CRMP-2 binds to tubulin heterodimers to promote microtubule assembly

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Nature Cell Biology

• Publication date

  2002-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ncb825PMID 12134159
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Phosphorylation of collapsin response mediator protein-2 by Rho-kinase : evidence for two separate signaling pathways for growth cone collapse

  2003cited by this paper
• Slow axonal transport: fast motors in the slow lane.

  2002cited by this paper
• CRMP-2 induces axons in cultured hippocampal neurons

  2001cited by this paper
• Going new places using an old MAP: tau, microtubules and human neurodegenerative disease.

  2001cited by this paper
• Evidence That Collapsin Response Mediator Protein-2 Is Involved in the Dynamics of Microtubules*

  2000cited by this paper
• Phosphorylation of Collapsin Response Mediator Protein-2 by Rho-kinase

  2000cited by this paper
• Identification of CRAM, a novel unc-33 gene family protein that associates with CRMP3 and protein-tyrosine kinase(s) in the developing rat brain.

  2000cited by this paper
• Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522.

  2000cited by this paper
• Different Contributions of Microtubule Dynamics and Transport to the Growth of Axons and Collateral Sprouts

  1999cited by this paper
• Microtubules and neuronal polarity: lessons from mitosis.

  1999cited by this paper
• Local Presentation of Substrate Molecules Directs Axon Specification by Cultured Hippocampal Neurons

  1999cited by this paper
• The Ulip family phosphoproteins--common and specific properties.

  1998cited by this paper
• The slow axonal transport of cytoskeletal proteins.

  1998cited by this paper
• Microtubules and axonal growth.

  1997cited by this paper
• Phosphorylation states of microtubule-associated protein 2 (MAP2) determine the regulatory role of MAP2 in microtubule dynamics.

  1997cited by this paper
• Brain CRMP Forms Heterotetramers Similar to Liver Dihydropyrimidinase

  1997cited by this paper
• Identification and Characterization of a Retinoic Acid-regulated Human Homologue of the unc-33-like Phosphoprotein Gene (hUlip) from Neuroblastoma Cells*

  1997cited by this paper
• Microtubule Stability Decreases Axon Elongation but Not Axoplasm Production

  1996cited by this paper
• Tau Is Enriched on Dynamic Microtubules in the Distal Region of Growing Axons

  1996cited by this paper
• Microtubule transport and assembly during axon growth

  1996cited by this paper
• Sorting mechanisms of tau and MAP2 in neurons: suppressed axonal transit of MAP2 and locally regulated microtubule binding.

  1995cited by this paper
• Microtubules released from the neuronal centrosome are transported into the axon.

  1995cited by this paper
• The growth of the axon is not dependent upon net microtubule assembly at its distal tip

  1995cited by this paper
• TOAD-64, a gene expressed early in neuronal differentiation in the rat, is related to unc-33, a C. elegans gene involved in axon outgrowth

  1995cited by this paper
• Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33

  1995cited by this paper
• Identification of tau protein regions required for process formation in PC12 cells.

  1994cited by this paper
• Microtubule fragmentation and partitioning in the axon during collateral branch formation

  1994cited by this paper
• Microtubule-stabilizing activity of microtubule-associated proteins (MAPs) is due to increase in frequency of rescue in dynamic instability: shortening length decreases with binding of MAPs onto microtubules.

  1994cited by this paper
• Changes in microtubule number and length during axon differentiation

  1994cited by this paper
• Domains of tau protein and interactions with microtubules.

  1994cited by this paper
• Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho

  1994cited by this paper
• Purified native microtubule associated protein MAP1A: kinetics of microtubule assembly and MAP1A/tubulin stoichiometry.

  1994cited by this paper
• Microtubule organization and dynamics dependent on microtubule-associated proteins.

  1994cited by this paper
• Neuronal polarity.

  1994cited by this paper
• Composite microtubules of the axon: quantitative analysis of tyrosinated and acetylated tubulin along individual axonal microtubules.

  1993cited by this paper
• Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau.

  1992cited by this paper
• Newly assembled microtubules are concentrated in the proximal and distal regions of growing axons

  1992cited by this paper
• Axonal transport.

  1989cited by this paper
• Experimental observations on the development of polarity by hippocampal neurons in culture

  1989cited by this paper
• The establishment of polarity by hippocampal neurons in culture

  1988cited by this paper
• Visualization of the dynamic instability of individual microtubules by dark-field microscopy

  1986cited by this paper
• Axonal guidance mutants of Caenorhabditis elegans identified by filling sensory neurons with fluorescein dyes.

  1985cited by this paper
• Reversible dissociation of the alpha beta dimer of tubulin from bovine brain.

  1978cited by this paper
• Structure of the tubulin dimer.

  1977cited by this paper
• Axonal transport.

  1976cited by this paper

• A Flupirtine Benzyl Carbamate Improves Neurocognitive Deficits and Molecular Pathology in the Cln6nclf Mouse

  2026cites this paper
• From Regeneration Failure to Functional Restoration: Unlocking the Neuronal‐Intrinsic Regenerative Capacity as a Therapeutic Frontier for Optic Neuropathy and Glaucoma

  2026cites this paper
• CRMP/UNC-33 maintains neuronal microtubule arrays by promoting individual microtubule rescue.

  2025cites this paper
• Top‐Down Proteomics Study of Aging and Sexual Dimorphism of Zebrafish Brains

  2025cites this paper
• Trio and CRMP2 regulate axon branching and Semaphorin3A signaling

  2025cites this paper
• Discovery and identification of semaphorin 4D as a bioindicator of high fracture incidence in type 2 diabetic mice with glucose control

  2025cites this paper
• Select NSAIDs enhance peripheral nerve growth and calcium signaling through PPARγ activation.

  2025cites this paper
• Glycogen synthase kinase 3β: a key player in progressive chronic kidney disease

  2025cites this paper
• Axon-specific microtubule regulation drives asymmetric regeneration of sensory neuron axons

  2025cites this paper
• Involvement of CRMP2 Phosphorylation in Amyloid Beta-induced Tau Phosphorylation of Hippocampal Neurons in Alzheimer’s Disease Mouse Model

  2025cites this paper
• GluN2B‐Derived Small Interfering Peptide (GluN2B‐Sip) Protects Against Sevoflurane‐Induced Neurotoxicity in Developing Rats

  2025cites this paper
• Lacosamide Is a Novel Drug That Improves AGTPBP1 Knockout-Mediated Impairment of Neuronal and Dopaminergic Function

  2025cites this paper
• Reduced exosomal miR-215-5p activates the NEAT1/MAPK1/p-CRMP2 pathway and contributes to social dysfunction in a VPA-induced autism model.

  2025cites this paper
• CRMP2 phosphorylation regulates polarization and spinal infiltration of CD4+ T lymphocytes, inhibits spinal glial activation, and arthritic pain

  2025cites this paper
• Isoaspartate formation and irreversible aggregation of collapsin response mediator protein 2: implications for the etiology of epilepsy and age-related cognitive decline

  2024cites this paper
• CRMP2 regulates mossy fiber sprouting and modulates microtubule dynamics in a pilocarpine induced rat model of epilepsy.

  2024cites this paper
• Zinc Deficiency Decreases Neurite Extension via CRMP2 Signal Pathway.

  2024cites this paper
• Peptide and Peptidomimetic Inhibitors Targeting the Interaction of Collapsin Response Mediator Protein 2 with the N-Type Calcium Channel for Pain Relief.

  2024cites this paper
• How does Nogo-A signalling influence mitochondrial function during multiple sclerosis pathogenesis?

  2024cites this paper
• Insular cortex stimulation alleviates neuropathic pain through changes in the expression of collapsin response mediator protein 2 involved in synaptic plasticity.

  2024cites this paper
• The ataxia-telangiectasia disease protein ATM controls vesicular protein secretion via CHGA and microtubule dynamics via CRMP5

  2024cites this paper
• Sinomenine ameliorates fibroblast-like synoviocytes dysfunction by promoting phosphorylation and nuclear translocation of CRMP2.

  2024cites this paper
• Elevated Hippocampal CRMP5 Mediates Chronic Stress-Induced Cognitive Deficits by Disrupting Synaptic Plasticity, Hindering AMPAR Trafficking, and Triggering Cytokine Release

  2023cites this paper
• Advances in Understanding the Molecular Mechanisms of Neuronal Polarity

  2023cites this paper
• The role of RhoA/ROCK pathway in the ischemic stroke-induced neuroinflammation.

  2023cites this paper
• How does Nogo receptor influence demyelination and remyelination in the context of multiple sclerosis?

  2023cites this paper
• Phosphorylated S6K1 and 4E-BP1 play different roles in constitutively active Rheb-mediated retinal ganglion cell survival and axon regeneration after optic nerve injury

  2023cites this paper
• Microtubule association of TRIM3 revealed by differential extraction proteomics

  2023cites this paper
• Involvement of protein L-isoaspartyl methyltransferase in the physiopathology of neurodegenerative diseases: Possible substrates associated with synaptic function.

  2023cites this paper
• Predicting phenotype to mechanotype relationships in cells based on intracellular signaling network

  2023cites this paper
• Contribution of the dihydropyrimidinase-like proteins family in synaptic physiology and in neurodevelopmental disorders

  2023influential citation
• Proteomic analysis of exosomes derived from human mature milk and colostrum of mothers with term, late preterm, or very preterm delivery.

  2023cites this paper
• Indolyl-chalcone derivatives trigger apoptosis in cisplatin-resistant mesothelioma cells through aberrant tubulin polymerization and deregulation of microtubule-associated proteins

  2023cites this paper
• Human Breast Milk microRNAs, Potential Players in the Regulation of Nervous System

  2023cites this paper
• Galectin-3 Mediates Tumor Progression in Astrocytoma by Regulating Glycogen Synthase Kinase-3β Activity

  2023cites this paper
• Deciphering the Tubulin Language: Molecular Determinants and Readout Mechanisms of the Tubulin Code in Neurons

  2023cites this paper
• Implication of Adipogenesis-Coupled CRMP2 Functional Profile in Metabolic Homeostasis and Imbalance

  2022cites this paper
• Characterization of Collapsin Response Mediator Protein 2 in Colorectal Cancer Progression in Subjects with Diabetic Comorbidity

  2022cites this paper
• Research Progress of Collapse Response Mediator Proteins in Neurodegenerative Diseases

  2022cites this paper
• Dual efficacy of Fasudil at improvement of survival and reinnervation of flap through RhoA/ROCK/PI3K/Akt pathway

  2022cites this paper
• CRMP4 Up-regulates M2 Macrophages and Myeloid-derived Suppressor Cells to Promote Pancreatic Cancer in Mice

  2022cites this paper
• Bridging the gap of axonal regeneration in the central nervous system: A state of the art review on central axonal regeneration

  2022cites this paper
• Focusing on cyclin-dependent kinases 5: A potential target for neurological disorders

  2022cites this paper
• Cypin binds to tubulin heterodimers and microtubule protofilaments and regulates microtubule spacing in developing hippocampal neurons.

  2022cites this paper
• Genome-wide translation control analysis of developing human neurons

  2022cites this paper
• Alleles of unc‐33/CRMP exhibit defects during Caenorhabditis elegans epidermal morphogenesis

  2022cites this paper
• Microtubule remodelling as a driving force of axon guidance and pruning.

  2022cites this paper
• Cdc42 Promotes Axonogenesis of Primary Hippocampal Neurons by Inhibiting Glycogen Synthase Kinase-3β.

  2022cites this paper
• Disentangling the roles of trauma and genetics in psychiatric disorders using an Electronic Health Records-based approach

  2022cites this paper
• The GADD45G/p38 MAPK/CDC25B signaling pathway enhances neurite outgrowth by promoting microtubule polymerization

  2022cites this paper
• Phosphorylated CRMP1, axon guidance protein, is a component of spheroids and is involved in axonal pathology in amyotrophic lateral sclerosis

  2022cites this paper
• The Nogo-66 Receptors NgR1 and NgR3 Are Required for Commissural Axon Pathfinding

  2022cites this paper
• De novo non-synonymous DPYSL2 (CRMP2) variants in two patients with intellectual disabilities and documentation of functional relevance through zebrafish rescue and cellular transfection experiments.

  2022cites this paper
• Metallothionein-3 attenuates the effect of Cu2+ ions on actin filaments

  2022cites this paper
• Drosophila GSK3β promotes microtubule disassembly and dendrite pruning in sensory neurons.

  2022cites this paper
• Somatostatin Ameliorates β-Amyloid-Induced Cytotoxicity via the Regulation of CRMP2 Phosphorylation and Calcium Homeostasis in SH-SY5Y Cells

  2021cites this paper
• Novel function of N-acetyltransferase for microtubule stability and JNK signaling in Drosophila organ development

  2021influential citation
• GSK3β Interacts With CRMP2 and Notch1 and Controls T-Cell Motility

  2021cites this paper
• Nogo-A Induced Polymerization of Microtubule Is Involved in the Inflammatory Heat Hyperalgesia in Rat Dorsal Root Ganglion Neurons

  2021cites this paper
• Regulation of CRMP2 by Cdk5 and GSK-3β Participates in Sevoflurane-induced Dendritic Development Abnormalities and Cognitive Dysfunction in Developing Rats.

  2021cites this paper
• CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway

  2021cites this paper
• CRMP2 as a Candidate Target to Interfere with Lung Cancer Cell Migration

  2021cites this paper
• Maternal deprivation induces cytoskeletal alterations and depressive-like behavior in adult male rats by regulating the AKT/GSK3β/CRMP2 signaling pathway.

  2021cites this paper
• CRMP2 Is Involved in Regulation of Mitochondrial Morphology and Motility in Neurons

  2021cites this paper
• Phosphorylation of CRMP2 by Cdk5 Negatively Regulates the Surface Delivery and Synaptic Function of AMPA Receptors

  2021cites this paper
• DPYSL2 as potential diagnostic and prognostic biomarker linked to immune infiltration in lung adenocarcinoma

  2021cites this paper
• The Rac-GAP alpha2-Chimaerin Signals via CRMP2 and Stathmins in the Development of the Ocular Motor System

  2021cites this paper
• Conditional knockout of CRMP2 in neurons, but not astrocytes, disrupts spinal nociceptive neurotransmission to control the initiation and maintenance of chronic neuropathic pain.

  2021cites this paper
• Swimming exercise reduces the vulnerability to stress and contributes to the AKT/GSK3β/CRMP2 pathway and microtubule dynamics mediated protective effects on neuroplasticity in male C57BL/6 mice.

  2021cites this paper
• With the Permission of Microtubules: An Updated Overview on Microtubule Function During Axon Pathfinding

  2021cites this paper
• The prefrontal cortex in depression: Use of proteomics

  2021cites this paper
• Spastin interacts with collapsin response mediator protein 3 to regulate neurite growth and branching

  2021cites this paper
• Beyond Neuronal Microtubule Stabilization: MAP6 and CRMPS, Two Converging Stories

  2021cites this paper
• Dysregulated CRMP Mediates Circadian Deficits in a Drosophila Model of Fragile X Syndrome

  2021cites this paper
• Effects of CRMP2 DNA Methylation in the Hippocampus on Depressive-Like Behaviors and Cytoskeletal Proteins in Rats

  2021cites this paper
• The life cycle of voltage-gated Ca2+ channels in neurons: an update on the trafficking of neuronal calcium channels

  2021cites this paper
• Betaine ameliorates schizophrenic traits by functionally compensating for KIF3-based CRMP2 transport.

  2021cites this paper
• A Review on Potential Footprints of Ferulic Acid for Treatment of Neurological Disorders

  2021cites this paper
• Effects of Low-Dose Gestational TCDD Exposure on Behavior and on Hippocampal Neuron Morphology and Gene Expression in Mice

  2021cites this paper
• Pax6 regulates the morphological and electrophysiological development of mouse prethalamic neurons

  2021cites this paper
• GPR3 accelerates neurite outgrowth and neuronal polarity formation via PI3 kinase-mediating signaling pathway in cultured primary neurons.

  2021cites this paper
• Mechanisms and Therapeutic Implications of GSK-3 in Treating Neurodegeneration

  2021cites this paper
• Cdc42 Facilitates Axonogenesis by Enhancing Microtubule Stabilization in Primary Hippocampal Neurons

  2021cites this paper
• Unrestrained growth of correctly oriented microtubules instructs axonal microtubule orientation

  2021cites this paper
• CRMP/UNC-33 organizes microtubule bundles for KIF5-mediated mitochondrial distribution to axon

  2021influential citation
• Schizophrenia risk-gene Crmp2 deficiency causes precocious critical period plasticity and deteriorated binocular vision.

  2021cites this paper
• Therapeutic repair for spinal cord injury: combinatory approaches to address a multifaceted problem

  2020cites this paper
• Discovery of suppressors of CRMP2 phosphorylation reveals compounds that mimic the behavioral effects of lithium on amphetamine-induced hyperlocomotion

  2020cites this paper
• USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor Suppressor, and Chromosome Instability Gene Deleted in Neuroblastoma

  2020cites this paper
• The intrinsic axon regenerative properties of mature neurons after injury.

  2020cites this paper
• Low Incidence of High-Grade Pancreatic Intraepithelial Neoplasia Lesions in a Crmp4 Gene–Deficient Mouse Model of Pancreatic Cancer

  2020cites this paper
• PlexinA3 interacts with CRMP2 to mediate Sema3A signalling during dendritic growth in cultured cerebellar granule neurons.

  2020influential citation
• Complementary Nucleobase Interactions Drive the Hierarchical Self-Assembly of Core–Shell Bottlebrush Block Copolymers toward Cylindrical Supramolecules

  2020cites this paper
• Nuclear Isoforms of Neurofibromin Are Required for Proper Spindle Organization and Chromosome Segregation

  2020influential citation
• Multifunctional compounds Lithium Chloride and Methylene Blue attenuate the negative effects of diisopropylfluorophosphate on axonal transport in rat cortical neurons.

  2020cites this paper
• Pivotal role of DPYSL2A in KLF4-mediated monocytic differentiation of acute myeloid leukemia cells

  2020cites this paper
• Topical ripasudil stimulates neuroprotection and axon regeneration in adult mice following optic nerve injury

  2020cites this paper
• Combined Treatment with Two Water Extracts of Eleutherococcus senticosus Leaf and Rhizome of Drynaria fortunei Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind Study in Healthy Adults

  2020cites this paper
• Radiolabeling of lacosamide using highly purified rhenium-188 as a prospective brain theranostic agent

  2020cites this paper
• Intravitreal application of AAV-BDNF or mutant AAV-CRMP2 protects retinal ganglion cells and stabilizes axons and myelin after partial optic nerve injury.

  2020cites this paper