Quercetin, a naturally occurring dietary flavonoid, is well known to ameliorate chronic diseases and aging processes in humans, and its antiviral properties have been investigated in numerous studies. In silico and in vitro studies demonstrated that quercetin can interfere with various stages of the coronavirus entry and replication cycle such as PLpro, 3CLpro, and NTPase/helicase. Due to its pleiotropic activities and lack of systemic toxicity, quercetin and its derivatives may represent target compounds to be tested in future clinical trials to enrich the drug arsenal against coronavirus infections. There is evidence that quercetin in combination with, for example, vitamins C and D, may exert a synergistic antiviral action that may provide either an alternative or additional therapeutic/preventive option due to overlapping antiviral and immunomodulatory properties. This review summarizes the antiviral significance of quercetin and proposes a possible strategy for the effective utilization of natural polyphenols in our daily diet for the prevention of viral infection.
Quercetin: Antiviral Significance and Possible COVID-19 Integrative Considerations
P. Agrawal,Chandan Agrawal,G. Blunden
Published 2020 in Natural Product Communications
ABSTRACT
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- Publication year
2020
- Venue
Natural Product Communications
- Publication date
2020-12-01
- Fields of study
Biology, Medicine, Chemistry
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Semantic Scholar
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