9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Nature

• Publication date

  1992-01-23

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/355359A0PMID 1309942
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characterization of DNA binding and retinoic acid binding properties of retinoic acid receptor.

  1991cited by this paper
• Retinoic acid receptor belongs to a subclass of nuclear receptors that do not form "docking" complexes with hsp90.

  1991cited by this paper
• RXRβ: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements

  1991cited by this paper
• A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR.

  1991cited by this paper
• 6'-substituted naphthalene-2-carboxylic acid analogs, a new class of retinoic acid receptor subtype-specific ligands.

  1991cited by this paper
• Retinoic acid is a negative regulator of AP-1-responsive genes.

  1991cited by this paper
• Antagonism between retinoic acid receptors

  1991cited by this paper
• RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements.

  1991cited by this paper
• A road less travelled: Normal phase microbore liquid chromatography—mass spectrometry using direct liquid introduction

  1991cited by this paper
• Selective high affinity retinoic acid receptor alpha or beta-gamma ligands.

  1991cited by this paper
• In vitro binding of retinoids to the nuclear retinoic acid receptor alpha.

  1990cited by this paper
• Multiple cell type-specific proteins differentially regulate target sequence recognition by the alpha retinoic acid receptor.

  1990cited by this paper
• Ligand specificities of recombinant retinoic acid receptors RAR alpha and RAR beta.

  1990cited by this paper
• Ligand-activated thyroid hormone and retinoic acid receptors inhibit growth factor receptor promoter expression.

  1990cited by this paper
• Mass spectrometry of methyl ester of retinoic acid.

  1990cited by this paper
• Nuclear receptor that identifies a novel retinoic acid response pathway

  1990cited by this paper
• Retinoic acid and synthetic analogs differentially activate retinoic acid receptor dependent transcription.

  1990cited by this paper
• Identification and characterization of nuclear retinoic acid-binding activity in human myeloblastic leukemia HL-60 cells.

  1989cited by this paper
• A third human retinoic acid receptor, hRAR-gamma.

  1989cited by this paper
• Dual regulatory role for thyroid-hormone receptors allows control of retinoic-acid receptor activity

  1989cited by this paper
• Positive and negative regulation of gene transcription by a retinoic acid-thyroid hormone receptor heterodimer.

  1989cited by this paper
• Identification of a second human retinoic acid receptor

  1988cited by this paper
• A versatile in vivo and in vitro eukaryotic expression vector for protein engineering

  1988cited by this paper
• A human retinoic acid receptor which belongs to the family of nuclear receptors

  1987cited by this paper
• Identification and spatial distribution of retinoids in the developing chick limb bud

  1987cited by this paper
• The effect of dibutyryl cyclic AMP and butyrate on F9 teratocarcinoma cellular retinoic acid-binding protein activity.

  1987cited by this paper
• High-efficiency transformation of mammalian cells by plasmid DNA.

  1987cited by this paper
• Identification of regulatory elements of cloned genes with functional assays.

  1987cited by this paper
• Identification of a receptor for the morphogen retinoic acid

  1987cited by this paper
• Quantification of physiological levels of retinoic acid.

  1986cited by this paper
• [13] Quantification of physiological levels of retinoic acid

  1986cited by this paper
• Cellular biology and biochem-istry of the retinoids

  1984cited by this paper
• Liquid-chromatographic assay for retinol (vitamin A) and retinol analogs in therapeutic trials.

  1982cited by this paper
• The retinol requirements of rats for spermatogenesis and vision

  1969cited by this paper
• THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

  1949cited by this paper

• Effect of retinoic acid treatment on the retinoic acid signaling pathway in a human siRNA-based aniridia limbal epithelial cell model, in vitro

  2025cites this paper
• From Molecules to Mechanisms: Integrating MD and Stochastic Modeling to Decipher RXR-RAR Gene Regulation.

  2025cites this paper
• Vitamin A5: Evidence, Definitions, Gaps, and Future Directions

  2025cites this paper
• Dual Anti-inflammatory Actions of a Novel Retinoid X Receptor Agonist Derived from a Natural Compound in Microglial Cells.

  2025cites this paper
• Rethinking retinoic acid self-regulation: A signaling robustness network approach.

  2025cites this paper
• Effects of dietary supplementation of vitamin A on the tibia quality of goslings

  2024cites this paper
• Vitamin A – discovery, metabolism, receptor signaling and effects on bone mass and fracture susceptibility

  2024cites this paper
• Roles of Nuclear Orphan Receptors TR2 and TR4 during Hematopoiesis

  2024cites this paper
• Rarγ-Foxa1 signaling promotes luminal identity in prostate progenitors and is disrupted in prostate cancer

  2024cites this paper
• Non-canonical retinoid signaling in neural development, regeneration and synaptic function

  2024cites this paper
• Stem cells tightly regulate dead cell clearance to maintain tissue fitness

  2024cites this paper
• Analysis of the current vitamin A terminology and dietary regulations from vitamin A1 to vitamin A5.

  2024cites this paper
• Rarγ -Foxa1 signaling promotes luminal identity in prostate progenitors and is disrupted in prostate cancer

  2024cites this paper
• Nuclear Receptors and the Hidden Language of the Metabolome

  2024cites this paper
• Adipocyte HSL is required for maintaining circulating vitamin A and RBP4 levels during fasting

  2024cites this paper
• Human nutritional relevance and suggested nutritional guidelines for vitamin A5/X and provitamin A5/X

  2023cites this paper
• Stem cells tightly regulate dead cell clearance to maintain tissue fitness

  2023cites this paper
• Energy status regulates levels of the RAR/RXR ligand 9-cis-retinoic acid in mammalian tissues: Glucose reduces its synthesis in β-cells

  2023cites this paper
• Binding of Per- and Polyfluoroalkyl Substances (PFAS) to the PPARγ/RXRα-DNA Complex

  2023cites this paper
• Selective effect of β-catenin on nuclear receptor-dependent hepatitis B virus transcription and replication.

  2022cites this paper
• Chronicle of a discovery: the retinoic acid receptor.

  2022cites this paper
• Molluscan RXR Transcriptional Regulation by Retinoids in a Drosophila CNS Organ Culture System

  2022cites this paper
• Retinoid Homeostasis and Beyond: How Retinol Binding Protein 4 Contributes to Health and Disease

  2022cites this paper
• Next-generation retinoid X receptor agonists increase ATRA signaling in organotypic epithelium cultures and have distinct effects on receptor dynamics

  2022cites this paper
• Retinoic acid receptor structures: the journey from single domains to full-length complex

  2022cites this paper
• Design and in vitro characterization of RXR variants as tools to investigate the biological role of endogenous rexinoids.

  2022cites this paper
• Mechanisms of Feedback Regulation of Vitamin A Metabolism

  2022cites this paper
• Carotenoid Metabolites, their Tissue and Blood Concentrations in Humans and further Bioactivity via Retinoid Receptor-Mediated Signalling.

  2022cites this paper
• Potencies of organotin compounds in scallop RXRa responsive activity with a GAL4-based reconstituted yeast assay in vitro

  2022cites this paper
• Targeting Nuclear Receptors in Neurodegeneration and Neuroinflammation.

  2021cites this paper
• Carotenoids Synthesis and Isomerism

  2021cites this paper
• 1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development.

  2021cites this paper
• 9-cis and all-trans beta-carotene isomers of super critical CO2-extracted Dunaliella oil are absorbed and accumulated in mouse tissues

  2021cites this paper
• Biological Functions of RBP4 and Its Relevance for Human Diseases

  2021cites this paper
• Similarities in DSG1 and KRT3 Downregulation through Retinoic Acid Treatment and PAX6 Knockdown Related Expression Profiles: Does PAX6 Affect RA Signaling in Limbal Epithelial Cells?

  2021cites this paper
• Deletion of fatty acid transport protein 2 (FATP2) in the mouse liver changes the metabolic landscape by increasing the expression of PPARα-regulated genes.

  2020cites this paper
• Tri-substituted organotin compounds, but not retinoic acid, are potent ligands of complement component 8 γ.

  2020cites this paper
• Isotretinoina: Possível Interferência na Cicatrização Pós-Exodontia

  2020cites this paper
• Vitamin A5/X, a New Food to Lipid Hormone Concept for a Nutritional Ligand to Control RXR-Mediated Signaling

  2020cites this paper
• Embryo-uterine interactions in pigs during week 2 of pregnancy.

  2020cites this paper
• Modulation of retinoid signaling: therapeutic opportunities in organ fibrosis and repair.

  2020cites this paper
• Intranasal Delivery: Effects on the Neuroimmune Axes and Treatment of Neuroinflammation

  2020influential citation
• Protection from Ultraviolet Damage and Photocarcinogenesis by Vitamin D Compounds.

  2020cites this paper
• Vitamin A as a Transcriptional Regulator of Cardiovascular Disease

  2020cites this paper
• Identification of Small-Molecule Regulators of Testicular Receptor 4 via a Drug Repurposing Screening

  2020cites this paper
• The development of methodologies for high-throughput retinoic acid binding assays in drug discovery and beyond.

  2020cites this paper
• Retinoid X Receptor α Regulates DHA-Dependent Spinogenesis and Functional Synapse Formation In Vivo.

  2020cites this paper
• Extraction and Analysis by HPLC-DAD of Carotenoids in Human Faeces from Spanish Adults

  2020cites this paper
• Deletion of fatty acid transport protein 2 (FATP2) in the mouse liver changes the metabolic landscape by increasing the expression of PPARα-regulated genes

  2020cites this paper
• Nuclear Hormone Receptors and Their Ligands: Metabolites in Control of Transcription

  2020cites this paper
• Vitamin A and its natural derivatives.

  2020cites this paper
• Comparative RNA-Seq transcriptome analyses reveal dynamic time-dependent effects of 56Fe, 16O, and 28Si irradiation on the induction of murine hepatocellular carcinoma

  2020cites this paper
• Upregulation of amphiregulin by retinoic acid and Wnt signalling promotes liver cancer cell proliferation

  2020cites this paper
• Pathophysiologic Basis for Alternative Therapies for Cholestasis

  2020cites this paper
• The retinoic acid receptor (RAR) in molluscs: Function, evolution and endocrine disruption insights.

  2019cites this paper
• A novel dual reporter embryonic stem cell line for toxicological assessment of teratogen-induced perturbation of anterior–posterior patterning of the heart

  2019influential citation
• β-Carotene in the human body: metabolic bioactivation pathways – from digestion to tissue distribution and excretion

  2019cites this paper
• Circadian modulation of genome-wide RXR binding in mouse liver tissue

  2019cites this paper
• Modern approaches to the prevention and correction of complications caused by systemic treatment of severe acne forms

  2019cites this paper
• Competitive Binding Assay with an Umbelliferone-based Fluorescent Rexinoid for Retinoid X Receptor Ligand Screening.

  2019cites this paper
• Apo-14´-Carotenoic Acid Is a Novel Endogenous and Bioactive Apo-Carotenoid

  2019cites this paper
• Discovery of retinoic acid receptor agonists as proliferators of cardiac progenitor cells through a phenotypic screening approach

  2019cites this paper
• Role of RXRβ in platelet function and arterial thrombosis

  2019cites this paper
• Receptor-binding affinities of bisphenol A and its next-generation analogs for human nuclear receptors.

  2019cites this paper
• AKR1C3 (type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase): Roles in malignancy and endocrine disorders.

  2019cites this paper
• Henry Ford Health System

  2019cites this paper
• Alternative retinoid X receptor (RXR) ligands.

  2019cites this paper
• Henry Ford Health System

  2019cites this paper
• Effects of Z-Isomerization on the Bioavailability and Functionality of Carotenoids: A Review

  2018cites this paper
• Nuevas aproximaciones toxicológicas para la detección de disruptores endocrinos y lipídicos en ecosistemas mediterráneos y sistemas celulares

  2018cites this paper
• Combination treatment of docosahexaenoic acid (DHA) and all-trans-retinoic acid (ATRA) inhibit IL-17 and RORγt gene expression in PBMCs of patients with relapsing-remitting multiple sclerosis

  2018cites this paper
• Métabolisme des rétinoïdes et facteurs d’influence dans l’obésité, la résistance à l’insuline et le diabète de type 2 : études chez l’animal et chez l’homme

  2018cites this paper
• Retinoic Acid, Leaky Gut, and Autoimmune Diseases

  2018cites this paper
• Marginal Vitamin A Deficiency Affects the Expression Levels and Localization of Retinoic Acid Receptor and Retinoid X Receptor in Rats Meibomian Gland

  2018influential citation
• Bexarotene – a novel modulator of AURKA and the primary cilium in VHL-deficient cells

  2018cites this paper
• Efficiency of All-Trans Retinoic Acid on Gastric Cancer: A Narrative Literature Review

  2018influential citation
• Estudio del papel de la vía de los retinoides en la patogenia de la artritis reumatoide

  2018cites this paper
• 9-Cis-13,14-dihydroretinoic acid, a new endogenous mammalian ligand of retinoid X receptor and the active ligand of a potential new vitamin A category: vitamin A5

  2018cites this paper
• Emerging therapeutic targets for primary sclerosing cholangitis

  2018cites this paper
• Computer Simulations of the Retinoid X Receptor: Conformational Dynamics and Allosteric Networks.

  2017cites this paper
• Molecular dynamics simulations and molecular flooding studies of the retinoid X-receptor ligand binding domain

  2017cites this paper
• Virtual screening and experimental validation identify novel modulators of nuclear receptor RXRα from Drugbank database.

  2017cites this paper
• Retinoic acid receptor gamma impacts cellular adhesion, Alpha5Beta1 integrin expression and proliferation in K562 cells

  2017cites this paper
• The interrelationship between bile acid and vitamin A homeostasis.

  2017cites this paper
• Retinoid X Receptor Ligands with Anti-Type 2 Diabetic Activity.

  2017cites this paper
• Natural and Structure-based RXR Ligand Scaffolds and Their Functions.

  2017cites this paper
• Cloning retinoid and peroxisome proliferator-activated nuclear receptors of the Pacific oyster and in silico binding to environmental chemicals

  2017cites this paper
• Pharmacological targeting of allergen-specific T lymphocytes.

  2017cites this paper
• Reproductive Organ Development in the Ivory Shell Babylonia japonica and the Rock Shell Thais clavigera

  2017cites this paper
• A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors

  2017cites this paper
• 9-cis retinoic acid induces neurorepair in stroke brain

  2017cites this paper
• Cloning and functional characterization of a retinoid X receptor orthologue in Platynereis dumerilii: An evolutionary and toxicological perspective.

  2017cites this paper
• Translation of a Tissue-Selective Rexinoid, UAB30, to the Clinic for Breast Cancer Prevention.

  2017cites this paper
• Effect of Topical Fluorouracil Cream on Photodamage: Secondary Analysis of a Randomized Clinical Trial

  2017cites this paper
• The molecular basis of the interactions between synthetic retinoic acid analogues and the retinoic acid receptors.

  2017cites this paper
• The Nuclear Receptor HIZR-1 Uses Zinc as a Ligand to Mediate Homeostasis in Response to High Zinc

  2017cites this paper
• Mode of Action of Organotins to Induce the Development of Imposex in Gastropods, Focusing on Steroid and the Retinoid X Receptor Activation Hypotheses

  2017cites this paper
• Novel endogenous negative modulators of platelet function as potential anti-thrombotic targets.

  2017cites this paper
• Classical dendritic cells mediate fibrosis directly via the retinoic acid pathway in severe eye allergy.

  2016cites this paper
• Comparison of the ligand binding site of CYP2C8 with CYP26A1 and CYP26B1: a structural basis for the identification of new inhibitors of the retinoic acid hydroxylases

  2016cites this paper