Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2003-08-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.1834399100PMID 12944565PMCID PMC196911
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome

  2003cited by this paper
• Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells.

  2002cited by this paper
• Perspective: Genetic causes of human reproductive disease

  2002cited by this paper
• Molecular basis of combined pituitary hormone deficiencies.

  2002cited by this paper
• Clinical review 148: Monogenic disorders of puberty.

  2002cited by this paper
• Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits

  2002cited by this paper
• Monogenic Disorders of Puberty

  2002cited by this paper
• Genetic causes of human reproductive disease.

  2002cited by this paper
• Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor

  2001cited by this paper
• Characterization of a cDNA encoding a novel avian hypothalamic neuropeptide exerting an inhibitory effect on gonadotropin release.

  2001cited by this paper
• The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54*

  2001cited by this paper
• AXOR12, a Novel Human G Protein-coupled Receptor, Activated by the Peptide KiSS-1*

  2001cited by this paper
• Uncovering molecular mechanisms involved in activation of G protein-coupled receptors.

  2000cited by this paper
• Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function.

  2000cited by this paper
• The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 2001 by The Endocrine Society Prevalence, Phenotypic Spectrum, and Modes of Inheritance of Gonadotropin-Releasing Hormone Receptor Mutations in Idiopathic

  2000cited by this paper
• Discovery of a receptor related to the galanin receptors

  1999cited by this paper
• A prolactin-releasing peptide in the brain

  1998cited by this paper
• Optimization of genome search strategies for homozygosity mapping: influence of marker spacing on power and threshold criteria for identification of candidate regions

  1998cited by this paper
• Expression of basigin, a member of the immunoglobulin superfamily, in the mouse central nervous system.

  1998cited by this paper
• Gonadotropin-releasing hormone deficiency in the human (idiopathic hypogonadotropic hypogonadism and Kallmann's syndrome): pathophysiological and genetic considerations.

  1998cited by this paper
• Overexpression of mouse follistatin causes reproductive defects in transgenic mice.

  1998cited by this paper
• A family with hypogonadotropic hypogonadism and mutations in the gonadotropin-releasing hormone receptor.

  1997cited by this paper
• The Eph family in the patterning of neural development.

  1997cited by this paper
• Physical and genetic mapping of novel microsatellite polymorphisms on human chromosome 19.

  1996cited by this paper
• A comprehensive genetic map of the human genome based on 5,264 microsatellites

  1996cited by this paper
• KiSS-1, a novel human malignant melanoma metastasis-suppressor gene.

  1996cited by this paper
• Parametric and nonparametric linkage analysis: a unified multipoint approach.

  1996cited by this paper
• Avoiding recomputation in linkage analysis.

  1994cited by this paper
• Faster sequential genetic linkage computations.

  1993cited by this paper
• A gene deleted in Kallmann's syndrome shares homology with neural cell adhesion and axonal path-finding molecules

  1991cited by this paper
• The candidate gene for the X-linked Kallmann syndrome encodes a protein related to adhesion molecules.

  1991cited by this paper

• Evidence for KISS-1 nuclear translocation and PI3K/AKT signaling in the ultrastructurally and morphometrically analyzed human endometriosis

  2026cites this paper
• Endocrine-metabolic effects of kisspeptin in mammals.

  2026cites this paper
• Evolution of neurohormone function revealed by actions of kisspeptin-type peptides in an echinoderm.

  2026cites this paper
• Preoptic kisspeptin-nNOS-GnRH (KiNG) neuronal network regulates LH rhythmicity through activation-inhibition in mice.

  2026cites this paper
• Microglia Rank signaling regulates GnRH function and the Hypothalamic-Pituitary-Gonadal axis

  2026cites this paper
• [Neuroendocrine regulation of the reproductive system: integration of research of neuropeptide and experimental pathophysiology of amenorrhea of different genesis (literature review)].

  2026cites this paper
• Date palm pollen extract improves fertility and pregnancy outcomes in letrozole-induced polycystic ovary syndrome rats

  2026cites this paper
• Relationship between kisspeptin-10, neurokinin B and dynorphin A in the course of normal and delayed puberty in ewes

  2026cites this paper
• Identification of a novel KISS1R (GPR54) gene variant (c.505+2T>G) in a patient with congenital hypogonadotropic hypogonadism: A case report and literature review.

  2026cites this paper
• Functional interactions between anteroventral periventricular kisspeptin neurons and gonadotropin-releasing hormone neurons in female mice

  2026cites this paper
• A Review on the Effects of Atrazine on Male Rat Reproductive System Cytoarchitecture, Steroidogenesis and Oxidative Pathway

  2026cites this paper
• Sodium benzoate induces reproductive toxicity via hormonal disruption, ovarian damage and altering kisspeptin/RFRP-3 expression.

  2026cites this paper
• Energy Homeostasis and Kisspeptin System, Roles of Exercise and Outcomes with a Focus on Male Reproductive Health

  2025cites this paper
• The Neuroendocrine Regulation of Reproductive Behavior and Emotional Control by Kisspeptin

  2025cites this paper
• Structural basis of peptide recognition and modulation for neuropeptide FF receptors.

  2025cites this paper
• KNDy Neurons and the Control of the Gonadotropic Axis in the Midgestation Fetal Sheep.

  2025cites this paper
• Effects of menopause on temperature regulation

  2025cites this paper
• Anatomic distribution of kisspeptin neurons in the adult sheep amygdala: Associations with sex, estrogen receptor alpha, androgen receptor, and sexual partner preference

  2025cites this paper
• Evaluation of leaf extracts of Moringa oleifera Lam. On testosterone enanthate-induced polycystic ovary syndrome (PCOS) in mice

  2025cites this paper
• Intranasal kisspeptin administration rapidly stimulates gonadotropin release in humans

  2025cites this paper
• Comprehensive chemoanatomical mapping, and the gonadal regulation, of seven kisspeptin neuronal populations in the mouse brain

  2025cites this paper
• Neuroendocrine mechanisms responsible for elevated gonadotrophin‐releasing hormone and luteinising hormone pulses in polycystic ovary syndrome

  2025cites this paper
• The ticking clock sets the pace for female fertility.

  2025cites this paper
• Structural insights into prolactin-releasing peptide receptor signaling and G-protein coupling selectivity.

  2025cites this paper
• Can kisspeptin be a new treatment for sexual dysfunction?

  2025cites this paper
• New Insights in Bovine Follicular Cysts

  2025cites this paper
• Brainstem noradrenergic neuronal populations: dual effects on regulating GnRH and LH secretion.

  2025cites this paper
• Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders.

  2025cites this paper
• Hypothalamic control of puberty: from neuronal circuits to mechanisms for its metabolic regulation.

  2025cites this paper
• Emerging Perspectives on Gonadotropin Regulation in Vertebrates Revealed by the Discovery of FSH‐RH in Teleosts

  2025cites this paper
• Potential Candidate Genes Associated with Litter Size in Goats: A Review

  2025cites this paper
• Puberty regulation in chub mackerel Scomber japonicus, an important aquaculture fish species, via reproductive endocrine mechanism.

  2025cites this paper
• Activity Changes of the Hypothalamus-Pituitary Hormonal Axis in Peripubertal Female Rats

  2025cites this paper
• Citalopram-induced decrease of CLOCK-ir and BMAL1-ir kisspeptin neurons in the anteroventral periventricular nucleus of adult male mice

  2025cites this paper
• Reversal of Congenital Hypogonadotropic Hypogonadism.

  2025cites this paper
• Deciphering protein-DNA interactions of KISS1 with transcription factors through molecular docking, molecular dynamics simulations, and gene expression analysis.

  2025cites this paper
• Exploring the Role of Kisspeptin in Polycystic Ovary Syndrome and Its Associated Pregnancy Complications

  2025cites this paper
• Neuronal plasticity at puberty in mouse hypothalamic Kiss1 neurons that control fertility.

  2025cites this paper
• Gonadotropin-releasing hormone and cognition.

  2025cites this paper
• Estrogen-Regulated Lateral Septal Kisspeptin Neurons Abundantly Project to GnRH Neurons and the Hypothalamic Supramammillary Nucleus

  2025cites this paper
• Kisspeptin control of hypothalamus-pituitary-ovarian functions.

  2025cites this paper
• Hormonology: A kaleidoscopic tale of dedication, serendipity, and ingenuity.

  2025cites this paper
• Kisspeptin Administration Stimulates Reproductive Hormones but Does Not Affect Anxiety in Humans

  2025cites this paper
• Prostaglandin synthesis mediates the suppression of arcuate Kiss1 neuron activation and pulsatile luteinizing hormone secretion during immune/inflammatory stress in female mice

  2025cites this paper
• Activity of KNDy Neurons and the Melanocortin System During Pubertal Development in Female Sheep.

  2025cites this paper
• The ventral premammillary nucleus at the interface of environmental cues and social behaviors

  2025cites this paper
• Expanded Targeted-Exome Sequencing and Functional Validation Improve Molecular Diagnosis and Refine Genotype-Phenotype Correlations in Congenital Hypogonadotropic Hypogonadism

  2025cites this paper
• The role of hypothalamic kisspeptin neurons in coordinating reproduction and metabolism

  2025cites this paper
• Lipopolysaccharide-induced inflammation modulates testicular kisspeptin system in mice.

  2025cites this paper
• Amenorree

  2025cites this paper
• Evidence for human kisspeptin receptor homo-oligomerization and its functional relevance.

  2025cites this paper
• Amenorreas

  2025cites this paper
• Metabolomics and transcriptomics analyses reveal the complex molecular mechanisms by which the hypothalamus regulates sexual development in female goats

  2025cites this paper
• Sodium benzoate exposure from juvenile to peripubertal period disrupts HPG-axis in both male and female rats

  2025cites this paper
• Potential role of kisspeptin in the estradiol-induced modulation of inhibin subunit gene expression: Insights from in vivo rat models and hypothalamic cell models

  2025cites this paper
• Kisspeptin isoforms: versatile players in reproduction and beyond.

  2025cites this paper
• Kisspeptin Receptor Agonists and Antagonists: Strategies for Discovery and Implications for Human Health and Disease

  2025cites this paper
• Kisspeptin and Neurokinin B: roles in reproductive health.

  2025cites this paper
• Sexually dimorphic distribution of Kiss1 neurons in the bed nucleus of the stria terminalis

  2025cites this paper
• Dynamic Upstream Controllers of Kisspeptin and its Possible Interactions: A Review Elucidating the Pleiotropic Regulators

  2025cites this paper
• Exogenous kisspeptin-10 treatment shows pleiotropy via induction of KISS1 expression, metastasis suppression, and promotes apoptosis in triple-negative breast cancer

  2025cites this paper
• Kisspeptin-Dependent Puberty Onset Triggered by Increased Kiss1 and Pdyn Expression in Arcuate Tac3 Neurons under Reduced Estrogen Negative Feedback and Sufficient Energy Balance in Female Rats

  2025cites this paper
• The role of enteroendocrine cells, hormones, and gut microbiota in anorexia nervosa: a complex interplay of the microbiome-gut-brain axis

  2025cites this paper
• Kisspeptins Regulating Fertility: Potential Future Therapeutic Approach in Infertility Treatment

  2025cites this paper
• Comprehensive Evaluation and Future Perspectives of Non-Surgical Contraceptive Methods in Female Cats and Dogs

  2025cites this paper
• Cell Type-Specific Expression of Purinergic P2X Receptors in the Hypothalamus

  2025cites this paper
• Kisspeptin system - physiology and clinical perspectives.

  2025cites this paper
• Cranial Nerve Zero: A Comprehensive Review of Literature

  2025cites this paper
• Association of Follicular Fluid Kisspeptin-54 Levels and Ovarian Response to Stimulation

  2025cites this paper
• Precocious Puberty and Benign Variants in Female Children: Etiology, Diagnostic Challenges, and Clinical Management

  2025cites this paper
• Gonadotropin secretion and ovarian response of KISS1 knockout gilts treated with hormone analogs activating the hypothalamic-pituitary-gonadal axis†.

  2025cites this paper
• The role of KNDy neurons in human reproductive health.

  2024cites this paper
• Restoring function to inactivating G protein‐coupled receptor variants in the hypothalamic–pituitary–gonadal axis 1

  2024cites this paper
• Malnutrition alters protein expression of KNDy neuropeptides in the arcuate nucleus of mature ewes

  2024cites this paper
• Endocrine toxicity of atrazine and its underlying mechanisms.

  2024cites this paper
• Hormonology: A tale of dedication, serendipity, and ingenuity

  2024cites this paper
• Structural basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor

  2024cites this paper
• Phenytoin causes behavioral abnormalities and suppresses kisspeptin expression, reducing reproductive performance in Japanese medaka.

  2024cites this paper
• Intracerebroventricular injection of kisspeptin in male rats activates hypothalamo-pituitary-gonadal axis, but not hypothalamo-pituitary-adrenal axis

  2024cites this paper
• Characterization of Kiss/Kissr system and expression profiling through developmental stages indicate kiss1 to be the active isotype in Clarias magur

  2024cites this paper
• Raphe glucose-sensing serotonergic neurons stimulate KNDy neurons to enhance LH pulses via 5HT2CR: rat and goat studies

  2024cites this paper
• Protective Effect of Petroselinum Crispum Methanolic Extract against Acrylamide-induced Reproductive Toxicity in Male Rats through NF-ĸB, Kinesin, steroidogenesis Pathways.

  2024cites this paper
• Estradiol action in the female hypothalamo–pituitary–gonadal axis

  2024cites this paper
• Spatial local expressions of kisspeptin in the uterus and uterine tubes and its relationship to the reproductive potential in goats.

  2024cites this paper
• Revolutionizing Infertility Management through Novel Peptide-based Targets.

  2024cites this paper
• Neuropeptides and receptors in the cephalochordate: a crucial model for understanding the origin and evolution of vertebrate neuropeptide systems.

  2024cites this paper
• G protein-coupled receptor (GPCR) gene variants and human genetic disease

  2024cites this paper
• Amenorree

  2024cites this paper
• Novel insights into minipuberty and GnRH: Implications on neurodevelopment, cognition, and COVID‐19 therapeutics

  2024cites this paper
• Maternal Age at Menarche Genes Determines Fetal Growth Restriction Risk

  2024cites this paper
• A comprehensive review of the new FIGO classification of ovulatory disorders.

  2024cites this paper
• Mini-Puberty, Physiological and Disordered: Consequences, and Potential for Therapeutic Replacement

  2024cites this paper
• Construction of an intranasal drug delivery system with hypothalamus‐targeting nanoparticles

  2024cites this paper
• Estradiol elicits distinct firing patterns in arcuate nucleus kisspeptin neurons of females through altering ion channel conductances

  2024cites this paper
• Current Insights in Prolactin Signaling and Ovulatory Function

  2024cites this paper
• "The significance of the GNRH 1 gene polymorphism (rs 6185, rs1812594) in the development of idiopathic hypogonadotropic hypogonadism."

  2024cites this paper
• Kisspeptin and neurokinin B neuroendocrine pathways in the control of human ovulation

  2024cites this paper
• Prolactin-mediates a lactation-induced suppression of arcuate kisspeptin neuronal activity necessary for lactational infertility in mice

  2024cites this paper
• Kisspeptin stimulates oestradiol biosynthesis by upregulating steroidogenic transcripts and proliferation markers in the bubaline granulosa cells in vitro.

  2024cites this paper
• Kisspeptin prevents pregnancy loss by modulating the immune microenvironment at the maternal‐fetal interface in recurrent spontaneous abortion

  2024cites this paper