Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Molecular Microbiology

• Publication date

  2003-09-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1046/j.1365-2958.2003.03571.xPMID 12940979
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Promoter constructions for efficient secretion expression in Streptomyces lividans

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• Increasing the efficiency of heterologous promoters in actinomycetes.

  2002cited by this paper
• Engineering specificity of starter unit selection by the erythromycin‐producing polyketide synthase

  2002cited by this paper
• Biochemical Evidence for an Editing Role of Thioesterase II in the Biosynthesis of the Polyketide Pikromycin*

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• The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum

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• Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units.

  2001cited by this paper
• Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase.

  2001cited by this paper
• Polyketide biosynthesis: a millennium review.

  2001cited by this paper
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  2001cited by this paper
• Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.

  1999cited by this paper
• A chain initiation factor common to both modular and aromatic polyketide synthases

  1999cited by this paper
• Role of Crotonyl Coenzyme A Reductase in Determining the Ratio of Polyketides Monensin A and Monensin B Produced byStreptomyces cinnamonensis

  1999cited by this paper
• Impact of thioesterase activity on tylosin biosynthesis in Streptomyces fradiae.

  1999cited by this paper
• Multiple regulatory genes in the tylosin biosynthetic cluster of Streptomyces fradiae.

  1999cited by this paper
• Interspecies complementation in Saccharopolyspora erythraea : elucidation of the function of oleP1, oleG1 and oleG2 from the oleandomycin biosynthetic gene cluster of Streptomyces antibioticus and generation of new erythromycin derivatives

  1999cited by this paper
• The biosynthetic gene cluster for the macrolactone ring of the immunosuppressant FK506.

  1998influential reference
• Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.

  1998cited by this paper
• A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.

  1998cited by this paper
• Crystal structure and enzyme mechanism of Delta 5-3-ketosteroid isomerase from Pseudomonas testosteroni.

  1998cited by this paper
• Novel erythromycins from a recombinant Saccharopolyspora erythraea strain NRRL 2338 pIG1. I. Fermentation, isolation and biological activity.

  1998cited by this paper
• Characterization of the potent in vitro and in vivo antimalarial activities of ionophore compounds

  1997cited by this paper
• Identification and characterization of the niddamycin polyketide synthase genes from Streptomyces caelestis

  1997cited by this paper
• Antibiotic resistance gene cassettes derived from the omega interposon for use in E. coli and Streptomyces.

  1997influential reference
• A novel family of proteins that regulates antibiotic production in streptomycetes appears to contain an OmpR‐like DNA‐binding fold

  1997cited by this paper
• Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase.

  1996cited by this paper
• Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase.

  1996cited by this paper
• Fatty acid synthase: in vitro complementation of inactive mutants.

  1996cited by this paper
• The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.

  1995cited by this paper
• Insights into the catalytic mechanism and active-site environment of Comamonas testosteroni delta 5-3-ketosteroid isomerase as revealed by site-directed mutagenesis of the catalytic base aspartate-38.

  1995cited by this paper
• An oligodeoxyribonucleotide-directed dual amber method for site-directed mutagenesis.

  1995influential reference
• Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage.

  1995cited by this paper
• A new DNA sequence assembly program.

  1995cited by this paper
• Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl‐CoA:acyl carrier protein transacylase domains in modular polyketide synthases

  1995cited by this paper
• Biosynthesis of tetronasin: Part 1 introduction and investigation of the diketide and triketide intermediates bound to the polyketide synthase

  1994cited by this paper
• The mRNA for the 23S rRNA methylase encoded by the ermE gene of Saccharopolyspora erythraea is translated in the absence of a conventional ribosome‐binding site

  1994cited by this paper
• Production of 26-deoxymonensins A and B by Streptomyces cinnamonensis in the presence of Metyrapone

  1994cited by this paper
• Widespread occurrence of three sequence motifs in diverse S-adenosylmethionine-dependent methyltransferases suggests a common structure for these enzymes.

  1994cited by this paper
• Limited proteolysis and active-site studies of the first multienzyme component of the erythromycin-producing polyketide synthase.

  1994cited by this paper
• Helix‐turn‐helix DNA‐binding motifs of Streptomyces— a cautionary note

  1993cited by this paper
• Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector.

  1992cited by this paper
• Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea.

  1992cited by this paper
• The Streptomyces glaucescens TcmR protein represses transcription of the divergently oriented tcmR and tcmA genes by binding to an intergenic operator region

  1992cited by this paper
• Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp.

  1992influential reference
• 6-Deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea. Cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme.

  1992cited by this paper
• Modular organization of genes required for complex polyketide biosynthesis.

  1991cited by this paper
• Cloning and sequence analysis of genes involved in erythromycin biosynthesis in Saccharopolyspora erythraea: sequence similarities between EryG and a family of S-adenosylmethionine-dependent methyltransferases

  1991cited by this paper
• EXPERIMENTS AND SPECULATIONS ON THE ROLE OF OXIDATIVE CYCLIZATION CHEMISTRY IN NATURAL PRODUCT BIOSYNTHESIS

  1991cited by this paper
• The P-loop--a common motif in ATP- and GTP-binding proteins.

  1990cited by this paper
• Synthesis of Putative Intermediates on the Monensin Biosynthetic Pathway and Incorporation Experiments with the Monensin-Producing Organism

  1990cited by this paper
• Improved detection of helix-turn-helix DNA-binding motifs in protein sequences.

  1990cited by this paper
• An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea

  1990cited by this paper
• 3-O-demethylmonensins A and B produced by Streptomyces cinnamonensis.

  1987cited by this paper
• Biosynthesis of lasalocid A: biochemical mechanism for assembly of the carbon framework.

  1987cited by this paper
• Cosmid vectors for rapid genomic walking, restriction mapping, and gene transfer.

  1987influential reference
• Biosynthesis of the polyether antibiotic narasin origins of the oxygen atoms and the mechanisms of ring formation

  1986cited by this paper
• Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors.

  1985cited by this paper
• Biosynthesis of the polyketide polyether antibiotic ICI 139603 in Streptomyces longisporoflavus from 18O-labelled acetate and propionate

  1985cited by this paper
• Mammalian fatty acid synthetase is a structurally and functionally symmetrical dimer.

  1985cited by this paper
• Selective isolation of cosmid clones by homologous recombination in Escherichia coli.

  1984cited by this paper
• Biosynthesis of the polyether antibiotic monensin-A. Incorporation of [2-2H2]-, (R)-[2-2H1]- and (S)-[2-2H1]-propionate

  1984cited by this paper
• The relationship between base composition and codon usage in bacterial genes and its use for the simple and reliable identification of protein-coding sequences.

  1984cited by this paper
• The utilization of oxygen atoms from molecular oxygen during the biosynthesis of monensin-A

  1983cited by this paper
• Unified stereochemical model of polyether antibiotic structure and biogenesis

  1983cited by this paper
• Polyether Antibiotics - Biosynthesis

  1981cited by this paper
• Biosynthesis of macrolides. 5. Regiochemistry of the labeling of lasalocid A by [13C,18O]-labeled precursors

  1981cited by this paper
• Polyether biosynthesis. 2. Origin of the oxygen atoms of monensin A

  1981cited by this paper
• Biosynthesis of Monensin

  1973cited by this paper

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  2026cites this paper
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  2025cites this paper
• Mechanistic and molecular insights into iterative triepoxidation catalyzed by monooxygenase MonCI using a natural substrate analog.

  2025cites this paper
• Fatty acid addition strategy redirected the metabolic flux towards an ultra-high monensin productivity of Streptomyces cinnamonensis

  2025cites this paper
• Genomic analysis and process optimization for nigericin production in a newly-isolated antimicrobial Streptomyces.

  2025cites this paper
• Chemical biology research in RIKEN NPDepo aimed at agricultural applications

  2025cites this paper
• Amycolatopsis mediterranei: A Sixty-Year Journey from Strain Isolation to Unlocking Its Potential of Rifamycin Analogue Production by Combinatorial Biosynthesis.

  2024cites this paper
• New myxobacteria of the Myxococcaceae clade produce angiolams with antiparasitic activities

  2024cites this paper
• An Integrated Module Performs Selective 'On-Line' Epoxidation in the Biosynthesis of the Antibiotic Mupirocin.

  2024cites this paper
• Transcriptional regulators of secondary metabolite biosynthesis in Streptomyces

  2024cites this paper
• Comparative and Functional Analyses Reveal Conserved and Variable Regulatory Systems That Control Lasalocid Biosynthesis in Different Streptomyces Species

  2023cites this paper
• Streptomyces changanensis sp. nov. Isolated from Soil in China

  2023cites this paper
• Triepoxide formation by a flavin-dependent monooxygenase in monensin biosynthesis

  2023influential citation
• Expanding Extender Substrate Selection for Unnatural Polyketide Biosynthesis by Acyltransferase Domain Exchange within a Modular Polyketide Synthase

  2023cites this paper
• Salinopyridins A and B, two novel polyethers with a unique pyridine moiety from Streptomyces sp. NA4227

  2022cites this paper
• Comparative Transcriptome-Based Mining of Genes Involved in the Export of Polyether Antibiotics for Titer Improvement

  2022cites this paper
• Studies on Streptomyces sp. SN-593: reveromycin biosynthesis, β-carboline biomediator activating LuxR family regulator, and construction of terpenoid biosynthetic platform

  2022cites this paper
• Characterization of Pathway-Specific Regulator NigR for High Yield Production of Nigericin in Streptomyces malaysiensis F913

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• Streptomyces: host for refactoring of diverse bioactive secondary metabolites

  2021cites this paper
• Production of novel pladienolide analogues through native expression of a pathway-specific activator

  2020cites this paper
• Offloading Role of a Discrete Thioesterase in Type II Polyketide Biosynthesis

  2020cites this paper
• Pharmaceutical and Biotechnological Importance of Actinobacterial Products

  2020cites this paper
• Complementary Genomic, Bioinformatics and Chemical Approaches Facilitate the Absolute Structure Assignment of Ionostatin, a Linear Polyketide from a Rare Marine-Derived Actinomycete.

  2020cites this paper
• Understanding Substrate Selectivity of Phoslactomycin Polyketide Synthase by Using Reconstituted in Vitro Systems

  2020cites this paper
• Regulatory Patterns of Crp on Monensin Biosynthesis in Streptomyces cinnamonensis

  2020cites this paper
• Reconstitution of a mini‐gene cluster combined with ribosome engineering led to effective enhancement of salinomycin production in Streptomyces albus

  2020influential citation
• Identification of crucial bottlenecks in engineered polyketide biosynthesis.

  2019cites this paper
• Genomics-driven discovery of the biosynthetic gene cluster of maduramicin and its overproduction in Actinomadura sp. J1-007

  2019cites this paper
• Exploring the Promiscuous Enzymatic Activation of Unnatural Polyketide Extender Units in Vitro and in Vivo for Monensin Biosynthesis

  2019cites this paper
• Enzymatic Cascade Reactions in Biosynthesis.

  2019cites this paper
• Enzymkaskadenreaktionen in der Biosynthese

  2019cites this paper
• Actinomycete-Derived Polyketides as a Source of Antibiotics and Lead Structures for the Development of New Antimicrobial Drugs

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• Research Progress in the Biosynthetic Mechanisms of Marine Polyether Toxins

  2019cites this paper
• Synthetic biology of polyketide synthases

  2018cites this paper
• Commodity Chemicals From Engineered Modular Type I Polyketide Synthases.

  2018cites this paper
• Comparison of Strategies to Overcome Drug Resistance: Learning from Various Kingdoms

  2018cites this paper
• Acyltransferases as Tools for Polyketide Synthase Engineering

  2018cites this paper
• Enzymatic Formation of Oxygen‐Containing Heterocycles in Natural Product Biosynthesis

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• Elucidation of the Cryptic Methyl Group Epimerase Activity of Dehydratase Domains from Modular Polyketide Synthases Using a Tandem Modules Epimerase Assay.

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  2017influential citation
• DasR positively controls monensin production at two-level regulation in Streptomyces cinnamonensis

  2016cites this paper
• Biosynthesis-driven structure-activity relationship study of premonensin-derivatives.

  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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• Polyketide biosynthesis in dinoflagellates: what makes it different?

  2014cites this paper
• Roles of type II thioesterases and their application for secondary metabolite yield improvement

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• Intermediates in monensin biosynthesis: A late step in biosynthesis of the polyether ionophore monensin is crucial for the integrity of cation binding

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  2014cites this paper
• 7.04 Oxidation by Microbial Methods

  2014cites this paper
• Antibiotic resistance Cell-cell signaling Carbon metabolism Nitrogen metabolism Lipid metabolism Co-factor metabolism

  2013cites this paper
• Eine enzymatische Domäne für die Erzeugung cyclischer Ether in komplexen Polyketiden

  2013cites this paper
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  2013cites this paper
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• An enzymatic domain for the formation of cyclic ethers in complex polyketides.

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• Exploring and Exploiting Gene Networks That Regulate Natural Products Biosynthesis in Actinobacteria

  2013cites this paper
• Site-Specific Recombination Strategies for Engineering Actinomycete Genomes

  2012cites this paper
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• Roles of fkbN in Positive Regulation and tcs7 in Negative Regulation of FK506 Biosynthesis in Streptomyces sp. Strain KCTC 11604BP

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• Minimally invasive mutagenesis gives rise to a biosynthetic polyketide library.

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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011influential citation
• Enzymatic epoxide-opening cascades catalyzed by a pair of epoxide hydrolases in the ionophore polyether biosynthesis.

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  2011cites this paper
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  2010cites this paper
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  2010cites this paper
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