Phosphorylation of caldesmon prevents its interaction with smooth muscle myosin.

No abstract is available for this paper.

• Publication year

  1989

• Venue

  Journal of Biological Chemistry

• Publication date

  1989-01-05

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  PMID 2909541
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Binding of caldesmon to smooth muscle myosin.

  1988cited by this paper
• Autophosphorylation of smooth-muscle caldesmon.

  1988cited by this paper
• Effect of caldesmon on the ATPase activity and the binding of smooth and skeletal myosin subfragments to actin.

  1988cited by this paper
• Cross-bridge phosphorylation and regulation of latch state in smooth muscle.

  1988cited by this paper
• Characterization of the autophosphorylation of chicken gizzard caldesmon.

  1988cited by this paper
• The effects of phosphorylation of smooth-muscle caldesmon.

  1987cited by this paper
• Caldesmon, a major actin- and calmodulin-binding protein of smooth muscle.

  1987cited by this paper
• Smooth muscle caldesmon is an extended flexible monomeric protein in solution that can readily undergo reversible intra- and intermolecular sulfhydryl cross-linking. A mechanism for caldesmon's F-actin bundling activity.

  1987cited by this paper
• Ca2+- and calmodulin-dependent stimulation of smooth muscle actomyosin Mg2+-ATPase by fodrin.

  1987cited by this paper
• Domain mapping of chicken gizzard caldesmon.

  1987cited by this paper
• Vascular smooth muscle caldesmon.

  1986cited by this paper
• The effects of caldesmon on smooth muscle heavy actomeromyosin ATPase activity and binding of heavy meromyosin to actin.

  1986cited by this paper
• The effects of caldesmon on the ATPase activities of rabbit skeletal-muscle myosin.

  1986cited by this paper
• Functional domain of caldesmon

  1986cited by this paper
• Identification by monoclonal antibodies and characterization of human platelet caldesmon

  1986cited by this paper
• Caldesmon: a calmodulin-binding actin-regulatory protein.

  1986cited by this paper
• Caldesmon association with smooth muscle thin filaments isolated in the presence and absence of calcium.

  1986cited by this paper
• Properties of caldesmon isolated from chicken gizzard.

  1985cited by this paper
• Smooth muscle caldesmon. Rapid purification and F-actin cross-linking properties.

  1984cited by this paper
• Ca2+-dependent hydrophobic-interaction chromatography. Isolation of a novel Ca2+-binding protein and protein kinase C from bovine brain.

  1984cited by this paper
• Isolation of the native form of chicken gizzard myosin light-chain kinase.

  1984cited by this paper
• Inhibition of smooth muscle actin-activated myosin Mg2+-ATPase activity by caldesmon.

  1984cited by this paper
• Smooth muscle myosin light chain kinase.

  1983cited by this paper
• Ca2+, cAMP, and changes in myosin phosphorylation during contraction of smooth muscle.

  1983cited by this paper
• Role of Ca2+ and myosin light chain phosphorylation in regulation of smooth muscle.

  1982cited by this paper
• Ca2+-induced hydrophobic site on calmodulin: application for purification of calmodulin by phenyl-Sepharose affinity chromatography.

  1982cited by this paper
• Phosphorylation of smooth muscle myosin: evidence for cooperativity between the myosin heads.

  1981cited by this paper
• Myosin phosphorylation and the cross-bridge cycle in arterial smooth muscle.

  1981cited by this paper
• Reliability of molecular weight determination of proteins by polyacrylamide gradient gel electrophoresis in the presence of sodium dodecyl sulfate.

  1978cited by this paper
• Phosphorylation of cardiac troponin by cyclic adenosine 3':5'-monophosphate-dependent protein kinase.

  1977cited by this paper
• Specific chemical cleavage in high yield at the amino peptide bonds of cysteine and cystine residues.

  1973cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper

• Molecular-level evidence of force maintenance by smooth muscle myosin during LC20 dephosphorylation

  2022cites this paper
• Calponin.

  2020cites this paper
• The Dynamic Actin Cytoskeleton in Smooth Muscle.

  2018cites this paper
• Length distribution of myosin filaments in smooth muscle and implications in the structure and function of contractile units

  2015cites this paper
• The role of caldesmon and its phosphorylation by ERK on the binding force of unphosphorylated myosin to actin.

  2014cites this paper
• Smooth Muscle‐Protein Translocation and Tissue Function

  2014cites this paper
• Tonic and Phasic Smooth Muscle Contraction Is Not Regulated by the PKCα - CPI-17 Pathway in Swine Stomach Antrum and Fundus

  2013cites this paper
• SMB myosin heavy chain knockout enhances tonic contraction and reduces the rate of force generation in ileum and stomach antrum.

  2013cites this paper
• Rho-kinase mediated cytoskeletal stiffness in skinned smooth muscle.

  2013cites this paper
• Myosin filaments in smooth muscle cells do not have a constant length

  2013cites this paper
• Myosin isoforms and regulation of tonic and phasic contraction in smooth muscle

  2012cites this paper
• PKCα and CPI‐17 expression and spatial‐temporal distribution with activation in pig stomach antrum and fundus

  2011cites this paper
• Phosphorylation of caldesmon by myosin light chain kinase increases its binding affinity for phosphorylated myosin filaments

  2010cites this paper
• A tris (2-carboxyethyl) phosphine (TCEP) related cleavage on cysteine-containing proteins

  2010cites this paper
• Fesselin and caldesmon: natively unfolded proteins in smooth muscle regulation

  2010cites this paper
• Mechanical behavior and length adaptation of rabbit bladder smooth muscle

  2009cites this paper
• Potent Inhibition of Arterial Smooth Muscle Tonic Contractions by the Selective Myosin II Inhibitor, Blebbistatin

  2007cites this paper
• Caldesmon is a cytoskeletal target for PKC in endothelium

  2006cites this paper
• Myosin filament assembly in an ever-changing myofilament lattice of smooth muscle.

  2005cites this paper
• Evidence for Absence of Latchbridge Formation in Phasic Saphenous Artery

  2005cites this paper
• Molecular Aspects of Arterial Smooth Muscle Contraction: Focus on Rho

  2005cites this paper
• Role of the basic C-terminal half of caldesmon in its regulation of F-actin: comparison between caldesmon and calponin.

  2005cites this paper
• ROK-induced cross-link formation stiffens passive muscle: reversible strain-induced stress softening in rabbit detrusor.

  2005cites this paper
• Regulation of actomyosin and contraction in smooth muscle

  2004cites this paper
• Calponin (CaP) as a latch-bridge protein — a new concept in regulation of contractility in smooth muscles

  2004cites this paper
• Caldesmon Tethers Myosin V to Actin and Facilitates in vitro Motility

  2004cites this paper
• Identification of alternative products and optimization of 2-nitro-5-thiocyanatobenzoic acid cyanylation and cleavage at cysteine residues.

  2004cites this paper
• Structure-function relationship in P-type ATPases--a biophysical approach.

  2003cites this paper
• Regulation of force in vascular smooth muscle.

  2003cites this paper
• Role of CaM kinase II and ERK activation in thrombin-induced endothelial cell barrier dysfunction.

  2003cites this paper
• Alpha1-adrenergic signaling mechanisms in contraction of resistance arteries.

  2003cites this paper
• Inhibition of ERK attenuates force development by lowering myosin light chain phosphorylation.

  2002cites this paper
• Die Bedeutung der p21-aktivierten Proteinkinase 1 (PAK1) für die Regulation der Myosin II-Phosphorylierung und der Kontraktion der glatten Muskulatur

  2002cites this paper
• The Major Myosin-binding Site of Caldesmon Resides Near Its N-terminal Extreme*

  2000cites this paper
• Regulation of smooth muscle contraction

  2000cites this paper
• Phosphorylation of caldesmon by ERK MAP kinases in smooth muscle.

  2000cites this paper
• Changes in the composition of myosin isoforms in smooth muscle hypertrophy following urinary bladder outlet obstruction

  2000cites this paper
• Casein kinase II phosphorylation of caldesmon downregulates myosin-caldesmon interactions.

  2000cites this paper
• Molecular mechanisms of smooth muscle contraction

  1999cites this paper
• cGMP modulation of Ca2+sensitivity in airway smooth muscle.

  1999cites this paper
• Tyrosine Phosphorylation of Caldesmon Is Required for Binding to the Shc·Grb2 Complex*

  1999cites this paper
• Characterization of the myosin light chain kinase from smooth muscle as an actin-binding protein that assembles actin filaments in vitro.

  1999influential citation
• Regulation of cross-bridge cycling by Ca2+ in smooth muscle.

  1999cites this paper
• Contractile protein changes in urinary bladder smooth muscle following outlet obstruction.

  1999cites this paper
• The Mechanics of Vascular Cell Motility

  1998cites this paper
• cGMP modulation of Ca 2 1 sensitivity in airway smooth muscle

  1998cites this paper
• Increased contractility of rat uterine smooth muscle at the end of pregnancy.

  1998cites this paper
• Identification and localization of caldesmon in cardiac muscle.

  1998cites this paper
• Caldesmon-actin-tropomyosin contains two types of binding sites for myosin S1.

  1998cites this paper
• Halothane inhibits agonist-induced potentiation of rMLC phosphorylation in permeabilized airway smooth muscle.

  1997cites this paper
• Functional and Structural Relationship between the Calmodulin-binding, Actin-binding, and Actomyosin-ATPase Inhibitory Domains on the C Terminus of Smooth Muscle Caldesmon*

  1997cites this paper
• Effect of Mts1 on the structure and activity of nonmuscle myosin II.

  1997cites this paper
• ROLE OF TACHYKININS IN BRONCHIAL HYPER‐RESPONSIVENESS

  1997cites this paper
• Arrangement of the COOH-terminal and NH2-terminal domains of caldesmon bound to actin.

  1997cites this paper
• Both N-terminal myosin-binding and C-terminal actin-binding sites on smooth muscle caldesmon are required for caldesmon-mediated inhibition of actin filament velocity.

  1997cites this paper
• Mechanisms of smooth muscle contraction.

  1996cites this paper
• Mutagenesis Analysis of Functionally Important Domains within the C-terminal End of Smooth Muscle Caldesmon*

  1996cites this paper
• Characterization of the Functional Domains on the C-terminal Region of Caldesmon Using Full-length and Mutant Caldesmon Molecules (*)

  1996cites this paper
• Regulation of force and shortening velocity by calcium and myosin phosphorylation in chemically skinned smooth muscle

  1996cites this paper
• Chapter 4 – Actin and the Structure of Smooth Muscle Thin Filaments

  1996cites this paper
• Halothane reduces myofilament Ca2+ sensitivity during muscarinic receptor stimulation of airway smooth muscle.

  1996cites this paper
• Activation of MAP kinases and phosphorylation of caldesmon in canine colonic smooth muscle.

  1996cites this paper
• Protein kinase C mediation of Ca(2+)-independent contractions of vascular smooth muscle.

  1996cites this paper
• Identification of protein kinase C isoenzymes in smooth muscle: partial purification and characterization of chicken gizzard PKC zeta.

  1996cites this paper
• Caldesmon and calponin – the thin filamentassociated proteins of smooth muscle: structure and mechanisms of functioning

  1996cites this paper
• Protein kinase C mediation of Ca2+-independent contractions of vascular smooth muscle

  1996cites this paper
• Architecture of the Smooth Muscle Cell

  1995cites this paper
• CALCIUMICALMODULIN­ DEPENDENT PROTEIN KINASE: From Form to Function

  1995cites this paper
• Location of smooth-muscle myosin and tropomyosin binding sites in the C-terminal 288 residues of human caldesmon.

  1995cites this paper
• Effect of unphosphorylated smooth muscle myosin on caldesmon-mediated regulation of actin filament velocity

  1995cites this paper
• Contractile proteins and their response to bladder outlet obstruction.

  1995cites this paper
• Effect of Caldesmon on the Assembly of Smooth Muscle Myosin (*)

  1995cites this paper
• Mode of caldesmon binding to smooth muscle thin filament: possible projection of the amino-terminal of caldesmon from native thin filament.

  1995influential citation
• Interaction of smooth muscle calponin with phospholipids

  1995cites this paper
• Alignment of caldesmon on the actin-tropomyosin filaments.

  1995cites this paper
• Role of ATP in the binding of caldesmon to smooth muscle myosin.

  1995cites this paper
• Cross-linking and fluorescence study of the COOH- and NH2-terminal domains of intact caldesmon bound to actin.

  1995cites this paper
• Motor proteins 2: myosin.

  1995cites this paper
• Pharmacological and physiological significance of ion channels and factors that modulate them in vascular tissues.

  1995cites this paper
• The multifunctional calcium/calmodulin-dependent protein kinase: from form to function.

  1995cites this paper
• Calmodulin and the regulation of smooth muscle contraction

  1994cites this paper
• Contractile units in stress fibers of fetal human astroglia in tissue culture.

  1994cites this paper
• Stimulation of the ATP-dependent interaction between actin and myosin by a myosin-binding fragment of smooth muscle caldesmon.

  1994cites this paper
• Phosphorylation of caldesmon by smooth-muscle casein kinase II

  1994cites this paper
• Overexpression, purification, and characterization of full-length and mutant caldesmons using a baculovirus expression system

  1994cites this paper
• Excitation-Contraction Coupling in Gastrointestinal Smooth Muscles

  1994cites this paper
• Excitation-Contraction Coupling Mechanisms in Visceral Smooth Muscle Cells

  1994cites this paper
• Actin and Thin-Filament-Associated Proteins in Smooth Muscle

  1994cites this paper
• Caldesmon enhances the binding of myosin to the cytoskeleton during platelet activation.

  1994cites this paper
• Identification of the regulatory site in smooth muscle calponin that is phosphorylated by protein kinase C.

  1993cites this paper
• Disulphide cross-linking of smooth-muscle and non-muscle caldesmon to the C-terminus of actin in reconstituted and native thin filaments.

  1993cites this paper
• Binding and regulatory properties of expressed functional domains of chicken gizzard smooth muscle caldesmon.

  1993cites this paper
• Phosphorylation-contraction coupling in smooth muscle: role of caldesmon.

  1993cites this paper
• Ca2+ regulation of the contractile apparatus in canine gastric smooth muscle.

  1993cites this paper
• Reversal of caldesmon binding to myosin with calcium-calmodulin or by phosphorylating caldesmon.

  1993cites this paper
• Identification of functioning regulatory sites and a new myosin binding site in the C-terminal 288 amino acids of caldesmon expressed from a human clone

  1993cites this paper
• Phosphorylation by casein kinase II affects the interaction of caldesmon with smooth muscle myosin and tropomyosin.

  1993cites this paper
• Smooth-muscle caldesmon phosphatase is SMP-I, a type 2A protein phosphatase.

  1993cites this paper
• Caldesmon.

  1993cites this paper
• In vitro studies of determinants of smooth muscle mechanics.

  1993cites this paper