Biomolecular bases of the senescence process and cancer. A new approach to oncological treatment linked to ageing.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Ageing Research Reviews

• Publication date

  2015-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.arr.2015.03.004PMID 25847820
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The tumor-suppressor gene LZTS1 suppresses colorectal cancer proliferation through inhibition of the AKT-mTOR signaling pathway.

  2015cited by this paper
• Prevention of Tumor Growth Driven by PIK3CA and HPV Oncogenes by Targeting mTOR Signaling with Metformin in Oral Squamous Carcinomas Expressing OCT3

  2015cited by this paper
• Silencing miR‐146a influences B cells and ameliorates experimental autoimmune myasthenia gravis

  2015cited by this paper
• The emerging roles of microRNAs in cancer metabolism.

  2015cited by this paper
• Targeting PI3 kinase in cancer.

  2015cited by this paper
• microRNAs: Promising Biomarkers and Therapeutic Targets of Acute Myocardial Ischemia.

  2015cited by this paper
• Potentially therapeutic levels of anti-sickling globin gene expression following lentivirus-mediated gene transfer in sickle cell disease bone marrow CD34+ cells.

  2015cited by this paper
• A systematic review of factors influencing older adults' decision to accept or decline cancer treatment.

  2015cited by this paper
• Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice.

  2015cited by this paper
• miRNAs and aging: a genetic perspective.

  2014cited by this paper
• The evolving understanding of microRNA in bladder cancer.

  2014cited by this paper
• Sirtuins: nodes connecting aging, metabolism and tumorigenesis.

  2014cited by this paper
• Components of cancer metabolism and therapeutic interventions.

  2014cited by this paper
• Tumor Suppression and Promotion by Autophagy

  2014cited by this paper
• A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer

  2014cited by this paper
• Oxidative stress and DNA damage in obesity-related tumorigenesis.

  2014cited by this paper
• DNA damage and lamins.

  2014cited by this paper
• Sperm epigenomics: challenges and opportunities

  2014cited by this paper
• The effects of age upon the expression of three miRNAs in muscle stem cells isolated from two different porcine skeletal muscles.

  2014cited by this paper
• Layered gadolinium-based nanoparticle as a novel delivery platform for microRNA therapeutics

  2014cited by this paper
• An Integrated Analysis of miRNA, lncRNA, and mRNA Expression Profiles

  2014cited by this paper
• Oxidative Stress in Obesity: A Critical Component in Human Diseases

  2014cited by this paper
• Methanol extracts of Euphorbia cooperi inhibit the production of inflammatory mediators by inhibiting the activation of c‑Jun N‑terminal kinase and p38 in murine macrophages.

  2014cited by this paper
• Contribution of p53 to metastasis.

  2014cited by this paper
• Geroconversion: irreversible step to cellular senescence

  2014cited by this paper
• Histone Deacetylases

  2014cited by this paper
• Physiological and pathological consequences of cellular senescence

  2014cited by this paper
• MicroRNA-100 promotes migration and invasion through mammalian target of rapamycin in esophageal squamous cell carcinoma.

  2014cited by this paper
• Common features of chromatin in aging and cancer: cause or coincidence?

  2014cited by this paper
• Biology of cancer and aging: a complex association with cellular senescence.

  2014cited by this paper
• Geriatric muscle stem cells switch reversible quiescence into senescence

  2014cited by this paper
• Age-dependent increase in miRNA-34a expression in the posterior pole of the mouse eye

  2014cited by this paper
• Tumor suppressive miRNA-34a suppresses cell proliferation and tumor growth of glioma stem cells by targeting Akt and Wnt signaling pathways

  2014cited by this paper
• Translational suppression of HIF-1α by miconazole through the mTOR signaling pathway

  2014cited by this paper
• Roles of tumor suppressors in regulating tumor-associated inflammation

  2014cited by this paper
• Microglia change from a reactive to an age-like phenotype with the time in culture

  2014cited by this paper
• Functional interactions among microRNAs and long noncoding RNAs.

  2014cited by this paper
• Comparative Analysis of Gene Expression Data Reveals Novel Targets of Senescence-Associated microRNAs

  2014cited by this paper
• Oxidative stress in Alzheimer’s disease

  2014cited by this paper
• Interleukins in chronic liver disease: lessons learned from experimental mouse models

  2014cited by this paper
• Battle Against Cancer: An Everlasting Saga of p53

  2014cited by this paper
• Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?☆

  2014cited by this paper
• Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion

  2014cited by this paper
• Role of microRNAs in skeletal muscle hypertrophy

  2014cited by this paper
• Sirtuins: guardians of mammalian healthspan.

  2014cited by this paper
• SIRT3 is a novel prognostic biomarker for esophageal squamous cell carcinoma

  2014cited by this paper
• Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5·24 million UK adults

  2014cited by this paper
• MicroRNA 145 may play an important role in uveal melanoma cell growth by potentially targeting insulin receptor substrate‐1

  2014cited by this paper
• Multimodality treatment of potentially curative gastric cancer: geographical variations and future prospects.

  2014cited by this paper
• Antioxidants, inflammation and cardiovascular disease.

  2014cited by this paper
• Energy crisis: the role of oxidative phosphorylation in acute inflammation and sepsis.

  2014cited by this paper
• Mitochondrial DNA Aberrations and Pathophysiological Implications in Hematopoietic Diseases, Chronic Inflammatory Diseases, and Cancers

  2014cited by this paper
• The mitochondrial genome in aging and senescence.

  2014cited by this paper
• Hypothalamic miR-103 Protects from Hyperphagic Obesity in Mice

  2014cited by this paper
• Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming

  2014cited by this paper
• Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?

  2014cited by this paper
• The hallmarks of aging.

  2013cited by this paper
• Immunosuppressants in cancer prevention and therapy

  2013cited by this paper
• The Warburg effect: insights from the past decade.

  2013cited by this paper
• Role of Redox Signaling in Neuroinflammation and Neurodegenerative Diseases

  2013cited by this paper
• miR-101 inhibits autophagy and enhances cisplatin-induced apoptosis in hepatocellular carcinoma cells.

  2013cited by this paper
• Up-regulation of NEK2 by MicroRNA-128 Methylation is Associated with Poor Prognosis in Colorectal Cancer

  2013cited by this paper
• The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling.

  2013cited by this paper
• The Role of SIRT6 Protein in Aging and Reprogramming of Human Induced Pluripotent Stem Cells*

  2013cited by this paper
• MicroRNA-34a regulates cardiac ageing and function

  2013influential reference
• Accelerated Aging in Major Depression: The Role of Nitro-Oxidative Stress

  2013cited by this paper
• MicroRNA miR‐24 promotes cell proliferation by targeting the CDKs inhibitors p27Kip1 and p16INK4a

  2013cited by this paper
• Senescence regulation by the p53 protein family.

  2013cited by this paper
• Overexpression of CDCA2 in Human Squamous Cell Carcinoma: Correlation with Prevention of G1 Phase Arrest and Apoptosis

  2013cited by this paper
• Aging, cellular senescence, and cancer.

  2013cited by this paper
• Mitochondrial Dysfunction in Cancer

  2013cited by this paper
• The role of the T cell in age-related inflammation

  2013cited by this paper
• Calorie restriction and sirtuins revisited

  2013cited by this paper
• Can exercise-related improvements in immunity influence cancer prevention and prognosis in the elderly?

  2013cited by this paper
• Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease

  2013cited by this paper
• The role of mitochondrial OXPHOS dysfunction in the development of neurologic diseases.

  2013cited by this paper
• Aging: seeking mitonuclear balance.

  2013cited by this paper
• DNA Damage in Inflammation-Related Carcinogenesis and Cancer Stem Cells

  2013cited by this paper
• The GH/IGF-1 axis in ageing and longevity

  2013cited by this paper
• Oxidative Stress in Aging-Matters of the Heart and Mind

  2013cited by this paper
• A regulatory circuit of miR-148a/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1.

  2013cited by this paper
• T cell replicative senescence in human aging.

  2013cited by this paper
• Histone methylation makes its mark on longevity.

  2012cited by this paper
• miR-34 – a microRNA replacement therapy is headed to the clinic

  2012cited by this paper
• The microcosmos of cancer

  2012cited by this paper
• Differential activation and functional specialization of miR-146 and miR-155 in innate immune sensing

  2012cited by this paper
• mTOR signalling: the molecular interface connecting metabolic stress, aging and cardiovascular diseases

  2012cited by this paper
• Senescence; an endogenous anticancer mechanism.

  2012cited by this paper
• Transcription factor FoxO1, the dominant mediator of muscle wasting in chronic kidney disease, is inhibited by microRNA-486

  2012cited by this paper
• “Is obesity linked to aging?” Adipose tissue and the role of telomeres

  2012cited by this paper
• mTOR signaling in growth control and disease.

  2012cited by this paper
• A Molecular Mechanism for Direct Sirtuin Activation by Resveratrol

  2012cited by this paper
• MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer

  2012cited by this paper
• Histone H2AX phosphorylation: a marker for DNA damage.

  2012cited by this paper
• Axis of ageing: telomeres, p53 and mitochondria

  2012cited by this paper
• Role of CD8 T Cell Replicative Senescence in Human Aging and in HIV-mediated Immunosenescence.

  2011cited by this paper
• HIV infection, inflammation, immunosenescence, and aging.

  2011cited by this paper
• Cellular aging and cancer.

  2011cited by this paper
• Four faces of cellular senescence

  2011cited by this paper
• The role of DNA damage in laminopathy progeroid syndromes.

  2011cited by this paper

• Analysis of prognostic factors and risk prediction in brain metastases: a SEER population-based study

  2025cites this paper
• Pan-cancer transcriptomic analysis identified six classes of immunosenescence genes revealed molecular links between aging, immune system and cancer

  2023cites this paper
• Stem Cell Therapy and Rejuvenation, and Their Impact on Society

  2023cites this paper
• Mechanism of Action of Cyanidin 3-O-Glucoside in Gluconeogenesis and Oxidative Stress-Induced Cancer Cell Senescence

  2022cites this paper
• Is There Such a Thing as a Genuine Cancer Stem Cell Marker? Perspectives from the Gut, the Brain and the Dental Pulp.

  2020cites this paper
• Cancer and older adult patient care

  2020cites this paper
• Is There Such a Thing as a Genuine Cancer Stem Cell Marker? Perspectives from the Gut, the Brain and the Dental Pulp

  2020cites this paper
• Prospective evaluation of functional brain activity and oxidative damage in breast cancer: changes in task-induced deactivation during a working memory task

  2020cites this paper
• Redox Balance-DDR-miRNA Triangle: Relevance in Genome Stability and Stress Responses in Plants

  2019cites this paper
• Episodic memory for visual scenes suggests compensatory brain activity in breast cancer patients: a prospective longitudinal fMRI study

  2019cites this paper
• Roles of Forkhead Box O (FoxO) Transcription Factors in Neurodegenerative Diseases: A panoramic view.

  2019cites this paper
• Stress-Induced Premature Senescence Promotes Proliferation by Activating the SENEX and p16INK4a/Retinoblastoma (Rb) Pathway in Diffuse Large B-Cell Lymphoma

  2019cites this paper
• N-Acetyl Cysteine as a Novel Polymethyl Methacrylate Resin Component: Protection against Cell Apoptosis and Genotoxicity

  2019cites this paper
• Effect of Moxibustion on Testosterone Secretion and Apoptosis of Spermatogenic Cells in Aging Rats

  2019cites this paper
• Integrated analysis of colorectal cancer microRNA datasets: identification of microRNAs associated with tumor development

  2018cites this paper
• The Role of Senescence in Hepatic Diseases

  2017cites this paper
• Arctigenin induced gallbladder cancer senescence through modulating epidermal growth factor receptor pathway

  2017cites this paper
• Double staining of β-galactosidase with fibrosis and cancer markers reveals the chronological appearance of senescence in liver carcinogenesis induced by diethylnitrosamine.

  2016cites this paper
• Ultraconserved region-containing Transformer 2β4 controls senescence of colon cancer cells

  2016cites this paper
• Cancer-related cognitive impairment in older adults

  2016cites this paper
• ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases

  2016cites this paper
• Targeting mTOR signaling by polyphenols: A new therapeutic target for ageing.

  2016cites this paper
• Explorer ROS , Cell Senescence , and Novel Molecular Mechanisms in Aging and Age-Related Diseases

  2016cites this paper