Advances in Pathogenesis and Management of Pruritus in Cholestasis

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Digestive Diseases

• Publication date

  2014-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1159/000360518PMID 25034299
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Bile acid receptors as targets for drug development

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• Effect of maternal cholestasis on TGR5 expression in human and rat placenta at term.

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• Clinical practice. Chronic pruritus.

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• The TGR5 receptor mediates bile acid-induced itch and analgesia.

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• The Cells and Circuitry for Itch Responses in Mice

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• Bhlhb5 and Prdm8 form a repressor complex involved in neuronal circuit assembly.

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• A subpopulation of nociceptors specifically linked to itch

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• Peripheral mechanisms of itch

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• Ursodeoxycholic acid versus placebo, and early term delivery versus expectant management, in women with intrahepatic cholestasis of pregnancy: semifactorial randomised clinical trial

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• European guideline on chronic pruritus.

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• Mechanisms of Itch Evoked by β-Alanine

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• AUTOIMMUNE , CHOLESTATIC AND BILIARY DISEASE Serum Autotaxin Is Increased in Pruritus of Cholestasis , but Not of Other Origin , and Responds To Therapeutic Interventions

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• TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch

  2011cited by this paper
• Lysophosphatidic acid directly activates TRPV1 through a C-terminal binding site.

  2011cited by this paper
• Insights into autotaxin: how to produce and present a lipid mediator

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• The itch of liver disease.

  2011cited by this paper
• Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids.

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• Farnesoid X receptor agonist for the treatment of liver and metabolic disorders: focus on 6-ethyl-CDCA.

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• Role of Spinal Neurotransmitter Receptors in Itch: New Insights into Therapies and Drug Development

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• Mouse models of acute, chemical itch and pain in humans

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• Pathophysiology and current management of pruritus in liver disease.

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• Autotaxin and LPA receptor signaling in cancer

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• Targeting Nuclear Bile Acid Receptors for Liver Disease

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• VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch.

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• Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice.

  2010cited by this paper
• The potent bile acid sequestrant colesevelam is not effective in cholestatic pruritus: Results of a double‐blind, randomized, placebo‐controlled trial

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• VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch.

  2010cited by this paper
• Supplemental Information Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb 5 mutant mice

  2010cited by this paper
• Lysophosphatidic acid is a potential mediator of cholestatic pruritus.

  2010cited by this paper
• Transgenic expression of interleukin-13 in the skin induces a pruritic dermatitis and skin remodeling.

  2009cited by this paper
• Identification of Igf2, Igfbp2 and Enpp2 as estrogen-responsive genes in rat hippocampus.

  2009cited by this paper
• Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus.

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• EASL Clinical Practice Guidelines: management of cholestatic liver diseases.

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• Intrahepatic cholestasis of pregnancy.

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• Cellular Basis of Itch Sensation

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• Regulation and biological activities of the autotaxin-LPA axis.

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• A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord

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• Endothelin‐1 activates ETA receptors to cause reflex scratching in BALB/c mice

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• Sertraline as a first‐line treatment for cholestatic pruritus

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• Effect of oral naltrexone on pruritus in cholestatic patients.

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• Frontiers in pruritus research: scratching the brain for more effective itch therapy.

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• Ursodeoxycholic acid treatment of vanishing bile duct syndromes.

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• Dermatological Manifestations in Primary Biliary Cirrhosis Patients: A Case Control Study

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• Drug Insight: mechanisms and sites of action of ursodeoxycholic acid in cholestasis

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• Autotaxin Stabilizes Blood Vessels and Is Required for Embryonic Vasculature by Producing Lysophosphatidic Acid*

  2006cited by this paper
• The pruritus of cholestasis.

  2005cited by this paper
• Extrahepatic manifestations of cholestatic liver diseases

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• Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice

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• Itch-Scratch Responses Induced by Lysophosphatidic Acid in Mice

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• Pruritus and fatigue in primary biliary cirrhosis.

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• Natural history of pruritus in primary biliary cirrhosis.

  2003cited by this paper
• Long-term efficacy of sertraline as a treatment for cholestatic pruritus in patients with primary biliary cirrhosis

  2003cited by this paper
• Efficacy and safety of oral naltrexone treatment for pruritus of cholestasis, a crossover, double blind, placebo-controlled study.

  2002cited by this paper
• Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

  2002cited by this paper
• Identification of Human Plasma Lysophospholipase D, a Lysophosphatidic Acid-producing Enzyme, as Autotaxin, a Multifunctional Phosphodiesterase*

  2002cited by this paper
• Liver transplantation for intractable pruritus is contraindicated before an adequate trial of opiate antagonist therapy

  2001cited by this paper
• Management of primary biliary cirrhosis

  2000cited by this paper
• Management of primary biliary cirrhosis. The American Association for the Study of Liver Diseases practice guidelines.

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• The pruritus of cholestasis

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• Extrahepatic manifestations of chronic hepatitis C. MULTIVIRC Group. Multidepartment Virus C.

  1999cited by this paper
• Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia.

  1999cited by this paper
• The pruritus of cholestasis

  1999cited by this paper
• Ursodeoxycholic acid therapy in children with cholestatic liver disease.

  1999cited by this paper
• Primary biliary cirrhosis

  1998cited by this paper
• Systematic cutaneous examination in hepatitis C virus infected patients.

  1998cited by this paper
• Pruritus as a Presenting Symptom of Chronic Hepatitis C

  1998cited by this paper
• Effect of ursodeoxycholic acid therapy on hepatic function in children with intrahepatic cholestatic liver disease.

  1998cited by this paper
• Primary biliary cirrhosis

  1998cited by this paper
• Oral naltrexone treatment for cholestatic pruritus: a double-blind, placebo-controlled study.

  1997cited by this paper
• Specific C-Receptors for Itch in Human Skin

  1997cited by this paper
• Ursodiol for primary sclerosing cholangitis. Mayo Primary Sclerosing Cholangitis-Ursodeoxycholic Acid Study Group.

  1997cited by this paper
• Ursodiol for Primary Sclerosing Cholangitis

  1997cited by this paper
• Pilot study of the use of naltrexone to treat the severe pruritus of cholestatic liver disease.

  1996cited by this paper
• Effect of ursodeoxycholic acid on the kinetics of the major hydrophobic bile acids in health and in chronic cholestatic liver disease

  1992cited by this paper
• Effects of long-term rifampicin administration in primary biliary cirrhosis.

  1992cited by this paper
• Primary biliary cirrhosis: Symptomatic treatment

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• Treatment of pruritus of primary biliary cirrhosis with rifampin

  1991cited by this paper
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• Liver Transplantation

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• Comparison of rifampicin with phenobarbitone for treatment of pruritus in biliary cirrhosis.

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• The incidence of pruritus after epidural morphine

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• Itching after epidural and spinal opiates

  1988cited by this paper
• Treatment of pruritus in primary biliary cirrhosis with rifampin. Results of a double-blind, crossover, randomized trial.

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• The incidence of pruritus after epidural morphine

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• Primary Biliary Cirrhosis

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• Double-blind placebo-controlled clinical trial of microporous cholestyramine in the treatment of intra- and extra-hepatic cholestasis: relationship between itching and serum bile acids.

  1984cited by this paper
• Treatment of pruritus due to chronic obstructive liver disease.

  1984cited by this paper
• Primary biliary cirrhosis--a revised clinical spectrum.

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• THE YALE JOURNAL OF BIOLOGY AND MEDICINE 52 (1979), 77-82 Itch in Liver Disease: Facts and Speculations

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• The presentation and diagnosis of 100 patients with primary biliary cirrhosis.

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• Liver transplantation.

  1967cited by this paper
• Cholestyramine for long term relief of the pruritus complicating intrahepatic cholestasis.

  1966cited by this paper
• Relief of pruritus by cholestyramine in chronic liver disease.

  1965cited by this paper
• PRURITUS AND JAUNDICE.

  1965cited by this paper
• Treatment of Pruritus in Obstructive Jaundice with Methyl Testosterone, Norethandrolone, Cholestyramine and Corn Oil*

  1963cited by this paper
• Treatment of Pruritus of Obstructive Jaundice with Cholestyramine

  1963cited by this paper
• The treatment of pruritus and hypercholesteremia of primary biliary cirrhosis with cholestyramine.

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• Remarkable Response to Odevixibat in an Adult With Progressive Familial Intrahepatic Cholestasis Type 1 and Intractable Pruritus.

  2026cites this paper
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  2026cites this paper
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  2025cites this paper
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  2025cites this paper
• A Retrospective Study of Clinical and Genetic Features in a Long-Term Cohort of Mexican Children with Alagille Syndrome

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• European Guideline on Chronic Pruritus

  2025cites this paper
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• Beyond Staphylococcus: The Cutaneous Microbiome in Itch Pathobiology

  2025cites this paper
• Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch.

  2024cites this paper
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• Pruritus in Dermatology: Part 2 - Diseases and Their Treatment.

  2023cites this paper
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  2023cites this paper
• [[Translated article]]Pruritus in Dermatology: Part 2 - Diseases and Their Treatment.

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