A mechanism for the segregation of age in mammalian neural stem cells

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Science

• Publication date

  2015-09-18

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1126/science.aac9868PMID 26383951
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2014cited by this paper
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  2014cited by this paper
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  1996cited by this paper

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