Discovery of Soluble Epoxide Hydrolase Inhibitors from Chemical Synthesis and Natural Products.

Soluble epoxide hydrolase (sEH) is an α/β hydrolase fold protein and widely distributed in numerous organs including the liver, kidney, and brain. The inhibition of sEH can effectively maintain endogenous epoxyeicosatrienoic acids (EETs) levels and reduce dihydroxyeicosatrienoic acids (DHETs) levels, resulting in therapeutic potentials for cardiovascular, central nervous system, and metabolic diseases. Therefore, since the beginning of this century, the development of sEH inhibitors is a hot research topic. A variety of potent sEH inhibitors have been developed by chemical synthesis or isolated from natural sources. In this review, we mainly summarized the interconnected aspects of sEH with cardiovascular, central nervous system, and metabolic diseases and then focus on representative inhibitors, which would provide some useful guidance for the future development of potential sEH inhibitors.

• Publication year

  2020

• Venue

  Journal of Medicinal Chemistry

• Publication date

  2020-12-28

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/acs.jmedchem.0c01507PMID 33369424PMCID PMC7942193
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Review of Rethinking Health Care Ethics by Stephen Scher and Kasia Kozlowska

  2020cited by this paper
• Computer-Aided Fragment Growing Strategies to Design Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase.

  2020cited by this paper
• A COX-2/sEH dual inhibitor PTUPB ameliorates cecal ligation and puncture-induced sepsis in mice via anti-inflammation and anti-oxidative stress.

  2020cited by this paper
• COX‐2/sEH dual inhibitor PTUPB alleviates bleomycin‐induced pulmonary fibrosis in mice via inhibiting senescence

  2020cited by this paper
• 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), a soluble epoxide hydrolase inhibitor, lowers L-NAME-induced hypertension through suppression of angiotensin-converting enzyme in rats.

  2020cited by this paper
• PTUPB ameliorates high-fat diet-induced non-alcoholic fatty liver disease via inhibiting NLRP3 inflammasome activation in mice.

  2020cited by this paper
• Protostane-type triterpenoids as natural soluble epoxide hydrolase inhibitors: Inhibition potentials and molecular dynamics.

  2020cited by this paper
• Soluble Epoxide Hydrolase Inhibition in Liver Diseases: A Review of Current Research and Knowledge Gaps

  2020cited by this paper
• Docosahexaenoic Acid Increases the Potency of Soluble Epoxide Hydrolase Inhibitor in Alleviating Streptozotocin-Induced Alzheimer’s Disease-Like Complications of Diabetes

  2019cited by this paper
• Inhibition of soluble epoxide hydrolase ameliorates hyperhomocysteinemia-induced hepatic steatosis by enhancing β-oxidation of fatty acid in mice.

  2019cited by this paper
• Soluble epoxide hydrolase modulates immune responses in activated astrocytes involving regulation of STAT3 activity

  2019cited by this paper
• Development of multitarget agents possessing soluble epoxide hydrolase inhibitory activity.

  2019cited by this paper
• TPPU, a Selective and Potent Dual Inhibitor of Soluble Epoxide Hydrolase and p38 Kinase Intervenes in Alzheimer's Signaling in Human Nerve Cells.

  2019cited by this paper
• Soluble Epoxide Hydrolase Inhibitor: A Novel Potential Therapeutic or Prophylactic Drug for Psychiatric Disorders

  2019cited by this paper
• Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer’s Disease

  2019cited by this paper
• Inhibition potential of phenolic constituents from the aerial parts of Tetrastigma hemsleyanum against soluble epoxide hydrolase and nitric oxide synthase

  2019cited by this paper
• Role of epoxy-fatty acids and epoxide hydrolases in the pathology of neuro-inflammation.

  2019cited by this paper
• Effect Of Dual sEH/COX-2 Inhibition on Allergen-Induced Airway Inflammation

  2019cited by this paper
• Soluble epoxide hydrolase inhibitor, TUPS, attenuates isoproterenol/angiotensin II‐induced cardiac hypertrophy through mammalian target of rapamycin‐mediated autophagy inhibition

  2019cited by this paper
• Role of Soluble Epoxide Hydrolase in Metabolism of PUFAs in Psychiatric and Neurological Disorders

  2019cited by this paper
• Epoxy-Oxylipins and Soluble Epoxide Hydrolase Metabolic Pathway as Targets for NSAID-Induced Gastroenteropathy and Inflammation-Associated Carcinogenesis

  2019cited by this paper
• Isolation of soluble epoxide hydrolase inhibitor of capsaicin analogs from Capsicum chinense Jacq. cv. Habanero.

  2019cited by this paper
• Humble beginnings with big goals: Small molecule soluble epoxide hydrolase inhibitors for treating CNS disorders

  2019cited by this paper
• Highly potent non-steroidal FXR agonists protostane-type triterpenoids: Structure-activity relationship and mechanism.

  2019cited by this paper
• Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor

  2019cited by this paper
• Uncarialins A-I, Monoterpenoid Indole Alkaloids from Uncaria rhynchophylla as Natural Agonists of the 5-HT1A Receptor.

  2019cited by this paper
• Phytochemical constituents from Scutellaria baicalensis in soluble epoxide hydrolase inhibition: Kinetics and interaction mechanism merged with simulations.

  2019cited by this paper
• Genetic deletion of soluble epoxide hydrolase delays the progression of Alzheimer’s disease

  2019cited by this paper
• Dual Farnesoid X Receptor/Soluble Epoxide Hydrolase Modulators Derived from Zafirlukast

  2019cited by this paper
• Neuroinflammation and Myelin Status in Alzheimer's Disease, Parkinson's Disease, and Normal Aging Brains: A Small Sample Study

  2019cited by this paper
• Neuroinflammation and fractalkine signaling in Alzheimer’s disease

  2019cited by this paper
• Discovery of novel drug candidates for inhibition of soluble epoxide hydrolase of arachidonic acid cascade pathway implicated in atherosclerosis

  2018cited by this paper
• Evaluation of antiparkinson activity of PTUPB by measuring dopamine and its metabolites in Drosophila melanogaster: LC–MS/MS method development

  2018cited by this paper
• Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.

  2018cited by this paper
• Synthesis of substituted fluorobenzimidazoles as inhibitors of 5‐lipoxygenase and soluble epoxide hydrolase for anti‐inflammatory activity

  2018cited by this paper
• Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology.

  2018cited by this paper
• Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson’s disease

  2018cited by this paper
• A novel dual PPAR-γ agonist/sEH inhibitor treats diabetic complications in a rat model of type 2 diabetes

  2018cited by this paper
• Soluble epoxide hydrolase inhibitors, t-AUCB, downregulated miR-133 in a mouse model of myocardial infarction

  2018cited by this paper
• Pyrimidinyl Biphenylureas Act as Allosteric Modulators to Activate Cannabinoid Receptor 1 and Initiate β-Arrestin–Dependent Responses

  2018cited by this paper
• Soluble epoxide hydrolase derived lipid mediators are elevated in bronchoalveolar lavage fluid from patients with sarcoidosis: a cross-sectional study

  2018cited by this paper
• Design and Potency of Dual Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase Inhibitors

  2018cited by this paper
• Effects of adamantane alterations on soluble epoxide hydrolase inhibition potency, physical properties and metabolic stability.

  2018cited by this paper
• Synthesis, Biological Evaluation and Structure–Activity Relationships of Diflapolin Analogues as Dual sEH/FLAP Inhibitors

  2018cited by this paper
• Inhibiting Effect of Zinc Oxide Nanoparticles on Advanced Glycation Products and Oxidative Modifications: a Potential Tool to Counteract Oxidative Stress in Neurodegenerative Diseases

  2018cited by this paper
• Role of oxylipins in cardiovascular diseases

  2018cited by this paper
• Targeting Neuroinflammation as a Therapeutic Strategy for Alzheimer's Disease: Mechanisms, Drug Candidates, and New Opportunities.

  2018cited by this paper
• Adamantyl thioureas as soluble epoxide hydrolase inhibitors.

  2018cited by this paper
• Discovery of polar spirocyclic orally bioavailable urea inhibitors of soluble epoxide hydrolase.

  2018cited by this paper
• Uncaria rhynchophylla Ameliorates Parkinson’s Disease by Inhibiting HSP90 Expression: Insights from Quantitative Proteomics

  2018cited by this paper
• Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia

  2018cited by this paper
• Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy

  2017cited by this paper
• SAMP8 mice as a neuropathological model of accelerated brain aging and dementia: Toshio Takeda's legacy and future directions

  2017cited by this paper
• Soluble epoxide hydrolase inhibitory activity of phenolic glycosides from Polygala tenuifolia and in silico approach

  2017cited by this paper
• Trial watch: Tracing investment in drug development for Alzheimer disease

  2017cited by this paper
• Modulation of mitochondrial dysfunction and endoplasmic reticulum stress are key mechanisms for the wide-ranging actions of epoxy fatty acids and soluble epoxide hydrolase inhibitors.

  2017cited by this paper
• Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase

  2017cited by this paper
• The effects of sEH inhibitor on depression‐like behavior and neurogenesis in male mice

  2017cited by this paper
• Soluble Epoxide Hydrolase Inhibitory Activity of Components Isolated from Apios americana Medik

  2017cited by this paper
• Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases☆

  2017cited by this paper
• In silico investigation of cycloartane triterpene derivatives from Cimicifuga dahurica (Turcz.) Maxim. roots for the development of potent soluble epoxide hydrolase inhibitors.

  2017cited by this paper
• A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis.

  2017cited by this paper
• Occurrence of urea-based soluble epoxide hydrolase inhibitors from the plants in the order Brassicales

  2017cited by this paper
• An Overview on the Enhancement of Enantioselectivity and Stability of Microbial Epoxide Hydrolases

  2017cited by this paper
• Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer's disease: the emerging role for microglia?

  2017cited by this paper
• Soluble epoxide hydrolase inhibitors of indolinone alkaloids and phenolic derivatives from Cimicifuga dahurica (Turcz.) Maxim.

  2017cited by this paper
• Inhibition Potential of Cycloartane-Type Glycosides from the Roots of Cimicifuga dahurica against Soluble Epoxide Hydrolase.

  2017cited by this paper
• Prenyl-flavonoids from Epimedium koreanum Nakai and their soluble epoxide hydrolase and tyrosinase inhibitory activities

  2017cited by this paper
• Phosphatase activity of soluble epoxide hydrolase.

  2017cited by this paper
• Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

  2017cited by this paper
• Discovering Drugs with DNA‐Encoded Library Technology: From Concept to Clinic with an Inhibitor of Soluble Epoxide Hydrolase

  2017cited by this paper
• COX-2/sEH dual inhibitor PTUPB suppresses glioblastoma growth by targeting epidermal growth factor receptor and hyaluronan mediated motility receptor

  2017cited by this paper
• Discovery of enantioselectivity of urea inhibitors of soluble epoxide hydrolase.

  2016cited by this paper
• Neuroinflammation in Alzheimer's disease: Current evidence and future directions

  2016cited by this paper
• Inhibition of mutant KrasG12D-initiated murine pancreatic carcinoma growth by a dual c-Raf and soluble epoxide hydrolase inhibitor t-CUPM.

  2016cited by this paper
• Soluble epoxide hydrolase inhibitory components from Rheum undulatum and in silico approach

  2016cited by this paper
• Feeling Nature's PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS).

  2016cited by this paper
• Investigation of the binding mode of 1, 3, 4-oxadiazole derivatives as amide-based inhibitors for soluble epoxide hydrolase (sEH) by molecular docking and MM-GBSA

  2016cited by this paper
• Inhibition of soluble epoxide hydrolase activity by compounds isolated from the aerial parts of Glycosmis stenocarpa

  2016cited by this paper
• Inhibition of soluble epoxide hydrolase alleviated atherosclerosis by reducing monocyte infiltration in Ldlr(-/-) mice.

  2016cited by this paper
• Behaviour and cognitive changes correlated with hippocampal neuroinflammaging and neuronal markers in female SAMP8, a model of accelerated senescence.

  2016cited by this paper
• Quercetin sensitizes glioblastoma to t-AUCB by dual inhibition of Hsp27 and COX-2 in vitro and in vivo

  2016cited by this paper
• Pharmacokinetics, pharmacodynamics and adverse event profile of GSK2256294, a novel soluble epoxide hydrolase inhibitor.

  2016cited by this paper
• N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor γ Modulators.

  2016cited by this paper
• Evaluation of the Intestinal Absorption Mechanism of Casearin X in Caco-2 Cells with Modified Carboxylesterase Activity.

  2016cited by this paper
• Epoxyeicosatrienoic Acids and 20-Hydroxyeicosatetraenoic Acid on Endothelial and Vascular Function.

  2016cited by this paper
• Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase

  2016cited by this paper
• Alkylphloroglucinol derivatives and triterpenoids with soluble epoxide hydrolase inhibitory activity from Callistemon citrinus.

  2016cited by this paper
• Soluble epoxide hydrolase inhibitory activity of anthraquinone components from Aloe.

  2015cited by this paper
• Inhibition of soluble epoxide hydrolase in mice promotes reverse cholesterol transport and regression of atherosclerosis.

  2015cited by this paper
• The Epoxyeicosatrienoic Acid Pathway Enhances Hepatic Insulin Signaling and is Repressed in Insulin-Resistant Mouse Liver*

  2015cited by this paper
• Structure-activity relationships of amide-phosphonate derivatives as inhibitors of the human soluble epoxide hydrolase.

  2015cited by this paper
• Soluble epoxide hydrolase inhibitory activity of phenolic components from the rhizomes and roots of Gentiana scabra

  2015cited by this paper
• 1,3-Disubstituted and 1,3,3-trisubstituted adamantyl-ureas with isoxazole as soluble epoxide hydrolase inhibitors.

  2015cited by this paper
• Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive.

  2015cited by this paper
• Soluble epoxide hydrolase inhibitory and anti-inflammatory components from the leaves of Eucommia ulmoides Oliver (duzhong).

  2015cited by this paper
• Constituents of the seeds of Cassia tora with inhibitory activity on soluble expoxide hydrolease.

  2015cited by this paper
• Schizophrenia and Depression: A systematic Review of the Effectiveness and the Working Mechanisms Behind Acupuncture.

  2015cited by this paper
• Potent Natural Soluble Epoxide Hydrolase Inhibitors from Pentadiplandra brazzeana Baillon: Synthesis, Quantification, and Measurement of Biological Activities In Vitro and In Vivo

  2015cited by this paper
• Impact of soluble epoxide hydrolase inhibition on early kidney damage in hyperglycemic overweight mice.

  2015cited by this paper

• A new era in targeted sEH therapy: strategic evolution from inhibition to protein degradation.

  2026cites this paper
• New Flavone O-Glycosides from Mentha × piperita

  2026cites this paper
• Novel fatty acid amide hydrolase (FAAH) inhibitors: a patent review from 2015 to 2025

  2026cites this paper
• Soluble epoxide hydrolase inhibitory constituents from the Heartwood of Toxicodendron vernicifluum: isolation, kinetic characterization, molecular modeling, and quantitative analysis

  2026cites this paper
• SMTP-44D Improves High Glucose-Induced Vascular Endothelial Dysfunction.

  2026cites this paper
• Functional consequences of soluble epoxide hydrolase inhibition in platelets: A comparative study of rat, mouse, and human platelets

  2025cites this paper
• Mapping Oxylipin Signatures in Human Diseases Using LC-MS/MS

  2025cites this paper
• Structure based design of Quinazoline-Ureido analogues for dual targeting of sEH and EGFR

  2025cites this paper
• Development of Potent and Selective Dual PPARδ/sEH Modulators from an AI-Designed Scaffold.

  2025cites this paper
• Harnessing structure-activity relationships to repurpose the FLAP inhibitor BRP-7 into potent and selective sEH inhibitors.

  2025cites this paper
• Inhibition of soluble epoxide hydrolase in endotoxin induced pig lung injury

  2025cites this paper
• Discovery of marine-derived ent-atisane diterpenoid lead compounds targeting sEH for Alzheimer's disease therapy

  2025cites this paper
• Epoxide Hydrolase Inhibitors for the Treatment of Alzheimer’s Disease and Other Neurological Disorders: A Comprehensive Review

  2025cites this paper
• Inflammatory Mechanisms of Dysmenorrhea: Novel Insights From Menstrual Effluent in an Adolescent Cohort

  2025cites this paper
• Seeking the root causes of menstrual pain: A systematic review of biomarkers in menstrual effluent

  2025cites this paper
• Substituted Ureas and Their Analogs Containing Cage Fragments: II. N,N′-(4-(Adamantan-1-yl)-1,2-phenylene)bis[N′-(R-phenyl)ureas and -thioureas]

  2025cites this paper
• Structure-Based Design of PROTACS for the Degradation of Soluble Epoxide Hydrolase

  2025cites this paper
• Indole Alkaloids and Phenolic Amides from the Rhizomes of Cimicifuga heracleifolia and Their In Vitro Soluble Epoxide Hydrolase (sEH) Inhibitory Activity

  2025cites this paper
• Potent soluble epoxide hydrolase inhibitors based on thiazole-5-carboxamide structure with imidazolidinone moiety as a secondary pharmacophore.

  2025cites this paper
• Identification of high-affinity inhibitors for epoxide hydrolase 2 from repurposed drugs in Parkinson’s disease therapeutics

  2025cites this paper
• Unraveling the Enigma: Exploring the Periphery’s Influence in Alzheimer’s Pathophysiology—Cause or Consequence?

  2025cites this paper
• Discovery of Phenylacylpiperidine as Novel sEH Inhibitors through Scaffold Hopping of Natural Stilbene.

  2025cites this paper
• tert-Butyl (6-(3-(3-Fluorophenyl)ureido)hexyl)carbamate

  2025cites this paper
• Polyunsaturated Fatty Acid Imbalance-A Contributor to SARS CoV-2 Disease Severity

  2025cites this paper
• Phenyl-benzyl-ureas with pyridazinone motif: Potent soluble epoxide hydrolase inhibitors with enhanced pharmacokinetics and efficacy in a paclitaxel-induced neuropathic pain model.

  2025cites this paper
• Discovery of soluble epoxide hydrolase inhibitors from Inula britannica: Inhibition kinetics, molecular dynamics simulation, biochemical, and in vitro cell-based studies.

  2025cites this paper
• Association of ethylene oxide exposure with all-cause mortality risk among adult population with different stages of diabetes progression

  2025cites this paper
• Hepatic soluble epoxide hydrolase mediates osteoclastogenesis by suppressing the Nrf2 signaling pathway: a novel mechanism of redox imbalance in osteoporosis.

  2025cites this paper
• Strategies for developing dual-targeted soluble epoxide hydrolase inhibitors.

  2025cites this paper
• The role of arachidonic acid metabolites in major depressive disorder: mechanisms and therapeutic implications

  2025cites this paper
• Developments in small-molecule soluble epoxide hydrolase inhibitors: synthetic advances and therapeutic applications.

  2025cites this paper
• Discovery of glycosidated glycyrrhetinic acid derivatives: Natural product-based soluble epoxide hydrolase inhibitors.

  2024cites this paper
• Enhancing cancer immunotherapy via inhibition of soluble epoxide hydrolase

  2024cites this paper
• An analysis of omega-3 clinical trials and a call for personalized supplementation for dementia prevention

  2024cites this paper
• The involvement of soluble epoxide hydrolase in the development of cardiovascular diseases through epoxyeicosatrienoic acids

  2024cites this paper
• The Inhibition Activity of Natural Methoxyflavonoid from Inula britannica on Soluble Epoxide Hydrolase and NO Production in RAW264.7 Cells

  2024influential citation
• Visible-light-mediated catalyst-free synthesis of trifluoromethyl(spiro)-epoxides bearing contiguous quaternary centers

  2024cites this paper
• Soluble epoxide hydrolase: An emerging target for nutraceuticals against inflammation and oxidative stress

  2024cites this paper
• Evaluation of the Therapeutic Potential of Sulfonyl Urea Derivatives as Soluble Epoxide Hydrolase (sEH) Inhibitors

  2024cites this paper
• Essential Oils of Laurus nobilis L.: From Chemical Analysis to In Silico Investigation of Anti-Inflammatory Activity by Soluble Epoxide Hydrolase (sEH) Inhibition

  2024cites this paper
• Corn Peptides Alleviate Nonalcoholic Fatty Liver Fibrosis in Mice by Inhibiting NLRP3 Inflammasome Activation and Regulating Gut Microbiota.

  2024cites this paper
• Inhibition of Soluble Epoxide Hydrolase by Cembranoid Diterpenes from Soft Coral Sinularia maxima: Enzyme Kinetics, Molecular Docking, and Molecular Dynamics

  2024cites this paper
• Targeting the soluble epoxide hydrolase pathway as a novel therapeutic approach for the treatment of pain.

  2024cites this paper
• Restoration of ARA metabolic disorders in vascular smooth muscle cells alleviates intimal hyperplasia.

  2024cites this paper
• Exploring the impact of sEH inhibition on intestinal cell differentiation and Colon Cancer: Insights from TPPU treatment.

  2024cites this paper
• Amelioration effect of dietary vitamin E on ovarian aging in quails: Integrated transcriptome and metabolome

  2024cites this paper
• Redesigning Berberines and Sanguinarines to Target Soluble Epoxide Hydrolase for Enhanced Anti-Inflammatory Efficacy.

  2024cites this paper
• Inhibitory Activity of Glycosides from Elsholtzia ciliata against Soluble Epoxide Hydrolase and Cytokines in RAW264.7 Cells

  2024cites this paper
• Substituted Ureas and Their Analogs Containing Framework Fragments: I. 1-(4-Hydroxyadamantan-1-yl)-3-(fluoro/chlorophenyl)ureas

  2024cites this paper
• Glimepiride, a novel soluble epoxide hydrolase inhibitor, protects against heart failure via increasing epoxyeicosatrienoic acids.

  2023cites this paper
• New Sight: Enzymes as Targets for Drug Development

  2023cites this paper
• Inhibitory activity of lignanamides isolated from hemp seed hulls(Cannabis sativa L.) against soluble epoxide hydrolase

  2023cites this paper
• IκB kinase β (IKKβ): Structure, transduction mechanism, biological function, and discovery of its inhibitors

  2023cites this paper
• Soluble epoxide hydrolase maintains steady-state lipid turnover linked with autocrine signaling in peritoneal macrophages

  2023cites this paper
• Genetic deletion or pharmacological inhibition of soluble epoxide hydrolase attenuated particulate matter 2.5 exposure mediated lung injury.

  2023cites this paper
• 1,3-Dichloroadamantyl-Containing Ureas as Potential Triple Inhibitors of Soluble Epoxide Hydrolase, p38 MAPK and c-Raf

  2023cites this paper
• Inhibitory effects of phenylpropanoids and lignans isolated from the bark of Cinnamomum cassia L. on soluble epoxide hydrolase: Spectroscopic, kinetic, molecular docking, and molecular dynamics studies

  2023cites this paper
• Effect of the sEH inhibitor AUDA on arachidonic acid metabolism and NF-κB signaling of rats with postpartum depression-like behavior.

  2023cites this paper
• Inhibitory Activity of Natural cis-Khellactone on Soluble Epoxide Hydrolase and Proinflammatory Cytokine Production in Lipopolysaccharides-Stimulated RAW264.7 Cells

  2023influential citation
• Direct targeting of sEH with alisol B alleviated the apoptosis, inflammation, and oxidative stress in cisplatin-induced acute kidney injury

  2023influential citation
• Benzoxazolone-5-Urea Derivatives as Human Soluble Epoxide Hydrolase (sEH) Inhibitors

  2023cites this paper
• Macrophage Inactivation by Small Molecule Wedelolactone via Targeting sEH for the Treatment of LPS-Induced Acute Lung Injury

  2023cites this paper
• Inhibition effect of 1-acetoxy-6α-(2-methylbutyryl)eriolanolide toward soluble epoxide hydrolase: Multispectral analysis, molecular dynamics simulation, biochemical, and in vitro cell-based studies.

  2023cites this paper
• Biomolecular interactions and inhibition kinetics of human soluble epoxide hydrolase by tetrapeptide YMSV

  2023cites this paper
• Evaluation of Antibacterial Activity of Thiourea Derivative TD4 against Methicillin-Resistant Staphylococcus aureus via Destroying the NAD+/NADH Homeostasis

  2023cites this paper
• Quantification of soluble epoxide hydrolase inhibitors in experimental and clinical samples using the nanobody-based ELISA

  2023cites this paper
• A Review of Oxylipins in Alzheimer’s Disease and Related Dementias (ADRD): Potential Therapeutic Targets for the Modulation of Vascular Tone and Inflammation

  2022cites this paper
• Total flavonoids of Inula japonica alleviated the inflammatory response and oxidative stress in LPS-induced acute lung injury via inhibiting the sEH activity: Insights from lipid metabolomics.

  2022cites this paper
• A Combined Chronic Low-Dose Soluble Epoxide Hydrolase and Acetylcholinesterase Pharmacological Inhibition Promotes Memory Reinstatement in Alzheimer’s Disease Mice Models

  2022cites this paper
• Synthesis and biological evaluation of new series of benzamide derivatives containing urea moiety as sEH inhibitors.

  2022cites this paper
• A Comprehensive Review on Soluble Epoxide Hydrolase Inhibitors Evaluating Their Structure-Activity Relationship.

  2022cites this paper
• Discovery of benzamide derivatives containing urea moiety as soluble epoxide hydrolase inhibitors.

  2022cites this paper
• Soluble Epoxide Hydrolase as a Therapeutic Target for Neuropsychiatric Disorders

  2022cites this paper
• Allosteric regulation of the soluble epoxide hydrolase by nitro fatty acids using a combined experimental and computational approach.

  2022cites this paper
• Soluble epoxide hydrolase inhibitors: an overview and patent review from the last decade

  2022cites this paper
• Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer’s Disease

  2022cites this paper
• Unprecedented diterpenoid dimers with soluble epoxide hydrolase inhibitory effect from Euphorbia fischeriana.

  2022cites this paper
• Kurarinone alleviated Parkinson's disease via stabilization of epoxyeicosatrienoic acids in animal model

  2022cites this paper
• Glomerular Biomechanical Stress and Lipid Mediators during Cellular Changes Leading to Chronic Kidney Disease

  2022cites this paper
• Screening and Identification of Novel Soluble Epoxide Hydrolase Inhibitors from Corn Gluten Peptides

  2022cites this paper
• Discovery and Optimization of Indoline-Based Compounds as Dual 5-LOX/sEH Inhibitors: In Vitro and In Vivo Anti-Inflammatory Characterization

  2022cites this paper
• Increased Soluble Epoxide Hydrolase Activity Positively Correlates with Mortality in Heart Failure Patients with Preserved Ejection Fraction: Evidence from Metabolomics

  2022cites this paper
• Role of epoxyeicosatrienoic acids in cardiovascular diseases and cardiotoxicity of drugs.

  2022cites this paper
• Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors

  2022cites this paper
• Quinazoline-4(3H)-one-7-carboxamide Derivatives as Human Soluble Epoxide Hydrolase Inhibitors with Developable 5-Lipoxygenase Activating Protein Inhibition

  2022cites this paper
• The 1,2,3-triazole ‘all-in-one’ ring system in drug discovery: a good bioisostere, a good pharmacophore, a good linker, and a versatile synthetic tool

  2022cites this paper
• Inhibitory Activity of Quaternary Isoquinoline Alkaloids on Soluble Epoxide Hydrolase

  2022cites this paper
• Inhibitors of soluble epoxide hydrolase on acute lung injury: a meta-analysis of preclinical studies

  2022cites this paper
• Natural soluble epoxide hydrolase inhibitors from Alisma orientale and their potential mechanism with soluble epoxide hydrolase.

  2021cites this paper
• Inhibition of soluble epoxide hydrolase by phytochemical constituents of the root bark of Ulmus davidiana var. japonica

  2021cites this paper
• Natural soluble epoxide hydrolase inhibitors from Inula britanica and their potential interactions with soluble epoxide hydrolase: Insight from inhibition kinetics and molecular dynamics.

  2021cites this paper
• Synthesis and Properties of N,N′-Disubstituted Ureas and Their Isosteric Analogs Containing Polycyclic Fragments: XI. 1-[(Adamantan-1 yl)alkyl]-3-arylselenoureas

  2021cites this paper
• Bisfischoids A and B, dimeric ent-abietane-type diterpenoids with anti-inflammatory potential from Euphorbia fischeriana Steud.

  2021cites this paper
• From the Design to the In Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis

  2021cites this paper
• Design, synthesis and mechanistic study of novel diarylpyrazole derivatives as anti-inflammatory agents with reduced cardiovascular side effects.

  2021cites this paper
• Activating endogenous resolution pathways by soluble epoxide hydrolase inhibitors for the management of COVID‐19

  2021cites this paper
• Discovery of Semi-Pinacolases from the Epoxide Hydrolase Family during Efficient Assembly of a Fungal Polyketide

  2021cites this paper
• 2-(Piperidin-4-yl)acetamides as Potent Inhibitors of Soluble Epoxide Hydrolase with Anti-Inflammatory Activity

  2021cites this paper