deficient mice.

  2005cited by this paper
• Gene and protein expression changes in human trabecular meshwork cells treated with transforming growth factor-beta.

  2004cited by this paper
• Differentially expressed genes in the lens of mimecan-null mice.

  2004cited by this paper
• Gene and Protein Expression Changes in Human Trabecular Meshwork Cells Treated with Transforming Growth Factor-β

  2004cited by this paper
• Bone Morphogenetic Protein-1/Tolloid-related Metalloproteinases Process Osteoglycin and Enhance Its Ability to Regulate Collagen Fibrillogenesis*

  2004cited by this paper
• Phenotype discovery by gene expression profiling: Mapping of biological processes linked to BMP‐2‐mediated osteoblast differentiation

  2003cited by this paper
• Interferon-gamma regulation of the human mimecan promoter.

  2003cited by this paper
• Osteoglycin expression and localization in rabbit tissues and atherosclerotic plaques

  2003cited by this paper
• Analysis of gene expression profiles of gastric normal and cancer tissues by SAGE.

  2003cited by this paper
• Effect of low-level laser irradiation on osteoglycin gene expression in osteoblasts

  2003cited by this paper
• The UV responsive elements in the human mimecan promoter: a functional characterization.

  2003cited by this paper
• IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program.

  2002cited by this paper
• IKKα, IKKβ, and NEMO/IKKγ Are Each Required for the NF-κB-mediated Inflammatory Response Program*

  2002cited by this paper
• Mimecan/osteoglycin-deficient mice have collagen fibril abnormalities.

  2002cited by this paper
• Production of prostaglandin D synthase as a keratan sulfate proteoglycan by cultured bovine keratocytes.

  2001cited by this paper
• Proteoglycan Expression during Transforming Growth Factor β-induced Keratocyte-Myofibroblast Transdifferentiation*

  2001cited by this paper
• Transcriptional activation of bovine mimecan by p53 through an intronic DNA-binding site.

  2001cited by this paper
• Molecular cloning and relative tissue expression of keratocan and mimecan in embryonic quail cornea.

  2000cited by this paper
• Super‐motifs and evolution of tandem leucine‐rich repeats within the small proteoglycans—biglycan, decorin, lumican, fibromodulin, PRELP, keratocan, osteoadherin, epiphycan, and osteoglycin

  2000cited by this paper
• Expression of the keratan sulfate proteoglycans lumican, keratocan and osteoglycin/mimecan during chick corneal development.

  2000cited by this paper
• Fibroblast Growth Factor-2 Promotes Keratan Sulfate Proteoglycan Expression by Keratocytes in Vitro *

  2000cited by this paper
• Identification and characterization of conserved cis-regulatory elements in the human keratocan gene promoter.

  2000cited by this paper
• The Bovine Mimecan Gene

  1999cited by this paper
• Corneal cell proteins and ocular surface pathology.

  1999cited by this paper
• Structure and sequence of the gene encoding human keratocan.

  1999cited by this paper
• The Cloning of Mouse Keratocan cDNA and Genomic DNA and the Characterization of Its Expression during Eye Development*

  1998cited by this paper
• Differential Splicing and Alternative Polyadenylation Generate Multiple Mimecan mRNA Transcripts*

  1997cited by this paper
• Mimecan, the 25-kDa Corneal Keratan Sulfate Proteoglycan, Is a Product of the Gene Producing Osteoglycin*

  1997influential reference
• Identification of osteoglycin as a component of the vascular matrix. Differential expression by vascular smooth muscle cells during neointima formation and in atherosclerotic plaques.

  1997influential reference
• The family of the small leucine-rich proteoglycans: key regulators of matrix assembly and cellular growth.

  1997cited by this paper
• Molecular cloning of the mouse osteoglycin-encoding gene.

  1995cited by this paper
• Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.

  1994cited by this paper

• Regenerative Therapeutics for Chronic Obstructive Pulmonary Disease

  2026cites this paper
• Intervertebral Disc Proteoglycans: Multifunctional Tissue Stabilizing and Instructional Cell Regulatory Proteins That Control Tissue Homeostasis

  2025cites this paper
• Changes in Nucleus Pulposus Cell Atlas and the Role of SPP1 During Intervertebral Disc Degeneration: Single-Cell Sequencing Analysis

  2025cites this paper
• Comprehensive bulk and single-cell RNA sequencing uncovers senescence-associated biomarkers in therapeutic mesenchymal stem cells

  2025cites this paper
• Identification and Validation of Fibroblast‐Associated Genes in Osteoarthritis Based on High‐Dimensional Weighted Gene Coexpression Network Analysis

  2025cites this paper
• Single cell RNA seq reveals the pro-regenerative phenotype of thrombospondin-2 deficient dermal fibroblasts

  2025cites this paper
• The Impact of Exercise Capacity on Complex Neuromuscular Adaptations: A Narrative Review Based on a Rat Model System Selectively Bred for Low and High Response to Training

  2025cites this paper
• Fibroblast-derived osteoglycin promotes epithelial cell repair

  2025influential citation
• Glycosaminoglycans, Instructive Biomolecules That Regulate Cellular Activity and Synaptic Neuronal Control of Specific Tissue Functional Properties

  2025cites this paper
• Extracellular matrix cancer‐associated fibroblasts promote stromal fibrosis and immune exclusion in triple‐negative breast cancer

  2025cites this paper
• Heterozygosity-Rich Regions in Canine Genome: Can They Serve as Indicators of Balancing Selection?

  2025cites this paper
• Integrated analysis of differentially expressed genes and miRNA expression profiles in dilated cardiomyopathy

  2024cites this paper
• Androgen receptor and osteoglycin gene expression predicting prognosis of metastatic prostate cancer

  2024cites this paper
• Alteration of skin fibroblast steady state contributes to healing outcomes

  2024cites this paper
• Analysis of Machine Learning Model of Gynaecological Cancer Diagnosis Using Multilayer Perceptron Network

  2024cites this paper
• Bacterial infection-biased abundance of proteins in the skin mucus of obscure puffer (Takifugu Obscurus).

  2024cites this paper
• Impact on the Transcriptome of Proton Beam Irradiation Targeted at Healthy Cardiac Tissue of Mice

  2024cites this paper
• Urinary proteomics reveals biological processes related to acute kidney injury in Bothrops atrox envenomings

  2024cites this paper
• Characterisation of Matrix-Bound Nanovesicles (MBVs) Isolated from Decellularised Bovine Pericardium: New Frontiers in Regenerative Medicine

  2024cites this paper
• Single-cell transcriptomics analysis reveals extracellular matrix remodelling in carious human dental pulp

  2023cites this paper
• Differential gene expression profiling implicates altered network development in rat postnatal day 4 cortex following 4-Methylimidazole (4-MeI) induced maternal seizures.

  2023cites this paper
• ASPORIN: A root of the matter in tumors and their host environment.

  2023cites this paper
• Soluble vascular endothelial glycocalyx proteoglycans as potential therapeutic targets in inflammatory diseases

  2023cites this paper
• Evaluating the causal effect of circulating proteome on the risk of osteoarthritis-related traits

  2023cites this paper
• Extracellular matrix remodelling in dental pulp tissue of carious human teeth through the prism of single-cell RNA sequencing

  2023cites this paper
• Increased neuron density in the midbrain of a foveate bird, pigeon, results from profound change in tissue morphogenesis.

  2023cites this paper
• Comparison between articular chondrocytes and mesenchymal stromal cells for the production of articular cartilage implants

  2023cites this paper
• Increased neuron density in the midbrain of foveate birds results from profound change in tissue morphogenesis

  2023cites this paper
• An integrated map of fibroblastic populations in human colon mucosa and cancer tissues

  2022cites this paper
• Osteoarthritis Data Integration Portal (OsteoDIP): A web-based gene and non-coding RNA expression database

  2022cites this paper
• Machine Learning analysis of high-grade serous ovarian cancer proteomic dataset reveals novel candidate biomarkers

  2022cites this paper
• Mass spectrometric profiling of tryptic digests of trifluoroethanol extracts from core needle biopsies of breast cancer tissues is a viable sample screening tool for biomarker discovery

  2022cites this paper
• A Novel Ex Vivo Approach Based on Proteomics and Biomarkers to Evaluate the Effects of Chrysene, MEHP, and PBDE-47 on Loggerhead Sea Turtles (Caretta caretta)

  2022cites this paper
• Osteoglycin (OGN) promotes tumorigenesis of pancreatic cancer cell via targeting ID4.

  2022cites this paper
• Serum levels of iCAF‐derived osteoglycin predict favorable outcome in pancreatic cancer

  2022cites this paper
• Decoding the transcriptome of calcified atherosclerotic plaque at single-cell resolution

  2022cites this paper
• Osteoinductive Factor and Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients: A Literature Review

  2022influential citation
• Glis1 and oxaloacetate in nucleus pulposus stromal cell somatic reprogramming and survival

  2022cites this paper
• Osteoglycin: An ECM Factor Regulating Fibrosis and Tumorigenesis

  2022cites this paper
• Apical Papilla Regulates Dental Follicle Fate via the OGN-Hh Pathway

  2022cites this paper
• Osteoglycin across the adult lifespan.

  2021cites this paper
• Responses to Mineral Supplementation and Salmon Lice (Lepeophtheirus salmonis) Infestation in Skin Layers of Atlantic Salmon (Salmo salar L.)

  2021cites this paper
• Nfib promotes chondrocyte proliferation and inhibits differentiation by mildly regulating Sox9 and its downstream genes

  2021cites this paper
• Biology of Proteoglycans and Associated Glycosaminoglycans

  2021cites this paper
• The Role of Competing Endogenous RNA (ceRNA) Network in Ischemic Cardiomyopathy by Bioinformatic Analysis

  2021cites this paper
• Osteoglycin as a Potential Biomarker of Mild Kidney Function Impairment in Type 2 Diabetes Patients

  2021cites this paper
• The expression of mimecan in adrenal tissue plays a role in an organism’s responses to stress

  2021cites this paper
• A comprehensive analysis of gene expression changes in a high replicate and open-source dataset of differentiating hiPSC-derived cardiomyocytes

  2021cites this paper
• Cell states beyond transcriptomics: integrating structural organization and gene expression in hiPSC-derived cardiomyocytes

  2020cites this paper
• Decoding the transcriptome of atherosclerotic plaque at single-cell resolution

  2020cites this paper
• Proteoglycans in Obesity-Associated Metabolic Dysfunction and Meta-Inflammation

  2020cites this paper
• Mimecan Regulates Corticosterone Secretion and Plays A Critical Role in Adrenal Responses to Stress

  2020cites this paper
• Exercise-mitigated gender-based differences in aging: From genetic alterations to heart performance.

  2020cites this paper
• In Vitro Cytological Responses against Laser Photobiomodulation for Periodontal Regeneration

  2020cites this paper
• Osteoglycin silencing exerts inhibitory effects on myocardial fibrosis and epithelial/endothelial‐mesenchymal transformation in a mouse model of myocarditis

  2020cites this paper
• The right ventricle of Tetralogy of Fallot patients undergoing pulmonary valve replacement has normal myofilament function but shows perturbations to the expression of extracellular matrix genes

  2020cites this paper
• Right Ventricle Has Normal Myofilament Function But Shows Perturbations in the Expression of Extracellular Matrix Genes in Patients With Tetralogy of Fallot Undergoing Pulmonary Valve Replacement

  2020cites this paper
• Molecular alterations in the extracellular matrix in the brains of newborns with congenital Zika syndrome

  2020cites this paper
• Osteoclasts secrete osteopontin into resorption lacunae during bone resorption

  2019cites this paper
• Sweet, yet underappreciated: Proteoglycans and extracellular matrix remodeling in heart disease.

  2019cites this paper
• Proteoglycans and dental biology: the first review.

  2019cites this paper
• Topical application of lyophilized and powdered human amniotic membrane promotes diabetic ulcer healing

  2019cites this paper
• Osteoglycin and Bone—a Systematic Review

  2019cites this paper
• Effects of long-term feeding of rapeseed meal on skeletal muscle transcriptome, production efficiency and meat quality traits in Norwegian Landrace growing-finishing pigs

  2019cites this paper
• The potential role of collagens in congenital Zika syndrome: A systems biology approach

  2019cites this paper
• Transcriptome analyses of ovarian stroma; tunica albuginea, interstitium and theca interna.

  2019cites this paper
• Low Levels of Plasma Osteoglycin in Patients with Complex Coronary Lesions

  2018cites this paper
• The composition of prostate core matrisome in vivo and in vitro unveiled by mass spectrometric analysis

  2018cites this paper
• Osteoglycin – A switch from angiogenesis to T-cell recruitment?

  2018cites this paper
• iTRAQ and PRM-based quantitative proteomics in T2DM-susceptible and -tolerant models of Bama mini-pig.

  2018cites this paper
• BACE2 distribution in major brain cell types and identification of novel substrates

  2018cites this paper
• EFFECTS OF MICROVESICLES ON CARDIOVASCULAR AGING

  2017cites this paper
• Osteoglycin prevents the development of age-related diastolic dysfunction during pressure overload by reducing cardiac fibrosis and inflammation.

  2017cites this paper
• Osteoglycin's embracement of VEGF receptor-2 limits angiogenesis and collateralization.

  2017cites this paper
• Osteoglycin's embracement of VEGF receptor-2 limits angiogenesis and collateralization.

  2017influential citation
• Improving the Delivery and Replication of Oncolytic Viruses

  2016cites this paper