Lack of correlation between the spatial distribution of A2E and lipofuscin fluorescence in the human retinal pigment epithelium.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Investigative Ophthalmology and Visual Science

• Publication date

  2013-08-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1167/iovs.13-12250PMID 23847313PMCID PMC3747789
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2012cited by this paper
• The bisretinoids of retinal pigment epithelium.

  2012influential reference
• Compositional studies of human RPE lipofuscin: mechanisms of molecular modifications.

  2011influential reference
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  2011cited by this paper
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  2011cited by this paper
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  2010cited by this paper
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  2009influential reference
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  2009influential reference
• Laser desorption ionization of red phosphorus clusters and their use for mass calibration in time-of-flight mass spectrometry.

  2009cited by this paper
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  2009cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2006cited by this paper
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  2005cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1986cited by this paper
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