Interactions of flecainide with guinea pig cardiac sodium channels. Importance of activation unblocking to the voltage dependence of recovery.

No abstract is available for this paper.

• Publication year

  1990

• Venue

  Circulation Research

• Publication date

  1990-03-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1161/01.RES.66.3.789PMID 2155069
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Renoprotective Benefit of Tolvaptan in Acute Decompensated Heart Failure Patients With Loop Diuretic-Resistant Status

  2018cited by this paper
• Effects of quinidine on the sodium current of guinea pig ventricular myocytes. Evidence for a drug-associated rested state with altered kinetics.

  1990cited by this paper
• Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction.

  1989cited by this paper
• Temperature and Voltage Dependence of Sodium Channel Blocking and Unblocking by O-Demethyl Encainide in Isolated Guinea Pig Myocytes

  1989cited by this paper
• Sodium channel-blocking properties of flecainide, a class IC antiarrhythmic drug, in guinea-pig papillary muscles An open channel blocker or an inactivated channel blocker

  1989cited by this paper
• Effects of Quinidine on Action Potentials and Ionic Currents in Isolated Canine Ventricular Myocytes

  1988cited by this paper
• Use-dependent block of sodium current by ethmozin in voltage-clamped internally perfused canine cardiac Purkinje cells.

  1988cited by this paper
• Activation block and trapping of penticainide, a disopyramide analogue, in the Na+ channel of rabbit cardiac Purkinje fibers.

  1988cited by this paper
• Evidence for Two Components of Sodium Channel Block by Lidocaine in Isolated Cardiac Myocytes

  1988cited by this paper
• Competition between lidocaine and one of its metabolites, glycylxylidide, for cardiac sodium channels.

  1988cited by this paper
• Progress and prospects for optimum antiarrhythmic drug design

  1987cited by this paper
• Sodium current in voltage clamped internally perfused canine cardiac Purkinje cells.

  1987cited by this paper
• Antiarrhythmic agents: modulated receptor applications.

  1987cited by this paper
• Molecular and structural basis of resting and use-dependent block of sodium current defined using disopyramide analogues.

  1987cited by this paper
• Block of activated and inactivated sodium channels by class-I antiarrhythmic drugs studied by using the maximum upstroke velocity (Vmax) of action potential in guinea-pig cardiac muscles.

  1987cited by this paper
• Fundamental properties of local anesthetics. I. The dependence of lidocaine's ionization and octanol:buffer partitioning on solvent and temperature.

  1986cited by this paper
• Characteristics of the time-dependent slow inward current in adult human atrial single myocytes.

  1986cited by this paper
• Na channel activation gate modulates slow recovery from use-dependent block by local anesthetics in squid giant axons.

  1985cited by this paper
• Cardiac Na currents and the inactivating, reopening, and waiting properties of single cardiac Na channels

  1985cited by this paper
• Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics.

  1984cited by this paper
• Antiarrhythmic agents: the modulated receptor mechanism of action of sodium and calcium channel-blocking drugs.

  1984cited by this paper
• Use-dependent block of cardiac sodium channels by quaternary derivatives of lidocaine

  1984cited by this paper
• Slow inactivation of Vmax in guinea pig ventricular myocardium.

  1984cited by this paper
• Lidocaine block of cardiac sodium channels

  1983cited by this paper
• Voltage- and use-dependent effects of lidocaine on sodium current in rat single ventricular cells.

  1983cited by this paper
• Voltage- and time-dependent depression of maximum rate of depolarisation of guinea-pig ventricular action potentials by two new antiarrhythmic drugs, flecainide and lorcainide.

  1983cited by this paper
• pH‐Dependent Effects of Quinidine on the Kinetics of dV/dtmax in Guinea Pig Ventricular Myocardium

  1982cited by this paper
• Effect of Flecainide on Action Potentials and Alternating Current‐Induced Arrhythmias in Mammalian Myocardium

  1982cited by this paper
• The Discontinuous Nature of Propagation in Normal Canine Cardiac Muscle: Evidence for Recurrent Discontinuities of Intracellular Resistance that Affect the Membrane Currents

  1981cited by this paper
• The Influence of pH on the Electrophysiological Effects of Lidocaine in Guinea Pig Ventricular Myocardium

  1980cited by this paper
• Anesthetics: molecular correlates of voltage- and frequency-dependent sodium channel block in nerve.

  1979cited by this paper
• Measurement of Vmax of the cardiac action potential with a sample/hold peak detector.

  1978cited by this paper
• Local anesthetics: hydrophilic and hydrophobic pathways for the drug- receptor reaction

  1977cited by this paper
• Local anesthetics. Effect of pH on use-dependent block of sodium channels in frog muscle.

  1977cited by this paper
• Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels.

  1977cited by this paper
• Effect of Lidocaine and Quinidine on Steady‐State: Characteristics and Recovery Kinetics of (dV/dt)max in Guinea Pig Ventricular Myocardium

  1975cited by this paper
• Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA.

  1975cited by this paper
• The Inhibition of Sodium Currents in Myelinated Nerve by Quaternary Derivatives of Lidocaine

  1973cited by this paper
• A quantitative description of membrane current and its application to conduction and excitation in nerve

  1952cited by this paper

• Antiarrhythmic drugs to prevent sudden cardiac death: Is there a way forward?

  2026cites this paper
• Flecainide Specifically Targets the Monovalent Countercurrent Through the Cardiac Ryanodine Receptor, While a Dominant Opposing Ca2+/Ba2+ Current Is Present

  2024cites this paper
• Pediatric flecainide pharmacogenomics: a roadmap to delivering precision-based care to pediatrics arrhythmias

  2024cites this paper
• Mechanisms of Chemical Atrial Defibrillation by Flecainide and Ibutilide

  2024cites this paper
• A structural atlas of druggable sites on Nav channels

  2023cites this paper
• Effect of Flecainide and Ibutilide Alone and in Combination to Terminate and Prevent Recurrence of Atrial Fibrillation

  2023cites this paper
• Modulation of KV4.3-KChIP2 Channels by IQM-266: Role of DPP6 and KCNE2

  2022cites this paper
• Flecainide How and When: A Practical Guide in Supraventricular Arrhythmias

  2021cites this paper
• Flecainide in Ventricular Arrhythmias: From Old Myths to New Perspectives

  2021cites this paper
• Clinical Management of LQTS Patients

  2019cites this paper
• Structure of the Cardiac Sodium Channel.

  2019cites this paper
• Maastricht antiarrhythmic drug evaluator (MANTA): a computational tool for better understanding of antiarrhythmic drugs.

  2019cites this paper
• Drug Effects on ECGs

  2018cites this paper
• Multiple targets for flecainide action: implications for cardiac arrhythmogenesis

  2018cites this paper
• Long-term flecainide therapy in type 3 long QT syndrome

  2018cites this paper
• Antiarrhythmic Medications for Cardioversion and Maintenance of Sinus Rhythm in Patients with Cardiac Arrhythmias: A Review of the Literature

  2017cites this paper
• Flecainide ameliorates arrhythmogenicity through NCX flux in Andersen-Tawil syndrome-iPS cell-derived cardiomyocytes

  2017cites this paper
• Ranolazine for Congenital Long-QT Syndrome Type III: Experimental and Long-Term Clinical Data

  2016cites this paper
• PITX2 Modulates Atrial Membrane Potential and the Antiarrhythmic Effects of Sodium-Channel Blockers

  2016cites this paper
• Optical imaging of cardiac atrial activation and repolarisation in genetically altered models

  2016influential citation
• Fast-onset lidocaine block of rat NaV1.4 channels suggests involvement of a second high-affinity open state.

  2016cites this paper
• PKPD modelling of PR and QRS intervals in conscious dogs using standard safety pharmacology data.

  2016cites this paper
• The novel late Na+ current inhibitor, GS‐6615 (eleclazine) and its anti‐arrhythmic effects in rabbit isolated heart preparations

  2016cites this paper
• Flecainide: Current status and perspectives in arrhythmia management.

  2015cites this paper
• Patch-Clamp and Voltage-Clamp Techniques

  2015cites this paper
• Synergistic antiarrhythmic effect of combining inhibition of Ca²⁺-activated K⁺ (SK) channels and voltage-gated Na⁺ channels in an isolated heart model of atrial fibrillation.

  2015cites this paper
• Different pH-sensitivity patterns of 30 sodium channel inhibitors suggest chemically different pools along the access pathway

  2015cites this paper
• Congenital Long QT Syndromes: Prevalence, Pathophysiology and Management

  2014cites this paper
• Multiple Modes of Ryanodine Receptor 2 Inhibition by Flecainide

  2014cites this paper
• NaV1.5 Modulation: From Ionic Channels to Cardiac Conduction and Substrate Heterogeneity

  2014cites this paper
• Pharmacokinetic-pharmacodynamic modeling of QRS-prolongation by flecainide: heart rate-dependent effects during sinus rhythm in conscious telemetered dogs.

  2014cites this paper
• Potassium channel activators differentially modulate the effect of sodium channel blockade on cardiac conduction

  2013cites this paper
• Flecainide acetate for the treatment of atrial and ventricular arrhythmias

  2013cites this paper
• Effects of ventricular pacing protocol on electrical restitution assessments in guinea‐pig heart

  2012cites this paper
• Flecainide-Induced Proarrhythmia Is Attributed to Abnormal Changes in Repolarization and Refractoriness in Perfused Guinea-Pig Heart

  2012cites this paper
• Chapter 29 – Ion Channels as Targets for Drugs

  2012cites this paper
• Translation of flecainide- and mexiletine-induced cardiac sodium channel inhibition and ventricular conduction slowing from nonclinical models to clinical.

  2011cites this paper
• Effects of flecainide and quinidine on action potential and ventricular arrhythmogenic properties in Scn3b knockout mice

  2010cites this paper
• An antidote for calcium leak: targeting molecular arrhythmia mechanisms.

  2010cites this paper
• Assessing use-dependent inhibition of the cardiac Na(+/-) current (I(Na)) in the PatchXpress automated patch clamp.

  2010cites this paper
• Twenty-five years in the making: flecainide is safe and effective for the management of atrial fibrillation

  2010cites this paper
• Predicting drug‐induced slowing of conduction and pro‐arrhythmia: identifying the ‘bad’ sodium current blockers

  2010cites this paper
• Regional variations in action potential alternans in isolated murine Scn5a+/− hearts during dynamic pacing

  2010cites this paper
• Effects of flecainide and quinidine on arrhythmogenic properties of Scn5a+/− murine hearts modelling the Brugada syndrome

  2007cites this paper
• Vernakalant (RSD1235): a novel, atrial-selective antifibrillatory agent

  2007cites this paper
• Flecainide sensitivity of a Na channel long QT mutation shows an open-channel blocking mechanism for use-dependent block.

  2006cites this paper
• Warming and response to contractile agents in calf cardiac vein: role of the Ca2+, KCa2+, and Na+ ion channel blockers.

  2005cites this paper
• Ectopic Atrial Automaticit and Conduction

  2005cites this paper
• Mechanism of local anesthetic drug action on voltage-gated sodium channels.

  2005cites this paper
• The Mechanism of Atrial Antiarrhythmic Action of RSD1235

  2005cites this paper
• State-dependent blocking actions of azimilide dihydrochlo-ride (NE-10064) on human cardiac Na(+) channels.

  2004cites this paper
• Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state‐dependent block

  2004cites this paper
• The Effects of Class Ic Antiarrhythmics on Tetrodotoxin-Resistant Na+ Currents in Rat Sensory Neurons

  2004cites this paper
• State‐dependent trapping of flecainide in the cardiac sodium channel

  2004cites this paper
• Synergistic Action of Atrial Dilation and Sodium Channel Blockade on Conduction in Rabbit Atria

  2004cites this paper
• 1 I FARMACI NELL'ARRESTO CIRCOLATORIO 2 NUOVI ANTIARITMICI: IMPLICAZIONI PER L'ANESTESISTA RIANIMATORE 3 VASODILATATORI ED IPOTENSIONE CONTROLLATA 4 INTERAZIONI FARMACOLOGICHE IN ANESTESIA: I CALCIO ANTAGONISTI

  2004cites this paper
• Electropharmacology of Na+ channel blockers with slow kinetics of dissociation

  2003cites this paper
• State-dependent Block of Wild-type and Inactivation-deficient Na (cid:2) Channels by Flecainide

  2003cites this paper
• State-dependent Block of Wild-type and Inactivation-deficient Na+ Channels by Flecainide

  2003cites this paper
• Common Molecular Determinants of Flecainide and Lidocaine Block of Heart NaChannels: Evidence from Experiments with Neutral and

  2003cites this paper
• Common Molecular Determinants of Flecainide and Lidocaine Block of Heart Na+ Channels

  2003cites this paper
• Channel Openings Are Necessary but not Sufficient for Use-dependent Block of Cardiac Na+ Channels by Flecainide

  2002cites this paper
• A‐Type potassium currents active at subthreshold potentials in mouse cerebellar purkinje cells

  2002cites this paper
• Gating-Dependent Mechanisms for Flecainide Action in SCN5A-Linked Arrhythmia Syndromes

  2001cites this paper
• Ion Channels as Targets for Drugs

  2001cites this paper
• Effects of flecainide in patients with new SCN5A mutation: mutation-specific therapy for long-QT syndrome?

  2000cites this paper
• Preferential Block of Late Sodium Current in the LQT3 ΔKPQ Mutant by the Class IC Antiarrhythmic Flecainide

  2000influential citation
• Molecular pharmacology of the sodium channel mutation D1790G linked to the long-QT syndrome.

  2000cites this paper
• Preferential block of late sodium current in the LQT3 DeltaKPQ mutant by the class I(C) antiarrhythmic flecainide.

  2000influential citation
• Sodium Channel Blockers and Activators

  2000cites this paper
• Ionic mechanisms for the antiarrhythmic action of cinnamophilin in rat heart.

  1999cites this paper
• Comparison of cocaine and Na+ channel blockers on cardio-respiratory function in the rabbit.

  1999cites this paper
• Ionic Mechanisms for the Antiarrhythmic Action of Cinnamophilin in Rat Heart

  1999cites this paper
• Profiles of aprindine, cibenzoline, pilsicainide and pirmenol in the framework of the Sicilian Gambit. The Guideline Committee for Clinical Use of Antiarrhythmic Drugs in Japan (Working Group of Arrhythmias of the Japanese Society of Electrocardiology).

  1999cites this paper
• Terfenadine block of sodium current in canine atrial myocytes.

  1999cites this paper
• ST Segment Elevation Induced by Class IC Antiarrhythmic Agents: Underlying Electrophysiologic Mechanisms and Insights into Drug‐Induced Proarrhythmia

  1998cites this paper
• Na+ channel blocking effects of cibenzoline on guinea-pig ventricular cells.

  1998cites this paper
• Antiarrhythmic drugs and cardiac ion channels: mechanisms of action.

  1998cites this paper
• Beta-adrenergic augmentation of flecainide-induced conduction slowing in canine Purkinje fibers.

  1997cites this paper
• Brown recluse spider envenomation: a prospective trial of hyperbaric oxygen therapy.

  1997cites this paper
• Negative dromotropic effects of class I antiarrhythmic drugs in anisotropic ventricular muscle.

  1996cites this paper
• Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels.

  1996cites this paper
• Electrophysiological mechanisms for the antiarrhythmic action of (-)-caryachine in rat heart.

  1996cites this paper
• Flecainide and the Electrophysiologic Matrix:

  1996cites this paper
• Ion channel blockers in the treatment of chronic heart failure.

  1996cites this paper
• Comparison of bidisomide, flecainide and dofetilide on action potential duration in isolated canine atria: effect of isoproterenol.

  1996cites this paper
• Kinetics of Frequency‐Dependent Conduction Delay by Class I Antiarrhythmic Drugs in Human Atrium

  1995cites this paper
• [Excitatory sodium current model and reconstruction of propagated and nonpropagated action potential upstroke].

  1995cites this paper
• Basic Concepts in Cellular Cardiac Electrophysiology: Part II: Block of Ion Channels by Antiarrhythmic Drugs

  1995cites this paper
• Reentrant arrhythmias in the subacute infarction period. The proarrhythmic effect of flecainide acetate on functional reentrant circuits.

  1995cites this paper
• Sodium Channel Blockade as an Antiarrhythmic Mechanism

  1995cites this paper
• Flecainide inhibits the transient outward current in atrial myocytes isolated from the rabbit heart.

  1995cites this paper
• Molecular Biology and Ion Channel Biophysics: Their Role in Rational Pharmacological Antiarrhythmic Therapy

  1995cites this paper
• Electrophysiological effects of flecainide on anisotropic conduction and reentry in infarcted canine hearts.

  1995cites this paper
• Terfenadine Blocks Time‐Dependent Ca2+, Na+, and K+ Channels in Guinea Pig Ventricular Myocytes

  1995cites this paper
• Electrophysiological effects of Ro 22–9194, a new antiarrhythmic agent, on guinea‐pig ventricular cells

  1995cites this paper
• Electrophysiological effects of SD‐3212, a new antiarrhythmic agent with vasodilator action, on guinea‐pig ventricular cells

  1995cites this paper
• The activation gate of cardiac Na+ channel modulates voltage- and pH-dependent unbinding of disopyramide.

  1995cites this paper
• Electrocardiographic interactions between pinacidil, a potassium channel opener and class I antiarrhythmic agents in guinea‐pig isolated perfused heart

  1995cites this paper
• Pharmacological modulation of human cardiac Na+ channels.

  1994cites this paper